Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis.

abstract：:A phenolic amine compound, 4-S-cysteaminylphenol (4-S-CAP), is a potent depigmenting agent. To develop more efficacious antimelanoma agents, we synthesized four homologues of 4-S-CAP: N-acetyl-4-S-CAP (N-Ac-4-S-CAP), alpha-methyl-4-S-CAP, 4-S-homo-CAP, and N,N'-dimethyl-4-S-CAP. We tested these five compounds in mice ...

journal_title：Cancer research

authors： Alena F,Jimbow K,Ito S

更新日期：1990-06-15 00:00:00

abstract：:To examine the oxygen-dependence of glucose consumption in solid tumors, we monitored gradients of glucose, lactate, and hypoxia in R3230Ac and FSA tumors growing in Fischer 344 rats. Bioluminescence imaging, detection of Hoechst 33342, and immunostaining of the hypoxia marker EF5 [2-8-N-(2,2,3,3,3-pentafluoropropyl)a...

journal_title：Cancer research

authors： Schroeder T,Yuan H,Viglianti BL,Peltz C,Asopa S,Vujaskovic Z,Dewhirst MW

更新日期：2005-06-15 00:00:00

abstract：:The mechanism whereby the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) is silenced in repair-deficient (Mer-) human tumor cells is unknown. The role of methylation of the 5' CpG island in MGMT gene suppression is controversial. Although we previously showed by restriction enzyme analysis that CpG m...

journal_title：Cancer research

authors： Qian XC,Brent TP

更新日期：1997-09-01 00:00:00

abstract：:Helicobacter pylori-induced gastritis is the strongest singular risk factor for gastric adenocarcinoma. Matrix metalloproteinase-7 (MMP-7) is a proteolytic enzyme that can modify the intestinal microbial replicative niche as well as affect tumorigenesis, and H. pylori stimulates expression of MMP-7 in gastric epitheli...

journal_title：Cancer research

authors： Ogden SR,Noto JM,Allen SS,Patel DA,Romero-Gallo J,Washington MK,Fingleton B,Israel DA,Lewis ND,Wilson KT,Chaturvedi R,Zhao Z,Shyr Y,Peek RM Jr

更新日期：2010-01-01 00:00:00

abstract：:The effects of quinacrine, an antimetabolite which intercalates into DNA, on the ultrastructure of interphase nuclei and on RNA turnover were studied in primary cultures of rat hepatocytes. Procedures included ultrastructural cytochemical staining for ribonucleoprotein and DNA, autoradiography, and measurement of labe...

journal_title：Cancer research

authors： Leduc EH,Bernhard W,Viron A,Fain J,Puvion E

更新日期：1981-07-01 00:00:00

abstract：:Deletion of endoplasmic reticulum resident chaperone Grp78 results in activation of the unfolded protein response and causes rapid depletion of the entire intestinal epithelium. Whether modest reduction of Grp78 may affect stem cell fate without compromising intestinal integrity remains unknown. Here, we employ a mode...

journal_title：Cancer research

authors： van Lidth de Jeude JF,Spaan CN,Meijer BJ,Smit WL,Soeratram TTD,Wielenga MCB,Westendorp BF,Lee AS,Meisner S,Vermeulen JLM,Wildenberg ME,van den Brink GR,Muncan V,Heijmans J

更新日期：2018-11-01 00:00:00

abstract：:Prognostic tests for patients with early-stage lung cancer may provide needed guidance on postoperative surveillance and therapeutic decisions. We used a novel strategy to develop and validate a prognostic classifier for early-stage lung cancer. Specifically, we focused on 42 genes with roles in lung cancer or cancer ...

journal_title：Cancer research

authors： Akagi I,Okayama H,Schetter AJ,Robles AI,Kohno T,Bowman ED,Kazandjian D,Welsh JA,Oue N,Saito M,Miyashita M,Uchida E,Takizawa T,Takenoshita S,Skaug V,Mollerup S,Haugen A,Yokota J,Harris CC

