Differences in the removal of N-methyl-N-nitrosourea-methylated products in DNase I-sensitive and -resistant regions of rat brain DNA.

abstract：:Signal transducers and activators of transcription 3 (Stat3) is activated by cytokines and growth factors in lung cancers and regulates expression of genes implicated in cell growth, survival, and transformation. Previously, we found that mice with a deletion of the G protein-coupled receptor, family C, group 5, membe...

journal_title：Cancer research

authors： Chen Y,Deng J,Fujimoto J,Kadara H,Men T,Lotan D,Lotan R

更新日期：2010-11-01 00:00:00

abstract：:Activation of c-src, a cellular human gene homologous in sequence to the v-src gene of Rous sarcoma virus, had been thought to play an important role in the progression of several types of human cancers, without having undergone any genetic changes. However, recently truncating mutations at codon 531 of the c-src gene...

journal_title：Cancer research

authors： Daigo Y,Furukawa Y,Kawasoe T,Ishiguro H,Fujita M,Sugai S,Nakamori S,Liefers GJ,Tollenaar RA,van de Velde CJ,Nakamura Y

更新日期：1999-09-01 00:00:00

abstract：:Prostate-specific membrane antigen (PSMA) is expressed in normal human prostate epithelium and is highly up-regulated in prostate cancer. We previously reported a series of novel small molecule inhibitors targeting PSMA. Two compounds, MIP-1072, (S)-2-(3-((S)-1-carboxy-5-(4-iodobenzylamino)pentyl)ureido)pentanedioic a...

journal_title：Cancer research

authors： Hillier SM,Maresca KP,Femia FJ,Marquis JC,Foss CA,Nguyen N,Zimmerman CN,Barrett JA,Eckelman WC,Pomper MG,Joyal JL,Babich JW

更新日期：2009-09-01 00:00:00

abstract：:Protein kinase Ciota (PKCiota) is an oncogene required for maintenance of the transformed phenotype of non-small cell lung cancer cells. However, the role of PKCiota in lung tumor development has not been investigated. To address this question, we established a mouse model in which oncogenic Kras(G12D) is activated by...

journal_title：Cancer research

authors： Regala RP,Davis RK,Kunz A,Khoor A,Leitges M,Fields AP

更新日期：2009-10-01 00:00:00

abstract：:The purpose of these studies was to select in vitro tumor cells that were resistant to macrophage-mediated lysis. Seven different heterogeneous murine neoplasms (four fibrosarcomas, a melanoma, a rhabdomyosarcoma, and an osteogenic sarcoma) and one cloned line of a fibrosarcoma were incubated in vitro with syngeneic t...

journal_title：Cancer research

authors： Fogler WE,Fidler IJ

更新日期：1985-01-01 00:00:00

abstract：:The Raf/mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK signaling cascade enhances tumor cell proliferation in many cases. Here, we show that adenovirus type 5, a small DNA tumor virus used in experimental cancer therapy, strongly induces ERK phosphorylation during the late phase...

journal_title：Cancer research

authors： Schümann M,Dobbelstein M

更新日期：2006-02-01 00:00:00

abstract：:Loss of hSNF5 function is usually observed in malignant rhabdoid tumor (MRT), a highly aggressive pediatric neoplasm. Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A), p21(CIP1/WAF1), and cyclin D1 playing key roles in MRT cell growth control. However...

journal_title：Cancer research

authors： Kuwahara Y,Charboneau A,Knudsen ES,Weissman BE

更新日期：2010-03-01 00:00:00

abstract：:We performed parallel array comparative genomic hybridization and array expression analysis of the 12p11-p12 amplicon in human testicular seminomas and an ovarian carcinoma cell line using an expressed sequence tags (ESTs) array spotted with 8254 ESTs. The data were normalized using a robust statistical modeling and t...

journal_title：Cancer research

authors： Bourdon V,Naef F,Rao PH,Reuter V,Mok SC,Bosl GJ,Koul S,Murty VV,Kucherlapati RS,Chaganti RS

更新日期：2002-11-01 00:00:00

abstract：:The chemotherapeutic effect of B859-35, the (-)-enantiomer of dihydropyrine 3-methyl-5-3-(4,4-diphenyl-1-piperidinyl)-propyl-1,4-dihydro-2,6-dimethy l-4- (3-nitrophenyl)-pyridine-3,5-dicarboxylate-hydrochloride (niguldipine), was tested on tumors induced in Syrian golden hamsters by N-nitrosodiethylamine (DEN). Periph...

journal_title：Cancer research

authors： Schuller HM,Correa E,Orloff M,Reznik GK

更新日期：1990-03-01 00:00:00

abstract：:Radiation exposure is related to risk of numerous types of cancer, but relatively little is known about its effect on risk of multiple primary cancers. Using follow-up data through 2002 from 77,752 Japanese atomic bomb survivors, we identified 14,048 participants diagnosed with a first primary cancer, of whom 1,088 we...

