Kv1.3 Channels Mark Functionally Competent CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Cancer.

abstract：:The immunobiology of Friend erythroleukemia virus (FLV) has been the focal point of much research into immunological control of leukemia. We have been studying a murine model in which a rapidly fatal FLV infection of DBA/2 mice is suppressed to a dormant state by treatment with statolon, a double stranded RNA extract ...

journal_title：Cancer research

authors： DiCicco LM,Truitt GA,Wheelock EF

更新日期：1986-01-01 00:00:00

abstract：:To assess the in vivo behavior of cytotoxic agents linked to antibodies, deferoxamine, known to form stable chelates with 67Ga, was conjugated with monoclonal antibodies using three different methods. One method used a homocoupling reagent, glutaraldehyde, whereas two other methods used heterocoupling reagents, N-succ...

journal_title：Cancer research

authors： Koizumi M,Endo K,Kunimatsu M,Sakahara H,Nakashima T,Kawamura Y,Watanabe Y,Saga T,Konishi J,Yamamuro T

更新日期：1988-03-01 00:00:00

abstract：:Genetic changes found in human osteogenic sarcoma cells, including loss of the p53 and Rb tumor suppressor elements and overexpression of the cyclin G1 (CYCG1) proto-oncogene, suggest the potential of gene transfer as a treatment for metastatic disease. In this study, we examined the effects of antisense cyclin G1, in...

journal_title：Cancer research

authors： Skotzko M,Wu L,Anderson WF,Gordon EM,Hall FL

更新日期：1995-12-01 00:00:00

abstract：:Granulocyte macrophage colony-stimulating factor (GMCSF) can mediate antitumor effects by recruiting natural killer cells and by induction of tumor-specific cytotoxic T-cells through antigen-presenting cells. Oncolytic tumor cell-killing can produce a potent costimulatory danger signal and release of tumor epitopes fo...

journal_title：Cancer research

authors： Cerullo V,Pesonen S,Diaconu I,Escutenaire S,Arstila PT,Ugolini M,Nokisalmi P,Raki M,Laasonen L,Särkioja M,Rajecki M,Kangasniemi L,Guse K,Helminen A,Ahtiainen L,Ristimäki A,Räisänen-Sokolowski A,Haavisto E,Oksanen M,

更新日期：2010-06-01 00:00:00

abstract：:Inflammatory pathways may mediate preparation of the "metastatic soil" in the lungs. Some of these pathways--activation and/or the recruitment of certain inflammatory cells--might depend on vascular endothelial growth factor receptor 1 (VEGFR1) activity. Thus, blocking the activity of VEGFR1 (or the interaction with i...

journal_title：Cancer research

authors： Duda DG,Jain RK

更新日期：2010-07-15 00:00:00

abstract：:The effects of four anti-GM2 monoclonal antibodies (DMAb-1, DMAb-2, DMAb-3, and DMAb-5) were studied on spheroid cultures from a human glioma cell line (D-54 MG) that is known to express high levels of GM2. The spheroids developed central necrosis 48 h after antibody exposures at concentrations greater than 6 microgra...

journal_title：Cancer research

authors： Bjerkvig R,Engebraaten O,Laerum OD,Fredman P,Svennerholm L,Vrionis FD,Wikstrand CJ,Bigner DD

更新日期：1991-09-01 00:00:00

abstract：:Eighteen-day-old fetal urogenital sinus mesenchyme (UGM), 0-day-old neonatal seminal vesicle mesenchyme (SVM), 0-day-old neonatal bulbourethral gland mesenchyme (BUG-M), and 3-day-old neonatal urinary bladder mesenchyme (BLM) were isolated from rats and combined in vitro with 0.5-mm cubes of the R3327 androgen-depende...

journal_title：Cancer research

authors： Hayashi N,Cunha GR,Wong YC

更新日期：1990-08-01 00:00:00

abstract：:We developed a fully automated three-dimensional cell tracking system that quantified the effect of extracellular matrix components on the infiltration and migration of tumor cells. The three-dimensional trajectories of two highly invasive cell lines, the human HT-1080 fibrosarcoma and the human MDA-MB-231 adenocarcin...

journal_title：Cancer research

authors： Demou ZN,McIntire LV

更新日期：2002-09-15 00:00:00

abstract：:Although monoallelic expression (MAE) is a frequent genomic event in normal tissues, its role in tumorigenesis remains unclear. Here we carried out single-nucleotide polymorphism arrays on DNA and RNA from a large cohort of pediatric and adult brain tumor tissues to determine the genome-wide rate of MAE, its role in s...

journal_title：Cancer research

authors： Walker EJ,Zhang C,Castelo-Branco P,Hawkins C,Wilson W,Zhukova N,Alon N,Novokmet A,Baskin B,Ray P,Knobbe C,Dirks P,Taylor MD,Croul S,Malkin D,Tabori U

更新日期：2012-02-01 00:00:00

abstract：:The spontaneous development of juvenile-onset ovarian granulosa cell tumors in mice of the SWXJ-9 recombinant inbred strain is a model for juvenile-type granulosa cell tumors that appear in very young girls. To expedite gene discovery in this mouse model of childhood cancer, we did a gene mapping study with the SWXJ-9...

