Multivesicular liposomes containing 1-beta-D-arabinofuranosylcytosine for slow-release intrathecal therapy.

abstract：:The mechanism of the previously reported cytotoxicity of liposomes containing plant phosphatidylinositol (PI) against numerous tumor cell lines was examined in detail by using liposomes containing synthetic PI specifically labeled either with radioactive myo-inositol, or in the sn-2 position with radioactive linoleic ...

journal_title：Cancer research

authors： Jett M,Chudzik J,Alving CR,Stanacev NZ

更新日期：1985-10-01 00:00:00

abstract：:Ras associated with diabetes (Rad) is a Ras-related GTPase that promotes cell growth by accelerating cell cycle transitions. Rad knockdown induced cell cycle arrest and premature senescence without additional cellular stress in multiple cancer cell lines, indicating that Rad expression might be critical for the cell c...

journal_title：Cancer research

authors： Lee I,Yeom SY,Lee SJ,Kang WK,Park C

更新日期：2010-06-01 00:00:00

abstract：:The effects of vascular endothelial growth factor-A (VEGF-A/VEGF) and its receptors on endothelial cells function have been studied extensively, but their effects on tumor cells are less well defined. Studies of human colorectal cancer cells where the VEGF gene has been deleted suggest an intracellular role of VEGF as...

journal_title：Cancer research

authors： Bhattacharya R,Ye XC,Wang R,Ling X,McManus M,Fan F,Boulbes D,Ellis LM

更新日期：2016-05-15 00:00:00

abstract：:Identification of human melanoma-associated peptide antigens for CTLs has opened unprecedented opportunities for active specific immunotherapy for melanoma with synthetic peptide. We have shown that immunization with a MAGE-1 gene encoded nonapeptide (EADPT-GHSY)-pulsed autologous antigen presenting cell-based vaccine...

journal_title：Cancer research

authors： Hu X,Chakraborty NG,Sporn JR,Kurtzman SH,Ergin MT,Mukherji B

更新日期：1996-06-01 00:00:00

abstract：:Multiple myeloma (MM) is a treatable, but incurable, malignancy of plasma cells (PC) in the bone marrow (BM). It represents the final stage in a continuum of PC dyscrasias and is consistently preceded by a premalignant phase termed monoclonal gammopathy of undetermined significance (MGUS). The existence of this well-d...

journal_title：Cancer research

authors： van Nieuwenhuijzen N,Spaan I,Raymakers R,Peperzak V

更新日期：2018-05-15 00:00:00

abstract：:The incidence, distribution, size, and histopathology of colonic tumors induced by parenteral administration of 1,2-dimethylhydrazine were examined in rats fed a chemically defined fiber-free diet or nutritionally and calorically equivalent diets containing either 4.5 or 9.0% purified cellulose or pectin. This double-...

journal_title：Cancer research

authors： Freeman HJ,Spiller GA,Kim YS

更新日期：1980-08-01 00:00:00

abstract：:Adrenocortical carcinoma (ACC) is a rare disease with an overall poor but heterogeneous prognosis. This heterogeneity could reflect different mechanisms of tumor development. Gene expression profiling by transcriptome analysis led to ACC being divided into two groups of tumors with very different outcomes. Somatic ina...

journal_title：Cancer research

authors： Ragazzon B,Libé R,Gaujoux S,Assié G,Fratticci A,Launay P,Clauser E,Bertagna X,Tissier F,de Reyniès A,Bertherat J

更新日期：2010-11-01 00:00:00

abstract：:The metabolism and mutagenic activation of the model carcinogens benzo(a)pyrene [B(a)P] and 2-acetylaminofluorene (AAF) by human and rat kidney cells were measured. A slicing technique followed by enzyme digestion was utilized to obtain the kidney cells. Although levels of total metabolism of B(a)P by rat and human ki...

journal_title：Cancer research

authors： Rudo KM,Dauterman WC,Langenbach R

更新日期：1989-03-01 00:00:00

abstract：:Phosphoglucose isomerase (PGI) is a multifunctional enzyme that functions in glucose metabolism as a glycolytic enzyme catalyzing an interconversion between glucose and fructose inside the cell, while it acts as cytokine outside the cell, with properties that include autocrine motility factor (AMF)-regulating tumor ce...

journal_title：Cancer research

authors： Niinaka Y,Harada K,Fujimuro M,Oda M,Haga A,Hosoki M,Uzawa N,Arai N,Yamaguchi S,Yamashiro M,Raz A

更新日期：2010-11-15 00:00:00

abstract：:We investigated the relationship between age-related changes in natural resistance and antitumor effects using a spontaneously hypertensive rat (SHR rat) strain which shows a progressive decline of the number of T-cells and their functions as a result of aging. The growth of a weakly antigenic mammary adenocarcinoma S...

