Intragenic mutation analysis of the human epidermal growth factor receptor (EGFR) gene in malignant human oral keratinocytes.

abstract：:The lymphoid tissue in the omentum, at the so-called milky spots, is known as an initial place for disseminated cancer cells to develop into solid tumors. In the present study, i.p. macrophages significantly took up oligomannose-coated liposomes (OMLs) that were injected into the peritoneal cavity, and then gradually ...

journal_title：Cancer research

authors： Ikehara Y,Niwa T,Biao L,Ikehara SK,Ohashi N,Kobayashi T,Shimizu Y,Kojima N,Nakanishi H

更新日期：2006-09-01 00:00:00

abstract：:Low-dose cyclophosphamide (LDC) induces selective apoptosis of endothelial cells within the vascular bed of tumors. Here, we investigated a hypothesis that the effect of LDC is mediated by the pro-apoptotic action of endogenous inhibitors of angiogenesis. Tumors treated with LDC demonstrate similar expression of matri...

journal_title：Cancer research

authors： Hamano Y,Sugimoto H,Soubasakos MA,Kieran M,Olsen BR,Lawler J,Sudhakar A,Kalluri R

更新日期：2004-03-01 00:00:00

abstract：:The influences of pure human pluripotent colony-stimulating factor, highly purified pluripoietin alpha, pure recombinant human tumor necrosis factor alpha, pure recombinant human gamma-interferon, and natural prostaglandin E1 (PGE1) were evaluated on colony formation of multipotential and erythroid progenitor cells in...

journal_title：Cancer research

authors： Lu L,Welte K,Gabrilove JL,Hangoc G,Bruno E,Hoffman R,Broxmeyer HE

更新日期：1986-09-01 00:00:00

abstract：:One of the major problems in the diagnosis of localized prostatic tumors is to predict the aggressiveness of an individual tumor, which is presumably associated with chance to progression. In an attempt to find molecular markers that are specific for aggressive prostatic cancer cells, we compared steady-state mRNA lev...

journal_title：Cancer research

authors： Bussemakers MJ,van de Ven WJ,Debruyne FM,Schalken JA

更新日期：1991-01-15 00:00:00

abstract：:We have measured the 31P nuclear magnetic resonance spectra of EMT6/Ro multicellular tumor spheroids over a wide range of sizes under constant nutrient conditions which matched those used for culturing the spheroids. The amount of nucleotide triphosphate per cell decreased with spheroid growth, roughly in proportion t...

journal_title：Cancer research

authors： Freyer JP,Schor PL,Jarrett KA,Neeman M,Sillerud LO

更新日期：1991-08-01 00:00:00

abstract：:Lymphoid cell subpopulations infiltrating into autografts of methylcholanthrene-induced sarcomas in rats immunized with autologous tumor cells were identified in terms of immunohistochemical and cytofluorographic techniques using various monoclonal antibodies raised against different classes of rat lymphohemopoietic c...

journal_title：Cancer research

authors： Ishii Y,Matsuura A,Takami T,Uede T,Ibayashi Y,Uede T,Imamura M,Kikuchi K,Kikuchi Y

更新日期：1984-09-01 00:00:00

abstract：:The unresponsiveness of metastatic melanoma to conventional chemotherapeutic and biological agents is largely due to the development of resistance to apoptosis. Pyrimethamine belongs to the group of antifolate drugs, and in addition to antiprotozoan effects, it exerts a strong proapoptotic activity, which we recently ...

journal_title：Cancer research

authors： Giammarioli AM,Maselli A,Casagrande A,Gambardella L,Gallina A,Spada M,Giovannetti A,Proietti E,Malorni W,Pierdominici M

更新日期：2008-07-01 00:00:00

abstract：:Astrocytoma, the most common brain tumor in humans, is usually malignant and virtually incurable. Two types of malignant astrocytomas can be distinguished histopathologically: anaplastic astrocytoma and glioblastoma multiforme. Studies using DNA markers that detect restriction fragment length polymorphisms have shown ...

journal_title：Cancer research

authors： Fults D,Pedone CA,Thomas GA,White R

更新日期：1990-09-15 00:00:00

abstract：:Children with the tumor predisposition syndrome, neurofibromatosis 1 (NF1), develop optic pathway gliomas. The NF1 gene product, neurofibromin, functions as a negative regulator of RAS, such that NF1 inactivation results in RAS hyperactivation. Recent studies have highlighted the divergent biological and biochemical p...

journal_title：Cancer research

authors： Dasgupta B,Li W,Perry A,Gutmann DH

更新日期：2005-01-01 00:00:00

abstract：:Inbred rodent strains with differing sensitivity to experimental tumor induction provide model systems for the detection of genes that either are responsible for cancer predisposition or modify the process of carcinogenesis. Rats of the inbred BD strains differ in their susceptibility to the induction of neural tumors...

