IA-1, a new marker for neuroendocrine differentiation in human lung cancer cell lines.

abstract：:A series of linkage studies was previously conducted to identify quantitative trait loci associated with chemically induced lung tumors. However, little is known of genetic susceptibility to spontaneously occurring lung tumorigenesis (SLT) in mice. In this study, we did a whole-genome linkage disequilibrium analysis f...

journal_title：Cancer research

authors： Wang D,You M

更新日期：2005-09-15 00:00:00

abstract：:A chimeric CYCLIN D1-TROP2 mRNA was isolated from human ovarian and mammary cancer cells. The CYCLIN D1-TROP2 mRNA was shown to be a potent oncogene as it transforms naïve, primary cells in vitro and induces aggressive tumor growth in vivo in cooperation with activated RAS. Silencing of the chimeric mRNA inhibits the ...

journal_title：Cancer research

authors： Guerra E,Trerotola M,Dell' Arciprete R,Bonasera V,Palombo B,El-Sewedy T,Ciccimarra T,Crescenzi C,Lorenzini F,Rossi C,Vacca G,Lattanzio R,Piantelli M,Alberti S

更新日期：2008-10-01 00:00:00

abstract：:SNAI2 overexpression appears to be associated with poor prognosis in breast cancer, yet it remains unclear in which breast cancer subtypes this occurs. Here we show that excess SNAI2 is associated with a poor prognosis of luminal B HER2+/ERBB2+ breast cancers in which SNAI2 expression in the stroma but not the epithel...

journal_title：Cancer research

authors： Blanco-Gómez A,Hontecillas-Prieto L,Corchado-Cobos R,García-Sancha N,Salvador N,Castellanos-Martín A,Sáez-Freire MDM,Mendiburu-Eliçabe M,Alonso-López D,De Las Rivas J,Lorente M,García-Casas A,Del Carmen S,Abad-Hernández MDM,C

更新日期：2020-12-01 00:00:00

abstract：:Estrogen receptor-related receptors (ERR) are orphan nuclear receptors, which are constitutively activated without estrogen binding. Recent evidence indicates that the ligand-independent ERRs may be involved in similar ER-mediated regulatory pathways and modulate estrogen responsiveness in certain target cells. We rec...

journal_title：Cancer research

authors： Yu S,Wang X,Ng CF,Chen S,Chan FL

更新日期：2007-05-15 00:00:00

abstract：:We are developing a noninvasive approach for targeting imaging and therapeutic radionuclides to prostate cancer. Our method, Enzyme-Mediated Cancer Imaging and Therapy (EMCIT), aims to use enzyme-dependent, site-specific, in vivo precipitation of a radioactive molecule within the extracellular space of solid tumors. A...

journal_title：Cancer research

authors： Pospisil P,Wang K,Al Aowad AF,Iyer LK,Adelstein SJ,Kassis AI

更新日期：2007-03-01 00:00:00

abstract：:Nickel is a toxic, mutagenic, and carcinogenic metal of significant occupational and environmental concern. Although several cellular targets of nickel have been identified, considerable evidence suggests that it can act indirectly upon DNA by inducing the formation of oxidized purines or pyrimidines that constitute p...

journal_title：Cancer research

authors： Higinbotham KG,Rice JM,Diwan BA,Kasprzak KS,Reed CD,Perantoni AO

更新日期：1992-09-01 00:00:00

abstract：:Viral vectors for cancer can be classified into those that do not replicate (replication-defective vectors) and those that selectively replicate in neoplastic cells (replication-conditional or oncolytic vectors). Both of these can deliver anticancer cDNAs for therapeutic purposes. Opposite hypotheses can be made regar...

journal_title：Cancer research

authors： Ichikawa T,Chiocca EA

更新日期：2001-07-15 00:00:00

abstract：:The C3H/10T1/2 CL8 cell line (10T1/2) is being widely used as a quantitative assay system for chemical and physical carcinogens. 10T1/2 cells, but not their transformed counterparts, exhibit a decreased final saturation density with decreasing serum concentration. Exposure of carcinogen-treated cultures to 5% serum 8 ...

