Abstract：
:Better therapies are urgently needed for ovarian cancer, which is associated with an overall median survival of less than 5 years from diagnosis. In this issue of Cancer Research, Tesfay and colleagues show that stearoyl CoA desaturase (SCD1) is expressed at high levels in different isotypes of ovarian cancer and that SCD1 protects ovarian cancer cells from cell death. Pharmaceutical inhibition of SCD1 induces apoptosis and ferroptosis in vitro and in vivo Combination therapies of SCD1 inhibitors and ferroptosis inducers significantly decrease ovarian tumor masses in mice. This novel therapy may prove useful to treat women with ovarian cancer.See related article by Tesfay et al., p. 5355.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Carbone M,Melino Gdoi
10.1158/0008-5472.CAN-19-2453subject
Has Abstractpub_date
2019-10-15 00:00:00pages
5149-5150issue
20eissn
0008-5472issn
1538-7445pii
79/20/5149journal_volume
79pub_type
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