Upregulation of Scavenger Receptor B1 Is Required for Steroidogenic and Nonsteroidogenic Cholesterol Metabolism in Prostate Cancer.

abstract：:Insulin receptor (IR) exists as two isoforms resulting from the alternative splicing of IR pre-mRNA. IR-B promotes the metabolic effects of insulin, whereas IR-A rather signals proliferative effects. IR-B is predominantly expressed in the adult liver. Here, we show that the alternative splicing of IR pre-mRNA is dysre...

journal_title：Cancer research

authors： Chettouh H,Fartoux L,Aoudjehane L,Wendum D,Clapéron A,Chrétien Y,Rey C,Scatton O,Soubrane O,Conti F,Praz F,Housset C,Rosmorduc O,Desbois-Mouthon C

更新日期：2013-07-01 00:00:00

abstract：:Delivery of therapeutic agents to the brain and its neoplasms depends on the presence of membrane transport proteins in the blood-brain barrier and in the target cells. The cellular and subcellular localization of these membrane transporters determines the drug accessibility to the brain and its tumors. We therefore a...

journal_title：Cancer research

authors： Bronger H,König J,Kopplow K,Steiner HH,Ahmadi R,Herold-Mende C,Keppler D,Nies AT

更新日期：2005-12-15 00:00:00

abstract：:This report describes an early and direct action of oncogenic agents and its apparent consequences. Chemical carcinogen has been found to interact principally with a specific polypeptide in livers of normal rats. Short-term ingestion of carcinogen causes marked reductions in the concentrations of both the carcinogen:p...

journal_title：Cancer research

authors： Blackburn GR,Andrews JP,Rao KV,Sorof S

更新日期：1980-12-01 00:00:00

abstract：:The effect of caerulein on the incidence and histology of gastric adenocarcinomas induced by N-methyl-N'-nitro-N-nitrosoguanidine was investigated in inbred Wistar rats. Prolonged alternate-day administration of caerulein at 10 micrograms/kg body weight after treatment with the carcinogen for 20 weeks significantly in...

journal_title：Cancer research

authors： Tatsuta M,Iishi H,Baba M,Yamamura H,Taniguchi H

更新日期：1988-11-15 00:00:00

abstract：:We cloned mouse ING1 homologue (mINGh), an A1/Bfl-1-interacting protein, from mouse mammary glands using a yeast two-hybrid assay and unexpectedly found four splicing variants of mINGh by reverse transcription-PCR assay and sequence analysis. The alternative splicing variants were mINGh-S, mINGh-M, mINGh-L, and mINGh-...

journal_title：Cancer research

authors： Ha S,Lee S,Chung M,Choi Y

更新日期：2002-03-01 00:00:00

abstract：:Many vaccines are dependent on adjuvants to augment the immunizing process. The vaccines being developed for active specific immunotherapy of cancer have also usually included an adjuvant in the clinical studies. Several cytokines have been identified which are participants in the immune response to new antigenic stim...

journal_title：Cancer research

authors： McCune CS,Marquis DM

更新日期：1990-02-15 00:00:00

abstract：:Hypoxia drives malignant progression in part by promoting accumulation of the oncogenic transcription factor hypoxia inducible factor-1α (HIF-1α) in tumor cells. Tumor aggressiveness also relates to elevation of the cancer stem cell-associated membrane protein CD24, which has been causally implicated in tumor formatio...

journal_title：Cancer research

authors： Thomas S,Harding MA,Smith SC,Overdevest JB,Nitz MD,Frierson HF,Tomlins SA,Kristiansen G,Theodorescu D

更新日期：2012-11-01 00:00:00

abstract：:Tumorigenesis can arise from inappropriate activation of developmental genes in mature tissues. Here, we show that the developmental regulator Six1 is overexpressed in ovarian carcinoma cell lines (OCC) compared with normal ovarian surface epithelium. As observed in other cancers, Six1 overexpression in OCC leads to i...

journal_title：Cancer research

authors： Behbakht K,Qamar L,Aldridge CS,Coletta RD,Davidson SA,Thorburn A,Ford HL

更新日期：2007-04-01 00:00:00

abstract：:Cultures of adult mouse epidermal keratinocytes (MEKs) were utilized to determine whether the metabolism and metabolic activation of polycyclic aromatic hydrocarbons varied as a function of extracellular calcium (Ca2+) concentration. MEKs grown in low Ca2+-containing medium (0.05-0.10 mM) maintain basal cell morpholog...

journal_title：Cancer research

authors： DiGiovanni J,Gill RD,Nettikumara AN,Colby AB,Reiners JJ Jr

更新日期：1989-10-15 00:00:00

abstract：:Aflatoxicol, R0, was isolated from Mt. Shasta strain rainbow trout (Salmo gairdneri), and liver homogenates were incubated with aflatoxin B1. Its identity was confirmed by mass, infrared, and ultraviolet spectrometry. The structure was identical to one of the diastereomers prepared by chemical reduction of aflatoxin B...