journal_title：Cancer research

authors： Bertram JS

更新日期：1977-02-01 00:00:00

abstract：:The MCT-1 oncogene was originally identified from lymphoma cell lines. Herein we establish that MCT-1 is highly expressed in 85% of human diffuse large B-cell lymphomas (DLBCL) and that knocking down MCT-1 by a specific short hairpin RNA in DLBCL cells induces apoptosis, supporting a critical role for MCT-1 in DLBCL c...

journal_title：Cancer research

authors： Dai B,Zhao XF,Hagner P,Shapiro P,Mazan-Mamczarz K,Zhao S,Natkunam Y,Gartenhaus RB

更新日期：2009-10-01 00:00:00

abstract：:15-Lipoxygenase (15-LOX)-2 is expressed in benign prostate secretory cells and benign prostate produces 15S-hydroxyeicosatetraenoic acid (15S-HETE) from exogenous arachidonic acid (AA). In contrast, 15S-LOX-2 and 15S-HETE formation are reduced in prostate carcinoma (Pca). The mechanisms whereby reduced 15-LOX-2 may co...

journal_title：Cancer research

authors： Shappell SB,Gupta RA,Manning S,Whitehead R,Boeglin WE,Schneider C,Case T,Price J,Jack GS,Wheeler TM,Matusik RJ,Brash AR,Dubois RN

更新日期：2001-01-15 00:00:00

abstract：:It has recently been reported that the human myeloma cell line U266 proceeds to undergo apoptosis after cultivation with the antiestrogen tamoxifen, thus raising the possibility that antiestrogens may be candidates for use in myeloma therapy. To obtain basic information on the effects of antiestrogens on myeloma cells...

journal_title：Cancer research

authors： Otsuki T,Yamada O,Kurebayashi J,Moriya T,Sakaguchi H,Kunisue H,Yata K,Uno M,Yawata Y,Ueki A

更新日期：2000-03-01 00:00:00

abstract：:Three Burkitt's lymphoma cell lines were studied for their response to cis-diamminedichloroplatinum(II) (cis-DDP) and L-phenylalanine mustard (L-PAM) with the objective of relating cytotoxicity to DNA cross-linking in human cells. Cytotoxicity was measured by cell proliferation and colony formation assays. DNA interst...

journal_title：Cancer research

authors： Ducore JM,Erickson LC,Zwelling LA,Laurent G,Kohn KW

更新日期：1982-03-01 00:00:00

abstract：:Biomarkers for early detection of epithelial ovarian cancer (EOC) are urgently needed. Patients can generate antibodies to tumor-associated antigens (TAAs). We tested multiplex detection of antibodies to candidate ovarian TAAs and statistical modeling for discrimination of sera of EOC patients and controls. Binding of...

journal_title：Cancer research

authors： Erkanli A,Taylor DD,Dean D,Eksir F,Egger D,Geyer J,Nelson BH,Stone B,Fritsche HA,Roden RB

更新日期：2006-02-01 00:00:00

abstract：:Microdialysis is a technique that enables measurement of extracellular concentrations of unbound analytes. A small probe with a semipermeable membrane is implanted in tissue and constantly perfused. Small analytes in the interstitial fluid diffuse into the perfusate and are collected. Often, microdialysate concentrati...

journal_title：Cancer research

authors： Ettinger SN,Poellmann CC,Wisniewski NA,Gaskin AA,Shoemaker JS,Poulson JM,Dewhirst MW,Klitzman B

更新日期：2001-11-01 00:00:00

abstract：:Reactive oxygen species play a critical role in the onset of apoptosis induced by various extracellular stimuli, including ionizing radiation. Therefore active regulation of reactive oxygen species-metabolizing enzymes may be one response to an apoptotic stimulus. In this regard, HP100 cells, H(2)O(2)-resistant varian...

journal_title：Cancer research

authors： Nenoi M,Ichimura S,Mita K,Yukawa O,Cartwright IL

更新日期：2001-08-01 00:00:00

abstract：:A two-stage genome-wide association study (GWAS) of the Cancer Genetic Markers of Susceptibility (CGEMS) initiative identified single nucleotide polymorphisms (SNP) in 150 regions across the genome that may be associated with prostate cancer (PCa) risk. We filtered these results to identify 43 independent SNPs where t...

