Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation.

abstract：:Destruction of cancer cells by cytotoxic T lymphocytes depends on immunogenic tumor peptides generated by proteasomes and presented by human leukocyte antigen (HLA) molecules. Functional differences arising from alleles of immunoproteasome subunits have not been recognized so far. We analyzed the genetic polymorphism ...

journal_title：Cancer research

authors： Fellerhoff B,Gu S,Laumbacher B,Nerlich AG,Weiss EH,Glas J,Kopp R,Johnson JP,Wank R

更新日期：2011-12-01 00:00:00

abstract：:Cancers of the upper aerodigestive tract (UADT) include malignant tumors of the oral cavity, pharynx, larynx, and esophagus and account for 6.4% of all new cancers in Europe. In the context of a multicenter case-control study conducted in 14 centers within 10 European countries and comprising 1,511 cases and 1,457 con...

journal_title：Cancer research

authors： Canova C,Hashibe M,Simonato L,Nelis M,Metspalu A,Lagiou P,Trichopoulos D,Ahrens W,Pigeot I,Merletti F,Richiardi L,Talamini R,Barzan L,Macfarlane GJ,Macfarlane TV,Holcátová I,Bencko V,Benhamou S,Bouchardy C,Kjaerheim

更新日期：2009-04-01 00:00:00

abstract：:Aberrant cholesterol metabolism is increasingly appreciated to be essential for prostate cancer initiation and progression. Transcript expression of the high-density lipoprotein-cholesterol receptor scavenger receptor B1 (SR-B1) is elevated in primary prostate cancer. Hypothesizing that SR-B1 expression may help facil...

journal_title：Cancer research

authors： Gordon JA,Noble JW,Midha A,Derakhshan F,Wang G,Adomat HH,Tomlinson Guns ES,Lin YY,Ren S,Collins CC,Nelson PS,Morrissey C,Wasan KM,Cox ME

更新日期：2019-07-01 00:00:00

abstract：:Lymphoid cell subpopulations infiltrating into autografts of methylcholanthrene-induced sarcomas in rats immunized with autologous tumor cells were identified in terms of immunohistochemical and cytofluorographic techniques using various monoclonal antibodies raised against different classes of rat lymphohemopoietic c...

journal_title：Cancer research

authors： Ishii Y,Matsuura A,Takami T,Uede T,Ibayashi Y,Uede T,Imamura M,Kikuchi K,Kikuchi Y

更新日期：1984-09-01 00:00:00

abstract：:A new tumor cell line, designated SU-CCS-1, was established from the malignant pleural effusion of a 16-year-old Caucasian girl with clear cell sarcoma. Morphological studies at the light- and electron-microscopic levels revealed similar features between the SU-CCS-1 cells and the primary tumor. Ultrastructural and cy...

journal_title：Cancer research

authors： Epstein AL,Martin AO,Kempson R

更新日期：1984-03-01 00:00:00

abstract：:Single-chain antigen-binding proteins, or sFvs, represent potentially unique molecules for targeted delivery of drugs, toxins, or radionuclides to a tumor site. In previous studies (Cancer Res., 51:6363-6371, 1991) using a human colon carcinoma xenograft model, it was demonstrated that the sFv has an extremely rapid p...

journal_title：Cancer research

authors： Yokota T,Milenic DE,Whitlow M,Schlom J

更新日期：1992-06-15 00:00:00

abstract：:Nitric oxide (NO) is a potent tumor radiosensitizer; however, its clinical use is limited by systemic side effects. We have demonstrated previously that gene transfer of the human inducible NO synthase (iNOS) gene into tumor cells and tumors induces high-output NO production that significantly enhances tumor radioresp...

journal_title：Cancer research

authors： Cook T,Wang Z,Alber S,Liu K,Watkins SC,Vodovotz Y,Billiar TR,Blumberg D

更新日期：2004-11-01 00:00:00

abstract：:Treatment of male rats with the anticancer drug cisplatin leads to feminization of the profile of cytochrome P-450 and other microsomal enzymes involved in steroid hormone and drug metabolism (G.A. LeBlanc, and D.J. Waxman, J. Biol. Chem., 263: 15732-15739, 1988). The present study uses the rat model to evaluate the d...

journal_title：Cancer research

authors： LeBlanc GA,Sundseth SS,Weber GF,Waxman DJ

更新日期：1992-02-01 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is the sixth most common cancer in women worldwide and, despite advances in detection and therapies, it still represents the most lethal gynecologic malignancy in the industrialized countries. Unfortunately, still relatively little is known about the molecular events that lead to the de...

journal_title：Cancer research

authors： Iorio MV,Visone R,Di Leva G,Donati V,Petrocca F,Casalini P,Taccioli C,Volinia S,Liu CG,Alder H,Calin GA,Ménard S,Croce CM

更新日期：2007-09-15 00:00:00

abstract：:Recent in vitro studies of the epidermal growth factor receptor (EGFR) family have revealed complex signaling interactions involving the production of ligand-mediated heterodimers synergistic for the transformation of cells in vitro. In a series of 70 patients with childhood medulloblastoma, we have used immunohistoch...

