Purification and identification of mouse lung microvessel endothelial cell-derived chemoattractant for lung-metastasizing murine RAW117 large-cell lymphoma cells: identification as mouse monocyte chemotactic protein 1.

abstract：:In estrogen-induced cancer, catechol formation from administered steroids has been postulated to be a necessary event for estrogen activation and subsequent damage to cellular macromolecules. In the present study, this hypothesis has been tested using two homologous series of structurally related estrogens: estradiol,...

journal_title：Cancer research

authors： Liehr JG,Purdy RH,Baran JS,Nutting EF,Colton F,Randerath E,Randerath K

更新日期：1987-05-15 00:00:00

abstract：:Gastrointestinal stromal tumors (GIST) are caused by activating mutations in the KIT or PDGFRA receptor tyrosine kinase genes. Although >85% of GIST patients treated with the small-molecule inhibitor imatinib mesylate (Gleevec) achieve disease stabilization, complete remissions are rare and a substantial proportion of...

journal_title：Cancer research

authors： Bauer S,Parry JA,Mühlenberg T,Brown MF,Seneviratne D,Chatterjee P,Chin A,Rubin BP,Kuan SF,Fletcher JA,Duensing S,Duensing A

更新日期：2010-01-01 00:00:00

abstract：:The cells of many solid tumors have been found to contain supernumerary centrosomes, a condition known as centrosome amplification. Centrosome amplification, accompanied by the overexpression of an associated kinase, Aurora A (AurA), has been implicated in mechanisms leading to mitotic spindle aberrations, aneuploidy,...

journal_title：Cancer research

authors： Goepfert TM,Adigun YE,Zhong L,Gay J,Medina D,Brinkley WR

更新日期：2002-07-15 00:00:00

abstract：:Prior investigations on the beneficial effect of dietary processed tomato products and lycopene on prostate cancer risk suggested that lycopene may require the presence of other constituents to exert its chemopreventive potential. We investigated whether ketosamines, a group of carbohydrate derivatives present in dehy...

journal_title：Cancer research

authors： Mossine VV,Chopra P,Mawhinney TP

更新日期：2008-06-01 00:00:00

abstract：:The idea of using oncolytic viruses for the treatment of cancers was proposed a century ago. During the last two decades, viruses able to replicate specifically in cancer cells and to induce their lysis were identified and were genetically modified to improve their viro-oncolytic properties. More recently, a new appro...

journal_title：Cancer research

authors： Gillet L,Dewals B,Farnir F,de Leval L,Vanderplasschen A

更新日期：2005-10-15 00:00:00

abstract：:Cells that overexpress high-mobility group A1 (HMGA1) proteins exhibit deficient nucleotide excision repair (NER) after exposure to DNA-damaging agents, a condition ameliorated by artificially lowering intracellular levels of these nonhistone proteins. One possible mechanism for this NER inhibition is down-regulation ...

journal_title：Cancer research

authors： Adair JE,Maloney SC,Dement GA,Wertzler KJ,Smerdon MJ,Reeves R

更新日期：2007-07-01 00:00:00

abstract：:The breast- and ovarian-specific tumor suppressor BRCA1 has been implicated in numerous cellular processes, including transcription, ubiquitination, and DNA repair. Its tumor suppression activity is tightly linked to that of BARD1, a protein that heterodimerizes with BRCA1. It has been previously shown that BRCA1 bind...

journal_title：Cancer research

authors： Simons AM,Horwitz AA,Starita LM,Griffin K,Williams RS,Glover JN,Parvin JD

更新日期：2006-02-15 00:00:00

abstract：:A series of purine nucleoside and dialdehyde analogues was studied to determine their potency as inhibitors of C-1300 murine neuroblastoma cell growth in tissue culture. Tumor cells were incubated with each analogue for 72 h, and the number of viable cells was determined at 24, 48, and 72 h. Dose-response curves were ...

journal_title：Cancer research

authors： Mirkin BL,O'Dea RF,Hogenkamp HP

更新日期：1987-07-15 00:00:00

abstract：:Anti-idiotypic monoclonal antibodies (MoAbs) were prepared in a syngeneic system against anti-carcinoembryonic antigen (CEA) MoAb 5B3 (IgG1), which reacted with a carbohydrate moiety on CEA, and MoAb MA208 (IgG1), which reacted with a peptide on CEA. Anti-idiotypic MoAb T3-503 and T4-202 recognized the private idiotyp...

journal_title：Cancer research

authors： Tsujisaki M,Imai K,Tokuchi S,Hanzawa Y,Ishida T,Kitagawa H,Hinoda Y,Yachi A

更新日期：1991-05-15 00:00:00

abstract：:Mutational synergism was examined in Chinese hamster V79 cells exposed to methyl methanesulfonate followed by N-acetoxy-2-acetylaminofluorene (AcAAF) at different time intervals. Treatment with 500 micron methyl methanesulfonate resulted in 95% survival of cloning ability and induced approximately 4 azaguanine-resista...