journal_title：Cancer research

authors： Kindler-Röhrborn A,Kölsch BU,Fischer C,Held S,Rajewsky MF

更新日期：1999-03-01 00:00:00

abstract：:Vaccination with antigens expressed by tumors is one strategy for stimulating enhanced T-cell responses against tumors. However, these peptide vaccines rarely result in efficient expansion of tumor-specific T cells or responses that protect against tumor growth. Mimotopes, or peptide mimics of tumor antigens, elicit i...

journal_title：Cancer research

authors： Buhrman JD,Jordan KR,U'ren L,Sprague J,Kemmler CB,Slansky JE

更新日期：2013-01-01 00:00:00

abstract：:Cutaneous melanomas have been found to express several immunogenic differentiation melanoma-associated antigens (MAAs) that have been suggested to play an important role in disease outcome. Adaptive host immunity to MAAs has shown some level of control on melanoma progression. To date, there has been no definitive rep...

journal_title：Cancer research

authors： Takeuchi H,Kuo C,Morton DL,Wang HJ,Hoon DS

更新日期：2003-01-15 00:00:00

abstract：:Cachexia is a life-threatening wasting syndrome lacking effective treatment, which arises in many cancer patients. Although ostensibly induced by multiple tumor-produced cytokines (tumorkines), their functional contribution to initiation and progression of this syndrome has proven difficult to determine. In this study...

journal_title：Cancer research

authors： Chen JL,Walton KL,Qian H,Colgan TD,Hagg A,Watt MJ,Harrison CA,Gregorevic P

更新日期：2016-09-15 00:00:00

abstract：:Mutations in the human adenomatous polyposis coli (APC) gene are responsible for not only familial adenomatous polyposis but also many sporadic cancers of the digestive tract. Using homologous recombination in embryonic stem cells, we recently constructed Apc gene knockout mice that contained a truncation mutation at ...

journal_title：Cancer research

authors： Oshima H,Oshima M,Kobayashi M,Tsutsumi M,Taketo MM

更新日期：1997-05-01 00:00:00

abstract：:To identify genetic events that characterize cancer progression, we conducted a comprehensive genetic evaluation of 161 primary breast tumors. Similar to the "mountain-and-hill" view of mutations, gene amplification also shows high- and low-frequency alterations in breast cancers. The frequently amplified genes includ...

journal_title：Cancer research

authors： Kadota M,Sato M,Duncan B,Ooshima A,Yang HH,Diaz-Meyer N,Gere S,Kageyama S,Fukuoka J,Nagata T,Tsukada K,Dunn BK,Wakefield LM,Lee MP

更新日期：2009-09-15 00:00:00

abstract：:When the human cell line NHIK 3025 was exposed to retinoic acid (1 nM; 10 microM), the cell cycle time was prolonged. Experiments using cells synchronized by mitotic selection showed that the retinoic acid induced growth delay was barely seen within the first cell cycle after exposure to 10 microM retinoic acid, where...

journal_title：Cancer research

authors： Bakke O

更新日期：1986-03-01 00:00:00

abstract：:While antiestrogens are useful agents in the treatment of breast cancer, the usefulness of these agents in the treatment of endometrial cancer remains controversial. There is some concern that the currently available antiestrogens may have partial agonist activity in uterine tissue. To better understand the mechanisms...

journal_title：Cancer research

authors： Gong Y,Ballejo G,Murphy LC,Murphy LJ

更新日期：1992-04-01 00:00:00

abstract：:A partial-length A-myb complementary DNA recently cloned by low-stringency hybridization with a c-myb probe to complementary DNA libraries derived from human cell lines showed a high degree of homology with the DNA-binding domain of c-myb and B-myb, suggesting that A-myb also encoded a DNA-binding protein. We report h...

journal_title：Cancer research

authors： Ma XP,Calabretta B

更新日期：1994-12-15 00:00:00

abstract：:Antiangiogenic therapies like bevacizumab offer promise for cancer treatment, but acquired resistance, which often includes an aggressive mesenchymal phenotype, can limit the use of these agents. Upregulation of β1 integrin (ITGB1) occurs in some bevacizumab-resistant glioblastomas (BRG) whereby, mediating tumor-micro...

journal_title：Cancer research

authors： Carbonell WS,DeLay M,Jahangiri A,Park CC,Aghi MK

更新日期：2013-05-15 00:00:00

abstract：:Sphingosine-1-phosphate is a potent lipid mediator formed by phosphorylation of sphingosine, a metabolite of sphingolipids, catalyzed by two sphingosine kinase (SphK) isoenzymes, SphK1 and SphK2. Expression of SphK2, which is enriched in the nucleus of MCF7 human breast cancer cells, increased expression of the cyclin...

journal_title：Cancer research

authors： Sankala HM,Hait NC,Paugh SW,Shida D,Lépine S,Elmore LW,Dent P,Milstien S,Spiegel S