journal_title：Cancer research

authors： Gilbertson RJ,Perry RH,Kelly PJ,Pearson AD,Lunec J

更新日期：1997-08-01 00:00:00

abstract：:The intranuclear mitosis of the plasmodial nuclei of myxomycetes permits the observation of defects in chromosomal repartition which would probably be lethal in other eukaryotic cells with open mitosis. We found that antitumoral platinum-amine compounds perturbed late mitotic events and induced the formation of giant ...

journal_title：Cancer research

authors： Wright M,Lacorre-Arescaldino I,Macquet JP,Daffé M

更新日期：1984-02-01 00:00:00

abstract：:Taxane antineoplastic agents are extensively taken up into hepatocytes by OATP1B-type transporters before metabolism and excretion. Because the biodistributional properties imposed upon these agents by different solubilizers drive clinically important pharmacodynamic endpoints, we tested the hypothesis that the in vit...

journal_title：Cancer research

authors： Nieuweboer AJ,Hu S,Gui C,Hagenbuch B,Ghobadi Moghaddam-Helmantel IM,Gibson AA,de Bruijn P,Mathijssen RH,Sparreboom A

更新日期：2014-06-01 00:00:00

abstract：:Human kallikrein 10 (hK10) is a secreted serine protease that is highly expressed in ovarian tissue. We hypothesized that hK10 might represent a novel serological marker for ovarian cancer. We quantified by immunoassay, hK10 in sera from 97 normal women (controls), 141 patients with benign gynecologic diseases, and 14...

journal_title：Cancer research

authors： Luo LY,Katsaros D,Scorilas A,Fracchioli S,Bellino R,van Gramberen M,de Bruijn H,Henrik A,Stenman UH,Massobrio M,van der Zee AG,Vergote I,Diamandis EP

更新日期：2003-02-15 00:00:00

abstract：:High-resolution magic angle spinning proton (HRMAS 1H) magnetic resonance spectroscopy produces well-resolved spectra of metabolites from intact tissue specimens. Here we report the results of a preliminary study of 19 human brain tumors obtained by applying this method. Among these 19 cases were 2 low-grade astrocyto...

journal_title：Cancer research

authors： Cheng LL,Chang IW,Louis DN,Gonzalez RG

更新日期：1998-05-01 00:00:00

abstract：:The HMGA1 protein is a major factor in chromatin architecture and gene control. It plays a critical role in neoplastic transformation. In fact, blockage of HMGA1 synthesis prevents rat thyroid cell transformation by murine transforming retroviruses, and an adenovirus carrying the HMGA1 gene in the antisense orientatio...

journal_title：Cancer research

authors： Fedele M,Fidanza V,Battista S,Pentimalli F,Klein-Szanto AJ,Visone R,De Martino I,Curcio A,Morisco C,Del Vecchio L,Baldassarre G,Arra C,Viglietto G,Indolfi C,Croce CM,Fusco A

更新日期：2006-03-01 00:00:00

abstract：:The in vitro effects of deoxyadenosine and an adenosine deaminase inhibitor, deoxycoformycin, on the synthesis of DNA and the metabolism of purines were investigated in human leukemic T-cells. In the presence of 10 microM deoxycoformycin, the synthesis of DNA was completely inhibited by concentrations of deoxyadenosin...

journal_title：Cancer research

authors： Yu AL,Bakay B,Kung FH,Nyhan WL

更新日期：1981-07-01 00:00:00

abstract：:Procarbazine, a chemotherapeutic hydrazine, is thought to be metabolized to an alkylating species similar to methyl carbonium ion by multistep reactions involving cytochrome P-450, monoamine oxidase, and cytosolic enzymes. The DNA-damaging and cytotoxic potential of procarbazine and its metabolites in murine L1210 leu...

journal_title：Cancer research

authors： Erikson JM,Tweedie DJ,Ducore JM,Prough RA

更新日期：1989-01-01 00:00:00

abstract：:We used three techniques to examine excision repair in human cells treated with ultraviolet radiation, N-acetoxy-2-acetylaminofluorene, and a combination of the two. The three techniques gave similar results. Two types of human cells were used: (a) excision repair proficient (normal human fibroblasts and xeroderma pig...

journal_title：Cancer research

authors： Ahmed FE,Setlow RB

更新日期：1979-02-01 00:00:00

abstract：:The present work compared the blood variations in some committed stem cells (CSC), and corresponding differentiated WBC during the first three courses of a 6-day sequential chemotherapy given to 16 breast cancer patients for 28 days each. The granulomonocytic and lymphocytic colony-forming unit levels in blood were si...

journal_title：Cancer research

authors： Rusé-Riol F,Legros M,Bernard D,Chassagne J,Clavel H,Ferriere JP,Chollet P,Plagne R

更新日期：1984-05-01 00:00:00

abstract：:BCL2 suppresses apoptosis by binding the BH3 domain of proapoptotic factors and thereby regulating outer mitochondrial membrane permeabilization. Many tumor types, including B-cell lymphomas and chronic lymphocytic leukemia, are dependent on BCL2 for survival but become resistant to apoptosis after treatment. Here, we...

