Comparative genomic hybridization analysis of breast tumors with predetermined profiles of DNA amplification.

abstract：:We evaluated the differences in prevalence and functional activity of human estrogen receptor alpha (hER) variant mRNA between 21 normal breast tissues and 41 primary breast carcinomas using a functional assay in yeast for the hER First, we found that the presence of wild-type hER, relative to the total amount of hER,...

journal_title：Cancer research

authors： van Dijk MA,Hart AA,van 't Veer LJ

更新日期：2000-02-01 00:00:00

abstract：:Elongation factor-2 kinase (eEF-2 kinase), also known as Ca(2+)/calmodulin-dependent kinase III, regulates protein synthesis by controlling the rate of peptide chain elongation. The activity of eEF-2 kinase is increased in glioblastoma and other malignancies, yet its role in neoplasia is uncertain. Recent evidence sug...

journal_title：Cancer research

authors： Wu H,Yang JM,Jin S,Zhang H,Hait WN

更新日期：2006-03-15 00:00:00

abstract：:The objective of the present investigation was to evaluate the immunomodulating properties of tetramethylenebisacetamide (N,N' 1-diacetylputrescine, DAP), a known inducer of cellular differentiation. We examined the effect of DAP administration in vivo on splenic and nonadherent peritoneal natural killer (NK) cell act...

journal_title：Cancer research

authors： Bowlin TL,Rosenberger A,Stemerick D,Edwards ML

更新日期：1990-09-01 00:00:00

abstract：:New sublines of Chinese hamster CHL cells stably expressing human NAT1 or NAT2 N-acetyltransferases or O-acetyltransferase of Salmonella typhimurium were established, and their sensitivities to carcinogenic nitroarenes and aromatic amines were compared using the in vitro micronucleus test. The subline expressing human...

journal_title：Cancer research

authors： Watanabe M,Matsuoka A,Yamazaki N,Hayashi M,Deguchi T,Nohmi T,Sofuni T

更新日期：1994-04-01 00:00:00

abstract：:KANSL2 is an integral subunit of the nonspecific lethal (NSL) chromatin-modifying complex that contributes to epigenetic programs in embryonic stem cells. In this study, we report a role for KANSL2 in regulation of stemness in glioblastoma (GBM), which is characterized by heterogeneous tumor stem-like cells associated...

journal_title：Cancer research

authors： Ferreyra Solari NE,Belforte FS,Canedo L,Videla-Richardson GA,Espinosa JM,Rossi M,Serna E,Riudavets MA,Martinetto H,Sevlever G,Perez-Castro C

更新日期：2016-09-15 00:00:00

abstract：:Using Mth1 and Ogg1 knockout mice, we evaluated the roles of these enzymes to prevent tumorigenesis and the accumulation of 8-oxoguanine (8-oxoG) in DNA. We found that lung adenoma/carcinoma spontaneously developed in Ogg1 knockout mice approximately 1.5 years after birth in which 8-oxoG was found to accumulate in the...

journal_title：Cancer research

authors： Sakumi K,Tominaga Y,Furuichi M,Xu P,Tsuzuki T,Sekiguchi M,Nakabeppu Y

更新日期：2003-03-01 00:00:00

abstract：:The complement cascade is a part of the innate immune system that acts primarily to remove pathogens and injured cells. However, complement activation is also peculiarly associated with tumor progression. Here we report mechanistic insights into this association in multiple immunocompetent orthotopic models of lung ca...

journal_title：Cancer research

authors： Kwak JW,Laskowski J,Li HY,McSharry MV,Sippel TR,Bullock BL,Johnson AM,Poczobutt JM,Neuwelt AJ,Malkoski SP,Weiser-Evans MC,Lambris JD,Clambey ET,Thurman JM,Nemenoff RA

更新日期：2018-01-01 00:00:00

abstract：:When newly hatched chicks are given injections of Rous sarcoma virus, a tumor develops at the site of injection. In spite of the presence of the virus in the blood, no other tumors are found distant from the site of inoculation during the life span of the animal (4-6 weeks). However, if a wound is made away from the p...

journal_title：Cancer research

authors： Martins-Green M,Boudreau N,Bissell MJ

更新日期：1994-08-15 00:00:00

abstract：:A role for proteolysis during chemical induction of endogenous xenotropic Type C virus from Kirsten sarcoma virus-transformed mouse cells was examined. Two distinct classes of protease inhibitors, the trypsin inhibitor, alpha-N-tosyl-L-lysine chloromethyl ketone, and two naturally occurring oligopeptide inhibitors, an...

journal_title：Cancer research

authors： Long CW,Bruszewski JA,Christensen WL,Suk WA

更新日期：1979-08-01 00:00:00

abstract：:The recent identification of cancer stem cells (CSCs) in multiple human cancers provides a new inroad to understanding tumorigenesis at the cellular level. CSCs are defined by their characteristics of self-renewal, multipotentiality, and tumor initiation upon transplantation. By testing for these defining characterist...

