Effect of the prostaglandin synthetase inhibitor indomethacin on 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in rats fed different levels of fat.

abstract：:Heparanase is an enzyme that cleaves heparan sulfate chains of proteoglycans, and its expression has been associated with increased growth, metastasis, and angiogenesis of some tumors. Because myeloma tumor cells express high levels of the syndecan-1 heparan sulfate proteoglycan and because these tumors grow as highly...

journal_title：Cancer research

authors： Kelly T,Miao HQ,Yang Y,Navarro E,Kussie P,Huang Y,MacLeod V,Casciano J,Joseph L,Zhan F,Zangari M,Barlogie B,Shaughnessy J,Sanderson RD

更新日期：2003-12-15 00:00:00

abstract：:Sodium saccharin and sodium ascorbate are known to promote urinary bladder carcinogenesis in rats following initiation with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) or N-butyl-N-(4-hydroxybutyl) nitrosamine. Sodium salts of other organic acids have also been shown to be bladder tumor promoters. In addition...

journal_title：Cancer research

authors： Cohen SM,Ellwein LB,Okamura T,Masui T,Johansson SL,Smith RA,Wehner JM,Khachab M,Chappel CI,Schoenig GP

更新日期：1991-04-01 00:00:00

abstract：:To determine alpha-fetoprotein (AFP) immunogenicity in vivo, the presence of antibodies in sera of 60 hepatocellular carcinoma, 15 liver cirrhosis, and 15 chronic hepatitis patients was evaluated by Western blotting and immunoprecipitation analyses using purified human AFP. High titers of anti-AFP immunoglobulins were...

journal_title：Cancer research

authors： Bei R,Budillon A,Reale MG,Capuano G,Pomponi D,Budillon G,Frati L,Muraro R

更新日期：1999-11-01 00:00:00

abstract：:We compared L-phenylalanine mustard (L-PAM)-induced cytotoxicity and DNA cross-linking with and without a 42-h preincubation with the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO, 1 mM) in a human lymphoma cell line. The combination showed increased toxicity with a Do ratio of 1.6. L-PAM-induc...

journal_title：Cancer research

authors： Ducore JM,McNamara L

更新日期：1986-03-01 00:00:00

abstract：:A significant impediment to the success of cancer chemotherapy is multidrug resistance (MDR). A typical form of MDR is attributable to the overexpression of membrane transport proteins, such as P-glycoprotein, resulting in an increased drug efflux. In this study, we show that adenovirus-mediated enhancement of the c-J...

journal_title：Cancer research

authors： Zhou J,Liu M,Aneja R,Chandra R,Lage H,Joshi HC

更新日期：2006-01-01 00:00:00

abstract：:Native chromosomal structure, breakage, and overall degradation were studied following the reaction of whole cells with the anticancer drug bleomycin and structurally related phleomycin. Electrophoretic analyses of cellular DNA established that phleomycin was more reactive with DNA than equimolar bleomycin in the rang...

journal_title：Cancer research

authors： Moore CW

更新日期：1988-12-01 00:00:00

abstract：:CD44 is an integral membrane glycoprotein that functions as a receptor for the extracellular matrix glycan, hyaluronan. Here we report that CD44 is a novel biomarker for non-small cell lung tumors, squamous metaplasia of the lung, and activated type II pneumocytes. We have examined the expression of CD44 in 12 human l...

journal_title：Cancer research

authors： Penno MB,August JT,Baylin SB,Mabry M,Linnoila RI,Lee VS,Croteau D,Yang XL,Rosada C

更新日期：1994-03-01 00:00:00

abstract：:Lymphangioleiomyomatosis (LAM) is a progressive destructive neoplasm of the lung associated with inactivating mutations in the TSC1 or TSC2 tumor suppressor genes. Cell or animal models that accurately reflect the pathology of LAM have been challenging to develop. Here, we generated a robust human cell model of LAM by...

