Abstract:
:Pregnancy at early, but not late age, has a strong and life-long protective effect against breast cancer. The expected overall increase in breast cancer incidence demands the development of a pharmaceutical mimicry of early-age pregnancy-mediated protection. Recently, converging results from rodent models and women on molecular and cellular mechanisms underlying the protective effect of early-age pregnancy have opened the door for translational studies on pharmacologic prevention against breast cancer. In particular, alterations in Wnt and TGFβ signaling in mammary stem/progenitor cells reveal new potential targets for preventive interventions, and thus might help to significantly reduce the incidence of breast cancer in the future.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Meier-Abt F,Bentires-Alj M,Rochlitz Cdoi
10.1158/0008-5472.CAN-14-2717subject
Has Abstractpub_date
2015-03-01 00:00:00pages
803-7issue
5eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-14-2717journal_volume
75pub_type
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