Overexpression of OATP1B3 confers apoptotic resistance in colon cancer.

abstract：:In vivo 31P nuclear magnetic resonance (MR) spectroscopy has shown great promise as a tool for cancer research and the clinical management of solid tumors. It is now possible in some cases to integrate MR spectroscopy with routine MR imaging of the cancer patient, so that tissue identified as tumor on an MR image can ...

journal_title：Cancer research

authors： Steen RG

更新日期：1989-08-01 00:00:00

abstract：:To reach a clinically detectable size, neoplasms must be able to suppress or evade a host immune response. Activated T cells may enter apoptosis in the presence of Fas ligand (FasL) (1), and tissue expression of FasL has been shown to contribute to immune privilege in the eye and testis (2, 3). We have demonstrated th...

journal_title：Cancer research

authors： Niehans GA,Brunner T,Frizelle SP,Liston JC,Salerno CT,Knapp DJ,Green DR,Kratzke RA

更新日期：1997-03-15 00:00:00

abstract：:Aniline of unknown purity has been reported to induce spleen hemangiosarcoma in rats. Aniline has been found to be negative in terms of mutagenicity in both bacteria and yeasts. We have found that both commercial (already rather pure) and repurified aniline are clearly positive to a similar extent in inducing DNA dama...

journal_title：Cancer research

authors： Parodi S,Pala M,Russo P,Zunino A,Balbi C,Albini A,Valerio F,Cimberle MR,Santi L

更新日期：1982-06-01 00:00:00

abstract：:Lymph node biopsies from 43 male homosexuals with persistent generalized lymphadenopathy and from ten acquired immunodeficiency syndrome patients, all with serum antibodies to human T-cell leukemia virus III, were studied with regard to histopathology, immunohistology, and T-cell subsets in cell suspensions. All acqui...

journal_title：Cancer research

authors： Biberfeld P,Porwit-Ksiazek A,Böttiger B,Morfeldt-Månsson L,Biberfeld G

更新日期：1985-09-01 00:00:00

abstract：:The small leucine-rich proteoglycan lumican was identified from a human placenta cDNA library by the expression cloning method as a gene product that interacts with membrane-type matrix metalloproteinase-1 (MT1-MMP). Coexpression of MT1-MMP with lumican in HEK293T cells reduced the concentration of lumican secreted in...

journal_title：Cancer research

authors： Li Y,Aoki T,Mori Y,Ahmad M,Miyamori H,Takino T,Sato H

更新日期：2004-10-01 00:00:00

abstract：:Pluripotent cells within embryonal carcinoma (EC) can differentiate in vivo or in vitro on treatment with specific agents. Differentiating EC cells express lower levels of stem cell-related genes, such as Cripto-1. We show that migration of human EC cells (NTERA/2 and NCCIT) can be reduced following treatment with the...

journal_title：Cancer research

authors： Mancino M,Esposito C,Watanabe K,Nagaoka T,Gonzales M,Bianco C,Normanno N,Salomon DS,Strizzi L

更新日期：2009-03-01 00:00:00

abstract：:We have compared the rate and extent of adhesion of various types of mouse tumor cells to endothelial cells derived from different organ sources. Our panel of tumors has included sarcoma, bladder carcinoma, glioma, teratoma, hepatoma, endothelioma, mammary adenocarcinoma, and lymphoma cells. Endothelial cell monolayer...

journal_title：Cancer research

authors： Auerbach R,Lu WC,Pardon E,Gumkowski F,Kaminska G,Kaminski M

更新日期：1987-03-15 00:00:00

abstract：:Interleukin-2-based regimens of biological therapy have shown some clinical promise for the treatment of kidney cancer in humans, although the mechanisms responsible for tumor regression occurring in these patients remain unclear. Preclinical insight into these mechanisms is limited by a paucity of orthotopic animal m...

journal_title：Cancer research

authors： Gruys ME,Back TC,Subleski J,Wiltrout TA,Lee JK,Schmidt L,Watanabe M,Stanyon R,Ward JM,Wigginton JM,Wiltrout RH

更新日期：2001-08-15 00:00:00

abstract：:Several metabolic processes, such as DNA organization and replication, transcription, and RNA processing are closely associated with the nuclear matrix. Nuclear matrix attachment regions are nucleotide sequences holding DNA tightly complexed with the nuclear scaffold and are resistant to extractions with detergents an...

journal_title：Cancer research

authors： Brylawski BP,Tsongalis GJ,Cordeiro-Stone M,May WT,Comeau LD,Kaufman DG

更新日期：1993-09-01 00:00:00

abstract：:The cadherin family of transmembrane glycoproteins plays a critical role in cell-to-cell adhesion and cadherin dysregulation is strongly associated with cancer metastasis and progression. In this study, we report a novel interaction between protein kinase D1 [PKD1; formerly known as protein kinase C mu (PKCmu)] and E-...