journal_title：Cancer research

authors： Julian LM,Delaney SP,Wang Y,Goldberg AA,Doré C,Yockell-Lelièvre J,Tam RY,Giannikou K,McMurray F,Shoichet MS,Harper ME,Henske EP,Kwiatkowski DJ,Darling TN,Moss J,Kristof AS,Stanford WL

更新日期：2017-10-15 00:00:00

abstract：:We applied 1H-decoupling and nuclear Overhauser enhancement to obtain well-resolved 31P magnetic resonance spectra accurately localized to 20 soft tissue sarcomas in vivo, using three-dimensional chemical shift imaging. Fifteen spectra had large phosphomonoester signals (21% of total phosphorus) that contained high am...

journal_title：Cancer research

authors： Li CW,Kuesel AC,Padavic-Shaller KA,Murphy-Boesch J,Eisenberg BL,Schmidt RG,von Roemeling RW,Patchefsky AS,Brown TR,Negendank WG

更新日期：1996-07-01 00:00:00

abstract：:C57BL/6J-Min/+mice (n = 56), heterozygous for a nonsense mutation in the Apc gene, were randomized at weaning to seven groups, including groups treated with piroxicam at 0, 50, 100, and 200 ppm in the AIN93G diet. After only 6 weeks of treatment, intestinal adenomas and aberrant crypt foci were counted, and serum leve...

journal_title：Cancer research

authors： Jacoby RF,Marshall DJ,Newton MA,Novakovic K,Tutsch K,Cole CE,Lubet RA,Kelloff GJ,Verma A,Moser AR,Dove WF

更新日期：1996-02-15 00:00:00

abstract：:Breast cancer stem-like cells (BCSC) have been implicated in tumor growth, metastasis, drug resistance, and relapse but druggable targets in appropriate subsets of this cell population have yet to be identified. Here we identify a fundamental role for the prolyl isomerase Pin1 in driving BCSC expansion, invasiveness, ...

journal_title：Cancer research

authors： Luo ML,Gong C,Chen CH,Lee DY,Hu H,Huang P,Yao Y,Guo W,Reinhardt F,Wulf G,Lieberman J,Zhou XZ,Song E,Lu KP

更新日期：2014-07-01 00:00:00

abstract：:Individuals with the genetic disease xeroderma pigmentosum (XP) have impaired nucleotide excision repair (NER). Group A XP cells are defective in the XPA protein essential for NER and serve, together with other NER proteins, as a nucleation factor for the demarcation of bulky DNA damage. Because XPA cells are extremel...

journal_title：Cancer research

authors： Rosenberg E,Taher MM,Kuemmerle NB,Farnsworth J,Valerie K

更新日期：2001-01-15 00:00:00

abstract：:Loss of expression of the apoptosis protease activator protein-1 (APAF-1) in human melanoma is thought to promote resistance to programmed cell death by preventing caspase-9 activation. However, the role of the APAF-1-dependent pathway in apoptosis activated by cellular stress and/or DNA damage has been recently quest...

journal_title：Cancer research

authors： Zanon M,Piris A,Bersani I,Vegetti C,Molla A,Scarito A,Anichini A

更新日期：2004-10-15 00:00:00

abstract：:Previous studies have shown that all-trans-retinoic acid fails to inhibit chemically induced transformation in 10T1/2 cells except at toxic levels, whereas retinol and many synthetic retinoids are potent inhibitors. In contrast, in many systems retinoic acid is a more effective modulator of differentiation and carcino...

journal_title：Cancer research

authors： Rundhaug J,Gubler ML,Sherman MI,Blaner WS,Bertram JS

更新日期：1987-11-01 00:00:00

abstract：:The development of myeloid and lymphoid neoplasms related to overexpression of FGFR1 kinases as a result of chromosome translocations depends on the promotion of a stem cell phenotype, suppression of terminal differentiation, and resistance to apoptosis. These phenotypes are related to the stem cell leukemia/lymphoma ...

