Abstract：
:A rat lung cell population had been treated with benzo(a)pyrene, and a set of different epithelial cell lines was derived from it. These cell lines carried either a wild-type or mutant p53 gene and represented grading states of neoplastic development. We demonstrate here that the cells lacking both wild-type p53 alleles display a significant decrease in survival after gamma-irradiation with doses of 2 to 12 Gy, compared with their counterparts carrying wild-type p53 alleles. This is the first reported model in which cells bearing a mutation of the p53 gene display enhanced sensitivity to ionizing radiation.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Biard DS,Martin M,Rhun YL,Duthu A,Lefaix JL,May E,May Psubject
Has Abstractpub_date
1994-07-01 00:00:00pages
3361-4issue
13eissn
0008-5472issn
1538-7445journal_volume
54pub_type
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