Inhibiting DX2-p14/ARF Interaction Exerts Antitumor Effects in Lung Cancer and Delays Tumor Progression.

abstract：:Tumor cell-derived selectin ligands mediate contact to the endothelium, platelets, and leukocytes through binding to selectins that facilitates metastasis. Here, we describe the mechanism of how endogenous (non-tumor derived) selectin ligands contribute to metastasis using α(1,3)fucosyltransferase 7 (Fuc-TVII(-/-))-de...

journal_title：Cancer research

authors： Hoos A,Protsyuk D,Borsig L

更新日期：2014-02-01 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is the sixth most common cancer in women worldwide and, despite advances in detection and therapies, it still represents the most lethal gynecologic malignancy in the industrialized countries. Unfortunately, still relatively little is known about the molecular events that lead to the de...

journal_title：Cancer research

authors： Iorio MV,Visone R,Di Leva G,Donati V,Petrocca F,Casalini P,Taccioli C,Volinia S,Liu CG,Alder H,Calin GA,Ménard S,Croce CM

更新日期：2007-09-15 00:00:00

abstract：:Increased activity, membrane association, and secretion of cathepsin B have been shown to correlate positively with invasiveness and the metastatic properties of many tumor entities. Cathepsin B is able to directly facilitate invasion by degrading extracellular matrix components or to indirectly facilitate invasion by...

journal_title：Cancer research

authors： Krueger S,Haeckel C,Buehling F,Roessner A

更新日期：1999-12-01 00:00:00

abstract：:The Ral family of small G proteins has been implicated in tumorigenesis, invasion, and metastasis. However, little emphasis has been placed on clarifying the individual roles of the two Ral proteins, RalA and RalB, in these processes in view of their high sequence homology. Here we analyze the separate contributions o...

journal_title：Cancer research

authors： Oxford G,Owens CR,Titus BJ,Foreman TL,Herlevsen MC,Smith SC,Theodorescu D

更新日期：2005-08-15 00:00:00

abstract：:The interactions of tumorigenic cells with the extracellular matrix play a critical role in the establishment of metastases. Thrombospondin (TSP) is prominent at sites of tissue injury and promotes the attachment, spreading, and motility of several cell types. We have investigated the relationship between human carcin...

journal_title：Cancer research

authors： Yabkowitz R,Mansfield PJ,Dixit VM,Suchard SJ

更新日期：1993-01-15 00:00:00

abstract：:We have used high-pressure liquid chromatography and the Salmonella/microsome mutagenicity test to look for mutagenic impurities in 11 carcinogens and noncarcinogens. Because of the million-fold range in mutagenic potency observed in the Salmonella test, even trace amounts of potent mutagenic impurities in a nonmutage...

journal_title：Cancer research

authors： Donahue EV,McCann J,Ames BN

更新日期：1978-02-01 00:00:00

abstract：:Several properties of four 1-deaza-7,8-dihydropteridines were compared with those of each other and with those of colchicine, nocodazole, podophyllotoxin, and vincristine. Compound NSC 370147 was more active than the other compounds of this type with respect to inhibition of proliferation of cultured L1210 cells and t...

journal_title：Cancer research

authors： Bowdon BJ,Waud WR,Wheeler GP,Hain R,Dansby L,Temple C Jr

更新日期：1987-03-15 00:00:00

abstract：:The ability of a motif of the CYP17 5' untranslated region, created by a polymorphic T to C substitution, to bind to the human transcription factor Sp-1 was investigated. No binding of any of the polymorphic alleles was observed in electromobility shift assay. No other sequence within +1 to +100 of each of the CYP17 a...

journal_title：Cancer research

authors： Nedelcheva Kristensen V,Haraldsen EK,Anderson KB,Lønning PE,Erikstein B,Kåresen R,Gabrielsen OS,Børresen-Dale AL

更新日期：1999-06-15 00:00:00

abstract：:Cyclopenta(cd)pyrene, a constituent of environmental emissions, has been found to mutate and transform mammalian cells in culture. Cyclopenta(cd)pyrene 3,4-oxide, a presumed metabolite, was found to be a direct-acting mutagen and to transform mammalian cells. These results suggest that cyclopenta(cd)pyrene 3,4-oxide m...

journal_title：Cancer research

authors： Gold A,Nesnow S,Moore M,Garland H,Curtis G,Howard B,Graham D,Eisenstadt E

更新日期：1980-12-01 00:00:00

abstract：:A case-control study was undertaken to evaluate the roles of the hepatitis B virus (HBV), cigarette smoking, and alcohol use in the etiology of hepatocellular carcinoma (HCC). A major purpose of the study was to evaluate the effect of cigarette smoking on HCC among hepatitis B surface antigen (HBsAg)-negative persons,...

journal_title：Cancer research

authors： Austin H,Delzell E,Grufferman S,Levine R,Morrison AS,Stolley PD,Cole P

更新日期：1986-02-01 00:00:00

abstract：:O(6)-Alkylguanine-DNA alkyltransferase (AGT) plays a critical role in protection from the carcinogenic effects of simple alkylating agents by repairing O(6)-alkylguanine adducts via a direct transfer reaction. Nitric oxide (NO) or species derived from it are known to be able to initiate neoplastic growth and cannot on...