journal_title：Cancer research

authors： Hu T,Chong Y,Lu S,Wang R,Qin H,Silva J,Kitamura E,Chang CS,Hawthorn L,Cowell JK

更新日期：2018-07-01 00:00:00

abstract：:Cobalamin (vitamin B12) binding protein was purified from gastric cancer extracts and from serum-free culture medium of cancer cell line KATOH-III. The molecular weight, determined by immunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis, was 70,000 and the pI was 2.8 to 3.2. From biochemic...

journal_title：Cancer research

authors： Wakatsuki Y,Inada M,Kudo H,Oshio G,Masuda T,Miyake T,Kita T

更新日期：1989-06-01 00:00:00

abstract：:EphA2 receptor tyrosine kinase is frequently overexpressed in different human cancers, suggesting that it may promote tumor development and progression. However, evidence also exists that EphA2 may possess antitumorigenic properties, raising a critical question on the role of EphA2 kinase in tumorigenesis in vivo. We ...

journal_title：Cancer research

authors： Guo H,Miao H,Gerber L,Singh J,Denning MF,Gilliam AC,Wang B

更新日期：2006-07-15 00:00:00

abstract：:The influence of phorbol diesters on the in vitro hydrolysis of diacylglycerols was examined using enzymes from rat serum, porcine pancreas, and Rhizopus delemar. Two main phenomena were observed: 12-O-tetradecanoylphorbol-13-acetate (TPA), when added to the enzyme assay system, stimulated 2- to 3-fold the hydrolysis ...

journal_title：Cancer research

authors： Zhang ZC,Cabot MC

更新日期：1987-01-01 00:00:00

abstract：:The formation of adducts of benzo(a)pyrene metabolites on DNA was investigated in endometrial tissue from humans, hamsters, mice, and rats. anti-Benzo(a)pyrene-7,8-diol-9,10-epoxide was the predominant adduct identified in all the species studied. The amount of (+)-anti-benzo(a)pyrene-7,8-diol-9,10-epoxide bound to DN...

journal_title：Cancer research

authors： Kulkarni MS,Calloway K,Irigaray MF,Kaufman DG

更新日期：1986-06-01 00:00:00

abstract：:The distribution in human tissues has been determined of the new DNA polymerase activity designated DNA polymerase Cm, first isolated from the human melanoma cell line A-375. Tissue samples were fractionated by ion exchange chromatography on diethylaminoethyl cellulose and phosphocellulose and by affinity chromatograp...

journal_title：Cancer research

authors： Loewenstein PM,Lange GW,Gerard GF

更新日期：1980-12-01 00:00:00

abstract：:By the use of a variety of cell culture and separation methods, four cell lines were isolated from a single autochthonous BALB/cfC3H mammary tumor. These lines differ markedly from each other in culture morphology, various in vitro growth properties, expression of murine mammary tumor virus antigen, and karyotype, yet...

journal_title：Cancer research

authors： Dexter DL,Kowalski HM,Blazar BA,Fligiel Z,Vogel R,Heppner GH

更新日期：1978-10-01 00:00:00

abstract：:Human kallikrein 10 (hK10) is a secreted serine protease that is highly expressed in ovarian tissue. We hypothesized that hK10 might represent a novel serological marker for ovarian cancer. We quantified by immunoassay, hK10 in sera from 97 normal women (controls), 141 patients with benign gynecologic diseases, and 14...

journal_title：Cancer research

authors： Luo LY,Katsaros D,Scorilas A,Fracchioli S,Bellino R,van Gramberen M,de Bruijn H,Henrik A,Stenman UH,Massobrio M,van der Zee AG,Vergote I,Diamandis EP