journal_title：Cancer research

authors： Dorward AM,Shultz KL,Horton LG,Li R,Churchill GA,Beamer WG

更新日期：2005-02-15 00:00:00

abstract：:MSN-1 is a monoclonal antibody, which was raised by immunizing mice with a human endometrial cancer cell line, SNG-II. The MSN-1 specifically recognizes a blood group carbohydrate antigen, Leb. We investigated the subcellular and suborganellar localization of the MSN-1-reactive carbohydrate antigens in the endometrial...

journal_title：Cancer research

authors： Susumu N,Kawakami H,Aoki D,Hirano H,Nozawa S

更新日期：1993-08-01 00:00:00

abstract：:Metastatic cases of breast cancer pose the primary challenge in clinical management of this disease, demanding the identification of effective therapeutic strategies that remain wanting. In this study, we report that elevated levels of α-tubulin acetylation are a sufficient cause of metastatic potential in breast canc...

journal_title：Cancer research

authors： Boggs AE,Vitolo MI,Whipple RA,Charpentier MS,Goloubeva OG,Ioffe OB,Tuttle KC,Slovic J,Lu Y,Mills GB,Martin SS

更新日期：2015-01-01 00:00:00

abstract：:The Siah (seven in absentia homolog) family of RING-domain proteins are components of ubiquitin ligase complexes, targeting proteins for proteasomal degradation. Siah family members have been reported to function in Ras, estrogen, DNA-damage, and hypoxia response pathways. Although earlier reports implicated Siah prot...

journal_title：Cancer research

authors： House CM,Möller A,Bowtell DD

更新日期：2009-12-01 00:00:00

abstract：:The critical region on human chromosome 3p21.3 harboring a putative lung cancer tumor suppressor gene (TSG) was previously defined by allelotyping and recently refined by overlapping homozygous deletions. We report the construction of a 700-kb (cosmid and one P1 phage) clone contig covering the deletion overlap and it...

journal_title：Cancer research

authors： Wei MH,Latif F,Bader S,Kashuba V,Chen JY,Duh FM,Sekido Y,Lee CC,Geil L,Kuzmin I,Zabarovsky E,Klein G,Zbar B,Minna JD,Lerman MI

更新日期：1996-04-01 00:00:00

abstract：:Hypoxia-inducible factor (HIF)-1, a heterodimeric transcription factor composed of HIF-1alpha and HIF-1beta subunits coordinates pathophysiologic responses toward decreased oxygen availability. It is now appreciated that enhanced protein translation of HIF-1alpha under normoxia accounts for an alternative regulatory c...

journal_title：Cancer research

authors： Zhou J,Callapina M,Goodall GJ,Brüne B

更新日期：2004-12-15 00:00:00

abstract：:A partial-length A-myb complementary DNA recently cloned by low-stringency hybridization with a c-myb probe to complementary DNA libraries derived from human cell lines showed a high degree of homology with the DNA-binding domain of c-myb and B-myb, suggesting that A-myb also encoded a DNA-binding protein. We report h...

journal_title：Cancer research

authors： Ma XP,Calabretta B

更新日期：1994-12-15 00:00:00

abstract：:Gastric cancer is the most common cancer in Asia and most developing countries. Despite the use of multimodality therapeutics, it remains the second leading cause of cancer death in the world. To identify the molecular underpinnings of gastric cancer in the Asian population, we applied an RNA-sequencing approach to ga...

journal_title：Cancer research

authors： Kim YH,Liang H,Liu X,Lee JS,Cho JY,Cheong JH,Kim H,Li M,Downey TJ,Dyer MD,Sun Y,Sun J,Beasley EM,Chung HC,Noh SH,Weinstein JN,Liu CG,Powis G

更新日期：2012-05-15 00:00:00

abstract：:It has previously been shown that 6-nitrochrysene can be activated to electrophilic species capable of reacting with DNA through metabolic pathways that form N-hydroxy-6-aminochrysene or trans-1,2-dihydroxy-1,2-dihydro-6-aminochrysene as critical intermediates. Since the lung is a known target tissue for the carcinoge...

journal_title：Cancer research

authors： Delclos KB,el-Bayoumy K,Casciano DA,Walker RP,Kadlubar FF,Hecht SS,Shivapurkar N,Mandal S,Stoner GD

更新日期：1989-06-01 00:00:00

abstract：:This study investigated the ultrastructure and development of virus particles detected in a spontaneous mammary tumor of an 8 year old rhesus monkey. During a 3-month period of tumor growth, several biopsies were performed. Thin section electron microscopy of the tumor tissue revealed 2 types of particles: 1) an in...

journal_title：Cancer research

authors： Chopra HC,Mason MM

更新日期：1970-08-01 00:00:00

abstract：:Translocations fusing the strong androgen-responsive gene, TMPRSS2, with ERG or other oncogenic ETS factors may facilitate prostate cancer development. Here, we studied 18 advanced prostate cancers for ETS factor alterations, using reverse transcription-PCR and DNA and RNA array technologies, and identified putative E...