journal_title：Cancer research

authors： Liu L,Xu-Welliver M,Kanugula S,Pegg AE

更新日期：2002-06-01 00:00:00

abstract：:The levels of protooncogene RNA in matched bone marrow and peripheral blood cells obtained from patients with newly diagnosed acute myelogenous leukemia were compared. While the absolute amounts of c-myc RNA in the matched specimens are similar, the levels are not correlated. In contrast, while the levels of c-fos RNA...

journal_title：Cancer research

authors： Preisler HD,Sato H,Li YQ,Stein G,Stein J

更新日期：1987-07-15 00:00:00

abstract：:The long latency period of cancer would suggest that timely measures to reduce the risk of cancer, such as dietary guidelines to the public, be an integral component of policy on cancer. Although criteria for acceptability of scientific evidence are often defined, judgment its required in interpreting the significance...

journal_title：Cancer research

authors： Palmer S

更新日期：1983-05-01 00:00:00

abstract：:(-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenol in green tea, has been shown to inhibit the growth of many cancer cell lines and to suppress the phosphorylation of epidermal growth factor receptor (EGFR). We observed similar effects of EGCG in esophageal squamous cell carcinoma KYSE 150 cells and epide...

journal_title：Cancer research

authors： Hou Z,Sang S,You H,Lee MJ,Hong J,Chin KV,Yang CS

更新日期：2005-09-01 00:00:00

abstract：:Our understanding of noncoding mutations in cancer genomes has been derived primarily from mutational recurrence analysis by aggregating clinical samples on a large scale. These cohort-based approaches cannot directly identify individual pathogenic noncoding mutations from personal cancer genomes. Therefore, although ...

journal_title：Cancer research

authors： Wang C,Li J

更新日期：2020-11-01 00:00:00

abstract：:1-beta-D-Arabinofuranosylcytosine (araC) is an effective drug in the i.p. therapy of ovarian carcinoma but little is known of its transport and metabolism in this tumor. Influx of araC at 1 microM into cultured human ovarian carcinoma cells (CI 80-13S) was largely inhibited by nanomolar concentrations of the nucleosid...

journal_title：Cancer research

authors： Jamieson GP,Snook MB,Bradley TR,Bertoncello I,Wiley JS

更新日期：1989-01-15 00:00:00

abstract：:Although adoptive transfer of cytotoxic T lymphocytes (CTL) offer a promising cancer therapeutic direction, the generation of antigen-specific CTL from patients has faced difficulty in efficient expansion in ex vivo culture. To resolve this issue, several groups have proposed that induced pluripotent stem cell technol...

journal_title：Cancer research

authors： Maeda T,Nagano S,Ichise H,Kataoka K,Yamada D,Ogawa S,Koseki H,Kitawaki T,Kadowaki N,Takaori-Kondo A,Masuda K,Kawamoto H

更新日期：2016-12-01 00:00:00

abstract：:IFNγ is conventionally recognized as an inflammatory cytokine that plays a central role in antitumor immunity. Although it has been used clinically to treat a variety of malignancies, low levels of IFNγ in the tumor microenvironment (TME) increase the risk of tumor metastasis during immunotherapy. Accumulating evidenc...

journal_title：Cancer research

authors： Song M,Ping Y,Zhang K,Yang L,Li F,Zhang C,Cheng S,Yue D,Maimela NR,Qu J,Liu S,Sun T,Li Z,Xia J,Zhang B,Wang L,Zhang Y

更新日期：2019-07-15 00:00:00

abstract：:Plasmacytoid dendritic cells (pDC) are the main producers of a key T-cell-stimulatory cytokine, IFNα, and critical regulators of antiviral immunity. Chronic myeloid leukemia (CML) is caused by BCR-ABL, which is an oncogenic tyrosine kinase that can be effectively inhibited with ABL-selective tyrosine kinase inhibitors...

journal_title：Cancer research

authors： Inselmann S,Wang Y,Saussele S,Fritz L,Schütz C,Huber M,Liebler S,Ernst T,Cai D,Botschek S,Brendel C,Calogero RA,Pavlinic D,Benes V,Liu ET,Neubauer A,Hochhaus A,Burchert A

更新日期：2018-11-01 00:00:00

abstract：:Protein kinase Cepsilon (PKCepsilon), a Ca(2+)-independent, phospholipid-dependent serine/threonine kinase, is among the PKC isoforms expressed in mouse epidermis. We reported that FVB/N transgenic mice that overexpress ( approximately 18-fold) PKCepsilon protein in basal epidermal cells and cells of the hair follicle...

journal_title：Cancer research

authors： Wheeler DL,Ness KJ,Oberley TD,Verma AK

更新日期：2003-10-01 00:00:00

abstract：:Allelic loss of chromosome 18q has been noted in intestinal type gastric adenocarcinomas. Smad4 is a gene located at 18q that was recently cloned in humans and found to be significantly altered in pancreatic cancers. We sought to determine whether Smad4 genetic alterations played a significant role in gastric tumorige...

