Abstract:
:The treatment of HeLa and HL-60 cells with various concentrations of pentakis(arizidino)thiatriazadiphosphorine oxide results in inhibition of growth and modification of cell cycle distribution. These phenomena were observed at 10(-4) M and 5 X 10(-5) M for HeLa cells and 10(-5) M and 5 X 10(-6) M for HL-60 cells. The estimation of DNA content by flow cytometry showed an important shift in the distribution of cycling cells with a striking arrest in G2 for both cell lines with a concomitant late S-phase accumulation for HeLa cells. Incubation of cells in drug-free medium 3 days after treatment did not show any change in DNA distribution, suggesting the irreversibility of drug action.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Hecquet C,Nafziger J,Ronot X,Marie JP,Adolphe Msubject
Has Abstractpub_date
1985-02-01 00:00:00pages
552-4issue
2eissn
0008-5472issn
1538-7445journal_volume
45pub_type
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