Abstract：
:Epigenetic alterations of the genome such as DNA promoter methylation and chromatin remodeling play an important role in tumorigenesis. These modifications take place throughout development with subsequent events occurring later in adulthood. Recent studies, however, suggest that some epigenetic alterations that influence cancer risk are inherited through the germline from parent to child and are observed in multiple generations. Epigenetic changes may be inherited as Mendelian, non-Mendelian, or environmentally induced traits. Here, we will discuss Mendelian, non-Mendelian, and environmentally induced patterns of multigenerational epigenetic alterations as well as some possible mechanisms for how these events may be occurring.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Fleming JL,Huang TH,Toland AEdoi
10.1158/0008-5472.CAN-08-2184subject
Has Abstractpub_date
2008-11-15 00:00:00pages
9116-21issue
22eissn
0008-5472issn
1538-7445pii
68/22/9116journal_volume
68pub_type
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