Genetic variants in oxidative stress-related genes predict chemoresistance in primary breast cancer: a prospective observational study and validation.

abstract：:Altered DNA methylation is a key feature of cancer, and aberrant methylation is important in nasopharyngeal carcinoma (NPC) development. However, the methylation mechanisms underlying metastasis of NPC remain unclear. Analyzing data from public databases and conducting our own experiments, we report here that promoter...

journal_title：Cancer research

authors： Zhang J,Li YQ,Guo R,Wang YQ,Zhang PP,Tang XR,Wen X,Hong XH,Lei Y,He QM,Yang XJ,Sun Y,Ma J,Liu N

更新日期：2019-02-15 00:00:00

abstract：:Glycolipids of murine lymphoma cell lines with low metastatic (Eb) and high metastatic (ESb) potentials have been investigated. The Eb cell line was characterized by a high quantity of gangliotriaosylceramide (Gg3), gangliotetraosylceramide (Gg4), GM1b, and a new type of disialoganglioside, termed GD1 alpha. In contra...

journal_title：Cancer research

authors： Murayama K,Levery SB,Schirrmacher V,Hakomori S

更新日期：1986-03-01 00:00:00

abstract：:The asymmetric organization of epithelial cells is a basic counter to cellular proliferation. However, the mechanisms whereby pro-growth pathways are modulated by intracellular factors that control cell shape are not well understood. This study demonstrates that the adaptor protein Amot, in addition to its established...

journal_title：Cancer research

authors： Ranahan WP,Han Z,Smith-Kinnaman W,Nabinger SC,Heller B,Herbert BS,Chan R,Wells CD

更新日期：2011-03-15 00:00:00

abstract：:Most patients' prostate cancers respond to androgen deprivation but relapse after periods of several months to years. Only two prostate cancer xenografts, LNCaP and PC-346, have been reported to be responsive to androgen deprivation and to relapse subsequently. Both of these tumors shrink slightly, if at all, and rela...

journal_title：Cancer research

authors： Nagabhushan M,Miller CM,Pretlow TP,Giaconia JM,Edgehouse NL,Schwartz S,Kung HJ,de Vere White RW,Gumerlock PH,Resnick MI,Amini SB,Pretlow TG

更新日期：1996-07-01 00:00:00

abstract：:Understanding molecular alterations in colorectal cancer (CRC) is needed to define new biomarkers and treatment targets. We used oligonucleotide microarrays to monitor gene expression of about 6,800 known genes and 35,000 expressed sequence tags (ESTs) on five pools (four to six samples in each pool) of total RNA from...

journal_title：Cancer research

authors： Birkenkamp-Demtroder K,Christensen LL,Olesen SH,Frederiksen CM,Laiho P,Aaltonen LA,Laurberg S,Sørensen FB,Hagemann R,ØRntoft TF

更新日期：2002-08-01 00:00:00

abstract：:Reactive oxygen species play a critical role in the onset of apoptosis induced by various extracellular stimuli, including ionizing radiation. Therefore active regulation of reactive oxygen species-metabolizing enzymes may be one response to an apoptotic stimulus. In this regard, HP100 cells, H(2)O(2)-resistant varian...

journal_title：Cancer research

authors： Nenoi M,Ichimura S,Mita K,Yukawa O,Cartwright IL

更新日期：2001-08-01 00:00:00

abstract：:Discovery of somatically mutated cells in human tissues has been less frequent than would be predicted by in vitro mutational rates. We analyzed the PTEN tumor suppressor gene as an early marker for endometrial carcinogenesis, and we show that 43% of histologically normal premenopausal endometria contain rare glands t...

journal_title：Cancer research

authors： Mutter GL,Ince TA,Baak JP,Kust GA,Zhou XP,Eng C

更新日期：2001-06-01 00:00:00

abstract：:A historical cohort of 68 female breast cancer patients from one institution who were enrolled in a multicenter randomized controlled trial between 1971 and 1973 were followed up to the beginning of 1986. Weight and height at the time of mastectomy were transformed into two indices of body size, namely the Quetelet In...

