VEGFC Antibody Therapy Drives Differentiation of AML.

abstract：:A transplanted rat lymphosarcoma (SGT-4), induced by Gross virus and inoculated s.c. into the foot of a normal syngeneic rat, initially grew but ultimately regressed. The tumor cells metastasized to the regional popliteal, lumbar, and inguinal lymph nodes and formed massive metastatic foci there. These lymph node meta...

journal_title：Cancer research

authors： Kodama T,Gotohda E,Takeichi N,Kuzumaki N,Kobayashi H

更新日期：1975-07-01 00:00:00

abstract：:Partial regression in cutaneous malignant melanoma has been reported by a number of observers, albeit not all, to be associated with a relatively poor prognosis; in contrast, a keratoacanthoma, which eventually regresses, does not metastasize. The Hammond effect could explain the possibly poor prognosis of the thin re...

journal_title：Cancer research

authors： Prehn RT

更新日期：1996-03-01 00:00:00

abstract：:Prostate cancer has become epidemic, and environmental factors such as cadmium may be partly responsible. This study reports malignant transformation of the nontumorigenic human prostatic epithelial cell line RWPE-1 by in vitro cadmium exposure. The cadmium-transformed cells exhibited a loss of contact inhibition in v...

journal_title：Cancer research

authors： Achanzar WE,Diwan BA,Liu J,Quader ST,Webber MM,Waalkes MP

更新日期：2001-01-15 00:00:00

abstract：:Fes is a protein tyrosine kinase with cell autonomous oncogenic activities that are well established in cell culture and animal models, but its involvement in human cancer has been unclear. Abundant expression of Fes in vascular endothelial cells and myeloid cell lineages prompted us to explore roles for Fes in the tu...

journal_title：Cancer research

authors： Zhang S,Chitu V,Stanley ER,Elliott BE,Greer PA

更新日期：2011-02-15 00:00:00

abstract：:When L1210 cells growing logarithmically were exposed for 8 hr to a nonlethal dose of 5-fluorouracil (FU) (0.25 microgram/ml), the percentage of cells in S phase increased from 74.9% in the asynchronous culture to 93% in the FU-treated culture. This resulted in increased cell-kill by S-phase-specific inhibitors [1-bet...

journal_title：Cancer research

authors： Bhuyan BK,Blowers CL,Neil GL,Bono VH,Day KJ

更新日期：1977-09-01 00:00:00

abstract：:SNAI2 overexpression appears to be associated with poor prognosis in breast cancer, yet it remains unclear in which breast cancer subtypes this occurs. Here we show that excess SNAI2 is associated with a poor prognosis of luminal B HER2+/ERBB2+ breast cancers in which SNAI2 expression in the stroma but not the epithel...

journal_title：Cancer research

authors： Blanco-Gómez A,Hontecillas-Prieto L,Corchado-Cobos R,García-Sancha N,Salvador N,Castellanos-Martín A,Sáez-Freire MDM,Mendiburu-Eliçabe M,Alonso-López D,De Las Rivas J,Lorente M,García-Casas A,Del Carmen S,Abad-Hernández MDM,C

更新日期：2020-12-01 00:00:00

abstract：:Herpesvirus saimiri (HVS) was propagated in vero cells for 3 passages at 39 degrees and cloned 3 times at 34 degrees. This virus was inoculated into cotton-topped marmoset and squirrel monkeys; all inoculated monkeys became infected as HVS was reisolated after their circulating lymphocytes were cultured with vero cell...

journal_title：Cancer research

authors： Falk L,Wright J,Deinhardt F,Wolfe L,Schaffer P,Benyesh-Melnick M

更新日期：1976-02-01 00:00:00

abstract：:Oncogenic transformation of mouse 10T 1/2 fibroblasts induced upon exposure to X-ray or N-methyl-N'-nitro-N-nitrosoguanidine was suppressed if lipopolysaccharide (LPS) was present in the culture medium. The suppressive effect of LPS was exerted within 24 h after irradiation. Suppression was dependent on the concentrat...

journal_title：Cancer research

authors： Sakiyama H,Yasukawa M,Terasima T,Kanegasaki S

更新日期：1986-08-01 00:00:00

abstract：:Pregnancy at early, but not late age, has a strong and life-long protective effect against breast cancer. The expected overall increase in breast cancer incidence demands the development of a pharmaceutical mimicry of early-age pregnancy-mediated protection. Recently, converging results from rodent models and women on...

journal_title：Cancer research

authors： Meier-Abt F,Bentires-Alj M,Rochlitz C

更新日期：2015-03-01 00:00:00

abstract：:The liver represents a major and frequently sole site of metastases for many types of cancer, particularly gastrointestinal cancers. We showed previously that coadministration of an engineered hepatic-targeting Listeria monocytogenes (LM) with a cancer vaccine enhanced the antitumor effect of vaccine-induced T cells s...

journal_title：Cancer research

authors： Yoshimura K,Laird LS,Chia CY,Meckel KF,Slansky JE,Thompson JM,Jain A,Pardoll DM,Schulick RD