journal_title：Cancer research

authors： Dutta C,Day T,Kopp N,van Bodegom D,Davids MS,Ryan J,Bird L,Kommajosyula N,Weigert O,Yoda A,Fung H,Brown JR,Shapiro GI,Letai A,Weinstock DM

更新日期：2012-08-15 00:00:00

abstract：:Normal or immortal epithelial cells are sensitive to a form of apoptosis, commonly referred to as anoikis, which is induced by detachment from the extracellular matrix (ECM). In contrast, development of carcinomas is associated with acquisition of cellular resistance to anoikis. However, whether human cancer cells dep...

journal_title：Cancer research

authors： Frankel A,Rosen K,Filmus J,Kerbel RS

更新日期：2001-06-15 00:00:00

abstract：:p53 is regulated at multiple levels. We report here that p53, in multiple lines of human cancer cells, is down-regulated by cardiac glycoside drugs digoxin and ouabain, potent inhibitors of Na(+)/K(+)-ATPase. These drugs reduced the basal levels of p53 protein at nanomolar concentrations in a dose-, time-, and cancer ...

journal_title：Cancer research

authors： Wang Z,Zheng M,Li Z,Li R,Jia L,Xiong X,Southall N,Wang S,Xia M,Austin CP,Zheng W,Xie Z,Sun Y

更新日期：2009-08-15 00:00:00

abstract：:Insulin-like growth factor (IGF) I has important growth regulatory functions in normal growth and development. IGF-I is also a mitogen for a number of cancer cell lines; however, its autocrine effect has not been well established. In this study, the expression of IGF-I, its receptor, and its major serum-binding protei...

journal_title：Cancer research

authors： Lee TC,Zhang Y,Aston C,Hintz R,Jagirdar J,Perle MA,Burt M,Rom WN

更新日期：1993-06-15 00:00:00

abstract：:Three Burkitt's lymphoma cell lines were studied for their response to cis-diamminedichloroplatinum(II) (cis-DDP) and L-phenylalanine mustard (L-PAM) with the objective of relating cytotoxicity to DNA cross-linking in human cells. Cytotoxicity was measured by cell proliferation and colony formation assays. DNA interst...

journal_title：Cancer research

authors： Ducore JM,Erickson LC,Zwelling LA,Laurent G,Kohn KW

更新日期：1982-03-01 00:00:00

abstract：:In 1956, Otto Warburg proposed that the origin of cancer cells was closely linked to a permanent respiratory defect that bypassed the Pasteur effect (i.e., the inhibition of anaerobic fermentation by oxygen). Since then, permanent defects in oxygen consumption that could explain the dependence of cancer cells on aerob...

journal_title：Cancer research

authors： Samudio I,Fiegl M,McQueen T,Clise-Dwyer K,Andreeff M

更新日期：2008-07-01 00:00:00

abstract：:The caudal-related homeobox transcription factor CDX2 has a key role in intestinal development and differentiation. CDX2 heterozygous mutant mice develop colonic polyps, and loss of CDX2 expression is seen in a subset of colon carcinomas in humans. Ectopic CDX2 expression in the stomach of transgenic mice promotes int...

journal_title：Cancer research

authors： Takakura Y,Hinoi T,Oue N,Sasada T,Kawaguchi Y,Okajima M,Akyol A,Fearon ER,Yasui W,Ohdan H

更新日期：2010-09-01 00:00:00

abstract：:Colorectal cancers with widespread CpG island methylation display a number of distinct clinicopathological features, and it has been suggested that the condition has an inheritable genetic component. To address this possibility, histories of cancer were obtained from 562 individuals undergoing curative surgery for uns...

journal_title：Cancer research

authors： Ward RL,Williams R,Law M,Hawkins NJ

更新日期：2004-10-15 00:00:00

abstract：:Stem cells are under strict regulation by both intrinsic factors and the microenvironment. There is increasing evidence that many cancers initiate through acquisition of genetic mutations (loss of intrinsic control) in stem cells or their progenitors, followed by alterations of the surrounding microenvironment (loss o...

journal_title：Cancer research

authors： Le LQ,Liu C,Shipman T,Chen Z,Suter U,Parada LF

更新日期：2011-07-01 00:00:00

abstract：:Tumor production of parathyroid hormone-related protein (PTHRP) is responsible for most cases of hypercalcemia of malignancy. The transplantable rat Leydig tumor H-500 is known to cause hypercalcemia in rats by the release of abundant PTHRP and to closely reproduce the human syndrome. We have demonstrated recently tha...

journal_title：Cancer research

authors： Aklilu F,Gladu J,Goltzman D,Rabbani SA

更新日期：2000-03-15 00:00:00

abstract：:Five patients with tongue carcinoma were treated for 20 days with bleomycin, 15 mg/day, given by one-shot infusion through the superficial temporal artery. Specimens were taken 7, 14, and 20 days after the initial administration for light and electron microscope observations. The first alterations observed were the de...

journal_title：Cancer research

authors： Yasuzumi G,Hyo Y,Hoshiya T,Yasuzumi F

更新日期：1976-10-01 00:00:00