journal_title：Cancer research

authors： Myhr BC,DiPaolo JA

更新日期：1978-08-01 00:00:00

abstract：:A novel matrix-degrading enzyme was identified from human breast cancer cells. This enzyme appears as major gelatinase in hormone-dependent breast cancer cell lines and has as an apparent molecular mass of 80 kDa on gelatin zymography. The 80-kDa enzyme has a unique metal ion specificity. In addition to calcium ions, ...

journal_title：Cancer research

authors： Shi YE,Torri J,Yieh L,Wellstein A,Lippman ME,Dickson RB

更新日期：1993-03-15 00:00:00

abstract：:Thirty-seven endometrial cancers were subjected to an allelotype analysis in an attempt to identify chromosomal regions that are lost in a significant portion of tumors and to identify tumors characterized by replication errors. Thirty-nine highly polymorphic microsatellite markers representing all chromosomal arms, e...

journal_title：Cancer research

authors： Peiffer SL,Herzog TJ,Tribune DJ,Mutch DG,Gersell DJ,Goodfellow PJ

更新日期：1995-05-01 00:00:00

abstract：:Estrogen receptors from rat uterus and human breast carcinoma were analyzed by diethylaminoethyl-cellulose chromatography. Cytosols which had been incubated for short periods of time demonstrated a single discrete elution peak, indicating a single ionic form, while cytosols incubated for longer periods of time generat...

journal_title：Cancer research

authors： Tilzer LL,McFarland RT,Plapp FV,Evans JP,Chiga M

更新日期：1981-03-01 00:00:00

abstract：:The in vitro effects of deoxyadenosine and an adenosine deaminase inhibitor, deoxycoformycin, on the synthesis of DNA and the metabolism of purines were investigated in human leukemic T-cells. In the presence of 10 microM deoxycoformycin, the synthesis of DNA was completely inhibited by concentrations of deoxyadenosin...

journal_title：Cancer research

authors： Yu AL,Bakay B,Kung FH,Nyhan WL

更新日期：1981-07-01 00:00:00

abstract：:Tumor metastasis is one of the most important clinical aspects of neoplastic disease because patient mortality is frequently attributable to disseminated rather than primary tumors. However, it still is not possible to definitively distinguish those individuals at high risk for disseminated disease, who would benefit ...

journal_title：Cancer research

authors： Hunter KW,Broman KW,Voyer TL,Lukes L,Cozma D,Debies MT,Rouse J,Welch DR

更新日期：2001-12-15 00:00:00

abstract：:The pancreatic carcinogen N-nitrosobis(2-oxopropyl)-amine was administered to Syrian golden hamsters after cholecystoduodenostomy and choledochostomy to investigate a possible bile reflux mechanism as a factor in pancreatic carcinogenesis. The induced lesions were similar in morphology, multiplicity, and distribution ...

journal_title：Cancer research

authors： Pour P,Donnelly T

更新日期：1978-07-01 00:00:00

abstract：:Hereditary nonpolyposis colorectal cancer (HNPCC) is commonly associated with at least three currently known DNA mismatch repair genes: (a) hMSH2; (b) hMLH1; and (c) hMSH6. A majority of HNPCC families has identifiable mutations in hMLH1 and hMSH2. When these mutations cause an inherited risk of colorectal cancer, the...

journal_title：Cancer research

authors： Liu HX,Zhou XL,Liu T,Werelius B,Lindmark G,Dahl N,Lindblom A

更新日期：2003-04-15 00:00:00

abstract：:Numerous studies show that nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in chemoprevention or treatment of cancer. Nevertheless, the mechanisms underlying these antineoplastic effects remain poorly understood. Here, we report that induction of the cancer-specific proapoptotic cytokine melanoma different...

journal_title：Cancer research

authors： Zerbini LF,Czibere A,Wang Y,Correa RG,Otu H,Joseph M,Takayasu Y,Silver M,Gu X,Ruchusatsawat K,Li L,Sarkar D,Zhou JR,Fisher PB,Libermann TA

更新日期：2006-12-15 00:00:00

abstract：:Cell suspensions derived from 2 specimens of normal human urothelium and 13 human transitional cell carcinomas were studied by discontinuous density gradient centrifugation. The histochemical and proliferative properties of the fractions were evaluated. In normal urothelium, DNA synthesis was restricted to a subpopula...

journal_title：Cancer research

authors： Mackillop WJ,Bizarri JP,Ward GK

更新日期：1985-09-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common primary cancer arising from the kidney in adults, with clear cell renal cell carcinoma (ccRCC) representing approximately 75% of all RCCs. Increased expression of the hypoxia-induced factors-1α (HIF1α) and HIF2α has been suggested as a pivotal step in ccRCC carcinogenesis,...

journal_title：Cancer research

authors： Fu L,Wang G,Shevchuk MM,Nanus DM,Gudas LJ

更新日期：2013-05-01 00:00:00

abstract：:Determination of neopterin [D-erythro-6-(1',2',3'-trihydroxypropyl)pterin] in body fluids is a powerful diagnostic tool in a variety of diseases in which activation of cellular immune mechanisms is involved, such as certain malignancies, allograft rejection, and autoimmune and infectious diseases. In vitro, neopterin ...