更新日期：2007-10-15 00:00:00

abstract：:Prostate cancer (PCa) is the most common male cancer in the United States. A major challenge that remains is to predict the clinical outcome in managing PCa patients. The prolyl isomerase Pin1 has been shown to be overexpressed in some human cancer tissues and thought to be an important player in several oncogenic pat...

journal_title：Cancer research

authors： Ayala G,Wang D,Wulf G,Frolov A,Li R,Sowadski J,Wheeler TM,Lu KP,Bao L

更新日期：2003-10-01 00:00:00

abstract：:alpha-Interferon (IFN-alpha) induced unique ultrastructural alterations in peripheral blood and splenic hairy cell leukemia (HCL) cells (14 of 20 cases) treated in vitro. To further investigate the effects of B-cell growth factor (BCGF) and IFN-alpha on target hairy cells (HCs), we utilized immunogold labeling in conj...

journal_title：Cancer research

authors： Gamliel H,Brownstein BH,Gurfel D,Wu SH,Rosner MC,Golomb HM

更新日期：1990-07-01 00:00:00

abstract：:Clinical efficacy of PD-1/PD-L1 targeting relies upon the reactivation of tumor-specific but functionally impaired PD-1+ T cells present before therapy. Thus, analyzing early-stage primary tumors may reveal the presence of T cells that are not yet functionally impaired. In this study, we report that activated (HLA-DR+...

journal_title：Cancer research

authors： Tassi E,Grazia G,Vegetti C,Bersani I,Bertolini G,Molla A,Baldassari P,Andriani F,Roz L,Sozzi G,Pastorino U,Mortarini R,Anichini A

更新日期：2017-02-15 00:00:00

abstract：:Experimentally induced breast cancer is often preceded by the appearance of preneoplastic lesions which possess the attributes of hyperplastic normal tissue. These lesions can be isolated and carried as stably transplantable outgrowth lines which continue to morphologically resemble differentiating mammary tissue (Med...

journal_title：Cancer research

authors： Smith GH,Vonderhaar BK,Graham DE,Medina D

更新日期：1984-08-01 00:00:00

abstract：:Tumorigenic activities of the (+)- and (-)-enantiomers of the diastereomeric, bay-region benzo(c)phenanthrene 3,4-diol-1,2-epoxides were evaluated in two mouse tumor models. In an initiation-promotion experiment on mouse skin, a single topical application of 10, 25, or 75 nmol of the compounds was followed by 20 weeks...

journal_title：Cancer research

authors： Levin W,Chang RL,Wood AW,Thakker DR,Yagi H,Jerina DM,Conney AH

更新日期：1986-05-01 00:00:00

abstract：:Loss of chromosome 19p is one of the most frequent allelic imbalances in esophageal squamous cell carcinoma (ESCC), suggesting the existence of one or more tumor suppressor genes within this region. In this study, we investigated a role in ESCCs for a candidate tumor suppressor gene located at 19p13.3, the Ras-like sm...

journal_title：Cancer research

authors： Zhu YH,Fu L,Chen L,Qin YR,Liu H,Xie F,Zeng T,Dong SS,Li J,Li Y,Dai Y,Xie D,Guan XY

更新日期：2013-04-01 00:00:00

abstract：:Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor protein that plays a critical role in FGFR signaling. FRS2 is located on chromosome 12q13-15 that is frequently amplified in liposarcomas. The significance of FRS2 and FGFR signaling in high-grade liposarcomas is unknown. Herein, we first ...

journal_title：Cancer research

authors： Zhang K,Chu K,Wu X,Gao H,Wang J,Yuan YC,Loera S,Ho K,Wang Y,Chow W,Un F,Chu P,Yen Y

更新日期：2013-02-15 00:00:00

abstract：:Karyotypic and molecular genetic evidence has indicated that deletion or rearrangement of both chromosomes 3 and 13 may be important in the pathology of human small cell lung cancer (SCLC). The retinoblastoma susceptibility gene, RB, on chromosome 13 band q14, has previously been shown to be altered in SCLC [J. W. Har...

journal_title：Cancer research

authors： Hensel CH,Hsieh CL,Gazdar AF,Johnson BE,Sakaguchi AY,Naylor SL,Lee WH,Lee EY

更新日期：1990-05-15 00:00:00

abstract：:To identify genetic events that characterize cancer progression, we conducted a comprehensive genetic evaluation of 161 primary breast tumors. Similar to the "mountain-and-hill" view of mutations, gene amplification also shows high- and low-frequency alterations in breast cancers. The frequently amplified genes includ...

journal_title：Cancer research

authors： Kadota M,Sato M,Duncan B,Ooshima A,Yang HH,Diaz-Meyer N,Gere S,Kageyama S,Fukuoka J,Nagata T,Tsukada K,Dunn BK,Wakefield LM,Lee MP

更新日期：2009-09-15 00:00:00

abstract：:The expression of epidermal growth factor receptor and transglutaminase type I, polyamine (putrescine, spermidine, and spermine) levels, ornithine decarboxylase activity, and micronuclei occurrence were assessed in the 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch model to elucidate the role and t...

journal_title：Cancer research

authors： Shin DM,Gimenez IB,Lee JS,Nishioka K,Wargovich MJ,Thacher S,Lotan R,Slaga TJ,Hong WK

