A new virus in a spontaneous mammary tumor of a rhesus monkey.

abstract：:Hepatocellular carcinoma is the fifth most common cancer worldwide, and there is no effective therapy for unresectable disease. We have developed a targeted systemic therapy for hepatocellular carcinoma. The gene for a foreign enzyme is selectively expressed in the tumor cells and a nontoxic prodrug is then given, whi...

journal_title：Cancer research

authors： Schepelmann S,Hallenbeck P,Ogilvie LM,Hedley D,Friedlos F,Martin J,Scanlon I,Hay C,Hawkins LK,Marais R,Springer CJ

更新日期：2005-06-15 00:00:00

abstract：:The WWOX (WW domain containing oxidoreductase) gene was recently identified as a candidate tumor suppressor gene at 16q23.3-24.1, a chromosome region that spans the common fragile site FRA16D. To evaluate the potential role of the WWOX gene in esophageal squamous cell carcinomas, we examined 36 tumors for genetic alte...

journal_title：Cancer research

authors： Kuroki T,Trapasso F,Shiraishi T,Alder H,Mimori K,Mori M,Croce CM

更新日期：2002-04-15 00:00:00

abstract：:Human papillomavirus (HPV) type 18 DNA was introduced into epithelial cell strains derived from normal and cancer tissues of human prostatectomy specimens by the lipofection transfection method. Two cell lines were established: PZ-HPV-7 (transfected normal cell) and CA-HPV-10 (transfected cancer-derived cell). These l...

journal_title：Cancer research

authors： Weijerman PC,König JJ,Wong ST,Niesters HG,Peehl DM

更新日期：1994-11-01 00:00:00

abstract：:Exposures to carcinogens present in the diet, in cigarette smoke, or in the environment have been associated with increased risk of bladder and colorectal cancer. The aromatic amines and their metabolites, a class of carcinogen implicated in these exposures, can be N- or O-acetylated by the NAT1 and NAT2 enzymes. Acet...

journal_title：Cancer research

authors： Bell DA,Badawi AF,Lang NP,Ilett KF,Kadlubar FF,Hirvonen A

更新日期：1995-11-15 00:00:00

abstract：:Insulin-like growth factor II is a growth factor important in fetal development. Several cancer tissues and cell lines have been reported to express IGF-II and rat IGF-II is mitogenic for breast cancer cell lines. Using Northern analysis and ribonuclease protection assays, IGF-II mRNA was detected in normal fibroblast...

journal_title：Cancer research

authors： Yee D,Cullen KJ,Paik S,Perdue JF,Hampton B,Schwartz A,Lippman ME,Rosen N

更新日期：1988-12-01 00:00:00

abstract：:Although more than 100 different BRCA1 germ-line mutations have already been identified in breast and/or ovarian cancer families, we report for the first time a deleterious genomic rearrangement in BRCA1. A 1-kb deletion comprising exon 17 was found in a large breast and ovarian cancer family, leading to a frameshift ...

journal_title：Cancer research

authors： Puget N,Torchard D,Serova-Sinilnikova OM,Lynch HT,Feunteun J,Lenoir GM,Mazoyer S

更新日期：1997-03-01 00:00:00

abstract：:Non-small cell lung cancer patients carrying oncogenic EGFR mutations initially respond to EGFR-targeted therapy, but later elicit minimal response due to dose-limiting toxicities and acquired resistance. EGF816 is a novel, irreversible mutant-selective EGFR inhibitor that specifically targets EGFR-activating mutation...

journal_title：Cancer research

authors： Jia Y,Juarez J,Li J,Manuia M,Niederst MJ,Tompkins C,Timple N,Vaillancourt MT,Pferdekamper AC,Lockerman EL,Li C,Anderson J,Costa C,Liao D,Murphy E,DiDonato M,Bursulaya B,Lelais G,Barretina J,McNeill M,Epple R,Mar

更新日期：2016-03-15 00:00:00

abstract：:Modern cancer therapy/care involves the integration of basic, clinical, and population-based research professionals using state-of-the-art science to achieve the best possible patient outcomes. A well-integrated team of basic, clinical, and population science professionals and educators working with a fully engaged gr...

journal_title：Cancer research

authors： Welch DR,Antalis TM,Burnstein K,Vona-Davis L,Jensen RA,Nakshatri H,Riegel AT,Spitz DR,Watson DK,Weiner GJ,Cancer Biology Training Consortium.