journal_title：Cancer research

authors： Harris MA,Yang H,Low BE,Mukherjee J,Guha A,Bronson RT,Shultz LD,Israel MA,Yun K

更新日期：2008-12-15 00:00:00

abstract：:The relevance of cysteine metabolism in cancer has gained considerable interest in recent years, largely focusing on its role in generating the antioxidant glutathione. Through metabolomic profiling using a combination of high-throughput liquid and gas chromatography-based mass spectrometry on a total of 69 patient-de...

journal_title：Cancer research

authors： Prabhu A,Sarcar B,Kahali S,Yuan Z,Johnson JJ,Adam KP,Kensicki E,Chinnaiyan P

更新日期：2014-02-01 00:00:00

abstract：:The nucleotide sequence complexity of murine leukemia virus *MuLV)-related RNA has been measured by RNA-complementary DNA hybridization analysis in nuclear and cytoplasmic RNA isolated from liver and brain of low-leukemia-strain C57BL/6J mice of different ages. In these two tissues, an approximate 1.5- to 2-fold incre...

journal_title：Cancer research

authors： Florine DL,Ono T,Cutler RG,Getz MJ

更新日期：1980-03-01 00:00:00

abstract：:Our goal is to develop peptide vaccines that stimulate tumor antigen-specific T-cell responses against frequently found cancers. Previous work has shown that to generate effective T-cell responses, peptides have to be administered in combination with strong adjuvants such as Toll-like receptor agonists. However, most ...

journal_title：Cancer research

authors： Nava-Parada P,Forni G,Knutson KL,Pease LR,Celis E

更新日期：2007-02-01 00:00:00

abstract：:A transplanted rat lymphosarcoma (SGT-4), induced by Gross virus and inoculated s.c. into the foot of a normal syngeneic rat, initially grew but ultimately regressed. The tumor cells metastasized to the regional popliteal, lumbar, and inguinal lymph nodes and formed massive metastatic foci there. These lymph node meta...

journal_title：Cancer research

authors： Kodama T,Gotohda E,Takeichi N,Kuzumaki N,Kobayashi H

更新日期：1975-07-01 00:00:00

abstract：:It has been postulated that the intestinal anaerobes play a role in the etiology of large bowel cancer. This study was designed to characterize and compare the fecal anaerobes of patients with large bowel cancer, patients with nonhereditary large bowel polyps, and healthy control subjects. Although some distributional...

journal_title：Cancer research

authors： Mastromarino AJ,Reddy BS,Wynder EL

更新日期：1978-12-01 00:00:00

abstract：:EphB4 receptor and its ligand ephrinB2 play an important role in vascular development during embryogenesis. In blood vessels, ephrinB2 is expressed in arterial endothelial cells (EC) and mesenchymal supporting cells, whereas EphB4 is only expressed in venous ECs. Previously, we reported that OP9 stromal cells, which s...

journal_title：Cancer research

authors： Huang X,Yamada Y,Kidoya H,Naito H,Nagahama Y,Kong L,Katoh SY,Li WL,Ueno M,Takakura N

更新日期：2007-10-15 00:00:00

abstract：:N-Demethylated metabolites of the antineoplastic agent hexamethylmelamine were synthesized, and their toxicities and antitumor activities were determined in vivo. Determinations of the lethal dose for 10% of the male C57BL X DBA/2 F1 (hereafter called BD2F1) mice showed hexamethylmelamine toxicity to be decreased by N...

journal_title：Cancer research

authors： Lake LM,Grunden EE,Johnson BM

更新日期：1975-10-01 00:00:00

abstract：:There is increasing evidence that high doses of radiotherapy, like those delivered in stereotactic body radiotherapy (SBRT), trigger indirect mechanisms of cell death. Such effect seems to be two-fold. High doses may trigger an immune response and may cause vascular damage, leading to cell starvation and death. Develo...

journal_title：Cancer research

authors： Rodríguez-Barbeito P,Díaz-Botana P,Gago-Arias A,Feijoo M,Neira S,Guiu-Souto J,López-Pouso Ó,Gómez-Caamaño A,Pardo-Montero J

更新日期：2019-12-01 00:00:00

abstract：:Sera from 91 adult acute nonlymphocytic leukemia patients were tested for circulating immune complexes by the C1q binding test. In 42 patients tested prior to the initiation of therapy, C1q binding activity was inversely correlated with leukemic infiltrate of the bone marrow (rs = -0.34, p less than 0.02), but it was ...

journal_title：Cancer research

authors： Crane MM,Rossen RD,McCredie KB,Trujillo JM

更新日期：1984-07-01 00:00:00

abstract：:Angiogenesis inhibitor TNP-470, 6-O-(N-chloroacetyl-carbamoyl)-fumagillol, semisynthetic analogue of fumagillin, has strong inhibitory activities against in vivo tumor growth and metastasis in a wide variety of tumors. However, it is still unknown whether this agent inhibits bone metastasis. We examined the effects of...