更新日期：2013-07-01 00:00:00

abstract：:The cytotoxicity of a diphtheria toxin-human epidermal growth factor fusion protein (DAB(389)EGF) was tested against 14 human glioma cell lines. After cells were cultured for 48 h with various concentrations of DAB(389)EGF, the percentage reduction in thymidine incorporation was determined. For 13 of 14 cell lines, po...

journal_title：Cancer research

authors： Liu TF,Cohen KA,Ramage JG,Willingham MC,Thorburn AM,Frankel AE

更新日期：2003-04-15 00:00:00

abstract：:Human malignant mesothelioma of the pleura was successfully transplanted s.c. into athymic nude mice and grew as a solid neoplastic mass. Tumor growth resulted in death of the animals between 98 and 161 days after implantation. Minced samples of the growing tumor were propagated as a malignant peritoneal effusion. Ani...

journal_title：Cancer research

authors： Reale FR,Griffin TW,Compton JM,Graham S,Townes PL,Bogden A

更新日期：1987-06-15 00:00:00

abstract：:Effective radiation treatment of thoracic tumors is often limited by radiosensitivity of surrounding tissues. Several experimental studies have suggested variations in radiosensitivity of different pulmonary regions. Mice and rat studies in part contradict each other and urge for a more detailed analysis. This study w...

journal_title：Cancer research

authors： Novakova-Jiresova A,van Luijk P,van Goor H,Kampinga HH,Coppes RP

更新日期：2005-05-01 00:00:00

abstract：:Strategies to address resistance to platin drugs are greatly needed in human epithelial cancers (e.g., ovarian, head/neck, and lung) where platins are used widely and resistance occurs commonly. We found that upon ΔNp63α overexpression, AKT1 and phospho-AKT1 levels are upregulated in cancer cells. Investigations using...

journal_title：Cancer research

authors： Sen T,Sen N,Brait M,Begum S,Chatterjee A,Hoque MO,Ratovitski E,Sidransky D

更新日期：2011-02-01 00:00:00

abstract：:In humans and rabbits, differences in the rate of N-acetylation of aromatic amines are under polymorphic genetic control. Individuals are classified as either rapid or slow acetylators. In the current study, the relationship between acetylator phenotype and susceptibility to the genotoxicities of benzidine, 4-aminobip...

journal_title：Cancer research

authors： McQueen CA,Maslansky CJ,Williams GM

更新日期：1983-07-01 00:00:00

abstract：:Aggressive tumor growth, diffuse tissue invasion, and neurodegeneration are hallmarks of malignant glioma. Although glutamate excitotoxicity is considered to play a key role in glioma-induced neurodegeneration, the mechanism(s) controlling this process is poorly understood. Astrocyte elevated gene-1 (AEG-1) is an onco...

journal_title：Cancer research

authors： Lee SG,Kim K,Kegelman TP,Dash R,Das SK,Choi JK,Emdad L,Howlett EL,Jeon HY,Su ZZ,Yoo BK,Sarkar D,Kim SH,Kang DC,Fisher PB

更新日期：2011-10-15 00:00:00

abstract：:Patients receiving cytotoxic drugs are at an increased risk of bacterial infection. Drug-induced leukopenia may be responsible for depression of host defenses; however, there is little information concerning the qualitative effects, if any, of cytotoxic agents on granulocyte antibacterial activity. Since methotrexate ...

journal_title：Cancer research

authors： Hyams JS,Donaldson MH,Metcalf JA,Root RK

更新日期：1978-03-01 00:00:00

abstract：:DNA methylation patterns are established and maintained by three DNA methyltransferases (DNMT): DNMT1, DNMT3A, and DNMT3B. Although essential for development, methylation patterns are frequently disrupted in cancer and contribute directly to carcinogenesis. Recent studies linking polycomb group repression complexes (P...