更新日期：2015-12-15 00:00:00

abstract：:An antigen(s) on the surface of embryonic and newly hatched chick red blood cells was studied with antiserum absorbed with adult red blood cells. Because of the reappearance of the antigen or some cross-reactive antigen during myeloblastosis, attempts at solubilization and characterization of the antigen were pursued....

journal_title：Cancer research

authors： O'Brien TJ,Teplitz RL

更新日期：1978-04-01 00:00:00

abstract：:Glycine N-methyltransferase (GNMT) affects genetic stability by (a) regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine and (b) binding to folate. Based on the identification of GNMT as a 4 S polyaromatic hydrocarbon-binding protein, we used liver cancer cell lines that expressed GNMT either transien...

journal_title：Cancer research

authors： Chen SY,Lin JR,Darbha R,Lin P,Liu TY,Chen YM

更新日期：2004-05-15 00:00:00

abstract：:Proteasome inhibitors such as bortezomib exhibit clinical efficacy in multiple myeloma, but studies in acute myeloid leukemia (AML) have been disappointing to date. The apparent failure in AML likely reflects a lack of biological understanding that might clarify applications of proteosome inhibitors in this disease. H...

journal_title：Cancer research

authors： Rushworth SA,Bowles KM,MacEwan DJ

更新日期：2011-03-01 00:00:00

abstract：:The ets oncogene superfamily codes for a family of transcriptional factors that are involved in gene regulation not only by autonomous DNA binding but also by indirect DNA binding through interaction with cellular factors. We have previously shown that a member of this superfamily, elk-1, is a sequence specific transc...

journal_title：Cancer research

authors： Rao VN,Reddy ES

更新日期：1993-01-15 00:00:00

abstract：:CD44 is an integral membrane glycoprotein that functions as a receptor for the extracellular matrix glycan, hyaluronan. Here we report that CD44 is a novel biomarker for non-small cell lung tumors, squamous metaplasia of the lung, and activated type II pneumocytes. We have examined the expression of CD44 in 12 human l...

journal_title：Cancer research

authors： Penno MB,August JT,Baylin SB,Mabry M,Linnoila RI,Lee VS,Croteau D,Yang XL,Rosada C

更新日期：1994-03-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF)-C is a lymphangiogenic factor implicated in lymphatic metastasis. In this study, we investigated the role of the type I insulin-like growth factor receptor (IGF-IR) in the regulation of VEGF-C expression. We used Lewis lung carcinoma subline M-27 cells transfected with human I...

journal_title：Cancer research

authors： Tang Y,Zhang D,Fallavollita L,Brodt P

更新日期：2003-03-15 00:00:00

abstract：:Strategies to address resistance to platin drugs are greatly needed in human epithelial cancers (e.g., ovarian, head/neck, and lung) where platins are used widely and resistance occurs commonly. We found that upon ΔNp63α overexpression, AKT1 and phospho-AKT1 levels are upregulated in cancer cells. Investigations using...

journal_title：Cancer research

authors： Sen T,Sen N,Brait M,Begum S,Chatterjee A,Hoque MO,Ratovitski E,Sidransky D

更新日期：2011-02-01 00:00:00

abstract：:Annexin II mRNA coding for a calcium binding protein was found to be absent in prostate cancer by subtractive hybridization and Northern analysis. In contrast to high expression in normal and benign hyperplastic glandular and basal epithelium, Annexin II heavy (p36) and light (p11) chains in 31/31 prostate cancer spec...

journal_title：Cancer research

authors： Chetcuti A,Margan SH,Russell P,Mann S,Millar DS,Clark SJ,Rogers J,Handelsman DJ,Dong Q

更新日期：2001-09-01 00:00:00

abstract：:The interaction between circulating tumor cells (CTC) and endothelial cells during extravasation is a critical process during metastatic colonization, but its mechanisms remain poorly characterized. Here we report that the luminal side of liver blood vessels contains fibronectin deposits that are enriched in mice bear...

journal_title：Cancer research

authors： Barbazán J,Alonso-Alconada L,Elkhatib N,Geraldo S,Gurchenkov V,Glentis A,van Niel G,Palmulli R,Fernández B,Viaño P,Garcia-Caballero T,López-López R,Abal M,Vignjevic DM

更新日期：2017-07-01 00:00:00

abstract：:The SK3 channel, a potassium channel, was recently shown to control cancer cell migration, a critical step in metastasis outgrowth. Here, we report that expression of the SK3 channel was markedly associated with bone metastasis. The SK3 channel was shown to control constitutive Ca(2+) entry and cancer cell migration t...

journal_title：Cancer research

authors： Chantôme A,Potier-Cartereau M,Clarysse L,Fromont G,Marionneau-Lambot S,Guéguinou M,Pagès JC,Collin C,Oullier T,Girault A,Arbion F,Haelters JP,Jaffrès PA,Pinault M,Besson P,Joulin V,Bougnoux P,Vandier C

更新日期：2013-08-01 00:00:00

abstract：:Motility related protein-1 (MRP-1) is a transmembrane glycoprotein that is identical to the CD9 antigen. In previous studies, we showed that various types of cultured tumor cells transfected with MRP-1/CD9 cDNA have low motility and diminished metastatic potential to the lung. More recently we used immunohistochemical...

journal_title：Cancer research

authors： Higashiyama M,Taki T,Ieki Y,Adachi M,Huang CL,Koh T,Kodama K,Doi O,Miyake M

更新日期：1995-12-15 00:00:00

abstract：:The antitumor effects of methotrexate with 5-fluorouracil against the Sarcoma 180 mouse tumor model were found to be schedule dependent. Pretreatment of tumor-bearing animals with methotrexate significantly enhanced the antitumor activity of the combination relative to simultaneous treatment or to those with methotrex...