journal_title：Cancer research

authors： Jaggi M,Rao PS,Smith DJ,Wheelock MJ,Johnson KR,Hemstreet GP,Balaji KC

更新日期：2005-01-15 00:00:00

abstract：:Sarcoma growth factor (SGF) induces proliferation and anchorage-independent growth of nonmalignant cells. It competes with epidermal growth factor (EGF) for the EGF-receptors at the cell surface. SGF-like factors have recently been isolated from embryos, suggesting that SGFs may represent embryonic forms of EGF. There...

journal_title：Cancer research

authors： Thesleff I,Ekblom P,Keski-Oja J

更新日期：1983-12-01 00:00:00

abstract：:MSN-1 is a monoclonal antibody, which was raised by immunizing mice with a human endometrial cancer cell line, SNG-II. The MSN-1 specifically recognizes a blood group carbohydrate antigen, Leb. We investigated the subcellular and suborganellar localization of the MSN-1-reactive carbohydrate antigens in the endometrial...

journal_title：Cancer research

authors： Susumu N,Kawakami H,Aoki D,Hirano H,Nozawa S

更新日期：1993-08-01 00:00:00

abstract：:Barrett's esophagus, a columnar metaplasia of the lower esophagus epithelium related to gastroesophageal reflux disease, is the strongest known risk factor for the development of esophageal adenocarcinoma (EAC). Understanding the signal transduction events involved in esophageal epithelium carcinogenesis may provide i...

journal_title：Cancer research

authors： Yen CJ,Izzo JG,Lee DF,Guha S,Wei Y,Wu TT,Chen CT,Kuo HP,Hsu JM,Sun HL,Chou CK,Buttar NS,Wang KK,Huang P,Ajani J,Hung MC

更新日期：2008-04-15 00:00:00

abstract：:Premature ovarian failure and reduced fecundity are well-documented consequences of cytotoxic chemotherapy used to treat patients with malignant diseases. To investigate the ability of different hormonal agents to block the effects of cyclophosphamide (CTX) on reproductive function, sexually mature female Long-Evans r...

journal_title：Cancer research

authors： Montz FJ,Wolff AJ,Gambone JC

更新日期：1991-04-15 00:00:00

abstract：:Reported estimates of ras mutation prevalence in lung adenocarcinoma of 15-24% may be underestimates because of the insensitivity of the assays used. We have devised a rapid, non-radioactive assay for ras mutations, which detects 1 mutant allele/10(3) normal alleles and have used it to study DNA isolated from 53 lung ...

journal_title：Cancer research

authors： Mills NE,Fishman CL,Rom WN,Dubin N,Jacobson DR

更新日期：1995-04-01 00:00:00

abstract：:Three human colon cancer lines (SW 480, SW 620, WIDR) were characterized as to their production of molecules with transforming growth factor (TGF)-like activity. Production of both TGF alpha-like and TGF beta-like activity was quantitated, as were cellular receptors for these molecules, and growth response in soft aga...

journal_title：Cancer research

authors： Coffey RJ Jr,Shipley GD,Moses HL

更新日期：1986-03-01 00:00:00

abstract：:2,6,10,14-Tetramethylpentadecane (pristane), s.c. injected simultaneously with plasmacytoma inocula, enhances the transplantability of tumor cells. The effect is dose and time dependent. The enhancement is shown only by plasmacytoma (MOPC-315 and MPC-11) and not by the murine lymphosarcoma and chondrosarcoma tested. V...

journal_title：Cancer research

authors： Platica M,Bojko C,Steiner G,Hollander VP

更新日期：1980-07-01 00:00:00

abstract：:We previously reported that intetumumab (CNTO 95), a fully human anti-αv integrin monoclonal antibody, is a radiosensitizer in mice with xenograft tumors. Because intetumumab does not cross-react with mouse integrins, but has cross-reactivity with rat integrins, we next studied the potential combined use of radiation ...

journal_title：Cancer research

authors： Ning S,Tian J,Marshall DJ,Knox SJ

更新日期：2010-10-01 00:00:00

abstract：:In this issue of Cancer Research, Xia and colleagues show that MYC-induced metabolic reprograming results in dependency on the serine-glycine-one-carbon (SGOC) metabolic pathway in neuroblastoma. This occurs through MYCN and ATF4 activation of the SGOC biosynthetic pathway in MYCN-amplified cells. Furthermore, inhibit...

journal_title：Cancer research

authors： Garcia AR,Arsenian-Henriksson M

更新日期：2019-08-01 00:00:00

abstract：:Recombinant human stem cell factor (SCF) binds to the c-kit receptor on human bone marrow progenitor cells and enhances their survival following irradiation. Since the c-kit receptor has also been detected on malignant cells, experiments were performed to study the effect of SCF on the proliferation and radiation surv...

