Response of solid tumors to chemotherapy monitored by in vivo 31P nuclear magnetic resonance spectroscopy: a review.

abstract：:Previous studies have suggested a "catalytic role" in neoplastic angiogenesis and cancer progression for bone marrow-derived endothelial progenitor cells (EPC). However, preclinical and clinical studies have shown that the quantitative role of marrow-derived EPCs in cancer vascularization is extremely variable. We hav...

journal_title：Cancer research

authors： Martin-Padura I,Gregato G,Marighetti P,Mancuso P,Calleri A,Corsini C,Pruneri G,Manzotti M,Lohsiriwat V,Rietjens M,Petit JY,Bertolini F

更新日期：2012-01-01 00:00:00

abstract：:Iodide uptake in the thyroid and breast is mediated by the sodium/iodide symporter (NIS). NIS activation is used for radioiodide imaging and therapeutic ablation of thyroid carcinoma. NIS is expressed in >70% of breast cancers but at a level insufficient for radioiodine treatment. All-trans retinoic acid (tRA) induces...

journal_title：Cancer research

authors： Ohashi E,Kogai T,Kagechika H,Brent GA

更新日期：2009-04-15 00:00:00

abstract：:Identification of human melanoma-associated peptide antigens for CTLs has opened unprecedented opportunities for active specific immunotherapy for melanoma with synthetic peptide. We have shown that immunization with a MAGE-1 gene encoded nonapeptide (EADPT-GHSY)-pulsed autologous antigen presenting cell-based vaccine...

journal_title：Cancer research

authors： Hu X,Chakraborty NG,Sporn JR,Kurtzman SH,Ergin MT,Mukherji B

更新日期：1996-06-01 00:00:00

abstract：:Inactivation of p53 by human papillomavirus 16/18 E6 plays a crucial role in cervical tumorigenesis. To investigate the involvement of HPV16/18 in lung tumorigenesis, the association between HPV16 or HPV18 E6 and p53 protein expression in 122 lung tumors was evaluated by immunohistochemistry, and data showed that HPV1...

journal_title：Cancer research

authors： Cheng YW,Wu MF,Wang J,Yeh KT,Goan YG,Chiou HL,Chen CY,Lee H

更新日期：2007-11-15 00:00:00

abstract：:Short-term exposure to diethyl ether strongly inhibits the metabolism of N-nitrosodimethylamine (NDMA). Twenty-six 6-week-old male Fischer 344 rats were exposed to ether vapor until their righting reflex was lost (approximately 2 min). The animals were removed from the ether and NDMA was immediately administered by i....

journal_title：Cancer research

authors： Keefer LK,Garland WA,Oldfield NF,Swagzdis JE,Mico BA

更新日期：1985-11-01 00:00:00

abstract：:Laminin (LN)-5, a heterotrimer of alpha3, beta3, and gamma2 chains, has been suggested to be involved in tumor cell invasion. The present immunohistochemical study investigated the distribution of the LN gamma2 chain in 48 different human gastric adenocarcinomas. The immunohistochemical analysis showed two distinct pa...

journal_title：Cancer research

authors： Koshikawa N,Moriyama K,Takamura H,Mizushima H,Nagashima Y,Yanoma S,Miyazaki K

更新日期：1999-11-01 00:00:00

abstract：:15-Lipoxygenase (15-LOX)-2 is expressed in benign prostate secretory cells and benign prostate produces 15S-hydroxyeicosatetraenoic acid (15S-HETE) from exogenous arachidonic acid (AA). In contrast, 15S-LOX-2 and 15S-HETE formation are reduced in prostate carcinoma (Pca). The mechanisms whereby reduced 15-LOX-2 may co...

journal_title：Cancer research

authors： Shappell SB,Gupta RA,Manning S,Whitehead R,Boeglin WE,Schneider C,Case T,Price J,Jack GS,Wheeler TM,Matusik RJ,Brash AR,Dubois RN

