Synergistic antitumor effects of immunotherapy with recombinant interleukin-2 and recombinant tumor necrosis factor-alpha.

abstract：:Retinoic acid receptors and retinoid X receptors form heterodimers, bind to retinoic acid response elements, and transactivate the transcription of retinoid-responsive genes. Two synthetic retinoids [4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid (TTAB) and 6-(5,6,7,8-tetrahydro-5,5,8,8-tetrameth...

journal_title：Cancer research

authors： Lotan R,Dawson MI,Zou CC,Jong L,Lotan D,Zou CP

更新日期：1995-01-15 00:00:00

abstract：:Activities of the adenine purine nucleotide cycle enzymes, i.e., adenylosuccinate (SAMP) synthetase, SAMP lyase, and adenosine 5'-monophosphate deaminse, were determined in hepatic tissue of rats fed and/or given injections of 3'-methyl-4-dimethylaminoazobenzene, 4'-methyl-4-dimethylaminoazobenzene, thioacetamide, eth...

journal_title：Cancer research

authors： Smith LD,Emerson RL,Nixon LK

更新日期：1979-06-01 00:00:00

abstract：:Hypoxic conditions exist within pancreatic adenocarcinoma, yet pancreatic cancer cells survive and replicate within this environment. To understand the mechanisms involved in pancreatic cancer adaptation to hypoxia, we analyzed expression of a regulator of hypoxia-induced cell death, Bcl-2/adenovirus E1B 19 kDa intera...

journal_title：Cancer research

authors： Okami J,Simeone DM,Logsdon CD

更新日期：2004-08-01 00:00:00

abstract：:LIGHT, a ligand for the lymphotoxin-beta receptor, establishes lymphoid-like tissues inside tumor sites and recruits naïve T cells into the tumor. However, whether these infiltrating T cells are specific for tumor antigens is not known. We hypothesized that therapy with LIGHT can expand functional tumor-specific CD8(+...

journal_title：Cancer research

authors： Kanodia S,Da Silva DM,Karamanukyan T,Bogaert L,Fu YX,Kast WM

更新日期：2010-05-15 00:00:00

abstract：:Cell-mediated cytotoxicity against syngeneic MC104 fibrosarcoma cells was detected in C57BL/6N mice 7 days after tumor inoculation in the hind foot. This cytotoxicity was undetectable by Day 14 in the Winn test using spleen and draining popliteal lymph node (DPLN) cells. Similar results were obtained with the 51Cr rel...

journal_title：Cancer research

authors： Kawase I,Uemiya M,Yoshimoto T,Ogura T,Hirao F,Yamamura Y

更新日期：1981-02-01 00:00:00

abstract：:This study was undertaken to examine relationships of the phenotype of malignant cells to target cell properties and to events early in the transformation process. Eighteen transformed lines were obtained by Kirsten murine sarcoma virus infection of cells from adrenal glands of rats ages 4 to 30 weeks, at first or sec...

journal_title：Cancer research

authors： Auersperg N,Wan MW,Sanderson RA,Wong KS,Mauldin D

更新日期：1981-05-01 00:00:00

abstract：:Intradermally injected tumor necrosis factor alpha (TNF-alpha) mimics the effects of UV B light (UVB) radiation and neutralizing anti-TNF-alpha antibodies abolish the deleterious effects of UVB on induction of contact hypersensitivity suggesting that TNF-alpha is the major mediator of UVB effects on cutaneous immunity...

journal_title：Cancer research

authors： Vincek V,Kurimoto I,Medema JP,Prieto E,Streilein JW

更新日期：1993-02-15 00:00:00

abstract：:In a previous study, we found that the small-molecule epidermal growth factor receptor (EGFR) inhibitor gefitinib (ZD1839, Iressa) blocked cell proliferation at biologically relevant concentrations in approximately one third (6 of 17) of human bladder cancer cell lines examined. Here, we studied the effects of gefitin...