journal_title：Cancer research

authors： Shui C,Khan WB,Leigh BR,Turner AM,Wilder RB,Knox SJ

更新日期：1995-08-01 00:00:00

abstract：:Although phosphoramide mustard (PM) is generally recognized as being the most genotoxic metabolite of cyclophosphamide (CP), the contribution of acrolein to the cytogenetic toxicity of CP is unclear. Besides covalently binding to DNA, acrolein can inactivate critical proteins necessary for replicative DNA synthesis, R...

journal_title：Cancer research

authors： Wilmer JL,Erexson GL,Kligerman AD

更新日期：1990-08-01 00:00:00

abstract：:N,N-Dimethylformamide treatment of cell cultures established from a transplantable murine rhabdomyosarcoma-induced morphological differentiation and a marked reduction in the tumorigenicity of the sarcoma cells. Fourteen of 17 CE/J mice receiving injections of inducer-treated cells did not develop tumors after 6 month...

journal_title：Cancer research

authors： Dexter DL

更新日期：1977-09-01 00:00:00

abstract：:XPC protein is a critical DNA damage recognition factor in nucleotide excision repair for which genetic deficiency confers a predisposition to cancer. In this study, we show that XPC has a function that is independent of its canonical function in DNA repair, potentially altering the interpretation of how XPC deficienc...

journal_title：Cancer research

authors： Wang QE,Han C,Zhang B,Sabapathy K,Wani AA

更新日期：2012-02-01 00:00:00

abstract：:The concentration of potassium (K+) and sodium (Na+) was measured in breast cyst fluid (BCF) from 611 cysts greater than 3 ml aspirated in 520 women with gross cystic disease of the breast. These women were enrolled, from 1983 on, in a cohort study aimed at assessing the relationship between cyst type, as defined by t...

journal_title：Cancer research

authors： Naldoni C,Costantini M,Dogliotti L,Bruzzi P,Bucchi L,Buzzi G,Torta M,Angeli A

更新日期：1992-04-01 00:00:00

abstract：:Cancer is associated with a prothrombogenic state capable of platelet activation. Platelets, on the other hand, can support angiogenesis, a process involved in the progression of tumor growth and metastasis. However, it is unclear whether platelet/tumor interactions substantially contribute to tumor physiology. We inv...

journal_title：Cancer research

authors： Ho-Tin-Noé B,Goerge T,Cifuni SM,Duerschmied D,Wagner DD

更新日期：2008-08-15 00:00:00

abstract：:Interleukin 15 (IL-15) is a novel cytokine that shares no homology with IL-2, but it requires the use of beta and gamma chains of the IL-2 receptor complex for binding and signaling. In vitro studies have shown induction of CTL and lymphokine-activated killer (LAK) cell activity in peripheral blood mononuclear cells (...

journal_title：Cancer research

authors： Gamero AM,Ussery D,Reintgen DS,Puleo CA,Djeu JY

更新日期：1995-11-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a heterogeneous clonal disorder with a poor clinical outcome. Previously, we showed that overproduction of reactive oxygen species (ROS), arising from constitutive activation of NOX2 oxidase, occurs in >60% of patients with AML and that ROS production promotes proliferation of AML cells...

journal_title：Cancer research

authors： Robinson AJ,Hopkins GL,Rastogi N,Hodges M,Doyle M,Davies S,Hole PS,Omidvar N,Darley RL,Tonks A

更新日期：2020-03-01 00:00:00

abstract：:This paper describes the laboratory discovery and clinical testing of the first nonsteroidal antiestrogen, MER-25 (ethamoxytriphetol). The compound blocks estrogen action in all species tested and has only slight but transient estrogenic effects. No other antisteroidal actions are noted. MER-25 is antiestrogenic in pr...

journal_title：Cancer research

authors： Lerner LJ,Jordan VC

更新日期：1990-07-15 00:00:00

abstract：:Oncogenic KRAS mutations occur frequently in lung adenocarcinoma. The signaling pathways activated by IL6 promote Kras-driven lung tumorigenesis, but the basis for this cooperation is uncertain. In this study, we used the gp130(F/F) (Il6st) knock-in mouse model to examine the pathogenic contribution of hyperactivation...

journal_title：Cancer research

authors： Brooks GD,McLeod L,Alhayyani S,Miller A,Russell PA,Ferlin W,Rose-John S,Ruwanpura S,Jenkins BJ

更新日期：2016-02-15 00:00:00

abstract：:Cytoplasmic RNA was isolated from control rats or at 48 hr following carcinogen administration. A significant quantity (0.6%) of double-stranded RNA was present in control preparations, as assessed by digestion with RNase III. Following carcinogen treatment of rats, this percentage increased significantly. The results...

journal_title：Cancer research

authors： Clawson GA,Smuckler EA

更新日期：1982-08-01 00:00:00