更新日期：2001-01-15 00:00:00

abstract：:Although the zinc finger transcription factor Krüppel-like factor 4 (KLF4) has been shown to be a negative regulator of cell proliferation, the mechanisms underlying the posttranslational modification of KLF4, especially at the level of protein degradation, are poorly understood. Here, we show that KLF4 protein levels...

journal_title：Cancer research

authors： Chen ZY,Wang X,Zhou Y,Offner G,Tseng CC

更新日期：2005-11-15 00:00:00

abstract：:A role for the immune system in controlling the progression of solid tumors has been established in several mouse models. However, the effect of immune responses and tumor escape on patient prognosis in the context of human cancer is poorly understood. Here, we investigate the cellular and molecular parameters that co...

journal_title：Cancer research

authors： Camus M,Tosolini M,Mlecnik B,Pagès F,Kirilovsky A,Berger A,Costes A,Bindea G,Charoentong P,Bruneval P,Trajanoski Z,Fridman WH,Galon J

更新日期：2009-03-15 00:00:00

abstract：:Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor protein that plays a critical role in FGFR signaling. FRS2 is located on chromosome 12q13-15 that is frequently amplified in liposarcomas. The significance of FRS2 and FGFR signaling in high-grade liposarcomas is unknown. Herein, we first ...

journal_title：Cancer research

authors： Zhang K,Chu K,Wu X,Gao H,Wang J,Yuan YC,Loera S,Ho K,Wang Y,Chow W,Un F,Chu P,Yen Y

更新日期：2013-02-15 00:00:00

abstract：:It was previously reported that the properties of alcohol dehydrogenase of a rat hepatocellular carcinoma (Becker H-252), a tumor of intermediate growth rate, were different from those of the liver enzyme, suggesting different isozymes. To determine whether the degree of differentiation affected the isozyme of alcohol...

journal_title：Cancer research

authors： Cederbaum AI,Rubin E

更新日期：1976-07-01 00:00:00

abstract：:Although monoallelic expression (MAE) is a frequent genomic event in normal tissues, its role in tumorigenesis remains unclear. Here we carried out single-nucleotide polymorphism arrays on DNA and RNA from a large cohort of pediatric and adult brain tumor tissues to determine the genome-wide rate of MAE, its role in s...

journal_title：Cancer research

authors： Walker EJ,Zhang C,Castelo-Branco P,Hawkins C,Wilson W,Zhukova N,Alon N,Novokmet A,Baskin B,Ray P,Knobbe C,Dirks P,Taylor MD,Croul S,Malkin D,Tabori U

更新日期：2012-02-01 00:00:00

abstract：:Resistance to anticancer therapeutics greatly affects the phenotypic and functional properties of tumor cells, but how chemoresistance contributes to the tumorigenic activities of cancer stem-like cells remains unclear. In this study, we found that a characteristic of cancer stem-like cells from chemoresistant tumors ...

journal_title：Cancer research

authors： Yamashina T,Baghdadi M,Yoneda A,Kinoshita I,Suzu S,Dosaka-Akita H,Jinushi M

更新日期：2014-05-15 00:00:00

abstract：:Topotecan (SK&F 104864, hycamptamine, NSC 609699) is believed to exert its cytotoxic effects through inhibition of topoisomerase I, the activity of which recovers rapidly on removal of the drug in vitro. In vivo studies show that the activity of topotecan is schedule dependent, favoring repeated doses. Early human stu...

journal_title：Cancer research

authors： Haas NB,LaCreta FP,Walczak J,Hudes GR,Brennan JM,Ozols RF,O'Dwyer PJ

更新日期：1994-03-01 00:00:00

abstract：:Notch signaling is an area of great interest in oncology. RO4929097 is a potent and selective inhibitor of gamma-secretase, producing inhibitory activity of Notch signaling in tumor cells. The RO4929097 IC50 in cell-free and cellular assays is in the low nanomolar range with >100-fold selectivity with respect to 75 ot...