journal_title：Cancer research

authors： Iljin K,Wolf M,Edgren H,Gupta S,Kilpinen S,Skotheim RI,Peltola M,Smit F,Verhaegh G,Schalken J,Nees M,Kallioniemi O

更新日期：2006-11-01 00:00:00

abstract：:verapamil, a calcium-influx blocker, enhanced the cytotoxicity of vincristine (VCR) in vitro 6- to 12-fold in eight human hemopoietic tumor cell lines established from acute lymphatic leukemia, acute myelogenous leukemia, and Burkitt's lymphoma. Great enhancement of VCR cytotoxicity was obtained in a VCR-resistant sub...

journal_title：Cancer research

authors： Tsuruo T,Iida H,Tsukagoshi S,Sakurai Y

更新日期：1983-05-01 00:00:00

abstract：:Neuroblastomas are extremely aggressive, although heterogeneous, cancers with a poor prognosis upon metastasis. Some evidence has suggested a correlative silencing of caspase-8 with MYCN amplification in neuroblastoma. A prognostic effect of this silencing, however, has been disputed. We report here hitherto undescrib...

journal_title：Cancer research

authors： Finlay D,Vuori K

更新日期：2007-12-15 00:00:00

abstract：:The renal handling of cis-diamminedichloroplatinum (CP) was investigated by measuring the renal clearance of creatinine, inulin, and free platinum in ten cancer patients. Free platinum clearances exceeded the glomerular filtration rate in all time periods. For example, at 1 to 2 hr, the mean clearance of free platinum...

journal_title：Cancer research

authors： Jacobs C,Coleman CN,Rich L,Hirst K,Weiner MW

更新日期：1984-08-01 00:00:00

abstract：:The numbers of ultraviolet light (UV)-induced pyrimidine dimers in the DNA of neonatal BALB/c mouse skin were measured by assessing the sensitivity of the DNA to Micrococcus luteus UV endonuclease. Irradiation of neonatal BALB/c mice with FS40 sunlamps caused a dose-dependent induction of endonuclease-sensitive sites ...

journal_title：Cancer research

authors： Ananthaswamy HN,Fisher MS

更新日期：1981-05-01 00:00:00

abstract：:The presence of metastases in the regional lymph nodes is the major prognostic factor in breast cancer in the absence of overt distant metastases and is also an important indicator of the need for adjuvant therapy in "early" breast cancer. Currently, the accurate assessment of axillary lymph node status requires axill...

journal_title：Cancer research

authors： Tjandra JJ,Russell IS,Collins JP,Andrews JT,Lichtenstein M,Binns D,McKenzie IF

更新日期：1989-03-15 00:00:00

abstract：:To study the long-term effects of estrogen deprivation on breast cancer, MCF-7Ca human estrogen receptor-positive breast cancer cells stably transfected with human aromatase gene were cultured in the steroid-depleted medium for 6 to 8 months until they had acquired the ability to grow. Proliferation of these cells (UM...

journal_title：Cancer research

authors： Sabnis GJ,Jelovac D,Long B,Brodie A

更新日期：2005-05-01 00:00:00

abstract：:In 10 separate experiments, mice with established chemically induced or UV light-induced skin papillomas were treated continuously with green tea in the drinking water or with i.p. injections of a green tea polyphenol fraction or (-)-epigallocatechin gallate three times a week for 4-10 weeks. Partial tumor regression ...

journal_title：Cancer research

authors： Wang ZY,Huang MT,Ho CT,Chang R,Ma W,Ferraro T,Reuhl KR,Yang CS,Conney AH

更新日期：1992-12-01 00:00:00

abstract：:An immunogenic tumor and a nonimmunogenic tumor were used in C57BL/Ka and CBA/Rij mice, respectively, in a study in which lymph node morphology was quantitatively measured. Lymph nodes were cut in semiseries, and a morphometrical analysis was done on the paracortical and cortical areas as major parts of the active lym...

journal_title：Cancer research

authors： van de Velde CJ,Meyer CJ,Cornellsse CJ,van der Velde EA,van Putten LM,Swaveling A

更新日期：1978-03-01 00:00:00

abstract：:The platelet-derived endothelial cell growth factor (PD-ECGF) level was significantly (P < 0.05) increased in 8 of 40 metastatic lymph node lesions of uterine cervical cancers. The prognosis of the eight patients with high PD-ECGF (>10,000 pg/mg protein) in metastatic lymph node lesions was extremely poor. On the othe...

journal_title：Cancer research

authors： Fujimoto J,Sakaguchi H,Hirose R,Wen H,Tamaya T

更新日期：1999-07-01 00:00:00

abstract：:EphA2 receptor tyrosine kinase is frequently overexpressed in different human cancers, suggesting that it may promote tumor development and progression. However, evidence also exists that EphA2 may possess antitumorigenic properties, raising a critical question on the role of EphA2 kinase in tumorigenesis in vivo. We ...

journal_title：Cancer research

authors： Guo H,Miao H,Gerber L,Singh J,Denning MF,Gilliam AC,Wang B

更新日期：2006-07-15 00:00:00