Abstract:
:A translationally regulated, dominant-negative isoform of CCAAT/enhancer-binding protein beta is expressed in transplantable and primary mouse mammary tumors of different etiologies but is not expressed in preneoplastic mammary hyperplasias or in primary prostate, lung, lens, ovary or lymphoid tumors. The eukaryotic initiation factor 2alpha protein is also expressed at significantly higher levels (69.8 +/- 7.2%) in these mammary tumors compared with normal and hyperplastic tissues. Thus, misregulation of eukaryotic initiation factor 2alpha may promote the expression of a dominant-negative CCAAT/enhancer-binding protein beta isoform, which may inhibit terminal differentiation and facilitate uncontrolled proliferation of mammary epithelial cells.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Raught B,Gingras AC,James A,Medina D,Sonenberg N,Rosen JMsubject
Has Abstractpub_date
1996-10-01 00:00:00pages
4382-6issue
19eissn
0008-5472issn
1538-7445journal_volume
56pub_type
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