Five loci, SLT1 to SLT5, controlling the susceptibility to spontaneously occurring lung cancer in mice.

abstract：:CDC25A phosphatase activates multiple cyclin-dependent kinases (CDK) during cell cycle progression. Inactivation of CDC25A by ubiquitin-mediated degradation is a major mechanism of DNA damage-induced S-G(2) checkpoint. Although increased CDC25A expression has been reported in various human cancer tissues, it remains u...

journal_title：Cancer research

authors： Ray D,Terao Y,Nimbalkar D,Hirai H,Osmundson EC,Zou X,Franks R,Christov K,Kiyokawa H

更新日期：2007-07-15 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen-presenting cells, well equipped to initiate an immune response. Currently, tumor antigen-derived peptide loaded DCs are used in clinical vaccination in cancer patients. However, the optimal dose and route of administration of a DC vaccine still remain to be determined. Us...

journal_title：Cancer research

authors： Eggert AA,Schreurs MW,Boerman OC,Oyen WJ,de Boer AJ,Punt CJ,Figdor CG,Adema GJ

更新日期：1999-07-15 00:00:00

abstract：:A dose-response study in carcinogenesis was carried out with N-nitrosomorpholine in female F344 rats. The compound was administered in drinking water, which was supplied in controlled amounts of 20 ml per day per rat, 5 days a wk. At the two highest dose rates, 100 mg/liter and 40 mg/liter, treatment lasted 25 and 40 ...

journal_title：Cancer research

authors： Lijinsky W,Kovatch RM,Riggs CW,Walters PT

更新日期：1988-04-15 00:00:00

abstract：:Advances in cancer research and personalized medicine will require significant new bridging infrastructures, including more robust biorepositories that link human tissue to clinical phenotypes and outcomes. In order to meet that challenge, four cancer centers formed the Text Information Extraction System (TIES) Cancer...

journal_title：Cancer research

authors： Jacobson RS,Becich MJ,Bollag RJ,Chavan G,Corrigan J,Dhir R,Feldman MD,Gaudioso C,Legowski E,Maihle NJ,Mitchell K,Murphy M,Sakthivel M,Tseytlin E,Weaver J

更新日期：2015-12-15 00:00:00

abstract：:Spontaneous juvenile ovarian granulosa cell (GC) tumors that occur in young girls are similar to GC carcinomas that develop in SWR-derived inbred mice. We analyzed female offspring from a series of matings among SWR and SJL inbred mice for chromosomal loci underlying tumor susceptibility. Intercross F2 female mice wer...

journal_title：Cancer research

authors： Beamer WG,Shultz KL,Tennent BJ,Nadeau JH,Churchill GA,Eicher EM

更新日期：1998-08-15 00:00:00

abstract：:Epidemiological studies provide evidence that environmental factors (external agents such as chemicals, radiation, and viruses) play a major role in the causation of the majority of human tumors. This is a highly optimistic message, since it implies that cancer is largely a preventable disease. To meet this challenge ...

journal_title：Cancer research

authors： Weinstein IB

更新日期：1988-08-01 00:00:00

abstract：:"Self" melanocyte differentiation antigens are potential targets for specific melanoma immunotherapy. Vaccination against murine tyrosinase-related protein (TRP)-1/gp75 was shown recently to cause melanoma rejection, which was accompanied by autoimmune skin depigmentation (vitiligo). To further explore the linkage bet...

journal_title：Cancer research

authors： Bronte V,Apolloni E,Ronca R,Zamboni P,Overwijk WW,Surman DR,Restifo NP,Zanovello P

更新日期：2000-01-15 00:00:00

abstract：:Early phase evaluation of anticancer drugs has traditionally used toxicity (usually hematological) rather than efficacy end points to establish appropriate dosing schedules. To establish a biochemical efficacy end point for overcoming alkylguanine DNA alkyltransferase (AGT)-mediated tumor cell resistance to 1,3-bis(2-...

journal_title：Cancer research

authors： Spiro TP,Gerson SL,Liu L,Majka S,Haaga J,Hoppel CL,Ingalls ST,Pluda JM,Willson JK

更新日期：1999-05-15 00:00:00

abstract：:LIGHT, a ligand for the lymphotoxin-beta receptor, establishes lymphoid-like tissues inside tumor sites and recruits naïve T cells into the tumor. However, whether these infiltrating T cells are specific for tumor antigens is not known. We hypothesized that therapy with LIGHT can expand functional tumor-specific CD8(+...

journal_title：Cancer research

authors： Kanodia S,Da Silva DM,Karamanukyan T,Bogaert L,Fu YX,Kast WM

更新日期：2010-05-15 00:00:00

abstract：:The relative effectiveness of either sodium selenite or selenomethionine in the inhibition of mammary carcinogenesis was studied in virgin female Sprague-Dawley rats. In one experiment, rats were given 50 mg of 1-methyl-1-nitrosourea per kg of body weight s.c. at 50 days of age. Beginning 7 days post-1-methyl-1-nitros...