journal_title：Cancer research

authors： Suissa S,Pollak M,Spitzer WO,Margolese R

更新日期：1989-06-01 00:00:00

abstract：:Friend erythroleukemia cells can be induced to undergo erythroid differentiation by a variety of unrelated compounds. The fact that sodium butyrate causes reversible alterations in growth, morphology, and biochemistry in many cell systems prompted us to reexamine its pattern of induction of differentiation and to comp...

journal_title：Cancer research

authors： Friend C,Zajac-Kaye M,Holland JG,Pogo BG

更新日期：1987-01-15 00:00:00

abstract：:Deleted in colorectal cancer (DCC), the receptor for the multifunctional cue netrin-1, acts as a tumor suppressor in intestinal cancer and lung metastasis by triggering cancer cell death when netrin-1 is lowly expressed. Recent genomic data highlighted that DCC is the third most frequently mutated gene in melanoma; we...

journal_title：Cancer research

authors： Boussouar A,Tortereau A,Manceau A,Paradisi A,Gadot N,Vial J,Neves D,Larue L,Battistella M,Leboeuf C,Lebbé C,Janin A,Mehlen P

更新日期：2020-02-15 00:00:00

abstract：:Transplabtable Zajdela rat ascites hepatoma cells, previously considered "nonproducers," synthesize detectable amounts of intracellular alpha-fetoprotein (AFP) and fibrinogen, but fail to secret or release these serum proteins. Evidence for defective secretory mechanisms for serum proteins in these hepatoma cells (a) ...

journal_title：Cancer research

authors： Sarcione EJ,Smalley JR

更新日期：1976-09-01 00:00:00

abstract：:The effects of retinyl acetate and all-trans-retinoic acid on the growth rate, saturation density, and cytoplasmic underlapping of normal and carcinogen-initiated C3H/1OT1/2 cells were examined. Retinyl acetate (a) decreased the saturation density by as much as 45%, (b) had no effect on the growth rate, (c) reduced cy...

journal_title：Cancer research

authors： Mordan LJ,Bertram JS

更新日期：1983-02-01 00:00:00

abstract：:Functional roles for the cancer cell-associated membrane type I matrix metalloproteinase (MT1-MMP) during early steps of the metastatic cascade in primary tumors remain unresolved. In an effort to determine its significance, we determined the in vivo effects of RNAi-mediated downregulation in mammary cancer cells on t...

journal_title：Cancer research

authors： Perentes JY,Kirkpatrick ND,Nagano S,Smith EY,Shaver CM,Sgroi D,Garkavtsev I,Munn LL,Jain RK,Boucher Y

更新日期：2011-07-01 00:00:00

abstract：:BALB/cJ X C57BL/10Sn F1 (hereafter called B10F1) hybrids resist challenge with the BALB/c plasmacytoma, MPC-11, by a radiation-sensitive, silica-insensitive mechanism, whereas BALB/cJ X BALB.B F1 (hereafter called BALB.BF1) hybrids are as susceptible to MPC-11 as are homozygous BALB/c mice themselves. To investigate t...

journal_title：Cancer research

authors： Marsili MA,Walker MC,Phillips-Quagliata JM

更新日期：1986-01-01 00:00:00

abstract：:Determining to what degree chemicals and environmental agents contribute to the development of cancer would be materially enhanced by the ability to distinguish chemically induced tumors from those that arise spontaneously. Using DNA fingerprinting as an assay, we investigated whether somatic DNA rearrangements are mo...

journal_title：Cancer research

authors： Ledwith BJ,Storer RD,Prahalada S,Manam S,Leander KR,van Zwieten MJ,Nichols WW,Bradley MO

更新日期：1990-09-01 00:00:00

abstract：:The secreted frizzled-related proteins (SFRPs) function as negative regulators of Wnt signaling and have important implications in tumorigenesis. Frequent promoter hypermethylation of SFRPs has been identified in human cancer. Restoration of SFRP function attenuates Wnt signaling and induces apoptosis in a variety of ...