更新日期：2003-02-15 00:00:00

abstract：:Deoxycytidine kinase (DCK) is a key enzyme for the activation of a broad spectrum of nucleoside-based chemotherapy drugs (e.g., gemcitabine); low DCK activity is one of the most important causes of cancer drug-resistance. Noninvasive imaging methods that can quantify DCK activity are invaluable for assessing tumor res...

journal_title：Cancer research

authors： Han Z,Li Y,Zhang J,Liu J,Chen C,van Zijl PC,Liu G

更新日期：2019-05-15 00:00:00

abstract：:We have used photoaffinity labeling to investigate the distribution and function of daunomycin binding sites in Sarcoma 180 cells. When native daunomycin is irradiated at 366 or 488 nm in the presence of cells, the drug is irreversibly incorporated into cellular molecules. The cellular acceptor for the photoincorporat...

journal_title：Cancer research

authors： Yee G,Carey M,Tritton TR

更新日期：1984-05-01 00:00:00

abstract：:Organic anion transporting polypeptide 1B3 (OATP1B3, SLCO1B3) is normally expressed in hepatocytes. In this study, we showed frequent overexpression of OATP1B3 in colorectal adenocarcinomas. Quantitative reverse transcription-PCR analysis of 17 colon tumors indicated tumoral overexpression of OATP1B3 by approximately ...

journal_title：Cancer research

authors： Lee W,Belkhiri A,Lockhart AC,Merchant N,Glaeser H,Harris EI,Washington MK,Brunt EM,Zaika A,Kim RB,El-Rifai W

更新日期：2008-12-15 00:00:00

abstract：:Cloning efficiencies of 67 fresh human tumor specimens, consisting of 29 ovarian, 10 lung, and 7 each of colon, breast, mesenchymal, and miscellaneous tumors, from 58 patients were studied using the technique of Hamburger and Salmon to evaluate the effect of incubation in a 5% rather than 20% oxygen environment. Under...

journal_title：Cancer research

authors： Sridhar KS,Plasse TF,Holland JF,Shapiro M,Ohnuma T

更新日期：1983-10-01 00:00:00

abstract：:The levels of serum thymic factor(s) (STF), of Thy-1.2 positivity of splenocytes [as measured by their azathioprine (AZ) sensitivity], and of Thy-1.2-positive "spontaneous" spleen rosette-forming cells (SSRFCs), as well as the presence of infectious virus in the thymus, were assessed as a function of time after virus ...

journal_title：Cancer research

authors： Tonietti G,Rossi GB,Del Gobbo V,Accinni L,Ranucci A,Titti F,Premrov MG,Garaci E

更新日期：1983-09-01 00:00:00

abstract：:The tumor microenvironment is characterized by regions of fluctuating and chronic hypoxia, low pH, and nutrient deprivation. It has been proposed that this unique tissue environment itself may constitute a major cause of the genetic instability seen in cancer. To investigate possible mechanisms by which the tumor micr...

journal_title：Cancer research

authors： Yuan J,Narayanan L,Rockwell S,Glazer PM

更新日期：2000-08-15 00:00:00

abstract：:Whole-slide histology images contain information that is valuable for clinical and basic science investigations of cancer, but extracting quantitative measurements from these images is challenging for researchers who are not image analysis specialists. In this paper, we describe HistomicsML2, a software tool for learn...

journal_title：Cancer research

authors： Lee S,Amgad M,Mobadersany P,McCormick M,Pollack BP,Elfandy H,Hussein H,Gutman DA,Cooper LA

更新日期：2020-12-21 00:00:00

abstract：:The formation of tumors in adult nude mice from transformed human mammary epithelial cells was drastically inhibited (greater than 80%) both after coinjection of tumoral cells and virus or after a single s.c. injection of parvovirus H-1 at the site of cell implantation prior to tumor formation. Moreover, when injected...

journal_title：Cancer research

authors： Dupressoir T,Vanacker JM,Cornelis JJ,Duponchel N,Rommelaere J

更新日期：1989-06-15 00:00:00