Effects of inhibitors of polyamine biosynthesis on the growth and melanogenesis of murine melanoma cells.

abstract：:Emerging studies indicate that DNA damage in cancer cells triggers antitumor immunity, but its intrinsic regulatory mechanism in breast cancer cells remains poorly understood. Here, we show that ZMYND8 is upregulated and inhibits micronucleus formation and DNA damage in breast cancer cells. Loss of ZMYND8 triggered ac...

journal_title：Cancer research

authors： Wang Y,Luo M,Chen Y,Wang Y,Zhang B,Ren Z,Bao L,Wang Y,Wang JE,Fu YX,Luo W,Wang Y

更新日期：2020-11-04 00:00:00

abstract：:Recent three genome-wide association studies have mapped a lung cancer susceptibility locus to chromosome 15q25 in Caucasians. However, the reported risk single nucleotide polymorphisms (SNPs) are extremely rare in Asians, arguing against any of these being causative variants. This study sought to identify other varia...

journal_title：Cancer research

authors： Wu C,Hu Z,Yu D,Huang L,Jin G,Liang J,Guo H,Tan W,Zhang M,Qian J,Lu D,Wu T,Lin D,Shen H

更新日期：2009-06-15 00:00:00

abstract：:Phosphorylation of histone H3 at Ser-10 is required for maintenance of properchromosome dynamics during mitosis. AIM-1, a mammalian Ipl1/aurora kinase involved in H3 phosphorylation, is transcriptionally overexpressed in many tumor cell lines. Increased expression of the AIM-1 gene has been observed in human colorecta...

journal_title：Cancer research

authors： Ota T,Suto S,Katayama H,Han ZB,Suzuki F,Maeda M,Tanino M,Terada Y,Tatsuka M

更新日期：2002-09-15 00:00:00

abstract：:Carcinomas of the exocrine pancreas are poorly understood and have a poor prognosis because of their highly malignant nature. Using two human pancreatic cancer cell lines, AsPc-1 and Capan-2, we have investigated avenues that might be useful in targeting the delivery of antineoplastic agents to such cancers. Qualitati...

journal_title：Cancer research

authors： Gonzalez DE,Covitz KM,Sadée W,Mrsny RJ

更新日期：1998-02-01 00:00:00

abstract：:The microbial alkaloid staurosporine is a potent but nonselective inhibitor of protein kinases. The derivative CGP 41251 has been shown to exert a high degree of selectivity for inhibition of protein kinase C activity. Both compounds are powerful inhibitors of proliferation of both normal and transformed cells in vitr...

journal_title：Cancer research

authors： Andrejauskas-Buchdunger E,Regenass U

更新日期：1992-10-01 00:00:00

abstract：:A synergistic interaction of Bcl-2 and c-Myc plays a role in lymphomagenesis in mice and in some patients as well. Progression of follicular lymphoma to a more aggressive lymphoma is seen in the majority of patients, and approximately 10% of the transformed lymphomas have a translocation of c-myc in addition to the tr...

journal_title：Cancer research

authors： Arcinas M,Heckman CA,Mehew JW,Boxer LM

更新日期：2001-07-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer, with a high propensity for distant metastasis and limited treatment options, yet its molecular underpinnings remain largely unknown. Microrchidia family CW-type zinc finger 2 (MORC2) is a newly identified chromatin remodeling protein who...

journal_title：Cancer research

authors： Zhang FL,Cao JL,Xie HY,Sun R,Yang LF,Shao ZM,Li DQ

更新日期：2018-10-15 00:00:00

abstract：:FOXP3 is inactivated in breast cancer cells by a number of mechanisms, including somatic mutations, deletion, and epigenetic silencing. Because the mutation and deletion are usually heterozygous in the cancer samples, it is of interest to determine whether the gene can be induced for the purpose of cancer therapy. Her...

journal_title：Cancer research

authors： Liu Y,Wang Y,Li W,Zheng P,Liu Y

更新日期：2009-07-15 00:00:00

abstract：:The epidermal growth factor (EGF) receptor in two colon carcinoma lines and in one vulval carcinoma line tested contains carbohydrate determinants that are recognized by monoclonal antibodies to tumor-associated antigens. These antibodies are directed to sialylated Lea and to difucosylated structures of the Y type. Ce...

journal_title：Cancer research

authors： Basu A,Murthy U,Rodeck U,Herlyn M,Mattes L,Das M

更新日期：1987-05-15 00:00:00

abstract：:Angiopoietin-1 (Ang1) mediates angiogenesis by enhancing endothelial cell survival and migration. It is also known that Ang1 activates Tie2, an endothelial-specific tyrosine kinase receptor, but the molecular mechanism of this process is not clear. In this study, we investigated whether reactive oxygen species (ROS) p...