journal_title：Cancer research

authors： Luistro L,He W,Smith M,Packman K,Vilenchik M,Carvajal D,Roberts J,Cai J,Berkofsky-Fessler W,Hilton H,Linn M,Flohr A,Jakob-Røtne R,Jacobsen H,Glenn K,Heimbrook D,Boylan JF

更新日期：2009-10-01 00:00:00

abstract：:The treatment of HeLa and HL-60 cells with various concentrations of pentakis(arizidino)thiatriazadiphosphorine oxide results in inhibition of growth and modification of cell cycle distribution. These phenomena were observed at 10(-4) M and 5 X 10(-5) M for HeLa cells and 10(-5) M and 5 X 10(-6) M for HL-60 cells. The...

journal_title：Cancer research

authors： Hecquet C,Nafziger J,Ronot X,Marie JP,Adolphe M

更新日期：1985-02-01 00:00:00

abstract：:Translocation of the bcl-2 gene to the immunoglobulin heavy chain gene is the most common alteration in follicular lymphoma. The result is the deregulated expression of bcl-2 and increased resistance to cell death. Regulation of the immunoglobulin heavy chain gene is controlled in part by four DNase I-hypersensitive r...

journal_title：Cancer research

authors： Heckman CA,Cao T,Somsouk L,Duan H,Mehew JW,Zhang CY,Boxer LM

更新日期：2003-10-15 00:00:00

abstract：:About 30% of all colorectal cancers are thought to have a genetic basis and the known predisposing genes can only account for a small fraction of cases. A previous report suggested that a colorectal cancer candidate gene, explaining at least 20% of colorectal cancer cases with family history, was located within a 25 c...

journal_title：Cancer research

authors： Kemp ZE,Carvajal-Carmona LG,Barclay E,Gorman M,Martin L,Wood W,Rowan A,Donohue C,Spain S,Jaeger E,Evans DG,Maher ER,Bishop T,Thomas H,Houlston R,Tomlinson I,Colorectal Tumour Gene Identification Study Consortium.

更新日期：2006-05-15 00:00:00

abstract：:The FLT3 gene is mutated by an internal tandem duplication (ITD) in 20-25% of adults with acute myeloid leukemia (AML). We studied 82 adults <60 years of age with primary AML and normal cytogenetics, who received uniform high-dose therapy and found FLT3 ITD in 23 (28%) patients. When the 23 FLT3 ITD+ cases were compar...

journal_title：Cancer research

authors： Whitman SP,Archer KJ,Feng L,Baldus C,Becknell B,Carlson BD,Carroll AJ,Mrózek K,Vardiman JW,George SL,Kolitz JE,Larson RA,Bloomfield CD,Caligiuri MA

更新日期：2001-10-01 00:00:00

abstract：:Cytochromes P-450IIB1 and P-450IIB2 were recently shown to be inducible in rat hepatocyte cultures maintained on a reconstituted extracellular tumor matrix (Matrigel) as indicated by increases in P-450IIB1 and -IIB2 mRNAs and immunoreactive proteins (J. Cell. Physiol., 134: 309-323, 1988). Here we show that treatment ...

journal_title：Cancer research

authors： Sinclair PR,Bement WJ,Haugen SA,Sinclair JF,Guzelian PS

更新日期：1990-09-01 00:00:00

abstract：:Loss of expression of the E-cadherin cell-cell adhesion molecule is important in carcinoma development and progression. Because previous data suggest that loss of E-cadherin expression in breast carcinoma may result from a dominant transcriptional repression pathway acting on the E-cadherin proximal promoter, we pursu...

journal_title：Cancer research

authors： Hajra KM,Chen DY,Fearon ER

更新日期：2002-03-15 00:00:00

abstract：:Proteasome inhibitors sensitize tumor cells to DNA-damaging agents, including ionizing radiation (IR), and DNA cross-linking agents (melphalan and cisplatin) through unknown mechanisms. The Fanconi anemia pathway is a DNA damage-activated signaling pathway, which regulates cellular resistance to DNA cross-linking agen...