journal_title：Cancer research

authors： Schoenhard GL,Lee DJ,Howell SE,Pawlowski NE,Libbey LM,Sinnhuber RO

更新日期：1976-06-01 00:00:00

abstract：:A single i.p. injection of butylated hydroxytoluene (BHT) 6 h before a single urethan injection had varying effects on lung tumorigenesis in mice of different strains and ages. Strains exhibiting both high (A/J, SWR/J) and low (BALB/cByJ, 129/J, C57BL/6J) susceptibility to urethan tumorigenesis were tested in this stu...

journal_title：Cancer research

authors： Malkinson AM,Thaete LG

更新日期：1986-04-01 00:00:00

abstract：:Cytochrome P450 aromatase (aromatase), a product of the CYP19 gene, catalyzes the synthesis of estrogens from androgens. Given the significance of estrogen synthesis in hormone-dependent breast carcinogenesis, it is important to elucidate the mechanisms that regulate CYP19 expression. The main objective of this study ...

journal_title：Cancer research

authors： Subbaramaiah K,Howe LR,Port ER,Brogi E,Fishman J,Liu CH,Hla T,Hudis C,Dannenberg AJ

更新日期：2006-05-15 00:00:00

abstract：:Deleterious mutations of the ubiquitin carboxy-terminal hydrolase BAP1 found in cancers are predicted to encode inactive truncated proteins, suggesting that loss of enzyme function is a primary tumorigenic mechanism. However, many tumors exhibit missense mutations or in-frame deletions or insertions, often outside the...

journal_title：Cancer research

authors： Peng H,Prokop J,Karar J,Park K,Cao L,Harbour JW,Bowcock AM,Malkowicz SB,Cheung M,Testa JR,Rauscher FJ 3rd

更新日期：2018-03-01 00:00:00

abstract：:Emerging evidence indicates the presence of tumor-initiating cells (TIC) or cancer stem cells in osteosarcoma. However, no study has shown specific markers to identify osteosarcoma TICs with in vivo tumor formation ability. Additionally, there has been a lack of investigations gauging the contribution of osteosarcoma ...

journal_title：Cancer research

authors： Adhikari AS,Agarwal N,Wood BM,Porretta C,Ruiz B,Pochampally RR,Iwakuma T

更新日期：2010-06-01 00:00:00

abstract：:The estimated growth rates for five lines of human fibroblasts (Human Genetic Mutant Cell Repository designations 0011, 2936B , 0038A , 2912A , and 3529), during the first few population doublings after establishment of the lines, were within the expected range, i.e., equivalent to doubling times from 16 to 28 hr, wit...

journal_title：Cancer research

authors： Tamm I,Kikuchi T,Wang E,Pfeffer LM

更新日期：1984-06-01 00:00:00

abstract：:Hybridoma-derived monoclonal anti-colorectal carcinoma antibodies suppressed the growth of colorectal carcinoma in nude mice as evidenced by a lower incidence of tumors, a longer latency period, and a smaller volume of tumors in antibody-treated than in control animals. The growth-inhibiting properties of monoclonal a...

journal_title：Cancer research

authors： Herlyn DM,Steplewski Z,Herlyn MF,Koprowski H

更新日期：1980-03-01 00:00:00

abstract：:Mean plasma hypoxanthine (Hyp) concentrations determined by high-pressure liquid chromatography were 0.56 microM (range, 0.2 to 1.9 microM) in 16 normal subjects, 0.68 microM (range, 0.1 to 1.1 microM) in 10 untreated acute leukemic subjects, and 0.89 microM (range, 0.3 to 2.6 microM) in 14 solid tumor patients. Despi...

journal_title：Cancer research

authors： Wung WE,Howell SB

更新日期：1984-07-01 00:00:00

abstract：:The pathogenesis of 210Po-induced tumors in the peripheral lung of Syrian golden hamsters has been studied in a serial sacrifice experiment utilizing both plastic (glycol methacrylate) and routine paraffin embedding procedures for lung sections. A rapid progression from hyperplasia of bronchiolar-type cells that appea...

journal_title：Cancer research

authors： Kennedy AR,McGundy RB,Little JB

更新日期：1978-04-01 00:00:00

abstract：:The antitumor effects of two immunotoxins were evaluated in vitro and in vivo against the human ovarian carcinoma cell line, OVCAR-3. The immunotoxins used were composed of recombinant ricin A chain (rRTA) covalently attached to a monoclonal antibody directed toward the human transferrin receptor (45412/rRTA, also cal...

journal_title：Cancer research

authors： Pearson JW,Hedrick E,Fogler WE,Bull RL,Ferris DK,Riggs CW,Wiltrout RH,Sivam G,Morgan AC,Groves E

更新日期：1990-10-01 00:00:00

abstract：:To test the hypothesis that genetic instability correlates with malignant potential, we compared the rate of generation of marker chromosomal abnormalities in clones of B16 F1 and B16 F10 murine melanoma. These rates were estimated through an adaptation of fluctuation analysis of Luria and Delbruck (S. E. Luria and M....