journal_title：Cancer research

authors： Jin B,Yao B,Li JL,Fields CR,Delmas AL,Liu C,Robertson KD

更新日期：2009-09-15 00:00:00

abstract：:Vinblastine was incubated in 0.2 M glycine buffer (pH 7.4 or 8.8) containing bovine serum albumin (1%) at 37 degrees C for 72 h. The reaction mixture was extracted with CH2Cl2, and the extract gave 6 major peaks (A, B, C, D, E, and F) with retention times of 5.0, 7.5, 11.0, 13.0, 23.0, and 30.0 min, respectively, in a...

journal_title：Cancer research

authors： Thimmaiah KN,Sethi VS

更新日期：1985-11-01 00:00:00

abstract：:Treatment of 9L rat brain tumor cells with 1.0 mM alpha-difluoromethylornithine (DFMO) produced a time-dependent depletion of cellular putrescine and spermidine. An increase in the potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) cytotoxicity, measured with a colony-forming efficiency assay, followed the ti...

journal_title：Cancer research

authors： Alhonen-Hongisto L,Deen DF,Marton LJ

更新日期：1984-05-01 00:00:00

abstract：:The presence of succinyl-coenzyme A:acetoacetate CoA transferase (CoA transferase) (EC 2.8.3.5), an initiator of ketone body utilization in nonhepatic tissue, was examined in liver from normal, partly hepatectomized, neonatal, and tumor-bearing rats, as well as in a series of transplantable rat hepatomas ranging widel...

journal_title：Cancer research

authors： Fenselau A,Wallis K,Morris HP

更新日期：1975-09-01 00:00:00

abstract：:Granulocyte macrophage colony-stimulating factor (GMCSF) can mediate antitumor effects by recruiting natural killer cells and by induction of tumor-specific cytotoxic T-cells through antigen-presenting cells. Oncolytic tumor cell-killing can produce a potent costimulatory danger signal and release of tumor epitopes fo...

journal_title：Cancer research

authors： Cerullo V,Pesonen S,Diaconu I,Escutenaire S,Arstila PT,Ugolini M,Nokisalmi P,Raki M,Laasonen L,Särkioja M,Rajecki M,Kangasniemi L,Guse K,Helminen A,Ahtiainen L,Ristimäki A,Räisänen-Sokolowski A,Haavisto E,Oksanen M,

更新日期：2010-06-01 00:00:00

abstract：:The semaphorins and their receptors, the neuropilins and the plexins, are constituents of a complex regulatory system that controls axonal guidance. Moreover, many types of tumor cells express various members of semaphorins and receptors, but the biological activities within tumor mass and the signal transduction mech...

journal_title：Cancer research

authors： Catalano A,Lazzarini R,Di Nuzzo S,Orciari S,Procopio A

更新日期：2009-02-15 00:00:00

abstract：:Human T-cell leukemia virus type 1 oncoprotein Tax is a transcriptional regulator that interacts with a large number of host cell factors. Here, we report the novel characterization of the interaction of Tax with a human cell protein named Tax1-binding protein 1 (TAX1BP1). We show that TAX1BP1 is a nuclear receptor co...

journal_title：Cancer research

authors： Chin KT,Chun AC,Ching YP,Jeang KT,Jin DY

更新日期：2007-02-01 00:00:00

abstract：:Immunotherapy for breast cancer using cytotoxic T cells (CTL) is hindered by the lack of well-characterized breast cancer antigens that are expressed in most breast tumor cells and recognized by CD8+ CTL. A recently described breast tissue differentiation antigen, NY-BR-1, is expressed in >80% breast tumors and elicit...

journal_title：Cancer research

authors： Wang W,Epler J,Salazar LG,Riddell SR

更新日期：2006-07-01 00:00:00

abstract：:The effect of the prostaglandin synthetase inhibitor indomethacin on the dietary fat enhancement of 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis has been examined in female Sprague-Dawley rats. Rats were fed either a normal-fat or high-fat diet (5 or 18% corn oil, respectively) with or without 0.004% i...