journal_title：Cancer research

authors： Thompson HJ,Meeker LD,Kokoska S

更新日期：1984-07-01 00:00:00

abstract：:The possible mutagenic potential of exposure to 1.5 GHz electromagnetic near field (EMF) was investigated using brain tissues of Big Blue mice (BBM). Male BBM were locally exposed to EMF in the head region at 2.0, 0.67, and 0 W/kg specific absorption rate for 90 min/day, 5 days/week, for 4 weeks. No gliosis or degener...

journal_title：Cancer research

authors： Takahashi S,Inaguma S,Cho YM,Imaida K,Wang J,Fujiwara O,Shirai T

更新日期：2002-04-01 00:00:00

abstract：:Epidemiological studies have shown that the regular consumption of red wine may in part account for the apparent compatibility of a high fat diet with a low incidence of coronary atherosclerosis. This phenomenon, commonly referred to as the French paradox, may be associated with red wine constituents that exhibit tumo...

journal_title：Cancer research

authors： Hsieh TC,Juan G,Darzynkiewicz Z,Wu JM

更新日期：1999-06-01 00:00:00

abstract：:We analyzed the epidermal growth factor receptor gene using a complementary DNA probe of the epidermal growth factor receptor gene in 21 uncultured primary breast carcinomas and found that the gene was amplified in three of these tumors. We further demonstrated by immunohistochemistry using a monoclonal antibody to th...

journal_title：Cancer research

authors： Ro J,North SM,Gallick GE,Hortobagyi GN,Gutterman JU,Blick M

更新日期：1988-01-01 00:00:00

abstract：:Repurposing "old" drugs can facilitate rapid clinical translation but necessitates novel mechanistic insight. Warfarin, a vitamin K "antagonist" used clinically for the prevention of thrombosis for more than 50 years, has been shown to have anticancer effects. We hypothesized that the molecular mechanism underlying it...

journal_title：Cancer research

authors： Kirane A,Ludwig KF,Sorrelle N,Haaland G,Sandal T,Ranaweera R,Toombs JE,Wang M,Dineen SP,Micklem D,Dellinger MT,Lorens JB,Brekken RA

更新日期：2015-09-15 00:00:00

abstract：:Successive B16 melanoma tumor lines were selected for their ability to form pulmonary tumor nodules. This was accomplished by injecting tumor cells i.v. into syngeneic C57BL/6 mice and 2 to 3 weeks later collecting the secondary tumor growths and placing them into tissue culture. These tumor cells were then injected i...

journal_title：Cancer research

authors： Fidler IJ

更新日期：1975-01-01 00:00:00

abstract：:In this report, we describe the immunomodulatory characteristics of poly(I,C)-LC, a synthetic, double-stranded nucleic acid polymer, polyinosinic-polycytidylic acid, that is complexed with poly-L-lysine and solubilized by the addition of carboxymethylcellulose. We consistently observed, both in vitro and in vivo, stim...

journal_title：Cancer research

authors： Talmadge JE,Adams J,Phillips H,Collins M,Lenz B,Schneider M,Schlick E,Ruffmann R,Wiltrout RH,Chirigos MA

更新日期：1985-03-01 00:00:00

abstract：:Low-grade serous ovarian carcinoma (LGSOC) is a rare tumor subtype with high case fatality rates in patients with metastatic disease. There is a pressing need to develop effective treatments using newly available preclinical models for therapeutic discovery and drug evaluation. Here we use multiomics integration of wh...

journal_title：Cancer research

authors： Shrestha R,Llaurado Fernandez M,Dawson A,Hoenisch J,Volik S,Lin YY,Anderson S,Kim H,Haegert AM,Colborne S,Wong NKY,McConeghy B,Bell RH,Brahmbhatt S,Lee CH,DiMattia GE,Le Bihan S,Morin GB,Collins CC,Carey MS

更新日期：2021-01-13 00:00:00

abstract：:Proline is a readily released stress substrate that can be metabolized by proline oxidase (POX) to generate either reactive oxygen species (ROS) to induce apoptosis or autophagy or ATP during times of nutrient stress. However, the contribution of proline metabolism to tumorigenesis in hypoxic microenvironments has not...

journal_title：Cancer research

authors： Liu W,Glunde K,Bhujwalla ZM,Raman V,Sharma A,Phang JM

更新日期：2012-07-15 00:00:00

abstract：:Cholangiocarcinoma is a strongly aggressive malignancy with a very poor prognosis. Effective therapeutic strategies are lacking because molecular mechanisms regulating cholangiocarcinoma cell growth are unknown. Furthermore, experimental in vivo animal models useful to study the pathophysiologic mechanisms of malignan...

journal_title：Cancer research

authors： Fava G,Alpini G,Rychlicki C,Saccomanno S,DeMorrow S,Trozzi L,Candelaresi C,Venter J,Di Sario A,Marzioni M,Bearzi I,Glaser S,Alvaro D,Marucci L,Francis H,Svegliati-Baroni G,Benedetti A

更新日期：2008-08-15 00:00:00

abstract：:The effect of dietary fat concentration and saturation on high energy phosphate metabolites and phospholipid turnover in transplanted line 168 murine mammary tumors was studied using surface coil 31P-nuclear magnetic resonance spectroscopy. Female BALB/c mice were fed one of five diets each containing at least the min...