journal_title：Cancer research

authors： Bertino JR,Sawicki WL,Lindquist CA,Gupta VS

更新日期：1977-01-01 00:00:00

abstract：:Immune effector cells integrate signals that define the nature and magnitude of the subsequent response. Experimental measures for immune cell-mediated lysis of tumors or virally infected targets rely on average responses of permeability or apoptotic changes within a population of targets. Here, we examined individual...

journal_title：Cancer research

authors： Buchser WJ,Laskow TC,Pavlik PJ,Lin HM,Lotze MT

更新日期：2012-06-15 00:00:00

abstract：:miRNAs (miR) are a critical class of small (21-25 nucleotides) noncoding endogenous RNAs implicated in gene expression regulation. We identified miR-23b and miR-27b as miRNAs that are highly upregulated in human breast cancer. We found that engineered knockdown of miR-23b and miR-27b substantially repressed breast can...

journal_title：Cancer research

authors： Jin L,Wessely O,Marcusson EG,Ivan C,Calin GA,Alahari SK

更新日期：2013-05-01 00:00:00

abstract：:A phosphorylation site was introduced into chimeric monoclonal antibody B72.3 (MAb-chB72.3) by site-specific mutation of the coding sequence. The phosphorylation site for the cAMP-dependent protein kinase was positioned at the carboxyl terminus of the heavy-chain constant region of MAb-chB72.3. The resultant modified ...

journal_title：Cancer research

authors： Lin L,Daugherty B,Schlom J,Pestka S

更新日期：1996-09-15 00:00:00

abstract：:MdmX and Mdm2 regulate p53 tumor suppressor functions by controlling p53 transcriptional activity and/or stability in cells exposed to DNA damage. Accumulating evidence indicates that ATM-mediated phosphorylation and degradation of Mdm2 and MdmX may be the initial driving force that induces p53 activity during the ear...

journal_title：Cancer research

authors： Zhang X,Lin L,Guo H,Yang J,Jones SN,Jochemsen A,Lu X

更新日期：2009-10-15 00:00:00

abstract：:Two lines of human colonic carcinoma cells have different sensitivities to 5-fluorouracil and 1-(2-chlorethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (methyl-CCNU). The growth of the BE line is 50% inhibited by 330 microM 5-fluorouracil and 15 microM methyl-CCNU, and the HT-29 line is 50% inhibited by 85 and 140 microM,...

journal_title：Cancer research

authors： Sutton JE,Roos IA,Hillcoat BL

更新日期：1982-12-01 00:00:00

abstract：:Identification of signaling pathways downstream of Abl tyrosine kinase may increase our understanding of the pathogenesis of chronic myelogenous leukemia (CML) and suggest strategies to improve clinical treatment of the disease. By combining the use of a phosphospecific antibody recognizing a substrate motif of serine...

journal_title：Cancer research

authors： Ly C,Arechiga AF,Melo JV,Walsh CM,Ong ST

更新日期：2003-09-15 00:00:00

abstract：:The AP-2 transcription factors are required for normal growth and morphogenesis during mammalian development. Previous in vitro studies have also indicated that the AP-2 family of proteins may be involved in the etiology of human breast cancer. The AP-2 genes are expressed in many human breast cancer cell lines, and c...

journal_title：Cancer research

authors： Turner BC,Zhang J,Gumbs AA,Maher MG,Kaplan L,Carter D,Glazer PM,Hurst HC,Haffty BG,Williams T

更新日期：1998-12-01 00:00:00

abstract：:Primary solid tumors were mechanically and/or enzymatically disassociated, and the resulting suspensions of single cells and small clumps of cells were seeded onto three different substrates, i.e., tissue culture plastic, rat smooth muscle cells (SMCs), and SMC-derived extracellular matrix. Tests of the relative effec...

journal_title：Cancer research

authors： Bogenmann E,Mark C,Isaacs H,Neustein HB,De Clerck YA,Laug WE,Jones PA

更新日期：1983-03-01 00:00:00

abstract：:Lymph node biopsies from 43 male homosexuals with persistent generalized lymphadenopathy and from ten acquired immunodeficiency syndrome patients, all with serum antibodies to human T-cell leukemia virus III, were studied with regard to histopathology, immunohistology, and T-cell subsets in cell suspensions. All acqui...

journal_title：Cancer research

authors： Biberfeld P,Porwit-Ksiazek A,Böttiger B,Morfeldt-Månsson L,Biberfeld G

更新日期：1985-09-01 00:00:00

abstract：:Caffeine is a key component of many popular drinks, especially tea and coffee. Previous reports have shown that caffeine may contribute to the chemopreventive effect of tea in animals. Here, we report that treatment with low concentrations of caffeine induced apoptosis in JB6 Cl41 cells. JB6 Cl41 cells were starved in...

journal_title：Cancer research

authors： He Z,Ma WY,Hashimoto T,Bode AM,Yang CS,Dong Z

更新日期：2003-08-01 00:00:00