journal_title：Cancer research

authors： Carter CA,Milholland RJ,Shea W,Ip MM

更新日期：1983-08-01 00:00:00

abstract：:Accurate diagnosis of primitive childhood sarcomas continues to be a formidable problem because these malignancies generally demonstrate very little morphological evidence of their tissue of origin. One of these tumor classes, the Ewing's sarcoma family of peripheral primitive neuroectodermal tumors (pPNETs), are thou...

journal_title：Cancer research

authors： Sorensen PH,Shimada H,Liu XF,Lim JF,Thomas G,Triche TJ

更新日期：1995-03-15 00:00:00

abstract：:Smad3, a major intracellular mediator of TGFβ signaling, functions as both a positive and negative regulator in carcinogenesis. In response to TGFβ, the TGFβ receptor phosphorylates serine residues at the Smad3 C-tail. Cancer cells often contain high levels of the MAPK and CDK activities, which can lead to the Smad3 l...

journal_title：Cancer research

authors： Bae E,Sato M,Kim RJ,Kwak MK,Naka K,Gim J,Kadota M,Tang B,Flanders KC,Kim TA,Leem SH,Park T,Liu F,Wakefield LM,Kim SJ,Ooshima A

更新日期：2014-11-01 00:00:00

abstract：:Of six prostatic carcinoma cell lines examined (ALVA31, DU145, JCA1, LNCaP, ND1, and PC3) by flow cytometric analysis, all were found to be positive for Fas antigen. Furthermore, of the prostate tissue specimens studied (six cases), all revealed Fas expression in benign and malignant epithelial cells. The agonistic an...

journal_title：Cancer research

authors： Rokhlin OW,Bishop GA,Hostager BS,Waldschmidt TJ,Sidorenko SP,Pavloff N,Kiefer MC,Umansky SR,Glover RA,Cohen MB

更新日期：1997-05-01 00:00:00

abstract：:The metabolism of vitamin B6 in McA-RH7777 cells has been characterized with respect to pyridoxal 5'-phosphate (PLP) levels, and the activities of pyridoxine (PN) kinase (EC 2.1.7.35) and pyridoxine 5'-phosphate (PNP) oxidase (EC 1.4.3.5). PLP levels (12.4 +/- 4.4 ng/mg protein) were at the lower end of the range foun...

journal_title：Cancer research

authors： Meisler NT,Thanassi JW

更新日期：1988-03-01 00:00:00

abstract：:The presence of specific antitumor immunity was examined by the tube leukocyte adherence inhibition (LAI) assay in patients with carcinomas of the larynx. Peripheral blood leukocytes (PBL) from patients with larynx cancer gave positive reactions in the LAI assay with the antigen prepared from the carcinoma of the lary...

journal_title：Cancer research

authors： Holán V,Síbl O,Hasek M

更新日期：1979-02-01 00:00:00

abstract：:Five different lipid conjugates of 1-beta-D-arabinofuranosylcytosine (ara-C) were tested for their therapeutic activity on the growth and metastasis of Lewis lung carcinoma (3-LL). Among 1 ester-linked lipid conjugate (Ara-CDP-L-dipalmitin), 3 1-O-alkyl-lipid conjugates (ara-CDP-D,L-PBA, ara-CDP-D,L-PCA, ara-CDP-D,L-M...

journal_title：Cancer research

authors： Berdel WE,Danhauser S,Hong CI,Schick HD,Reichert A,Busch R,Rastetter J,Vogler WR

更新日期：1988-02-15 00:00:00

abstract：:In vitro cell-mediated cytotoxicity (CMC) assays have been carried out in human melanoma system with blood effector lymphocytes on [3H]proline-labeled target cells in a 48-hr microcytotoxicity technique. Three lymphocyte purification procedures (Ficoll:Hypaque gradient, plasma gel sedimentation followed by nylon colum...

journal_title：Cancer research

authors： Mukherji B,Vassos D,Flowers A,Binder SC,Nathanson L

更新日期：1975-12-01 00:00:00