Cyclic adenosine 3':5'-monophosphate phosphodiesterase activity in normal and chronic lymphocytic leukemia lymphocytes.

Abstract:

:The specific activity of cyclic adenosine 3':5'-monophosphate phosphodiesterase was measured in lymphocytes isolated from the blood of normal subjects, from patients with chronic lymphocytic leukemia, and from tonsil tissue. The mean specific activity of cyclic adenosine 3':5'-monophosphate phosphodiesterase in the lymphocytes from patients with untreated chronic lymphocytic leukemia was lower than that in lymphocytes from the blood of normal subjects or from tonsils. Cyclic adenosine 3':5'-monophosphate phosphodiesterase levels did not correlate with differences in B- and T-cell lymphocyte subpopulations or with peripheral blood lymphocyte counts.

journal_name

Cancer Res

journal_title

Cancer research

authors

Scher NS,Quagliata F,Malathi VG,Faig D,Melton RA,Silber R

subject

Has Abstract

pub_date

1976-11-01 00:00:00

pages

3958-62

issue

11 Pt 1

eissn

0008-5472

issn

1538-7445

journal_volume

36

pub_type

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