A novel pathway involving melanoma differentiation associated gene-7/interleukin-24 mediates nonsteroidal anti-inflammatory drug-induced apoptosis and growth arrest of cancer cells.

abstract：:We reported previously that 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3], a hormonally active form of vitamin D3, markedly enhanced methylcholanthrene-induced transformation of BALB 3T3 A31-1-1 cells. When the cells were treated with methylcholanthrene (1 microgram/ml) for 72 h and then with 1 alpha,25(OH)2D3 (5...

journal_title：Cancer research

authors： Sasaki K,Chida K,Hashiba H,Kamata N,Abe E,Suda T,Kuroki T

更新日期：1986-02-01 00:00:00

abstract：:UV radiation has been shown to play a role in the initiation of human cutaneous melanoma, but its role in the development of malignant melanoma to the metastatic state is not very well defined. Although previous studies have concentrated on the effect of UV-B on the host immune response, the effect of UV-B on the tumo...

journal_title：Cancer research

authors： Singh RK,Gutman M,Reich R,Bar-Eli M

更新日期：1995-08-15 00:00:00

abstract：:A role for proteolysis during chemical induction of endogenous xenotropic Type C virus from Kirsten sarcoma virus-transformed mouse cells was examined. Two distinct classes of protease inhibitors, the trypsin inhibitor, alpha-N-tosyl-L-lysine chloromethyl ketone, and two naturally occurring oligopeptide inhibitors, an...

journal_title：Cancer research

authors： Long CW,Bruszewski JA,Christensen WL,Suk WA

更新日期：1979-08-01 00:00:00

abstract：:Human breast cancers include cancer stem cell populations as well as nontumorigenic cancer cells. Breast cancer stem cells have self-renewal capability and are resistant to conventional chemotherapy. miRNAs regulate the expression of many target genes; therefore, dysregulation of miRNAs has been associated with the pa...

journal_title：Cancer research

authors： Park EY,Chang E,Lee EJ,Lee HW,Kang HG,Chun KH,Woo YM,Kong HK,Ko JY,Suzuki H,Song E,Park JH

更新日期：2014-12-15 00:00:00

abstract：:Mutations that alter normal splice patterns and genomic rearrangements are common causes of hereditary diseases including hereditary nonpolyposis colorectal cancer. However, abnormal transcripts can be difficult to detect and interpret because splicing patterns are often heterogeneous even in normal cells. Standard te...

journal_title：Cancer research

authors： Nakagawa H,Yan H,Lockman J,Hampel H,Kinzler KW,Vogelstein B,De La Chapelle A

更新日期：2002-08-15 00:00:00

abstract：:Animal models, particularly mouse models, play a central role in the study of the etiology, prevention, and treatment of human prostate cancer. While tissue culture models are extremely useful in understanding the biology of prostate cancer, they cannot recapitulate the complex cellular interactions within the tumor m...

journal_title：Cancer research

authors： Ittmann M,Huang J,Radaelli E,Martin P,Signoretti S,Sullivan R,Simons BW,Ward JM,Robinson BD,Chu GC,Loda M,Thomas G,Borowsky A,Cardiff RD

更新日期：2013-05-01 00:00:00

abstract：:SUMO-1 conjugation modulates numerous cellular functions, including the subnuclear localization of its target proteins. The WT1 tumor suppressor encodes a four-zinc finger protein with distinct splicing isoforms. WT1(-KTS), encoding uninterrupted zinc fingers, functions as a transcription factor and has a diffusely nu...

journal_title：Cancer research

authors： Smolen GA,Vassileva MT,Wells J,Matunis MJ,Haber DA

更新日期：2004-11-01 00:00:00

abstract：:Glioblastoma (GBM) is often treated with the cytotoxic drug temozolomide, but the disease inevitably recurs in a drug-resistant form after initial treatment. Here, we report that in GBM cells, even a modest decrease in the mismatch repair (MMR) components MSH2 and MSH6 have profound effects on temozolomide sensitivity...

journal_title：Cancer research

authors： McFaline-Figueroa JL,Braun CJ,Stanciu M,Nagel ZD,Mazzucato P,Sangaraju D,Cerniauskas E,Barford K,Vargas A,Chen Y,Tretyakova N,Lees JA,Hemann MT,White FM,Samson LD

更新日期：2015-08-01 00:00:00

abstract：:Multimodal therapy is generally more effective than single-agent treatment for cancer. rRp450 is an engineered herpes simplex viral mutant that replicates in and kills tumor cells in a relatively selective fashion. It also expresses, in infected cells, the cyclophosphamide (CPA)-sensitive rat cytochrome P450 2B1 (CYP2...

journal_title：Cancer research

authors： Aghi M,Chou TC,Suling K,Breakefield XO,Chiocca EA

更新日期：1999-08-15 00:00:00

abstract：:Primary prostate cancer can have extensive microheterogeneity, but its contribution to the later emergence of metastatic castration-resistant prostate cancer (mCRPC) remains unclear. In this study, we microdissected residual prostate cancer foci in radical prostatectomies from 18 men treated with neoadjuvant-intensive...

