Abstract:
:Using Mth1 and Ogg1 knockout mice, we evaluated the roles of these enzymes to prevent tumorigenesis and the accumulation of 8-oxoguanine (8-oxoG) in DNA. We found that lung adenoma/carcinoma spontaneously developed in Ogg1 knockout mice approximately 1.5 years after birth in which 8-oxoG was found to accumulate in their genomes. The mean number of tumors/mouse was 0.71 for the Ogg1 knockout mice, which was five times higher than that observed in wild-type mice (0.14). Although the accumulation of 8-oxoG was also confirmed in the Ogg1, Mth1 double knockout mice, we found no tumor in the lungs of these mice. This observation suggests that Mth1 gene disruption resulted in a suppression of the tumorigenesis caused by an Ogg1 deficiency.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Sakumi K,Tominaga Y,Furuichi M,Xu P,Tsuzuki T,Sekiguchi M,Nakabeppu Ysubject
Has Abstractpub_date
2003-03-01 00:00:00pages
902-5issue
5eissn
0008-5472issn
1538-7445journal_volume
63pub_type
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