journal_title：Cancer research

authors： Kim YM,Kim KE,Koh GY,Ho YS,Lee KJ

更新日期：2006-06-15 00:00:00

abstract：:The Chinese hamster ovary cell line xrs-1 is hypersensitive to gamma-radiation. This sensitivity has been attributed to an inability of this cell line to efficiently repair gamma-ray induced double-strand breaks (DSBs). We have recently reported that xrs-1 is also sensitive to topoisomerase II inhibitors that stabiliz...

journal_title：Cancer research

authors： Caldecott K,Banks G,Jeggo P

更新日期：1990-09-15 00:00:00

abstract：:Immunostimulatory CpG oligodeoxynucleotides (ODNs) can enhance the therapeutic effect of monoclonal antibodies (mAbs) by enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Distinct classes of CpG ODNs have been found recently to stimulate different effector cell populations. We used murine cancer models t...

journal_title：Cancer research

authors： van Ojik HH,Bevaart L,Dahle CE,Bakker A,Jansen MJ,van Vugt MJ,van de Winkel JG,Weiner GJ

更新日期：2003-09-01 00:00:00

abstract：:Human and mouse paralogues of the evolutionarily conserved mammalian HRAD9 and Mrad9 cell cycle checkpoint control genes have been isolated and called HRAD9B and Mrad9B, respectively. HRAD9B encodes a protein that is 414 amino acids long and is 55% similar and 35% identical to the HRAD9 gene product. The Mrad9B protei...

journal_title：Cancer research

authors： Hopkins KM,Wang X,Berlin A,Hang H,Thaker HM,Lieberman HB

更新日期：2003-09-01 00:00:00

abstract：:[3H]Pregn-4-ene-3,20-dione ([3H]progesterone)-receptor complexes from human mammary carcinoma were found to be stabilized in the presence of glycerol. The dissociation rate constant was lowered and the equilibrium dissociation constant was decreased (KD=3 nM in the absence of glycerol and 1.1 nM in the presence of 30%...

journal_title：Cancer research

authors： Pichon MF,Milgrom E

更新日期：1977-02-01 00:00:00

abstract：:The prostate-specific antigen (PSA) promoter (PSA-P) has been identified, characterized, and determined to be tissue specific. Compared with high expression of the genomic PSA gene in prostate cells, expression of the transgene driven by the putative PSA promoter is low. This suggests that the identified promoter may ...

journal_title：Cancer research

authors： Pang S,Dannull J,Kaboo R,Xie Y,Tso CL,Michel K,deKernion JB,Belldegrun AS

更新日期：1997-02-01 00:00:00

abstract：:Tyrosine phosphorylation (pTyr) plays a pivotal role in signal transduction and is commonly dysregulated in cancer. As a result, profiling tumor pTyr levels may reveal therapeutic insights critical to combating disease. Existing discovery and targeted mass spectrometry-based methods used to monitor pTyr networks invol...

journal_title：Cancer research

authors： Stopfer LE,Flower CT,Gajadhar AS,Patel B,Gallien S,Lopez-Ferrer D,White FM

更新日期：2021-01-28 00:00:00

abstract：:Cells lacking the tumor suppressor gene LKB1/STK11 alter their metabolism to match the demands of accelerated growth, leaving them highly vulnerable to stress. However, targeted therapy for LKB1-deficient cancers has yet to be reported. In both Kras/p53/Lkb1 cell lines and a genetically engineered mouse model of Kras/...

journal_title：Cancer research

authors： Liu Y,Li Y,Wang X,Liu F,Gao P,Quinn MM,Li F,Merlino AA,Benes C,Liu Q,Gray NS,Wong KK

更新日期：2017-09-15 00:00:00

abstract：:Tn and sialylated Tn (sTn) are blood group-related epitopes expressed on mucins of colon carcinoma and other epithelial tumors and are, therefore, potential targets for immunological control. We have immunized 20 colorectal cancer patients at high risk for recurrence with a vaccine consisting of partially desialylated...

journal_title：Cancer research

authors： O'Boyle KP,Zamore R,Adluri S,Cohen A,Kemeny N,Welt S,Lloyd KO,Oettgen HF,Old LJ,Livingston PO

更新日期：1992-10-15 00:00:00

abstract：:Intentional bacterial infections can produce efficacious antitumor responses in mice, rats, dogs, and humans. However, low overall success rates and intense side effects prevent such approaches from being employed clinically. In this work, we titered bacteria and/or the proinflammatory cytokine TNFα in a set of establ...

journal_title：Cancer research

authors： Hatzikirou H,López Alfonso JC,Leschner S,Weiss S,Meyer-Hermann M

更新日期：2017-04-01 00:00:00

abstract：:Cyclooxygenase-2 is a valid target for cancer prevention and treatment. This has been shown in preclinical and clinical cancer prevention studies by using a cyclooxygenase-2 inhibitor, celecoxib. When used in a randomized cancer prevention clinical trial on patients with the inherited autosomal dominant condition, fam...

journal_title：Cancer research

authors： Xiao Z,Luke BT,Izmirlian G,Umar A,Lynch PM,Phillips RK,Patterson S,Conrads TP,Veenstra TD,Greenwald P,Hawk ET,Ali IU