journal_title：Cancer research

authors： Li CI,Nishi N,McDougall JA,Semmens EO,Sugiyama H,Soda M,Sakata R,Hayashi M,Kasagi F,Suyama A,Mabuchi K,Davis S,Kodama K,Kopecky KJ

更新日期：2010-09-15 00:00:00

abstract：:The ability of the phorbol ester tumor promoter 12-O-tetradecanoylphorbol- 13-acetate (TPA) to lead to the activation of cyclic adenosine 3':5'-monophosphate (cAMP)-dependent protein kinase was investigated in three cell lines. In the Reuber H35 hepatoma cells, TPA (1.6 microM) led to an increase in the protein kinase...

journal_title：Cancer research

authors： Byus CV,Trevillyan JM,Cavit LJ,Fletcher WH

更新日期：1983-07-01 00:00:00

abstract：:BD-40, a pyridopyrroloisoquinoline analogue of ellipticines, has dose-dependent cytostatic and cytotoxic effects on cultures of Saccharomyces cerevisiae. These inhibitory effects take place only in growing cells and are enhanced in the presence of oxygen. Among the different repair-deficient mutants examined, a mutant...

journal_title：Cancer research

authors： Moustacchi E,Favaudon V,Bisagni E

更新日期：1983-08-01 00:00:00

abstract：:Experimentally induced breast cancer is often preceded by the appearance of preneoplastic lesions which possess the attributes of hyperplastic normal tissue. These lesions can be isolated and carried as stably transplantable outgrowth lines which continue to morphologically resemble differentiating mammary tissue (Med...

journal_title：Cancer research

authors： Smith GH,Vonderhaar BK,Graham DE,Medina D

更新日期：1984-08-01 00:00:00

abstract：:The Na+/H+ exchanger is involved in a variety of cellular processes, including regulation of intracellular pH and possibly the control of cell growth and proliferation. To study the role of the Na+/H+ exchanger in tumor growth, human sodium proton exchanger-deficient (HSPD) mutants were derived from the human bladder ...

journal_title：Cancer research

authors： Rotin D,Steele-Norwood D,Grinstein S,Tannock I

更新日期：1989-01-01 00:00:00

abstract：:Checkpoint inhibitors are relatively inefficacious in head and neck cancers, despite an abundance of genetic alterations and a T-cell-inflamed phenotype. One significant barrier to efficacy may be the recruitment of myeloid-derived suppressor cells (MDSC) into the tumor microenvironment. Here we demonstrate functional...

journal_title：Cancer research

authors： Davis RJ,Moore EC,Clavijo PE,Friedman J,Cash H,Chen Z,Silvin C,Van Waes C,Allen C

更新日期：2017-05-15 00:00:00

abstract：:Fifty-five hematopoietic cell lines, including 19 T-, 16 B-, 5 pre-B-, 5 non-T non-B-, 1 erythroid, and 9 myeloid-monocytoid cells, were screened for production of human hematopoietic survival and stem cell growth factor (SCGF) by enzyme immunoassay using anti-SCGF monoclonal antibody. The KPB-M15 myeloid cell line co...

journal_title：Cancer research

authors： Hiraoka A,Ohkubo T,Fukuda M

更新日期：1987-10-01 00:00:00

abstract：:Although a majority of malignant testicular Leydig cell tumors induced in the mouse by chronic estrogenization remain dependent upon estrogen stimulation for growth during early transplant generations, we have observed tumors of two lines, no longer growth dependent upon estrogen, that regressed when hosts bearing pal...

journal_title：Cancer research

authors： Huseby RA

更新日期：1983-11-01 00:00:00

abstract：:We have previously reported that abdominal irradiation prior to i.v. injection of syngeneic tumor cells reduced metastases in lung. Our report described an investigation of the significance of intestinal organisms in the radiation effect. We found that eliminating intestinal organisms with antibiotics totally abolishe...

journal_title：Cancer research

authors： Matsumoto T,Ando K,Koike S

更新日期：1988-06-01 00:00:00

abstract：:Glycolipids of murine lymphoma cell lines with low metastatic (Eb) and high metastatic (ESb) potentials have been investigated. The Eb cell line was characterized by a high quantity of gangliotriaosylceramide (Gg3), gangliotetraosylceramide (Gg4), GM1b, and a new type of disialoganglioside, termed GD1 alpha. In contra...

journal_title：Cancer research

authors： Murayama K,Levery SB,Schirrmacher V,Hakomori S

更新日期：1986-03-01 00:00:00

abstract：:A model for medulloblastoma-like primitive neuroectodermal tumors was established in rat using retrovirally transduced SV40 large T antigen (LT) as an inducing agent (O. D. Wiestler et al., Brain Pathol., 2: 47-59, 1992). A cell line isolated from such a tumor and clonal derivatives thereof were biologically and molec...