journal_title：Cancer research

authors： Jacquemont C,Taniguchi T

更新日期：2007-08-01 00:00:00

abstract：:The retinoic acid receptor type beta (RAR beta) complementary DNA from a small cell tumor line was amplified, sequenced, and found to be homologous to the murine RAR beta 1. Seventeen lung tumor lines were analyzed. Five of seven small cell lung carcinoma lines expressed RAR beta 1, but only one other line (epidermoid...

journal_title：Cancer research

authors： Houle B,Pelletier M,Wu J,Goodyer C,Bradley WE

更新日期：1994-01-15 00:00:00

abstract：:Pathways relevant to cancer are well known to overlap with fetal development, as reflected in reactivation of embryonic genes in tumors. However, molecular evidence for this notion has gathered in piecemeal fashion, and systematic approaches have rarely been applied to gauge the extent and global characteristics of th...

journal_title：Cancer research

authors： Hu M,Shivdasani RA

更新日期：2005-10-01 00:00:00

abstract：:We investigated the potential role of mitochondrial manganese superoxide dismutase (Mn-SOD) in protective activity against irradiation by analyzing cell viability by a colony formation assay and by detecting apoptosis in stably human Mn-SOD gene-transfected HLE, a hepatocellular carcinoma cell line. We found that over...

journal_title：Cancer research

authors： Motoori S,Majima HJ,Ebara M,Kato H,Hirai F,Kakinuma S,Yamaguchi C,Ozawa T,Nagano T,Tsujii H,Saisho H

更新日期：2001-07-15 00:00:00

abstract：:Microcephalin (MCPH1) is a BRCA1 COOH terminal (BRCT) domain containing protein involved in the cellular response to DNA damage that has been implicated in autosomal recessive primary microcephaly. MCPH1 is recruited to sites of DNA double-strand breaks by phosphorylated histone H2AX (gammaH2AX), but the mechanism by ...

journal_title：Cancer research

authors： Wu X,Mondal G,Wang X,Wu J,Yang L,Pankratz VS,Rowley M,Couch FJ

更新日期：2009-07-01 00:00:00

abstract：:Anthracycline, either daunomycin or doxorubicin, was site specifically attached to the carbohydrate moiety of a monoclonal anticarcinoembryonic antigen antibody by using amino-dextran as the intermediate carrier. The reaction resulted in an immunoconjugate that contains approximately 20 to 25 molecules of drug per mol...

journal_title：Cancer research

authors： Shih LB,Goldenberg DM,Xuan H,Lu H,Sharkey RM,Hall TC

更新日期：1991-08-15 00:00:00

abstract：:Pancreatic adenocarcinomas are among the most malignant forms of cancer and, therefore, it is of especial interest to set new strategies aimed at improving the prognostic of this deadly disease. The present study was undertaken to investigate the action of cannabinoids, a new family of potential antitumoral agents, in...

journal_title：Cancer research

authors： Carracedo A,Gironella M,Lorente M,Garcia S,Guzmán M,Velasco G,Iovanna JL

更新日期：2006-07-01 00:00:00

abstract：:Prostate cancer is the most common cancer in men. Advanced prostate cancer spreading beyond the gland is incurable. Identifying factors that regulate the spread of tumor into the regional nodes and distant sites would guide the development of novel diagnostic, prognostic, and therapeutic targets. The aim of our study ...

journal_title：Cancer research

authors： Xia G,Kumar SR,Masood R,Zhu S,Reddy R,Krasnoperov V,Quinn DI,Henshall SM,Sutherland RL,Pinski JK,Daneshmand S,Buscarini M,Stein JP,Zhong C,Broek D,Roy-Burman P,Gill PS

更新日期：2005-06-01 00:00:00

abstract：:A detailed analysis of the gamma-glutamylation of methotrexate has been conducted in primary cultures of rat hepatic parenchymal cells in monolayer culture. The rates of glutamylation are concentration dependent and saturable when measured over a 6-h period at concentrations between 2 and 50 microM. The removal of fol...

journal_title：Cancer research

authors： Galivan J,Pupons A,Rhee MS

更新日期：1986-02-01 00:00:00