journal_title：Cancer research

authors： Matsuoka T,Takeichi N,Kobayashi H

更新日期：1987-07-01 00:00:00

abstract：:Glycosylation, a posttranslational modification, has a major role in recombinant anticancer therapeutic proteins, as most of the approved recombinant therapeutics are glycoproteins. The constant amino acid sequence of therapeutics determines the enzymatic activity, while the presence of glycans influences their pharma...

journal_title：Cancer research

authors： Nadeem T,Khan MA,Ijaz B,Ahmed N,Rahman ZU,Latif MS,Ali Q,Rana MA

更新日期：2018-06-01 00:00:00

abstract：:Hypoxia occurs in two forms in tumors. Chronic or diffusion-limited hypoxia is relatively well characterized. In contrast, intermittent or perfusion-limited hypoxia is not well characterized, and it is not known how common it is in tumors. The purpose of this study was to determine whether spontaneous fluctuations in ...

journal_title：Cancer research

authors： Kimura H,Braun RD,Ong ET,Hsu R,Secomb TW,Papahadjopoulos D,Hong K,Dewhirst MW

更新日期：1996-12-01 00:00:00

abstract：:In this report, we describe methods used to analyze the protein composition of sectioned frozen prostatic tissues by two-dimensional gel electrophoresis. Our results show a high degree of homology in two-dimensional electrophoretograms of proteins extracted from frozen sections of malignant prostate glands. Such homol...

journal_title：Cancer research

authors： Guevara J Jr,Herbert BH,Raymond AK,Batsakis JG

更新日期：1986-07-01 00:00:00

abstract：:The growth-inhibitory effect of 6-methylmercaptopurine riboside (MMPR) against leukemia L1210 cells in culture was dramatically potentiated by the addition of guanine nucleosides to the medium. In the presence of either deoxyguanosine or guanosine, the concentration of MMPR that caused 50% inhibition of growth was 35 ...

journal_title：Cancer research

authors： Grindey GB,Lowe JK,Divekar AY,Hakala MT

更新日期：1976-02-01 00:00:00

abstract：:Using the phage lambdaLIZ-based transgenic in vivo mutagenesis assay, mean mutant rates were determined in the spleen of mice exposed to sustained oxidative stress and were found to be increased approximately 3-fold in plasmacytoma-susceptible BALB/c and C.D2-Idh1-Pep3 mice, but not in plasmacytoma-resistant DBA/2N mi...

journal_title：Cancer research

authors： Felix K,Kelliher K,Bornkamm GW,Janz S

更新日期：1998-04-15 00:00:00

abstract：:Tumor necrosis factor (TNF) acts via a cell surface receptor to induce a variety of cellular events including cytolysis, differentiation, and mitogenesis. The mechanisms underlying the cell specific actions of TNF are not known. In the present study, postreceptor events associated with the autoinduction of TNF express...

journal_title：Cancer research

authors： Spriggs DR,Sherman ML,Imamura K,Mohri M,Rodriguez C,Robbins G,Kufe DW

更新日期：1990-11-15 00:00:00

abstract：:PARP-1 is a nuclear protein that has important roles in maintenance of genomic integrity. During genotoxic stress, PARP-1 recruits to sites of DNA damage where PARP-1 domain architecture initiates catalytic activation and subsequent poly(ADP-ribose)-dependent DNA repair. PARP-1 inhibition is a promising new way to sel...

journal_title：Cancer research

authors： Steffen JD,Tholey RM,Langelier MF,Planck JL,Schiewer MJ,Lal S,Bildzukewicz NA,Yeo CJ,Knudsen KE,Brody JR,Pascal JM

更新日期：2014-01-01 00:00:00

abstract：:Glutathione S-transferases have been purified to homogeneity from Chinese hamster liver. Three enzyme forms were separated and designated Forms I, II, and III in order of their elution from carboxymethylcellulose columns. The forms exhibit close physical similarities to glutathione S-transferases B (ligandin) of rat l...

journal_title：Cancer research

authors： Smith GJ,Ohl VS,Litwack G

更新日期：1980-06-01 00:00:00

abstract：:The therapeutic efficacy of anthracyclines relies, at least partially, on the induction of a dendritic cell- and T-lymphocyte-dependent anticancer immune response. Here, we show that anthracycline-based chemotherapy promotes the recruitment of functional CD11b(+)CD11c(+)Ly6C(high)Ly6G(-)MHCII(+) dendritic cell-like an...

journal_title：Cancer research

authors： Ma Y,Mattarollo SR,Adjemian S,Yang H,Aymeric L,Hannani D,Portela Catani JP,Duret H,Teng MW,Kepp O,Wang Y,Sistigu A,Schultze JL,Stoll G,Galluzzi L,Zitvogel L,Smyth MJ,Kroemer G

更新日期：2014-01-15 00:00:00

abstract：:IA-1 is a recently isolated novel complementary DNA which encodes a protein of 510 amino acids that contains both a zinc finger DNA-binding domain and a putative prohormone domain. mRNA expression of IA-1 has been found thus far only in tumors of neuroendocrine origin. In this report we describe the expression of IA-1...