journal_title：Cancer research

authors： Sowalsky AG,Ye H,Bhasin M,Van Allen EM,Loda M,Lis RT,Montaser-Kouhsari L,Calagua C,Ma F,Russo JW,Schaefer RJ,Voznesensky OS,Zhang Z,Bubley GJ,Montgomery B,Mostaghel EA,Nelson PS,Taplin ME,Balk SP

更新日期：2018-08-15 00:00:00

abstract：:MHC class I-restricted tumor antigen can be presented to CD8+ T cells by two distinct mechanisms. Direct presentation involves degradation of cytosolic proteins by the proteosome into peptides, transport of the peptides across the endoplasmic reticulum membrane, and expression of the MHC-peptide complex on the tumor c...

journal_title：Cancer research

authors： Guilloux Y,Bai XF,Liu X,Zheng P,Liu Y

更新日期：2001-02-01 00:00:00

abstract：:Two opposing clusters of transcription factors (TF) have been associated with the differential risks of estrogen receptor positive or negative breast cancers, but the mechanisms underlying the opposing functions of the two clusters are undefined. In this study, we identified NFIB and YBX1 as novel interactors of the e...

journal_title：Cancer research

authors： Campbell TM,Castro MAA,de Oliveira KG,Ponder BAJ,Meyer KB

更新日期：2018-01-15 00:00:00

abstract：:The progression from normal breast epithelium to a malignant phenotype may depend on changes in genetic events as well as failure of host mechanisms. Intermediate biomarkers are needed to more effectively identify malignant progression as well as to develop the potential for more specific treatments and prevention str...

journal_title：Cancer research

authors： Khanuja PS,Lehr JE,Soule HD,Gehani SK,Noto AC,Choudhury S,Chen R,Pienta KJ

更新日期：1993-07-15 00:00:00

abstract：:We have used culture conditions which simulate the microenvironment of breast tumors for the isolation and propagation of primary breast tumor cells in vitro. In this monolayer setup, the mixture of cells dissociated from primary breast tumors is subjected to self-created gradients of oxygen and nutrients as well as m...

journal_title：Cancer research

authors： Dairkee SH,Deng G,Stampfer MR,Waldman FM,Smith HS

更新日期：1995-06-15 00:00:00

abstract：:CI-921, an analogue of amsacrine with superior activity against in vivo and in vitro experimental tumor models, has been studied in 16 patients with solid tumors refractory to chemotherapy or for which conventional therapy does not exist. Thirty-nine cycles were given and doses escalated from 39 to 810 mg/m2. This tot...

journal_title：Cancer research

authors： Hardy JR,Harvey VJ,Paxton JW,Evans P,Smith S,Grove W,Grillo-Lopez AJ,Baguley BC

更新日期：1988-11-15 00:00:00

abstract：:High-resolution magic angle spinning proton (HRMAS 1H) magnetic resonance spectroscopy produces well-resolved spectra of metabolites from intact tissue specimens. Here we report the results of a preliminary study of 19 human brain tumors obtained by applying this method. Among these 19 cases were 2 low-grade astrocyto...

journal_title：Cancer research

authors： Cheng LL,Chang IW,Louis DN,Gonzalez RG

更新日期：1998-05-01 00:00:00

abstract：:Human papillomavirus (HPV) type 18 DNA was introduced into epithelial cell strains derived from normal and cancer tissues of human prostatectomy specimens by the lipofection transfection method. Two cell lines were established: PZ-HPV-7 (transfected normal cell) and CA-HPV-10 (transfected cancer-derived cell). These l...

journal_title：Cancer research

authors： Weijerman PC,König JJ,Wong ST,Niesters HG,Peehl DM

更新日期：1994-11-01 00:00:00

abstract：:Estrogen receptor α (ERα) is a key regulator of breast growth and breast cancer development. Here, we report how ERα impacts these processes by reprogramming metabolism in malignant breast cells. We employed an integrated approach, combining genome-wide mapping of chromatin-bound ERα with estrogen-induced transcript a...

journal_title：Cancer research

authors： Jia M,Andreassen T,Jensen L,Bathen TF,Sinha I,Gao H,Zhao C,Haldosen LA,Cao Y,Girnita L,Moestue SA,Dahlman-Wright K

更新日期：2016-10-01 00:00:00

abstract：:The tumor localization of various anti-CD5 immunotoxins (ITs) was studied in vivo in BALB/c nude mice bearing human ascitic Ichikawa tumor cells. Plasma and ascitic clearance of IT as well as the number of intact IT molecules taken up per tumor cell was measured with a highly sensitive immunoenzymometric assay. This a...

journal_title：Cancer research

authors： Rostaing-Capaillon O,Casellas P

更新日期：1990-05-15 00:00:00

abstract：:The interleukin (IL)-13 receptor alpha2 (IL-13Ralpha2) chain is a primary binding and internalization subunit for a Th2-derived immune regulatory cytokine, IL-13. Although extremely high levels of IL-13Ralpha2 chain are expressed on a variety of human tumor cells and specimens, its precise role in tumor immunology has...