journal_title：Cancer research

authors： Powell SM,Harper JC,Hamilton SR,Robinson CR,Cummings OW

更新日期：1997-10-01 00:00:00

abstract：:The lipid hydrolase enzyme acid sphingomyelinase (ASM) is required for the conversion of the lipid cell membrane component sphingomyelin into ceramide. In cancer cells, ASM-mediated ceramide production is important for apoptosis, cell proliferation, and immune modulation, highlighting ASM as a potential multimodal the...

journal_title：Cancer research

authors： Kachler K,Bailer M,Heim L,Schumacher F,Reichel M,Holzinger CD,Trump S,Mittler S,Monti J,Trufa DI,Rieker RJ,Hartmann A,Sirbu H,Kleuser B,Kornhuber J,Finotto S

更新日期：2017-11-01 00:00:00

abstract：:The antitumor effects of two immunotoxins were evaluated in vitro and in vivo against the human ovarian carcinoma cell line, OVCAR-3. The immunotoxins used were composed of recombinant ricin A chain (rRTA) covalently attached to a monoclonal antibody directed toward the human transferrin receptor (45412/rRTA, also cal...

journal_title：Cancer research

authors： Pearson JW,Hedrick E,Fogler WE,Bull RL,Ferris DK,Riggs CW,Wiltrout RH,Sivam G,Morgan AC,Groves E

更新日期：1990-10-01 00:00:00

abstract：:EBV-infected B-cell lymphomas are a potentially life-threatening complication in bone marrow and solid organ transplant recipients. Immunosuppressive drugs required to prevent allograft rejection also impair anti-EBV T-cell immunity, thereby increasing the risk of EBV-associated disease. Here we demonstrate that the i...

journal_title：Cancer research

authors： Nepomuceno RR,Balatoni CE,Natkunam Y,Snow AL,Krams SM,Martinez OM

更新日期：2003-08-01 00:00:00

abstract：:Mitotic and labeling indices of bone marrow tumor cells were determined from patients with disseminated neuroblastoma. Although pretreatment values were variable, the median indices indicated that only a small proportion of tumor cells were proliferating. The pretreatment indices could not be correlated with presentin...

journal_title：Cancer research

authors： Hayes FA,Green AA,Mauer AM

更新日期：1977-10-01 00:00:00

abstract：:Ionizing radiation (IR) and concomitant angiostatin (AS) produce greater than additive local antitumor effects. We examined whether prolonged AS treatment added to IR reduces proliferation of lung metastases from LLC primary tumors. Flank tumors were treated with 40 Gy with or without AS (25 mg/kg/day). IR plus a 14-d...

journal_title：Cancer research

authors： Gorski DH,Mauceri HJ,Salloum RM,Halpern A,Seetharam S,Weichselbaum RR

更新日期：2003-01-15 00:00:00

abstract：:Chronic pancreatitis, K-ras oncogene mutations, and the subsequent generation of reactive oxygen species (ROS) appear to be linked to pancreatic cancer. ROS have also been suggested to be mitogenic and capable of stimulating cell proliferation. Cells contain antioxidant enzymes to regulate steady state levels of ROS p...

journal_title：Cancer research

authors： Cullen JJ,Weydert C,Hinkhouse MM,Ritchie J,Domann FE,Spitz D,Oberley LW

更新日期：2003-03-15 00:00:00

abstract：:Melanomas harboring BRAF mutations can be treated with BRAF inhibitors (BRAFi), but responses are varied and tumor recurrence is inevitable. Here we used an integrative approach of experimentation and mathematical flux balance analyses in BRAF-mutated melanoma cells to discover that elevated antioxidant capacity is li...

journal_title：Cancer research

authors： Paudel BB,Lewis JE,Hardeman KN,Hayford CE,Robbins CJ,Stauffer PE,Codreanu SG,Sherrod SD,McLean JA,Kemp ML,Quaranta V

更新日期：2020-10-15 00:00:00

abstract：:Previous studies have shown that among populations with a high rate of consanguinity, there is a significant increase in the prevalence of cancer. Single nucleotide polymorphism (SNP) array data (Affymetrix, 50K XbaI) analysis revealed long regions of homozygosity in genomic DNAs taken from tumor and matched normal ti...

journal_title：Cancer research

authors： Bacolod MD,Schemmann GS,Wang S,Shattock R,Giardina SF,Zeng Z,Shia J,Stengel RF,Gerry N,Hoh J,Kirchhoff T,Gold B,Christman MF,Offit K,Gerald WL,Notterman DA,Ott J,Paty PB,Barany F

更新日期：2008-04-15 00:00:00

abstract：:To identify mechanisms of camptothecin (CPT) resistance and the relationship between CPT-resistant cells and other anticancer agents, a CPT-resistant cell line (CPT30) and its partial revertant cell line (CPT30R) were established from a human nasopharyngeal carcinoma cell line (HONE-1). CPT30 and CPT30R cells displaye...

journal_title：Cancer research

authors： Chang JY,Liu JF,Juang SH,Liu TW,Chen LT

更新日期：2002-07-01 00:00:00