journal_title：Cancer research

authors： Kendal WS,Wang RY,Hsu TC,Frost P

更新日期：1987-07-15 00:00:00

abstract：:The antitumor activity of combination therapy with recombinant tumor necrosis-alpha (rhTNF-alpha) and recombinant interleukin-2 (rhIL-2) was assessed against established immunogenic (MCA-106) and nonimmunogenic (MCA-102) sarcomas at both s.c. and visceral (hepatic) sites. C57BL/6 (B6) mice were treated with a single i...

journal_title：Cancer research

authors： McIntosh JK,Mulé JJ,Merino MJ,Rosenberg SA

更新日期：1988-07-15 00:00:00

abstract：:Changes in the structure of the surface of mastocytoma cells were induced by hyperthermia and were investigated by means of cell electrophoresis. A decrease in the cell electrophoretic mobility was detected as early as 15 min after treatment at 42 degrees and progressed more rapidly under hypoxic conditions than under...

journal_title：Cancer research

authors： Sato C,Nakayama T,Kojima K,Nishimoto Y,Nakamura W

更新日期：1981-10-01 00:00:00

abstract：:Monoclonal antibodies (MoAbs) against human osteosarcoma cells were obtained by the fusion of NS/1 mouse myeloma cells with spleen cells from the human osteosarcoma cell line-immunized BALB/c mice. Two hybrid clones were established and designated as 2H10 and 2D3. Both MoAbs reacted strongly with all osteosarcoma tiss...

journal_title：Cancer research

authors： Wada T,Uede T,Ishii S,Matsuyama K,Yamawaki S,Kikuchi K

更新日期：1988-04-15 00:00:00

abstract：:BCL2 suppresses apoptosis by binding the BH3 domain of proapoptotic factors and thereby regulating outer mitochondrial membrane permeabilization. Many tumor types, including B-cell lymphomas and chronic lymphocytic leukemia, are dependent on BCL2 for survival but become resistant to apoptosis after treatment. Here, we...

journal_title：Cancer research

authors： Dutta C,Day T,Kopp N,van Bodegom D,Davids MS,Ryan J,Bird L,Kommajosyula N,Weigert O,Yoda A,Fung H,Brown JR,Shapiro GI,Letai A,Weinstock DM

更新日期：2012-08-15 00:00:00

abstract：:The metastasizing MDAY-D2 tumor of DBA/2 mice disseminates in BALB/c allogeneic athymic nude (nu/nu) mice in a manner identical to that observed in the syngeneic host. Both the kinetics and organ distribution pattern of metastases from s.c. implants of MDAY-D2 are routinely predictable at any given tumor dose. BALB/c ...

journal_title：Cancer research

authors： Wiltrout RH,Frost P,Morrison MK,Kerbel RS

更新日期：1979-10-01 00:00:00

abstract：:Three Burkitt's lymphoma cell lines were studied for their response to cis-diamminedichloroplatinum(II) (cis-DDP) and L-phenylalanine mustard (L-PAM) with the objective of relating cytotoxicity to DNA cross-linking in human cells. Cytotoxicity was measured by cell proliferation and colony formation assays. DNA interst...

journal_title：Cancer research

authors： Ducore JM,Erickson LC,Zwelling LA,Laurent G,Kohn KW

更新日期：1982-03-01 00:00:00

abstract：:The transcription factor nuclear factor-kappaB (NF-kappaB) is constitutively activated in many types of cancers and has been implicated in gene expression important for angiogenesis, tumor growth, progression, and metastasis. Here, we show that the NF-kappaB activator, IkappaB kinase-alpha (IKKalpha), but not IKKbeta,...

journal_title：Cancer research

authors： DeBusk LM,Massion PP,Lin PC

更新日期：2008-12-15 00:00:00

abstract：:Carefully orchestrated interactions between mitochondrial proteins that facilitate cell death remain a topic of intense research, however, key steps remain to be elucidated, especially those that drive selective killing in cancer cells. How mitochondrial dysfunction and its regulation in cancer can be robustly leverag...

journal_title：Cancer research

authors： Rao VA

更新日期：2019-12-15 00:00:00

abstract：:Elucidation of the underlying molecular mechanisms of immune evasion in cancer is critical for the development of immunotherapies aimed to restore and stimulate effective antitumor immunity. Here, we evaluate the role of the actin cytoskeleton in breast cancer cell resistance to cytotoxic natural killer (NK) cells. A ...

journal_title：Cancer research

authors： Al Absi A,Wurzer H,Guerin C,Hoffmann C,Moreau F,Mao X,Brown-Clay J,Petrolli R,Casellas CP,Dieterle M,Thiery JP,Chouaib S,Berchem G,Janji B,Thomas C

更新日期：2018-10-01 00:00:00

abstract：:Bortezomib (Velcade, formerly known as PS-341) is a boronic acid dipeptide derivative that is a selective and potent inhibitor of the proteasome. We hypothesized that proteasome inhibition would lead to an accumulation of misfolded proteins in the cell resulting in endoplasmic reticulum (ER) stress. The ability of bor...

journal_title：Cancer research

authors： Nawrocki ST,Carew JS,Dunner K Jr,Boise LH,Chiao PJ,Huang P,Abbruzzese JL,McConkey DJ

更新日期：2005-12-15 00:00:00