更新日期：2007-11-01 00:00:00

abstract：:Cervical cancer develops from precancerous high-grade cervical intraepithelial neoplasia (CIN) harboring a transforming infection with high-risk human papillomavirus, which is characterized by p16(INK4a) overexpression. Once such a lesion has developed, progression toward an invasive squamous cell carcinoma (SCC) may ...

journal_title：Cancer research

authors： Wilting SM,Steenbergen RD,Tijssen M,van Wieringen WN,Helmerhorst TJ,van Kemenade FJ,Bleeker MC,van de Wiel MA,Carvalho B,Meijer GA,Ylstra B,Meijer CJ,Snijders PJ

更新日期：2009-01-15 00:00:00

abstract：:The basal layer of the epidermis and hair follicles is composed of actively cycling, transit-amplifying cells and quiescent cells including stem cells. To determine which population is the target of carcinogenic chemicals, we treated CD-1 female mice topically with 5-fluorouracil (5-FU), an agent known to kill cycling...

journal_title：Cancer research

authors： Morris RJ,Coulter K,Tryson K,Steinberg SR

更新日期：1997-08-15 00:00:00

abstract：:Epidemiological and animal model studies indicate that increased calorie intake increases the risk for colon cancer development. Previous studies in animal models restricted the calorie intake severely, and none of these studies have investigated a dose-response effect of different levels of calorie restriction on col...

journal_title：Cancer research

authors： Kumar SP,Roy SJ,Tokumo K,Reddy BS

更新日期：1990-09-15 00:00:00

abstract：:Optimal anticancer treatment with cell cycle-specific antimetabolites requires maintenance of a cytotoxic drug level for a prolonged period of time. We explored the use of multivesicular liposomes as a slow-release depot of 1-beta-D-arabinofuranosylcytosine for intrathecal administration. The intrathecal half-life of ...

journal_title：Cancer research

authors： Kim S,Kim DJ,Geyer MA,Howell SB

更新日期：1987-08-01 00:00:00

abstract：:We have demonstrated the intracellular expression of sex hormone-binding globulin (SHBG) exon VII splicing variant mRNA in human uterine endometrial cancer using the reverse transcription-PCR-Southern blot and DNA sequencing analyses. Analysis of the missing base pairs proved that they corresponded to the entire exon ...

journal_title：Cancer research

authors： Misao R,Nakanishi Y,Fujimoto J,Tamaya T

更新日期：1997-12-15 00:00:00

abstract：:Defining tumor stage at diagnosis is a pivotal point for clinical decisions about patient treatment strategies. In this respect, early detection of occult metastasis invisible to current imaging methods would have a major impact on best care and long-term survival. Mathematical models that describe metastatic spreadin...

journal_title：Cancer research

authors： Hartung N,Mollard S,Barbolosi D,Benabdallah A,Chapuisat G,Henry G,Giacometti S,Iliadis A,Ciccolini J,Faivre C,Hubert F

更新日期：2014-11-15 00:00:00

abstract：:Cancer stem cells (CSC) play a central role in cancer metastasis and development of drug resistance. miRNA are important in regulating CSC properties and are considered potential therapeutic targets. Here we report that miR-328-3p (miR-328) is significantly upregulated in ovarian CSC. High expression of miR-328 mainta...

journal_title：Cancer research

authors： Srivastava AK,Banerjee A,Cui T,Han C,Cai S,Liu L,Wu D,Cui R,Li Z,Zhang X,Xie G,Selvendiran K,Patnaik S,Karpf AR,Liu J,Cohn DE,Wang QE

更新日期：2019-05-01 00:00:00

abstract：:Black cohosh is an herbal extract that is often used as an alternative to estrogen-based replacement therapies to treat hot flushes that frequently accompany the transition to menopause. Although cancer-free women as well as breast cancer patients and survivors use black cohosh to relieve vasomotor symptoms, there is ...

journal_title：Cancer research

authors： Davis VL,Jayo MJ,Ho A,Kotlarczyk MP,Hardy ML,Foster WG,Hughes CL

更新日期：2008-10-15 00:00:00

abstract：:In a preceding paper (D. B. Alexander et al., Cancer Res., 53: 1808-1815, 1993), we demonstrated that the in vitro glucocorticoid inhibition of Con8 mammary tumor cell growth is accompanied by the disruption of a transforming growth factor alpha (TGF-alpha) autocrine loop. This growth suppression response functions in...

journal_title：Cancer research

authors： Goya L,Alexander DB,Webster MK,Kern FG,Guzman RC,Nandi S,Firestone GL

更新日期：1993-04-15 00:00:00

abstract：:The presence of a non-small cell lung carcinoma (NSCLC)-related gene or genes on chromosome band 11p15.5 is of particular interest, given the specific loss of heterozygosity (LOH) measured in this region for lung as well as many other pediatric and adult neoplasms. We have undertaken high-density polymorphic marker an...

journal_title：Cancer research

authors： Tran YK,Newsham IF

更新日期：1996-07-01 00:00:00