journal_title：Cancer research

authors： Buckman DK,Erickson KL,Ross BD

更新日期：1987-11-01 00:00:00

abstract：:Angiogenesis is a crucial step in tumor growth and progression. Its quantitation by microvessel counting is of prognostic value in several types of malignancies. Scarce data are available on angiogenesis in gastrointestinal tumors. We studied 36 adenomas and 178 large bowel carcinomas to evaluate the onset of angiogen...

journal_title：Cancer research

authors： Bossi P,Viale G,Lee AK,Alfano R,Coggi G,Bosari S

更新日期：1995-11-01 00:00:00

abstract：:The invasive transformation of A-459 lung epithelial carcinoma cells has been linked to the autocrine regulation of malignant phenotypic changes by transforming growth factor beta (TGF-beta). Here we demonstrate, using stable 13C glucose isotopes, that the transformed phenotype is characterized by decreased CO2 produc...

journal_title：Cancer research

authors： Boros LG,Torday JS,Lim S,Bassilian S,Cascante M,Lee WN

更新日期：2000-03-01 00:00:00

abstract：:Loss of serine or threonine phosphorylation sites from exon 3 of beta-catenin has been identified in approximately half of colorectal tumors which lack adenomatous polyposis coli (APC) mutations, but the overall contribution of beta-catenin mutations to sporadic colorectal tumorigenesis is unclear. We therefore used P...

journal_title：Cancer research

authors： Samowitz WS,Powers MD,Spirio LN,Nollet F,van Roy F,Slattery ML

更新日期：1999-04-01 00:00:00

abstract：:Serial pulmonary function tests including single-breath carbon monoxide-diffusing capacity (DLCO), forced vital capacity (FVC), and forced expiratory volume in 1 sec were performed in a relatively homogeneous group of male patients with germ cell tumors treated with vinblastine, bleomycin, and cis-diamminedichloroplat...

journal_title：Cancer research

authors： Comis RL,Kuppinger MS,Ginsberg SJ,Crooke ST,Gilbert R,Auchincloss JH,Prestayko AW

更新日期：1979-12-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a developmental program, which is associated with breast cancer progression and metastasis. Here, we report that ectopic overexpression of SOX4 in immortalized human mammary epithelial cells is sufficient for acquisition of mesenchymal traits, enhanced cell migration, and inv...

journal_title：Cancer research

authors： Zhang J,Liang Q,Lei Y,Yao M,Li L,Gao X,Feng J,Zhang Y,Gao H,Liu DX,Lu J,Huang B

更新日期：2012-09-01 00:00:00

abstract：:Chemotherapy response in patients with primary breast cancer is difficult to predict and the role of host genetic factors has not been thoroughly investigated. We hypothesized that polymorphisms in oxidative stress (OS)-related genes, including estrogen-quinone metabolizing enzymes NQO2 and GSTM1-5, may influence dise...

journal_title：Cancer research

authors： Yu KD,Huang AJ,Fan L,Li WF,Shao ZM

更新日期：2012-01-15 00:00:00

abstract：:Native chromosomal structure, breakage, and overall degradation were studied following the reaction of whole cells with the anticancer drug bleomycin and structurally related phleomycin. Electrophoretic analyses of cellular DNA established that phleomycin was more reactive with DNA than equimolar bleomycin in the rang...

journal_title：Cancer research

authors： Moore CW

更新日期：1988-12-01 00:00:00

abstract：:The growth and survival of many types of cancer cells are known to be supported by specific growth factor/cytokine systems. Among these, the activation of c-kit receptor and its ligand steel factor participates in several types of human carcinogenesis. W mutations of laboratory mouse strains are loss of functional mut...

journal_title：Cancer research

authors： Li Q,Kondoh G,Inafuku S,Nishimune Y,Hakura A

更新日期：1996-10-01 00:00:00

abstract：:Neuroblastoma (NB), a common pediatric neoplasm, consists of two main cell populations: neuroblastic/ganglionic cells and Schwann cells. NB tumors with abundant Schwannian stroma display a more benign clinical behavior than stroma-poor tumors. Recent studies suggest that Schwann cells influence NB tumor growth via sec...

journal_title：Cancer research

authors： Chlenski A,Liu S,Crawford SE,Volpert OV,DeVries GH,Evangelista A,Yang Q,Salwen HR,Farrer R,Bray J,Cohn SL

更新日期：2002-12-15 00:00:00

abstract：:Ionizing radiation (IR) and concomitant angiostatin (AS) produce greater than additive local antitumor effects. We examined whether prolonged AS treatment added to IR reduces proliferation of lung metastases from LLC primary tumors. Flank tumors were treated with 40 Gy with or without AS (25 mg/kg/day). IR plus a 14-d...

journal_title：Cancer research

authors： Gorski DH,Mauceri HJ,Salloum RM,Halpern A,Seetharam S,Weichselbaum RR

更新日期：2003-01-15 00:00:00