journal_title：Cancer research

authors： Salewski H,Bayer TA,Eidhoff U,Preuss U,Weggen S,Scheidtmann KH

更新日期：1999-04-15 00:00:00

abstract：:Subcutaneous inoculation of Epstein-Barr virus (EBV) transformed peripheral blood B-lymphocytes (PBL) from an untreated chronic lymphocytic leukemia (CLL) patient produced progressively growing lethal tumors in 4 of 11 whole body irradiated (440 rads) nude mice. In one tumor bearing mouse there was splenomegaly and ge...

journal_title：Cancer research

authors： Lee CL,Uniyal S,Fernandez LA,Lee SH,Ghose T

更新日期：1986-05-01 00:00:00

abstract：:The aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) splice variant designated DX2 is induced by cigarette smoke carcinogens and is often detected in human lung cancer specimens. However, the function of DX2 in lung carcinogenesis is obscure. In this study, we found that DX2 expression w...

journal_title：Cancer research

authors： Oh AY,Jung YS,Kim J,Lee JH,Cho JH,Chun HY,Park S,Park H,Lim S,Ha NC,Park JS,Park CS,Song GY,Park BJ

更新日期：2016-08-15 00:00:00

abstract：:Emerging evidence suggests that cancer preventative agents might be combined with chemotherapy or radiotherapy for the more effective treatment of cancer. Recent studies suggest that genistein and other dietary compounds that prevent cancer may enhance the efficacy of cancer therapeutics by modifying the activity of k...

journal_title：Cancer research

authors： Sarkar FH,Li Y

更新日期：2006-04-01 00:00:00

abstract：:Correlation was greater than 90% between feline leukemia virus (FeLV), group-specific antigen (GSA) in leukocytes, and viral infectivity (VI) in serum or plasma from 132 cats infected with either the Rickard strain of FeLV, the Snyder-Theilen strain of feline sarcoma virus, or field strains of FeLV. Detection of GSA i...

journal_title：Cancer research

authors： Hoover EA,Olsen RG,Mathes LE,Schaller JP

更新日期：1977-10-01 00:00:00

abstract：:Clonal proliferation of human T-lymphotropic virus type I (HTLV-I)-infected cells has been detected by Southern blot analysis and inverse PCR in patients with adult T-cell leukemia, patients with HTLV-I-associated diseases, and even in asymptomatic carriers. Combining inverse PCR with long PCR, we amplified the genomi...

journal_title：Cancer research

authors： Etoh K,Tamiya S,Yamaguchi K,Okayama A,Tsubouchi H,Ideta T,Mueller N,Takatsuki K,Matsuoka M

更新日期：1997-11-01 00:00:00

abstract：:Cytogenetic analyses of intraspecies human HeLa X fibroblast hybrid cell populations have provided tentative evidence for the correlation of loss of a single copy of chromosomes 11 and 14 with reexpression of tumorigenicity. In this study paired combinations of nontumorigenic and tumorigenic segregant HeLa X fibroblas...

journal_title：Cancer research

authors： Srivatsan ES,Benedict WF,Stanbridge EJ

更新日期：1986-12-01 00:00:00

abstract：:Delivery of therapeutic agents to the brain and its neoplasms depends on the presence of membrane transport proteins in the blood-brain barrier and in the target cells. The cellular and subcellular localization of these membrane transporters determines the drug accessibility to the brain and its tumors. We therefore a...

journal_title：Cancer research

authors： Bronger H,König J,Kopplow K,Steiner HH,Ahmadi R,Herold-Mende C,Keppler D,Nies AT

更新日期：2005-12-15 00:00:00

abstract：:A common pathobiological feature of malignant gliomas is the insidious infiltration of single tumor cells into the brain parenchyma, rendering these deadly tumors virtually incurable with available therapies. In this study, we report that ADP-ribosylation factor 6 (ARF6), a Ras superfamily small GTPase, is abundantly ...

journal_title：Cancer research

authors： Hu B,Shi B,Jarzynka MJ,Yiin JJ,D'Souza-Schorey C,Cheng SY

更新日期：2009-02-01 00:00:00

abstract：:It has been claimed that the commercially available Ki-67 monoclonal antibody recognizes a nuclear antigen which is solely expressed in cycling cells. Therefore, at present, Ki-67 is increasingly used as a tool in evaluating growth fractions (GFs) of human tumors. Here we describe specific patterns in the expression a...

journal_title：Cancer research

authors： van Dierendonck JH,Keijzer R,van de Velde CJ,Cornelisse CJ

更新日期：1989-06-01 00:00:00

abstract：:We have investigated the effect of partial hepatectomy (HEP) on tumor growth. MH-134 hepatoma cells, which were inoculated in syngeneic C3H/He mice from 3 to 10 days after HEP, grew with a linear increase in size until 7 days, began to regress, and disappeared 14 days after the inoculation. The survival rate was 100%,...

journal_title：Cancer research

authors： Ono M,Tanaka N,Orita K

更新日期：1986-10-01 00:00:00