Abstract：
:The WWOX (WW domain containing oxidoreductase) gene was recently identified as a candidate tumor suppressor gene at 16q23.3-24.1, a chromosome region that spans the common fragile site FRA16D. To evaluate the potential role of the WWOX gene in esophageal squamous cell carcinomas, we examined 36 tumors for genetic alterations of the WWOX gene. Loss of heterozygosity (LOH) at the WWOX locus was observed in 14 (39%) tumors. A tumor-specific missense mutation was found in one tumor, and LOH analysis had shown that the other allele was missing. Furthermore, we detected aberrant WWOX gene transcripts with absence of exons 6-8 in two tumors, and complete absence of transcript in one tumor. These results indicate that alteration and inactivation of the WWOX gene may play a role in esophageal squamous cell carcinogenesis.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Kuroki T,Trapasso F,Shiraishi T,Alder H,Mimori K,Mori M,Croce CMsubject
Has Abstractpub_date
2002-04-15 00:00:00pages
2258-60issue
8eissn
0008-5472issn
1538-7445journal_volume
62pub_type
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