Establishment and characterization of four new human non-small cell lung cancer cell lines.

abstract：:Molecular markers of pancreatic neoplasia could aid in the evaluation of visible pancreatic lesions and indicate neoplasia invisible to imaging. We evaluated methylation-specific PCR (MSP) assays that detect aberrantly methylated DNA for their use as markers of pancreatic neoplasia. Methylation analysis was done on pa...

journal_title：Cancer research

authors： Matsubayashi H,Canto M,Sato N,Klein A,Abe T,Yamashita K,Yeo CJ,Kalloo A,Hruban R,Goggins M

更新日期：2006-01-15 00:00:00

abstract：:The conversion of transforming growth factor beta (TGF-beta) from a tumor suppressor to a tumor promoter occurs frequently during mammary tumorigenesis, yet the molecular mechanisms underlying this phenomenon remain undefined. We show herein that TGF-beta repressed nuclear factor-kappaB (NF-kappaB) activity in normal ...

journal_title：Cancer research

authors： Neil JR,Schiemann WP

更新日期：2008-03-01 00:00:00

abstract：:Chromatin modification is pivotal to the epithelial-mesenchymal transition (EMT), which confers potent metastatic potential to cancer cells. Here, we report a role for the chromatin remodeling factor lymphoid-specific helicase (LSH) in nasopharyngeal carcinoma (NPC), a prevalent cancer in China. LSH expression was inc...

journal_title：Cancer research

authors： He X,Yan B,Liu S,Jia J,Lai W,Xin X,Tang CE,Luo D,Tan T,Jiang Y,Shi Y,Liu Y,Xiao D,Chen L,Liu S,Mao C,Yin G,Cheng Y,Fan J,Cao Y,Muegge K,Tao Y

更新日期：2016-10-01 00:00:00

abstract：:One major rationale for using interleukin-2 and IFN-alpha in cancer immunotherapy is to activate tumor-specific T cells at the tumor site. To study the in situ T-cell response, we determined the T-cell receptor (TCR) repertoire in six melanoma metastases regressing after cytokine treatment obtained from five patients....

journal_title：Cancer research

authors： Willhauck M,Scheibenbogen C,Pawlita M,Möhler T,Thiel E,Keilholz U

更新日期：2003-07-01 00:00:00

abstract：:A potential tumor suppressor gene, STK11 , encoding a serine threonine kinase, has recently been identified on chromosome 19p13. Germ-line mutations of this gene have been found in patients with Peutz-Jeghers syndrome (PJS). To further investigate the relevance of STK11 mutations in PJS, we analyzed its coding sequenc...

journal_title：Cancer research

authors： Resta N,Simone C,Mareni C,Montera M,Gentile M,Susca F,Gristina R,Pozzi S,Bertario L,Bufo P,Carlomagno N,Ingrosso M,Rossini FP,Tenconi R,Guanti G

更新日期：1998-11-01 00:00:00

abstract：:Tumor-derived cell lines are used as in vitro cancer models, but their ability to accurately reflect the phenotype and genotype of the parental histology remains questionable, given the prevalence of documented cell line-specific cytogenetic changes. We have addressed the issue of whether copy number alterations seen ...

journal_title：Cancer research

authors： Greshock J,Nathanson K,Martin AM,Zhang L,Coukos G,Weber BL,Zaks TZ

更新日期：2007-04-15 00:00:00

abstract：:This study investigates whether and to what extent cyclooxygenase type-2 (COX-2) and inducible nitric oxide-synthase (iNOS), both known to have an immunosuppressive effect, are expressed in human ovarian tumors. Because COX-2 and iNOS can be expressed by activated macrophages, the presence of tumor-associated macropha...

journal_title：Cancer research

authors： Klimp AH,Hollema H,Kempinga C,van der Zee AG,de Vries EG,Daemen T

更新日期：2001-10-01 00:00:00

abstract：:Tumor-infiltrating lymphocytes (TIL) are potent mediators of an antitumor response. However, their function is attenuated in solid tumors. CD8+ T-cell effector functions, such as cytokine and granzyme production, depend on cytoplasmic Ca2+, which is controlled by ion channels. In particular, Kv1.3 channels regulate th...

journal_title：Cancer research

authors： Chimote AA,Hajdu P,Sfyris AM,Gleich BN,Wise-Draper T,Casper KA,Conforti L

更新日期：2017-01-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immature myeloid cells that expand in tumor-bearing hosts in response to soluble factors produced by tumor and stromal cells. MDSC expansion has been linked to loss of immune effector cell function and reduced efficacy of immune-based cancer therapie...

journal_title：Cancer research

authors： Stiff A,Trikha P,Wesolowski R,Kendra K,Hsu V,Uppati S,McMichael E,Duggan M,Campbell A,Keller K,Landi I,Zhong Y,Dubovsky J,Howard JH,Yu L,Harrington B,Old M,Reiff S,Mace T,Tridandapani S,Muthusamy N,Caligiuri MA