journal_title：Cancer research

authors： He B,Lee AY,Dadfarmay S,You L,Xu Z,Reguart N,Mazieres J,Mikami I,McCormick F,Jablons DM

更新日期：2005-02-01 00:00:00

abstract：:We have studied the cellular expression of NB/70K, a glycoprotein proposed to be human ovarian tumor associated described previously. Analysis of cells bearing this antigen in malignant ascites shows expression in tumor cells of gynecological origin (ovarian, endometrial) and to a limited degree in breast cancer cells...

journal_title：Cancer research

authors： Bizzari JP,Mackillop WJ,Buick RN

更新日期：1983-02-01 00:00:00

abstract：:CTLA4 is a cell surface receptor on T cells that functions as an immune checkpoint molecule to enforce tolerance to cognate antigens. Anti-CTLA4 immunotherapy is highly effective at reactivating T-cell responses against melanoma, which is postulated to be due to targeting CTLA4 on T cells. Here, we report that CTLA4 i...

journal_title：Cancer research

authors： Mo X,Zhang H,Preston S,Martin K,Zhou B,Vadalia N,Gamero AM,Soboloff J,Tempera I,Zaidi MR

更新日期：2018-01-15 00:00:00

abstract：:Triple-negative breast cancer (TNBC) commonly develops resistance to chemotherapy, yet markers predictive of chemoresistance in this disease are lacking. Here, we define WNT10B-dependent biomarkers for β-CATENIN/HMGA2/EZH2 signaling predictive of reduced relapse-free survival. Concordant expression of HMGA2 and EZH2 p...

journal_title：Cancer research

authors： El Ayachi I,Fatima I,Wend P,Alva-Ornelas JA,Runke S,Kuenzinger WL,Silva J,Silva W,Gray JK,Lehr S,Barch HC,Krutilina RI,White AC,Cardiff R,Yee LD,Yang L,O'Regan RM,Lowry WE,Seagroves TN,Seewaldt V,Krum SA,Miranda

更新日期：2019-03-01 00:00:00

abstract：:Dysregulation in patterns of alternative RNA splicing in cancer cells is emerging as a significant factor in cancer pathophysiology. In this study, we investigated the little known alternative splice isoform survivin-3B (S-3B) that is overexpressed in a tumor-specific manner. Ectopic overexpression of S-3B drove tumor...

journal_title：Cancer research

authors： Végran F,Mary R,Gibeaud A,Mirjolet C,Collin B,Oudot A,Charon-Barra C,Arnould L,Lizard-Nacol S,Boidot R

更新日期：2013-09-01 00:00:00

abstract：:Early diagnosis of lung cancer based on conventional screening procedures has been unable thus far to decrease lung cancer mortality. We explored the possibility of using microsatellite instability in the detection and screening of early phases of lung carcinogenesis. We studied tumor, histopathologically normal bronc...

journal_title：Cancer research

authors： Miozzo M,Sozzi G,Musso K,Pilotti S,Incarbone M,Pastorino U,Pierotti MA

更新日期：1996-05-15 00:00:00

abstract：:We investigated the effect of iododeoxyuridine (IdUrd) exposure on cis-diamminedichloroplatinum (CDDP) cytotoxicity in the human bladder cancer cell line 647V. Following a 48-h incubation with 2-20 microM IdUrd, a 1-h exposure to 0-120 microM CDDP produced a dose-dependent increase in CDDP cytotoxicity as measured by ...

journal_title：Cancer research

authors： Chi KH,Kunugi KA,Kinsella TJ

更新日期：1994-05-15 00:00:00

abstract：:The breakpoint of t(11;14)(q23;q32) chromosome translocation in a B-cell lymphoma line, RC-K8, was cloned. Immunoglobulin heavy chain (IGH) constant gene, C gamma 2 at the 5' end, was involved in this translocation, and the DNA segment juxtaposed to the C gamma 2 was proved to be derived from chromosome 11 by somatic ...