journal_title：Cancer research

authors： Hsu FC,Sun J,Wiklund F,Isaacs SD,Wiley KE,Purcell LD,Gao Z,Stattin P,Zhu Y,Kim ST,Zhang Z,Liu W,Chang BL,Walsh PC,Duggan D,Carpten JD,Isaacs WB,Grönberg H,Xu J,Zheng SL

更新日期：2009-04-01 00:00:00

abstract：:Adenylate cyclase responses to pituitary hormones including adrenocorticotropic hormone (ACTH), biogenetic amines, prostaglandin E1 (PGE1), angiotensin II, and glucagon were evaluated in adrenocortical tumors and hyperplastic adrenal tissues, obtained from patients with Cushing's syndrome at surgery, and in normal adr...

journal_title：Cancer research

authors： Matsukura S,Kakita T,Sueoka S,Yoshimi H,Hirata Y,Yokota M,Fujita T

更新日期：1980-10-01 00:00:00

abstract：:To evaluate the role of chronic inflammation in the development of gallstones and biliary tract cancer, we examined the risk associated with 62 single nucleotide polymorphisms (SNPs), in 22 inflammation-related genes, in a population-based case-control study conducted in Shanghai, China, where the incidence of biliary...

journal_title：Cancer research

authors： Hsing AW,Sakoda LC,Rashid A,Andreotti G,Chen J,Wang BS,Shen MC,Chen BE,Rosenberg PS,Zhang M,Niwa S,Chu L,Welch R,Yeager M,Fraumeni JF Jr,Gao YT,Chanock SJ

更新日期：2008-08-01 00:00:00

abstract：:Curcumin, a natural compound, is a well-known chemopreventive agent with potent anticarcinogenic activity in a wide variety of tumor cells. Curcumin inhibits cancer cell proliferation in part by suppressing cyclin D1 and inducing expression of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). Both p53-dependent an...

journal_title：Cancer research

authors： Choi BH,Kim CG,Bae YS,Lim Y,Lee YH,Shin SY

更新日期：2008-03-01 00:00:00

abstract：:Endometria of normal histology from postmenopausal women receiving either estrogen or estrogen plus a progestin have been analyzed for nuclear estradiol receptor, epithelial DNA synthesis, isocitric dehydrogenase, and estradiol dehydrogenase activities. Epithelial DNA synthesis correlated positively with nuclear estra...

journal_title：Cancer research

authors： King RJ,Raju KS,Siddle NC,Taylor RW,Whitehead MI

更新日期：1983-10-01 00:00:00

abstract：:In cancer cell lines and rodent models, calcium and vitamin D favorably modulate cell proliferation, differentiation, and apoptosis in colonic epithelia. These effects may be modulated by local expression of the calcium receptor (CaR), the vitamin D receptor (VDR), and the P450 cytochromes, CYP27B1 and CYP24A1; howeve...

journal_title：Cancer research

authors： Ahearn TU,McCullough ML,Flanders WD,Long Q,Sidelnikov E,Fedirko V,Daniel CR,Rutherford RE,Shaukat A,Bostick RM

更新日期：2011-01-15 00:00:00

abstract：:Better therapies are urgently needed for ovarian cancer, which is associated with an overall median survival of less than 5 years from diagnosis. In this issue of Cancer Research, Tesfay and colleagues show that stearoyl CoA desaturase (SCD1) is expressed at high levels in different isotypes of ovarian cancer and that...

journal_title：Cancer research

authors： Carbone M,Melino G

更新日期：2019-10-15 00:00:00

abstract：:Breast cancer is a heterogeneous disease with distinct molecular subtypes characterized by differential response to targeted and chemotherapeutic agents. Enhanced understanding of the genetic alterations characteristic of different subtypes is needed to pave the way for more personalized administration of therapeutic ...