journal_title：Cancer research

authors： Sasaki A,Alcalde RE,Nishiyama A,Lim DD,Mese H,Akedo H,Matsumura T

更新日期：1998-02-01 00:00:00

abstract：:We have examined three methods that may be useful for improving the therapeutic efficacy of antibody-targeted radionuclides. The principal limitation of radioimmunotherapy is myelotoxicity and thrombocytopenia. These are due mainly to the length of time the radioantibody remains in the blood. The clearance time of a r...

journal_title：Cancer research

authors： Sharkey RM,Blumenthal RD,Hansen HJ,Goldenberg DM

更新日期：1990-02-01 00:00:00

abstract：:Colorectal cancer cells with stem-like properties, referred to as colon cancer-initiating cells (CCIC), have high tumorigenic potential. While CCIC can differentiate to promote cellular heterogeneity, it remains unclear whether CCIC within a tumor contain distinct subpopulations. Here, we describe the co-existence of ...

journal_title：Cancer research

authors： Srinivasan T,Walters J,Bu P,Than EB,Tung KL,Chen KY,Panarelli N,Milsom J,Augenlicht L,Lipkin SM,Shen X

更新日期：2016-06-01 00:00:00

abstract：:The relationship between tumorigenicity and enhanced chromosomal radiosensitivity during the G2 cell cycle phase was examined through the use of nontumorigenic human cell hybrids and their nontumorigenic and tumorigenic segregants. The hybrid cells were produced by fusion of a normal and tumor cell. The parental lines...

journal_title：Cancer research

authors： Sanford KK,Parshad R,Stanbridge EJ,Frost JK,Jones GM,Wilkinson JE,Tarone RE

更新日期：1986-04-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) is etiologically linked to the endothelial tumor Kaposi's sarcoma and with two lymphoproliferatve disorders, primary effusion lymphoma and multicentric Castleman's disease. HHV-8 infects a variety of target cells both in vivo and in vitro, binds to the in vitro targ...

journal_title：Cancer research

authors： Naranatt PP,Krishnan HH,Svojanovsky SR,Bloomer C,Mathur S,Chandran B

更新日期：2004-01-01 00:00:00

abstract：:Little is known about the molecular mechanisms responsible for the development of intracranial germ cell tumors (ICGTs). Recently, we demonstrated that the balance of the p53-mdm2 interactions is disrupted in ICGTs. The p14ARF product, a tumor suppresser gene located on the INK4a/ARF locus, acts as one of the major fa...

journal_title：Cancer research

authors： Iwato M,Tachibana O,Tohma Y,Arakawa Y,Nitta H,Hasegawa M,Yamashita J,Hayashi Y

更新日期：2000-04-15 00:00:00

abstract：:Ionizing radiation is a major tool for cancer treatment. The response of eukaryotic cells to ionizing radiation includes apoptosis, a process which requires activation of multiple genes. We sought to determine whether radiation-induced gene expression plays a role in radiation-induced apoptosis. We found Apo2 ligand (...

journal_title：Cancer research

authors： Gong B,Almasan A

更新日期：2000-10-15 00:00:00

abstract：:Combining microtubule-targeting antimitotic drugs with targeted apoptosis potentiators is a promising new chemotherapeutic strategy to treat cancer. In this study, we investigate the cellular mechanism by which navitoclax (previously called ABT-263), a Bcl-2 family inhibitor, potentiates apoptosis triggered by paclita...

journal_title：Cancer research

authors： Shi J,Zhou Y,Huang HC,Mitchison TJ

更新日期：2011-07-01 00:00:00

abstract：:Translocations fusing the strong androgen-responsive gene, TMPRSS2, with ERG or other oncogenic ETS factors may facilitate prostate cancer development. Here, we studied 18 advanced prostate cancers for ETS factor alterations, using reverse transcription-PCR and DNA and RNA array technologies, and identified putative E...

journal_title：Cancer research

authors： Iljin K,Wolf M,Edgren H,Gupta S,Kilpinen S,Skotheim RI,Peltola M,Smit F,Verhaegh G,Schalken J,Nees M,Kallioniemi O

更新日期：2006-11-01 00:00:00

abstract：:The effect of culture conditions on the glutamylation of methotrexate by intact H35 hepatoma cells and folylpolyglutamate synthetase (FPGS) activity in the corresponding crude extracts has been examined. The rate of cellular glutamylation of methotrexate observed in rapidly dividing cultures was 4-fold higher than con...

journal_title：Cancer research

authors： Johnson TB,Nair MG,Galivan J

更新日期：1988-05-01 00:00:00

abstract：:For many solid tumors, surgical resection remains the gold standard and tumor-involved margins are associated with poor clinical outcomes. Near-infrared (NIR) fluorescence imaging using molecular agents has shown promise for in situ imaging during resection. However, for cancers with difficult imaging conditions, surg...

journal_title：Cancer research

authors： Gao RW,Teraphongphom NT,van den Berg NS,Martin BA,Oberhelman NJ,Divi V,Kaplan MJ,Hong SS,Lu G,Ertsey R,Tummers WSFJ,Gomez AJ,Holsinger FC,Kong CS,Colevas AD,Warram JM,Rosenthal EL

更新日期：2018-09-01 00:00:00