journal_title：Cancer research

authors： Lan MS,Russell EK,Lu J,Johnson BE,Notkins AL

更新日期：1993-09-15 00:00:00

abstract：:Tn and sialylated Tn (sTn) are blood group-related epitopes expressed on mucins of colon carcinoma and other epithelial tumors and are, therefore, potential targets for immunological control. We have immunized 20 colorectal cancer patients at high risk for recurrence with a vaccine consisting of partially desialylated...

journal_title：Cancer research

authors： O'Boyle KP,Zamore R,Adluri S,Cohen A,Kemeny N,Welt S,Lloyd KO,Oettgen HF,Old LJ,Livingston PO

更新日期：1992-10-15 00:00:00

abstract：:Gene-encoded host defense peptides are used as part of the innate immunity, and many of them act by directly lysing the cell membrane of the pathogen. A few of these peptides showed anticancer activity in vitro but could not be used in vivo because of their inactivation by serum. We designed a 15-amino acid peptide, c...

journal_title：Cancer research

authors： Papo N,Braunstein A,Eshhar Z,Shai Y

更新日期：2004-08-15 00:00:00

abstract：:Obesity is associated with increased cancer incidence and mortality. We have previously found that obesity in children is associated with a 50% increased recurrence of acute lymphoblastic leukemia (ALL) in high-risk patients. We have therefore developed novel in vivo and in vitro preclinical models to study the mechan...

journal_title：Cancer research

authors： Behan JW,Yun JP,Proektor MP,Ehsanipour EA,Arutyunyan A,Moses AS,Avramis VI,Louie SG,Butturini A,Heisterkamp N,Mittelman SD

更新日期：2009-10-01 00:00:00

abstract：:Serine/arginine (SR) protein-specific kinase (SRPK), a family of cell cycle-regulated protein kinases, phosphorylate SR domain-containing proteins in nuclear speckles and mediate the pre-mRNA splicing. However, the physiologic roles of this event in cell cycle are incompletely understood. Here, we show that SRPK2 bind...

journal_title：Cancer research

authors： Jang SW,Yang SJ,Ehlén A,Dong S,Khoury H,Chen J,Persson JL,Ye K

更新日期：2008-06-15 00:00:00

abstract：:The ability of the in vitro sister chromatid exchange (SCE) assay to predict in vivo tumor drug sensitivity was investigated using a spontaneous hepatocarcinoma in C3Hf/Kam mice and 3 chemotherapeutic agents: melphalan; cis-platinum; and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). For hepatocarcinoma cells grown in m...

journal_title：Cancer research

authors： Tofilon PJ,Basic I,Milas L

更新日期：1985-05-01 00:00:00

abstract：:Heteroantisera were produced in rabbits by immunization with cultivated cells from rat intestinal carcinomas. The sera were made specific by in vivo absorption in syngeneic rats. On immunofluorescence, these sera recognized a membrane-associated antigen common to five different intestinal carcinomas and to fetal intes...

journal_title：Cancer research

authors： Martin F,Knobel S,Martin M,Bordes M

更新日期：1975-02-01 00:00:00

abstract：:IgG polyclonal antiserum was generated in New Zealand White rabbits immunized with a 16-mer peptide consisting of a specific amino acid sequence at residues corresponding to the sixth to seventh predicted transmembrane domain of the human reduced folate carrier (RFC). Using Western immunoblotting to examine the cytoso...

journal_title：Cancer research

authors： Trippett TM,Garcia S,Manova K,Mody R,Cohen-Gould L,Flintoff W,Bertino JR

更新日期：2001-03-01 00:00:00

abstract：:Bifunctional alkylating agents are known to cross-link DNA by simultaneously alkylating two guanine residues located on opposite strands. Despite this apparent requirement for bifunctionality, 1-(2-chloroethyl)-1-nitrosoureas bearing a single alkylating function were found to cross-link DNA in vitro. Cross-linking was...

journal_title：Cancer research

authors： Kohn KW

更新日期：1977-05-01 00:00:00

abstract：:Tumor development is angiogenesis dependent, and vascular endothelial growth factor (VEGF) is a key growth factor in this process. We demonstrate that high expression of VEGF mRNA in 55 superficial bladder cancers was associated with earlier recurrence (P = 0.001; hazard ratio, 3.09) and progression to a more invasive...

journal_title：Cancer research

authors： Crew JP,O'Brien T,Bradburn M,Fuggle S,Bicknell R,Cranston D,Harris AL

更新日期：1997-12-01 00:00:00

abstract：:In our previous studies carried out on inbred rats of the Sprague-Dawley strain (L. Gross and Y. Dreyfuss, Proc. Natl. Acad. Sci. USA, 76: 5910-5913, 1979), the tumor incidence was increased following irradiation (150 rads, 5 times, at weekly intervals), from 22 to 93% in females and from 5 to 59% in males. Experiment...

journal_title：Cancer research

authors： Gross L,Dreyfuss Y,Faraggiana T

更新日期：1988-05-01 00:00:00