journal_title：Cancer research

authors： Shrader M,Pino MS,Lashinger L,Bar-Eli M,Adam L,Dinney CP,McConkey DJ

更新日期：2007-02-15 00:00:00

abstract：:Knockout and expression studies suggest that estrogen receptor beta (ERbeta) plays a prominent role in ovarian function and pathology. Moreover, ovarian cancers are characterized by high morbidity and low responsiveness to anti-estrogens. Here we demonstrate, using quantitative PCR to measure ERalpha and ERbeta levels...

journal_title：Cancer research

authors： Bardin A,Hoffmann P,Boulle N,Katsaros D,Vignon F,Pujol P,Lazennec G

更新日期：2004-08-15 00:00:00

abstract：:Our objectives were to test whether polymorphic variation in the (CAG)n repeat of the androgen receptor (AR) gene affects penetrance of germ-line BRCA mutations for ovarian cancer or age of diagnosis for ovarian cancer. Using a case-series study design, 179 consecutive Ashkenazi Jewish ovarian cancer patients were gen...

journal_title：Cancer research

authors： Levine DA,Boyd J

更新日期：2001-02-01 00:00:00

abstract：:Among the many proteases associated with human cancer, seprase or fibroblast activation protein alpha, a type II transmembrane glycoprotein, has two types of EDTA-resistant protease activities: dipeptidyl peptidase and a 170-kDa gelatinase activity. To test if activation of gelatinases associated with seprase could be...

journal_title：Cancer research

authors： Chen D,Kennedy A,Wang JY,Zeng W,Zhao Q,Pearl M,Zhang M,Suo Z,Nesland JM,Qiao Y,Ng AK,Hirashima N,Yamane T,Mori Y,Mitsumata M,Ghersi G,Chen WT

更新日期：2006-10-15 00:00:00

abstract：:Transformation with ras oncogenes results in increased radiation sur vival in many but not all cells. In addition, prenyltransferase inhibitors which inhibit ras proteins by blocking posttranslational modification radiosensitize cells with oncogenic ras. These findings suggest that oncogenic ras contributes to intrins...

journal_title：Cancer research

authors： Bernhard EJ,Stanbridge EJ,Gupta S,Gupta AK,Soto D,Bakanauskas VJ,Cerniglia GJ,Muschel RJ,McKenna WG

更新日期：2000-12-01 00:00:00

abstract：:We have examined the properties of the estrogen receptor and progesterone receptor in MDA-MB-134 human breast cells and have evaluated the effects of estrogen on cell proliferation and progesterone receptor levels in these cells as indices of hormonal sensitivity. These cells contain high levels of estrogen receptor (...

journal_title：Cancer research

authors： Reiner GC,Katzenellenbogen BS

更新日期：1986-03-01 00:00:00

abstract：:Previously, we identified an amplified gene in a stomach cancer cell line, KATO-III, and designated it K-sam. This gene was later found to be identical with a gene for a receptor tyrosine kinase, bek/FGFR2. One of the characteristics of the K-sam gene is structural diversity of its transcripts; K-sam complementary DNA...

journal_title：Cancer research

authors： Ishii H,Hattori Y,Itoh H,Kishi T,Yoshida T,Sakamoto H,Oh H,Yoshida S,Sugimura T,Terada M

更新日期：1994-01-15 00:00:00

abstract：:Certain bis(2,6-dioxopiperazine) derivatives, which include ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl]propane; ADR-529) and its racemic compound ICRF 159 (Razoxane), have been investigated as antineoplastic agents. In addition, ICRF-187 is currently under intense study as an agent to ameliorate the cardiac toxic...

journal_title：Cancer research

authors： Gorbsky GJ

更新日期：1994-02-15 00:00:00

abstract：:Repurposing "old" drugs can facilitate rapid clinical translation but necessitates novel mechanistic insight. Warfarin, a vitamin K "antagonist" used clinically for the prevention of thrombosis for more than 50 years, has been shown to have anticancer effects. We hypothesized that the molecular mechanism underlying it...