更新日期：2016-04-15 00:00:00

abstract：:Chronic exposures to cadmium compounds are carcinogenic. It was hypothesized that the development of resistance to cadmium may drive carcinogenesis. This is achieved by selection of resistant cells in which the apoptotic response is significantly attenuated. The induction of cadmium resistance in rat lung epithelial c...

journal_title：Cancer research

authors： Lau AT,Chiu JF

更新日期：2007-03-01 00:00:00

abstract：:We demonstrate that a mouse-human chimeric anti-ganglioside GD2-interleukin (IL)-2 fusion protein (ch14.18-IL2) substantially amplifies tumor-protective immunity against murine melanoma induced by an autologous oral DNA vaccine containing the murine ubiquitin gene fused to murine melanoma peptide epitopes gp100(25-35)...

journal_title：Cancer research

authors： Niethammer AG,Xiang R,Ruehlmann JM,Lode HN,Dolman CS,Gillies SD,Reisfeld RA

更新日期：2001-08-15 00:00:00

abstract：:Class I major histocompatibility complex (MHC) antigen expression in neuroblastoma may play a role in the oncogenicity of this embryonal tumor of childhood. Since N-myc amplification in neuroblastoma tumors is associated with rapid tumor progression (33) and N-myc decreases Class I MHC antigen expression in rat neurob...

journal_title：Cancer research

authors： Cooper MJ,Hutchins GM,Mennie RJ,Israel MA

更新日期：1990-06-15 00:00:00

abstract：:Berberine, a natural product derived from a plant used in Chinese herbal medicine, is reported to exhibit anticancer effects; however, its mechanism of action is not clearly defined. Herein, we demonstrate that berberine induces apoptosis in acute lymphoblastic leukemia (ALL) cells by downregulating the MDM2 oncoprote...

journal_title：Cancer research

authors： Zhang X,Gu L,Li J,Shah N,He J,Yang L,Hu Q,Zhou M

更新日期：2010-12-01 00:00:00

abstract：:Stem cells are under strict regulation by both intrinsic factors and the microenvironment. There is increasing evidence that many cancers initiate through acquisition of genetic mutations (loss of intrinsic control) in stem cells or their progenitors, followed by alterations of the surrounding microenvironment (loss o...

journal_title：Cancer research

authors： Le LQ,Liu C,Shipman T,Chen Z,Suter U,Parada LF

更新日期：2011-07-01 00:00:00

abstract：:In the present study, we assessed the susceptibility of freshly isolated neuroblastoma cells to killing mediated by normal human natural killer (NK) cells and analyzed the receptor-ligand interactions that regulate this event. We show that killing of freshly isolated neuroblasts, similar to neuroblastoma cell lines, i...

journal_title：Cancer research

authors： Castriconi R,Dondero A,Corrias MV,Lanino E,Pende D,Moretta L,Bottino C,Moretta A

更新日期：2004-12-15 00:00:00

abstract：:Cyclin-dependent kinase 2 activated by cyclin E is involved in the initiation of DNA replication and other S phase functions. Consistent with this role, cyclin E protein accumulates at the G1-S phase transition and declines during early S phase. This profile of expression is the result of periodic transcription and ub...

journal_title：Cancer research

authors： Spruck CH,Strohmaier H,Sangfelt O,Müller HM,Hubalek M,Müller-Holzner E,Marth C,Widschwendter M,Reed SI

更新日期：2002-08-15 00:00:00

abstract：:In the last decade, large-scale genomic studies in patients with hematologic malignancies identified recurrent somatic alterations in epigenetic modifier genes. Among these, the de novo DNA methyltransferase DNMT3A has emerged as one of the most frequently mutated genes in adult myeloid as well as lymphoid malignancie...

journal_title：Cancer research

authors： Venugopal K,Feng Y,Shabashvili D,Guryanova OA

更新日期：2021-01-15 00:00:00

abstract：:The effect of a continuous i.v. infusion of alpha-difluoromethylornithine (DFMO) on the polyamine metabolism of tumor and normal host tissue was determined. Non-tumor-bearing Fischer 344 rats or rats bearing a transplantable fibrosarcoma received continuous infusions of DFMO through a central venous catheter at three ...

journal_title：Cancer research

authors： Grossie VB Jr,Ota DM,Ajani JA,Nishioka K

更新日期：1987-04-01 00:00:00

abstract：:Changes in the structure of the surface of mastocytoma cells were induced by hyperthermia and were investigated by means of cell electrophoresis. A decrease in the cell electrophoretic mobility was detected as early as 15 min after treatment at 42 degrees and progressed more rapidly under hypoxic conditions than under...

journal_title：Cancer research

authors： Sato C,Nakayama T,Kojima K,Nishimoto Y,Nakamura W

更新日期：1981-10-01 00:00:00

abstract：:Male Sprague-Dawley rats were given weekly s.c. injections of 1,2-dimethylhydrazine (21 mg/kg) for 20 weeks. The injections were then discontinued, and, after an interval of 2 to 8 weeks, experimental animals were given i.p. injections of 5,6-dihydroxytryptamine (5,6DHT) at a dose of 40 mg/kg and sacrificed at interva...

