Abstract：
:The ability of a motif of the CYP17 5' untranslated region, created by a polymorphic T to C substitution, to bind to the human transcription factor Sp-1 was investigated. No binding of any of the polymorphic alleles was observed in electromobility shift assay. No other sequence within +1 to +100 of each of the CYP17 alleles formed complex with the Sp-1 or enhanced binding to the polymorphic CACC box. Genotyping of 510 breast cancer patients and 201 controls revealed no difference in genotype frequencies. Age at onset, tumor grade, lymph node status and distant metastases, stage, and estrogen and progesterone receptor status were not associated with the CYP17 genotype.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Nedelcheva Kristensen V,Haraldsen EK,Anderson KB,Lønning PE,Erikstein B,Kåresen R,Gabrielsen OS,Børresen-Dale ALsubject
Has Abstractpub_date
1999-06-15 00:00:00pages
2825-8issue
12eissn
0008-5472issn
1538-7445journal_volume
59pub_type
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