journal_title：Cancer research

authors： O'Brien C,Cavet G,Pandita A,Hu X,Haydu L,Mohan S,Toy K,Rivers CS,Modrusan Z,Amler LC,Lackner MR

更新日期：2008-07-01 00:00:00

abstract：:The alpha(v)beta(3) integrin is expressed on proliferating endothelial cells such as those present in growing tumors, as well as on tumor cells of various origin. Tumor-induced angiogenesis can be blocked in vivo by antagonizing the alpha(v)beta(3) integrin with small peptides containing the Arg-Gly-Asp (RGD) amino ac...

journal_title：Cancer research

authors： Janssen ML,Oyen WJ,Dijkgraaf I,Massuger LF,Frielink C,Edwards DS,Rajopadhye M,Boonstra H,Corstens FH,Boerman OC

更新日期：2002-11-01 00:00:00

abstract：:The tumor suppressor gene p53 regulates G1 checkpoint prior to the initiation of DNA synthesis, which can either induce G1 arrest or signal apoptosis. The involvement of p53 in apoptosis may also be related to its ability to down-regulate transcription of the bcl-2 gene. The bcl-2 gene product prevents most types of a...

journal_title：Cancer research

authors： Upadhyay S,Li G,Liu H,Chen YQ,Sarkar FH,Kim HR

更新日期：1995-10-15 00:00:00

abstract：:Integrin β3 is critical for tumor invasion, neoangiogenesis, and inflammation, making it a promising cancer target. However, preclinical and clinical data of integrin β3 antagonists have demonstrated no benefit or worse outcomes. We hypothesized that integrin β3 could affect tumor immunity and evaluated tumors in mice...

journal_title：Cancer research

authors： Su X,Esser AK,Amend SR,Xiang J,Xu Y,Ross MH,Fox GC,Kobayashi T,Steri V,Roomp K,Fontana F,Hurchla MA,Knolhoff BL,Meyer MA,Morgan EA,Tomasson JC,Novack JS,Zou W,Faccio R,Novack DV,Robinson SD,Teitelbaum SL,DeNar

更新日期：2016-06-15 00:00:00

abstract：:The renal uptake of radiolabeled antibody fragments and peptides is a problem in radioimmunodetection and radioimmunotherapy, especially with intracellular retained radiometals. The aim of this study was to develop suitable methods to reduce this kidney uptake. BALB/c mice or nude mice bearing the human GW-39 colon ca...

journal_title：Cancer research

authors： Behr TM,Sharkey RM,Juweid ME,Blumenthal RD,Dunn RM,Griffiths GL,Bair HJ,Wolf FG,Becker WS,Goldenberg DM

更新日期：1995-09-01 00:00:00

abstract：:Heparanase is an enzyme that cleaves heparan sulfate chains of proteoglycans, and its expression has been associated with increased growth, metastasis, and angiogenesis of some tumors. Because myeloma tumor cells express high levels of the syndecan-1 heparan sulfate proteoglycan and because these tumors grow as highly...

journal_title：Cancer research

authors： Kelly T,Miao HQ,Yang Y,Navarro E,Kussie P,Huang Y,MacLeod V,Casciano J,Joseph L,Zhan F,Zangari M,Barlogie B,Shaughnessy J,Sanderson RD

更新日期：2003-12-15 00:00:00

abstract：:Recent work has begun to explore the instrumental role that small noncoding RNA species, particularly microRNAs (miRNA), have both in classifying human tumors and in directing embryonic development. These studies suggest that developmental programs in essentially all organisms studied are set, in part, by varied expre...

journal_title：Cancer research

authors： Marsit CJ,Eddy K,Kelsey KT

更新日期：2006-11-15 00:00:00

abstract：:The cytotoxic, antimitotic, and growth inhibition properties of a photoactive analogue of vinblastine, N-(p-azidobenzoyl)-N'-beta-aminoethylvindesine (NABV), and vinblastine on P388 murine leukemia cells were compared. After 72-h exposure, the 50% drug-inhibitory concentrations for exponentially growing P388 leukemic ...

journal_title：Cancer research

authors： Safa AR,Glover CJ,Felsted RL

更新日期：1987-10-01 00:00:00