journal_title：Cancer research

authors： Akao Y,Seto M,Takahashi T,Kubonishi I,Miyoshi I,Nakazawa S,Tsujimoto Y,Croce CM,Ueda R

更新日期：1991-03-01 00:00:00

abstract：:Wnt ligand-driven tumor growth is inhibited by the soluble Wnt inhibitor Fzd8CRD, but the mechanism through which this effect is mediated is unknown. In the MMTV-Wnt1 mouse model, regression of mammary tumors by Fzd8CRD treatment coincides with an acute and strong induction of insulin-like growth factor (IGF)-binding ...

journal_title：Cancer research

authors： Liu BY,Soloviev I,Huang X,Chang P,Ernst JA,Polakis P,Sakanaka C

更新日期：2012-03-15 00:00:00

abstract：:Clear cell renal carcinomas are most frequently characterized by loss of function of both copies of the von Hippel-Lindau (VHL) disease gene, suggesting that the VHL gene product plays an important role in regulating renal cell proliferation. To directly assess the function of the VHL gene product, we transfected the ...

journal_title：Cancer research

authors： Chen F,Kishida T,Duh FM,Renbaum P,Orcutt ML,Schmidt L,Zbar B

更新日期：1995-11-01 00:00:00

abstract：:Using alternative reading frames, the human ARF-INK4a locus encodes two unrelated proteins that both function in tumor suppression. p16(INK4a) maintains the retinoblastoma protein in its growth-suppressive state through inhibition of cyclin D-dependent kinase activity, whereas ARF binds with MDM2 and stabilizes p53. T...

journal_title：Cancer research

authors： Yarbrough WG,Bessho M,Zanation A,Bisi JE,Xiong Y

更新日期：2002-02-15 00:00:00

abstract：:Primary melanocytes attach poorly to collagen type IV and laminin, in contrast to their firm attachment to collagen type I/III and fibronectin [Gilchrest et al., In vitro (Rockville), 21: 114-120, 1985]. We have now found that metastatic B16 melanoma cells attach well to collagen type IV, laminin, vitronectin, and fib...

journal_title：Cancer research

authors： Rieber M,Gross A,Rieber MS

更新日期：1987-10-01 00:00:00

abstract：:Primary and metastatic bone cancers are difficult to eradicate and novel approaches are needed to improve treatment and extend life. As bone cancer grows, osteoclasts, the principal bone-resorbing cells of the body, are recruited to and activated at sites of cancer. In this investigation, we determined if osteoclast l...

journal_title：Cancer research

authors： Ramnaraine ML,Mathews WE,Donohue JM,Lynch CM,Goblirsch MJ,Clohisy DR

更新日期：2006-11-15 00:00:00

abstract：:High expression of VEGFC predicts adverse prognosis in acute myeloid leukemia (AML). We therefore explored VEGFC-targeting efficacy as an AML therapy using a VEGFC mAb. VEGFC antibody therapy enforced myelocytic differentiation of clonal CD34+ AML blasts. Treatment of CD34+ AML blasts with the antibody reduced expansi...

journal_title：Cancer research

authors： Kampen KR,Scherpen FJG,Mahmud H,Ter Elst A,Mulder AB,Guryev V,Verhagen HJMP,De Keersmaecker K,Smit L,Kornblau SM,De Bont ESJM

更新日期：2018-10-15 00:00:00

abstract：:The ability of the in vitro sister chromatid exchange (SCE) assay to predict in vivo tumor drug sensitivity was investigated using a spontaneous hepatocarcinoma in C3Hf/Kam mice and 3 chemotherapeutic agents: melphalan; cis-platinum; and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). For hepatocarcinoma cells grown in m...

journal_title：Cancer research

authors： Tofilon PJ,Basic I,Milas L

更新日期：1985-05-01 00:00:00