journal_title：Cancer research

authors： Kirane A,Ludwig KF,Sorrelle N,Haaland G,Sandal T,Ranaweera R,Toombs JE,Wang M,Dineen SP,Micklem D,Dellinger MT,Lorens JB,Brekken RA

更新日期：2015-09-15 00:00:00

abstract：:Histone demethylase LSD1 (also known as KDM1 and AOF2) is active in various cancer cells, but its biological significance in human carcinogenesis is unexplored. In this study, we explored hypothesized interactions between LSD1 and MYPT1, a known regulator of RB1 phosphorylation. We found that MYPT1 was methylated in v...

journal_title：Cancer research

authors： Cho HS,Suzuki T,Dohmae N,Hayami S,Unoki M,Yoshimatsu M,Toyokawa G,Takawa M,Chen T,Kurash JK,Field HI,Ponder BA,Nakamura Y,Hamamoto R

更新日期：2011-02-01 00:00:00

abstract：:Leucine-rich repeat-containing 3B (LRRC3B) is an evolutionarily highly conserved leucine-rich repeat-containing protein, but its biological significance is unknown. Using restriction landmark genomic scanning and pyrosequencing, we found that the promoter region of LRRC3B was aberrantly methylated in gastric cancer. G...

journal_title：Cancer research

authors： Kim M,Kim JH,Jang HR,Kim HM,Lee CW,Noh SM,Song KS,Cho JS,Jeong HY,Hahn Y,Yeom YI,Yoo HS,Kim YS

更新日期：2008-09-01 00:00:00

abstract：:Aldophosphamide (NSC 254), a putative key metabolite of cyclophosphamide, has now been isolated as a cyanohydrin derivative from an incubation mixture of cyclophosphamide with mouse liver microsomes in vitro and from the plasma of a cyclophosphamide-treated patient. The cyanohydrin has been shown to be identical with ...

journal_title：Cancer research

authors： Fenselau C,Kan MN,Rao SS,Myles A,Friedman OM,Colvin M

更新日期：1977-08-01 00:00:00

abstract：:A human melanoma cell line (MM253c1-3D) having an induced stable resistance to the methylating agents 5-(3'-methyl-1-triazeno)imidazole-4-carboxamide, methylnitrosourea, and N-methyl-N'-nitro-N-nitrosoguanidine gave more efficient replication of 5-(3'-methyl-1-triazeno)imidazole-4-carboxamide-treated adenovirus 5 than...

journal_title：Cancer research

authors： Hayward IP,Parsons PG

更新日期：1984-01-01 00:00:00

abstract：:Loss of heterozygosity (LOH) and replication error (RER) are important phenomena in tumor development, with diagnostic and prognostic relevance. Therefore, screening for LOH and RER is a desirable first step in the molecular analysis of tumors. We used semiautomated procedures based on multicolor fluorescently labeled...

journal_title：Cancer research

authors： Canzian F,Salovaara R,Hemminki A,Kristo P,Chadwick RB,Aaltonen LA,de la Chapelle A

更新日期：1996-07-15 00:00:00

abstract：:More than 35 different partner genes with the mixed lineage leukemia (MLL) gene have been cloned from leukemia cells with translocations involving chromosome 11 band q23. In this study, we report on a novel fusion partner of the MLL gene, AF4p12, which we have identified as the human homologue to the furry gene of Dro...

journal_title：Cancer research

authors： Hayette S,Cornillet-Lefebvre P,Tigaud I,Struski S,Forissier S,Berchet A,Doll D,Gillot L,Brahim W,Delabesse E,Magaud JP,Rimokh R

更新日期：2005-08-01 00:00:00

abstract：:It has been shown in previous studies that a variety of estrogen receptor (ER) beta mRNA transcripts are expressed in human breast cancer cell lines and tumors. To complement the RNA expression studies, we have developed ER-beta-specific antibodies to characterize ER-beta protein expression in breast cancer cell lines...