更新日期：2004-04-15 00:00:00

abstract：:Consequences of the obesity epidemic on cancer morbidity and mortality are not fully appreciated. Obesity is a risk factor for many cancers, but the mechanisms by which it contributes to cancer development and patient outcome have yet to be fully elucidated. Here, we examined the effects of coculturing human-derived a...

journal_title：Cancer research

authors： Picon-Ruiz M,Pan C,Drews-Elger K,Jang K,Besser AH,Zhao D,Morata-Tarifa C,Kim M,Ince TA,Azzam DJ,Wander SA,Wang B,Ergonul B,Datar RH,Cote RJ,Howard GA,El-Ashry D,Torné-Poyatos P,Marchal JA,Slingerland JM

更新日期：2016-01-15 00:00:00

abstract：:Germ-line p53 mutations have been identified in most families with Li-Fraumeni syndrome (LFS). For germ-line p53 mutation carriers, there is considerable variability with respect to age of cancer onset and tumor type, suggesting that additional genetic effects influence the clinical severity and tumor spectrum. To ide...

journal_title：Cancer research

authors： Wu CC,Shete S,Amos CI,Strong LC

更新日期：2006-08-15 00:00:00

abstract：:Two distinct marker chromosomes, presenting with intercalated C- and distamycin A-Dapi-positive regions, were observed in a metastatic and a primary melanoma. To establish the origin of these heterochromatic sequences, we performed in situ hybridization analysis using specific probes for human repetitive DNA. The mark...

journal_title：Cancer research

authors： Doneda L,Ginelli E,Agresti A,Larizza L

更新日期：1989-01-15 00:00:00

abstract：:Hypomethylation of CpG dinucleotides in genomic DNA was one of the first somatic epigenetic alterations discovered in human cancers. DNA hypomethylation is postulated to occur very early in almost all human cancers, perhaps facilitating genetic instability and cancer initiation and progression. We therefore examined t...

journal_title：Cancer research

authors： Yegnasubramanian S,Haffner MC,Zhang Y,Gurel B,Cornish TC,Wu Z,Irizarry RA,Morgan J,Hicks J,DeWeese TL,Isaacs WB,Bova GS,De Marzo AM,Nelson WG

更新日期：2008-11-01 00:00:00

abstract：:Cancer is associated with a prothrombogenic state capable of platelet activation. Platelets, on the other hand, can support angiogenesis, a process involved in the progression of tumor growth and metastasis. However, it is unclear whether platelet/tumor interactions substantially contribute to tumor physiology. We inv...

journal_title：Cancer research

authors： Ho-Tin-Noé B,Goerge T,Cifuni SM,Duerschmied D,Wagner DD

更新日期：2008-08-15 00:00:00

abstract：:Angiogenesis is essential for the growth of solid tumors. We have observed previously that the vascular endothelial cells of astrocytic brain tumors express human telomerase reverse transcriptase (hTERT) mRNA, suggesting a role for telomerase in the angiogenesis of these neoplasms. Here, we used an in vitro model to d...

journal_title：Cancer research

authors： Falchetti ML,Pierconti F,Casalbore P,Maggiano N,Levi A,Larocca LM,Pallini R

更新日期：2003-07-01 00:00:00

abstract：:Most cancer-associated single-nucleotide polymorphisms (SNP) identified using genome-wide association studies are located outside of protein-coding regions, and their significance and mode of action have been a source of continuing debate. One proposed mechanism of action of the SNPs is that they would affect the acti...

journal_title：Cancer research

authors： Sur I,Tuupanen S,Whitington T,Aaltonen LA,Taipale J

更新日期：2013-07-15 00:00:00

abstract：:Activation-induced cytidine deaminase (AID) is essential for somatic hypermutation and class switch recombination of the immunoglobulin (IG) genes in B cells. It has recently been proposed that AID, as the newly identified DNA mutator in man, may be instrumental in initiation and progression of B-cell non-Hodgkin's ly...

journal_title：Cancer research

authors： Smit LA,Bende RJ,Aten J,Guikema JE,Aarts WM,van Noesel CJ

更新日期：2003-07-15 00:00:00

abstract：:We reported recently that medium conditioned with mouse lung microvessel endothelial cells possessed chemotactic activity for a highly lung-metastatic variant (L17) of the RAW117 murine large-cell lymphoma cell line but not for the poorly metastatic parental cells (P) or a liver-metastasizing variant (H10). The chemot...

journal_title：Cancer research

authors： Wakabayashi H,Cavanaugh PG,Nicolson GL

更新日期：1995-10-01 00:00:00

abstract：:We have used a quantitative "experimental" metastasis assay in the embryonic chick, an immunodeficient host, to examine in vivo growth properties of ras oncogene-transformed NIH3T3 cells. We found that two independently derived populations of NIH3T3 cells that had been morphologically transformed with the T24 human H-...

journal_title：Cancer research

authors： Bondy GP,Wilson S,Chambers AF

更新日期：1985-12-01 00:00:00