Abstract：
:The Adenomatous polyposis coli (Apc) gene is mutated in up to 80% of sporadic colorectal cancers. After Apc loss, there is deregulation of the Wnt signaling pathway and transactivation of T-cell factor/leukemia enhancing factor target genes such as C-Myc. This review focuses on recent data highlighting the importance of the C-Myc oncogene and its transcriptional targets in establishing all of the phenotypes caused by the deletion of the Apc tumor suppressor gene within the intestinal epithelium. The importance of investigating Apc and C-Myc gene function in the correct tissue context is also discussed.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Wilkins JA,Sansom OJdoi
10.1158/0008-5472.CAN-07-5558subject
Has Abstractpub_date
2008-07-01 00:00:00pages
4963-6issue
13eissn
0008-5472issn
1538-7445pii
68/13/4963journal_volume
68pub_type
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