journal_title：Cancer research

authors： Fuqua SA,Schiff R,Parra I,Friedrichs WE,Su JL,McKee DD,Slentz-Kesler K,Moore LB,Willson TM,Moore JT

更新日期：1999-11-01 00:00:00

abstract：:NADPH-fortified human liver microsomes were examined with regard to ability to detoxicate several chemicals that do not require enzymatic oxidation to elicit a genotoxic response in a Salmonella typhimurium TA1535/pSK1002 system where umu response is used as an indicator of DNA damage. Microsomes did not affect the re...

journal_title：Cancer research

authors： Shimada T,Guengerich FP

更新日期：1990-04-01 00:00:00

abstract：:The development of prophylactic cancer vaccines that protect healthy hosts from tumor development leaves open the question whether such vaccines are also effective against established tumors and metastases. We tested the therapeutic activity of a proven prophylactic anti-HER-2/neu vaccine against successive stages of ...

journal_title：Cancer research

authors： Nanni P,Nicoletti G,Palladini A,Croci S,Murgo A,Antognoli A,Landuzzi L,Fabbi M,Ferrini S,Musiani P,Iezzi M,De Giovanni C,Lollini PL

更新日期：2007-11-15 00:00:00

abstract：:Four new human non-small cell lung cancer cell lines have been established in vitro. These cell lines have been characterized by (a) growth of a tumor in nude mice with histopathology similar to that of the primary, (b) isoenzyme patterns phenotypically human and distinct from each other, (c) distinguishing karyotypic...

journal_title：Cancer research

authors： Loh PM,Clamon GH,Robinson RA,White ML,Hukku B,Rossi NP,Peterson WD

更新日期：1984-08-01 00:00:00

abstract：:N,N-Dimethylformamide treatment of cell cultures established from a transplantable murine rhabdomyosarcoma-induced morphological differentiation and a marked reduction in the tumorigenicity of the sarcoma cells. Fourteen of 17 CE/J mice receiving injections of inducer-treated cells did not develop tumors after 6 month...

journal_title：Cancer research

authors： Dexter DL

更新日期：1977-09-01 00:00:00

abstract：:Anticancer vaccine strategies can now target intracellular antigens that are involved in the process of malignant transformation, such as oncogene products or mutated tumor suppressor genes. Fragments of these antigens, generally 8-10 amino acids in length and complexed with MHC class I molecules, can be recognized by...

journal_title：Cancer research

authors： McCabe BJ,Irvine KR,Nishimura MI,Yang JC,Spiess PJ,Shulman EP,Rosenberg SA,Restifo NP

更新日期：1995-04-15 00:00:00

abstract：:alpha-Interferon (IFN alpha) potentiates the cytotoxicity of 5-fluorouracil (FUra) in vitro, and the combination has clinical efficacy in advanced colorectal cancer. We have reported previously an IFN alpha-mediated elevation in cellular FdUMP levels accompanied by the stimulation of thymidine phosphorylase (TP) activ...

journal_title：Cancer research

authors： Schwartz EL,Baptiste N,O'Connor CJ,Wadler S,Otter BA

更新日期：1994-03-15 00:00:00

abstract：:Osteosarcoma is the most common malignant bone tumor in children. Osteosarcoma patients who respond poorly to chemotherapy are at a higher risk of relapse and adverse outcome. Therefore, it was the aim of this study to identify prognostic factors at the time of diagnosis to characterize the genes predictive of poor su...

journal_title：Cancer research

authors： Mintz MB,Sowers R,Brown KM,Hilmer SC,Mazza B,Huvos AG,Meyers PA,Lafleur B,McDonough WS,Henry MM,Ramsey KE,Antonescu CR,Chen W,Healey JH,Daluski A,Berens ME,Macdonald TJ,Gorlick R,Stephan DA

更新日期：2005-03-01 00:00:00