Abstract：
:Pluripotent cells within embryonal carcinoma (EC) can differentiate in vivo or in vitro on treatment with specific agents. Differentiating EC cells express lower levels of stem cell-related genes, such as Cripto-1. We show that migration of human EC cells (NTERA/2 and NCCIT) can be reduced following treatment with the guidance molecule Netrin-1. Moreover, Netrin-1 treatment increased the levels of beta-III tubulin, glial filament acidic protein, Nestin, and gamma-aminobutyric acid and reduced the expressions of Cripto-1, Nanog, and Oct4 in EC cells. These Netrin-1-induced effects in the EC cells were mediated via binding of Netrin-1 to the Neogenin receptor and activation of SHP-2, resulting in increased levels of inactive phosphorylated c-src((Y527)). These results suggest that Netrin-1 can induce neuroectodermal-like differentiation of human EC cells by affecting c-src signaling via SHP-2 activation and regulation of Nanog, Oct4, and Cripto-1 expressions.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Mancino M,Esposito C,Watanabe K,Nagaoka T,Gonzales M,Bianco C,Normanno N,Salomon DS,Strizzi Ldoi
10.1158/0008-5472.CAN-08-2985subject
Has Abstractpub_date
2009-03-01 00:00:00pages
1717-21issue
5eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-08-2985journal_volume
69pub_type
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