journal_title：Cancer research

authors： Kawakami K,Terabe M,Kawakami M,Berzofsky JA,Puri RK

更新日期：2006-04-15 00:00:00

abstract：:The concept that different leukemias are developmentally distinct and, like in normal hematopoiesis, generated by restricted populations of cells named leukemia-initiating cells (LIC), is becoming more established. These cancer stem-like cells have been assumed to have unique properties, including the capability of se...

journal_title：Cancer research

authors： Tamiro F,Weng AP,Giambra V

更新日期：2021-01-07 00:00:00

abstract：:Although altered expression of platelet-derived growth factor (PDGF)-A is a hallmark of many cancers, the importance of pro-PDGF-A conversion to PDGF-A in tumorigenesis and the cognate protease(s) is unknown. Pro-PDGF-A processing occurs at pairs of basic residues, likely involving the proprotein convertases (PCs). In...

journal_title：Cancer research

authors： Siegfried G,Khatib AM,Benjannet S,Chrétien M,Seidah NG

更新日期：2003-04-01 00:00:00

abstract：:Two human erythroleukemia cell lines, HEL and K562, express transglutaminase activity. The enzyme was identified as a tissue transglutaminase following chromatographic purification. All-trans-retinoic acid (10 microM) stimulated differentiation in HEL cells as judged by a 4-fold increase in hemoglobin content and a re...

journal_title：Cancer research

authors： Suedhoff T,Birckbichler PJ,Lee KN,Conway E,Patterson MK Jr

更新日期：1990-12-15 00:00:00

abstract：:The secreted frizzled-related proteins (SFRPs) function as negative regulators of Wnt signaling and have important implications in tumorigenesis. Frequent promoter hypermethylation of SFRPs has been identified in human cancer. Restoration of SFRP function attenuates Wnt signaling and induces apoptosis in a variety of ...

journal_title：Cancer research

authors： He B,Lee AY,Dadfarmay S,You L,Xu Z,Reguart N,Mazieres J,Mikami I,McCormick F,Jablons DM

更新日期：2005-02-01 00:00:00

abstract：:Resistance to anticancer therapeutics greatly affects the phenotypic and functional properties of tumor cells, but how chemoresistance contributes to the tumorigenic activities of cancer stem-like cells remains unclear. In this study, we found that a characteristic of cancer stem-like cells from chemoresistant tumors ...

journal_title：Cancer research

authors： Yamashina T,Baghdadi M,Yoneda A,Kinoshita I,Suzu S,Dosaka-Akita H,Jinushi M

更新日期：2014-05-15 00:00:00

abstract：:Bladder cancer progression is thought to be associated with sequential genetic events. To search for the specific genetic changes associated with the metastatic process, comparative genomic hybridization was performed on 22 primary tumors and 24 metastases (10 distant and 14 nodal metastases) from 17 patients with sta...

journal_title：Cancer research

authors： Hovey RM,Chu L,Balazs M,DeVries S,Moore D,Sauter G,Carroll PR,Waldman FM

更新日期：1998-08-15 00:00:00

abstract：:The mitotic kinase Aurora A is an important therapeutic target for cancer therapy. This study evaluated new mechanism-based pharmacodynamic biomarkers in cancer patients in two phase I studies of MLN8054, a small-molecule inhibitor of Aurora A kinase. Patients with advanced solid tumors received MLN8054 orally for 7 c...

journal_title：Cancer research

authors： Chakravarty A,Shinde V,Tabernero J,Cervantes A,Cohen RB,Dees EC,Burris H,Infante JR,Macarulla T,Elez E,Andreu J,Rodriguez-Braun E,Rosello S,von Mehren M,Meropol NJ,Langer CJ,ONeil B,Bowman D,Zhang M,Danaee H,Faron

更新日期：2011-02-01 00:00:00

abstract：:Both 2-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (EC 4.1.1.17), and methylglyoxal bis(guanylhydrazone) (MGBG), a competitive inhibitor of S-adenosylmethionine decarboxylase (EC 4.1.1.50), strikingly stimulated melanotic expression of murine Cloudman S91 melanoma cells. The st...

journal_title：Cancer research

authors： Käpyaho K,Sinervirta R,Jänne J

更新日期：1985-04-01 00:00:00

abstract：:Defective repair of sunlight-induced DNA photodamage, coupled with an unusually high occurrence of multiple primary basal cell carcinomas (BCCs), is the major characteristic of xeroderma pigmentosum. Our recent work has indicated that this etiological paradigm may apply to skin cancer patients without an apparent here...

journal_title：Cancer research

authors： Wei Q,Matanoski GM,Farmer ER,Hedayati MA,Grossman L

更新日期：1994-01-15 00:00:00

abstract：:The autogenous humoral immune response of mice to their endogenous leukemia virus (MuLV) has been examined with respect to the reactivities of natural antibodies to MuLV envelope antigens and virus-induced cells surface antigens. The natural reactivity of MuLV envelope antigens was evaluated by means of a radioimmune ...

journal_title：Cancer research

authors： Hanna MG Jr,Ihle JN,Batzing BL,Tennant TW,Schenley CK

更新日期：1975-01-01 00:00:00