更新日期：1990-04-15 00:00:00

abstract：:In the present study, we examined hemodynamics in vasculogenic mimicry (VM) and angiogenesis of inflammatory breast cancer (IBC) xenografts (WIBC-9), having previously reported on the unique histological features and molecular basis of these processes (K. Shirakawa et al., Cancer Res., 61: 445-451, 2001). Histological...

journal_title：Cancer research

authors： Shirakawa K,Kobayashi H,Heike Y,Kawamoto S,Brechbiel MW,Kasumi F,Iwanaga T,Konishi F,Terada M,Wakasugi H

更新日期：2002-01-15 00:00:00

abstract：:One hundred seven Chinese patients with primary hepatocellular carcinoma (PHC) were compared with 107 hospital controls for the presence of hepatitis B surface antigen and smoking, drinking, and dietary habits. Eighty-two % of PHC cases were hepatitis B surface antigen positive compared to 18% of controls (relative ri...

journal_title：Cancer research

authors： Lam KC,Yu MC,Leung JW,Henderson BE

更新日期：1982-12-01 00:00:00

abstract：:Alpha-particle immunotherapy by targeted alpha-emitters or alpha-emitting isotope generators is a novel form of extraordinarily potent cancer therapy. A major impediment to the clinical use of targeted actinium-225 (225Ac) in vivo generators may be the radiotoxicity of the systemically released daughter radionuclides....

journal_title：Cancer research

authors： Jaggi JS,Kappel BJ,McDevitt MR,Sgouros G,Flombaum CD,Cabassa C,Scheinberg DA

更新日期：2005-06-01 00:00:00

abstract：:Organization of cancer cells into endothelial-like cell-lined structures to support neovascularization and to fuel solid tumors is a hallmark of progression and poor outcome. In triple-negative breast cancer (TNBC), PDGFRβ has been identified as a key player of this process and is considered a promising target for bre...

journal_title：Cancer research

authors： D'Ippolito E,Plantamura I,Bongiovanni L,Casalini P,Baroni S,Piovan C,Orlandi R,Gualeni AV,Gloghini A,Rossini A,Cresta S,Tessari A,De Braud F,Di Leva G,Tripodo C,Iorio MV

更新日期：2016-09-15 00:00:00

abstract：:A monoclonal antibody, CSTO-1, has been produced against a stomach adenocarcinoma-associated antigen. The antibody is cytotoxic to stomach, colon, and lung adenocarcinoma lines but is completely noncytotoxic to normal blood elements and leukemic cell lines. The monoclonal antibody reacts with tumor cell membranes in e...

journal_title：Cancer research

authors： Togashi H,Terasaki PI,Chia D,Kukes G,Mugishima H,Kasai K,Suyama N,Fukushima K,Hirota M

更新日期：1984-09-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a pleiotropic cytokine with a broad range of physiologic and pathologic functions. Because in cancer, IL-6 contributes to a microenvironment that promotes tumor cell survival, angiogenesis, and inflammation, understanding the mechanism responsible for its production is important. In neuroblasto...

journal_title：Cancer research

authors： Silverman AM,Nakata R,Shimada H,Sposto R,DeClerck YA

更新日期：2012-05-01 00:00:00

abstract：:Both 2-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (EC 4.1.1.17), and methylglyoxal bis(guanylhydrazone) (MGBG), a competitive inhibitor of S-adenosylmethionine decarboxylase (EC 4.1.1.50), strikingly stimulated melanotic expression of murine Cloudman S91 melanoma cells. The st...

journal_title：Cancer research

authors： Käpyaho K,Sinervirta R,Jänne J

更新日期：1985-04-01 00:00:00

abstract：:Expression of death-associated protein (DAP) kinase, a proapoptotic serine/threonine protein kinase, is frequently lost in human tumors. In a study of 134 primary breast cancer specimens hypermethylation of the DAP kinase gene was found in 13% of cases. A highly significant difference (P < 0.001) of DAP kinase inactiv...

journal_title：Cancer research

authors： Lehmann U,Celikkaya G,Hasemeier B,Länger F,Kreipe H

更新日期：2002-11-15 00:00:00

abstract：:UV radiation is a potent DNA-damaging agent and a known inducer of skin cancer in experimental animals. To elucidate the role of oncogenes in UV carcinogenesis, we analyzed UV-induced murine skin tumors for mutations in codon 12, 13, or 61 of Ha-ras, Ki-ras, and N-ras oncogenes by amplification of genomic tumor DNAs b...

journal_title：Cancer research

authors： Pierceall WE,Kripke ML,Ananthaswamy HN

更新日期：1992-07-15 00:00:00

abstract：:An interstitial deletion of the short arm of a chromosome 11 was found in Wilms' tumor cells of a patient without aniridia. The chromosomes in her peripheral blood lymphocytes were normal. The karyotype of the tumor cells is similar to that reported for the somatic cells of patients with aniridia-Wilms' tumor associat...

journal_title：Cancer research

authors： Kaneko Y,Egues MC,Rowley JD

更新日期：1981-11-01 00:00:00