journal_title：Cancer research

authors： Werner-Felmayer G,Werner ER,Fuchs D,Hausen A,Reibnegger G,Wachter H

更新日期：1990-05-15 00:00:00

abstract：:The Th2 cytokines interleukin (IL)-4 and -13 are acknowledged regulators of lymphocyte proliferation and activation. They have also been well studied in the regulation of various myeloid-derived populations in tumor biology. It has become clear, however, that both cytokines can have direct effects on epithelial tumor ...

journal_title：Cancer research

authors： Hallett MA,Venmar KT,Fingleton B

更新日期：2012-12-15 00:00:00

abstract：:We have developed a new strain of rats (resistant rat) which exhibit resistance against the carcinogenic action of several carcinogenic compounds. In the present study, we compared the ability of resistant rat liver to activate 3'-methyl-4-dimethylaminoazobenzene and 2-acetylaminofluorene to highly reactive metabolite...

journal_title：Cancer research

authors： Yano M,Higashi T,Kano S,Tateishi N,Kido Y,Mori T,Higashi K,Sakamoto Y

更新日期：1989-10-01 00:00:00

abstract：:Identification of factors that mediate visceral and bone metastatic spread and subsequent bone remodeling events is highly relevant to successful therapeutic intervention in advanced human prostate cancer. TBX2, a T-box family transcription factor that negatively regulates cell-cycle inhibitor p21, plays critical role...

journal_title：Cancer research

authors： Nandana S,Tripathi M,Duan P,Chu CY,Mishra R,Liu C,Jin R,Yamashita H,Zayzafoon M,Bhowmick NA,Zhau HE,Matusik RJ,Chung LW

更新日期：2017-03-15 00:00:00

abstract：:Protein kinases of the Raf family act as signal-transducing elements downstream of activated cell surface receptors and are involved in the regulation of proliferation, differentiation, and cell survival. Whereas the role of c-Raf-1 as a mitogen-activated protein/extracellular signal-regulated kinase activator within ...

journal_title：Cancer research

authors： Kalmes A,Hagemann C,Weber CK,Wixler L,Schuster T,Rapp UR

更新日期：1998-07-15 00:00:00

abstract：:Groups of 120 male and 120 female rats were exposed by inhalation to 0, 2, 6, or 15 ppm formaldehyde vapor 6 hr/day, 5 days/week, for 18 months of a 24-month study. The present communication describes interim findings based on data available after 18 months of exposure. Squamous cell carcinomas occurred in the nasal c...

journal_title：Cancer research

authors： Swenberg JA,Kerns WD,Mitchell RI,Gralla EJ,Pavkov KL

更新日期：1980-09-01 00:00:00

abstract：:By subjecting radiosensitive human neuroblastoma IMR 32 cells to a regime of fractionated X-irradiation, a radioresistant variant, XRIMR 32, was obtained. Radiation resistance of XRIMR 32 cells was demonstrated by clonogenic and spheroid regrowth delay assays. The XRIMR 32 cultures were phenotypically unstable, with t...

journal_title：Cancer research

authors： Russell J,Wheldon TE,Stanton P

更新日期：1995-11-01 00:00:00

abstract：:Because of their short range and high linear energy transfer, alpha-particles may be particularly effective in the treatment of neoplastic meningitis. Monoclonal antibody 81C6 was labeled with alpha-particle-emitting 211At using N-succinimidyl3-[211At]astatobenzoate, and the efficacy and toxicity of this immunoconjuga...

journal_title：Cancer research

authors： Zalutsky MR,McLendon RE,Garg PK,Archer GE,Schuster JM,Bigner DD

更新日期：1994-09-01 00:00:00

abstract：:Human kallikrein 10 (hK10) is a secreted serine protease that is highly expressed in ovarian tissue. We hypothesized that hK10 might represent a novel serological marker for ovarian cancer. We quantified by immunoassay, hK10 in sera from 97 normal women (controls), 141 patients with benign gynecologic diseases, and 14...

journal_title：Cancer research

authors： Luo LY,Katsaros D,Scorilas A,Fracchioli S,Bellino R,van Gramberen M,de Bruijn H,Henrik A,Stenman UH,Massobrio M,van der Zee AG,Vergote I,Diamandis EP

更新日期：2003-02-15 00:00:00

abstract：:Elimination of both alleles of the gene that encodes the cyclin kinase inhibitor p21(WAF1/cip1) increases the frequency and size of intestinal tumors in Apc1638+/- mice that inherit a mutant allele of the Apc gene, and intermediate effects are seen if a single p21 allele is inactivated. The increased tumor formation i...

journal_title：Cancer research

authors： Yang WC,Mathew J,Velcich A,Edelmann W,Kucherlapati R,Lipkin M,Yang K,Augenlicht LH

更新日期：2001-01-15 00:00:00