journal_title：Cancer research

authors： Tutton PJ,Barkla DH

更新日期：1977-04-01 00:00:00

abstract：:Members of the phosphatidylinositol 3-kinase-related kinase family, in particular the ataxia-telangiectasia mutated (ATM) kinase and the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs), regulate cellular responses to DNA double-strand breaks. Increased sensitivity to ionizing radiation (IR) in DNA-PKc...

journal_title：Cancer research

authors： Arlander SJ,Greene BT,Innes CL,Paules RS

更新日期：2008-01-01 00:00:00

abstract：:The effect of phenobarbital (PB) pretreatment of rats on both hepatic aflatoxin B1 (AFB1)-DNA binding and AFB1-glutathione (AFB1-SG) conjugation have been examined in studies in vivo and in vitro. Male Sprague-Dawley rats fed a commercial diet with 0.1% PB in their drinking water for 1 week had total wet liver weight ...

journal_title：Cancer research

authors： Lotlikar PD,Raj HG,Bohm LS,Ho LL,Jhee EC,Tsuji K,Gopalan P

更新日期：1989-02-15 00:00:00

abstract：:Many tumor types have p53 and/or RB mutations, and it is unclear what role the mutations of these tumor suppressor genes have on the efficacy of chemotherapeutic agents. The effect of p53 and RB inactivation on sensitivity to chemotherapeutic drugs was examined using a model system in which p53 or RB was inactivated i...

journal_title：Cancer research

authors： Hawkins DS,Demers GW,Galloway DA

更新日期：1996-02-15 00:00:00

abstract：:Genetically engineered single-chain Fvs (sFv) are defined as recombinant proteins composed of a variable light chain amino acid sequence of an immunoglobulin tethered to a variable heavy chain sequence by a designed peptide. Previous studies using iodine-labeled sFv, derived from the anticarcinoma monoclonal antibody ...

journal_title：Cancer research

authors： Schott ME,Milenic DE,Yokota T,Whitlow M,Wood JF,Fordyce WA,Cheng RC,Schlom J

更新日期：1992-11-15 00:00:00

abstract：:Nkx2.8, a homeodomain transcription factor, has been characterized in liver cancer and in the developing central nervous system. We now show that this factor is also expressed in the lung, where it localizes in adults to a discrete population of tracheobronchial basal cells. To target the mouse gene, the first exon wa...

journal_title：Cancer research

authors： Tian J,Mahmood R,Hnasko R,Locker J

更新日期：2006-11-01 00:00:00

abstract：:The activity of the serine protease plasminogen activator (PA), which correlates with tumorigenicity and metastatic capacity, was examined using the 125I-labeled fibrin plate assay in cell extracts from four human glioma lines as a function of growth in vitro. Cell-associated inhibitory activity to plasmin and urokina...

journal_title：Cancer research

authors： Gross JL,Behrens DL,Mullins DE,Kornblith PL,Dexter DL

更新日期：1988-01-15 00:00:00

abstract：:The underlying mechanism regulating the expression of the cancer stem cell/tumor-initiating cell marker CD133/prominin-1 in cancer cells remains largely unclear, although knowledge of this mechanism would likely provide important biological information regarding cancer stem cells. Here, we found that the inhibition of...

journal_title：Cancer research

authors： Matsumoto K,Arao T,Tanaka K,Kaneda H,Kudo K,Fujita Y,Tamura D,Aomatsu K,Tamura T,Yamada Y,Saijo N,Nishio K

更新日期：2009-09-15 00:00:00

abstract：:Chromosomal analysis of 16 rhabdomyosarcomas was done from four primary tumors and from 12 tumors after nude mouse passage. Seven tumors were alveolar; four of these had t(2;13)(q37;q14) and in two tumors it was the only structural abnormality. The other three alveolar tumors were near tetraploid with marker chromosom...

journal_title：Cancer research

authors： Wang-Wuu S,Soukup S,Ballard E,Gotwals B,Lampkin B

更新日期：1988-02-15 00:00:00

abstract：:An inbred-strain (C57BL/6) transgenic (Tyr-SV40E) mouse model of ultraviolet radiation (UVR)-induced metastatic cutaneous melanoma was produced without the use of chemical carcinogens and without resulting in other skin malignancies. Expression of this transgene occurs specifically in melanocytic-lineage cells. In unt...

journal_title：Cancer research

authors： Kelsall SR,Mintz B

更新日期：1998-09-15 00:00:00

abstract：:The reverse hemolytic plaque assay (RHPA) was used to detect hormone release from cultured normal, hyperplastic, and neoplastic rat pituitary cells. Hyperplastic pituitary cells were produced by s.c. diethylstilbestrol (DES) treatment (10 mg in Silastic tubes) for 3, 6, and 9 weeks. Neoplastic pituitary cells from rat...

journal_title：Cancer research

authors： Lloyd RV,Coleman K,Fields K,Nath V

更新日期：1987-02-15 00:00:00