Immunohistochemical staining of human spermidine/spermine N1-acetyltransferase superinduced in response to treatment with antitumor polyamine analogues.

abstract：:We have developed a model system which can be utilized for characterizing both the molecular basis of natural killer (NK):tumor interactions and the consequences of these interactions on tumor growth in vivo. This model system consists of several tumor lines which were derived from the murine lymphoma ASL1w under cond...

journal_title：Cancer research

authors： Smithson G,Wolcott RM,Chervenak R

更新日期：1992-08-01 00:00:00

abstract：:Splenocytes from mice bearing a cachexia-inducing tumor (MAC16) have been fused with mouse myeloma cells to produce hybridomas, which have been cloned to produce antibody reactive to a material which copurified with a lipid-mobilizing factor isolated from the same tumor. The monoclonal antibody has been used to invest...

journal_title：Cancer research

authors： Todorov PT,McDevitt TM,Cariuk P,Coles B,Deacon M,Tisdale MJ

更新日期：1996-03-15 00:00:00

abstract：:Because of their short range and high linear energy transfer, alpha-particles may be particularly effective in the treatment of neoplastic meningitis. Monoclonal antibody 81C6 was labeled with alpha-particle-emitting 211At using N-succinimidyl3-[211At]astatobenzoate, and the efficacy and toxicity of this immunoconjuga...

journal_title：Cancer research

authors： Zalutsky MR,McLendon RE,Garg PK,Archer GE,Schuster JM,Bigner DD

更新日期：1994-09-01 00:00:00

abstract：:Copper plays an essential role in promoting angiogenesis. Tumors that become angiogenic acquire the ability to enter a phase of rapid growth and exhibit increased metastatic potential, the major cause of morbidity in cancer patients. We report that copper deficiency induced by tetrathiomolybdate (TM) significantly imp...

journal_title：Cancer research

authors： Pan Q,Kleer CG,van Golen KL,Irani J,Bottema KM,Bias C,De Carvalho M,Mesri EA,Robins DM,Dick RD,Brewer GJ,Merajver SD

更新日期：2002-09-01 00:00:00

abstract：:Physiological cell conditions, such as glucose deprivation and hypoxia, play a role in developing drug resistance in solid tumors. These tumor-specific conditions cause decreased expression of DNA topoisomerase IIalpha (topo IIalpha), rendering cells resistant to topo II-targeted drugs, such as etoposide and doxorubic...

journal_title：Cancer research

authors： Ogiso Y,Tomida A,Lei S,Omura S,Tsuruo T

更新日期：2000-05-01 00:00:00

abstract：:Cancer radiotherapy may be immunogenic, but it is unclear why its immunogenic effects are rarely sufficient to prevent tumor recurrence. Here, we report a novel Toll-like receptor 9 (TLR9)-dependent mechanism that initiates tumor regrowth after local radiotherapy. Systemic inhibition of TLR9, but not TLR4, delayed tum...

journal_title：Cancer research

authors： Gao C,Kozlowska A,Nechaev S,Li H,Zhang Q,Hossain DM,Kowolik CM,Chu P,Swiderski P,Diamond DJ,Pal SK,Raubitschek A,Kortylewski M

更新日期：2013-12-15 00:00:00

abstract：:Although adherent junctions have been extensively studied, the role of tight junctions in cancer cell invasion is not sufficiently explored. We investigated whether claudin-1, a component of tight junctions, regulated invasion activity in oral squamous cell carcinoma (OSC) cells. The expression of claudin-1, activity ...

journal_title：Cancer research

authors： Oku N,Sasabe E,Ueta E,Yamamoto T,Osaki T

更新日期：2006-05-15 00:00:00

abstract：:Experiments were performed to assess the role of liver cell necrosis in the induction of early steps in liver carcinogenesis with diethylnitrosamine, as measured by the appearance of foci of resistant hepatocytes that stain for gamma-glutamyl transpeptidase and that are presumptive preneoplastic lesions in the rat. Wi...

journal_title：Cancer research

authors： Ying TS,Sarma DS,Farber E

更新日期：1981-06-01 00:00:00

abstract：:Fusions of the ETV6/TEL gene to receptor or protein tyrosine kinases (TKs), such as PDGFRbeta, JAK2, ABL, ABL2, TRKC, and Syk, have been reported in various hematological malignancies. Expression of the resultant chimeric proteins is believed to lead to constitutive TK activity through activation by the helix-loop-hel...

journal_title：Cancer research

authors： Yagasaki F,Wakao D,Yokoyama Y,Uchida Y,Murohashi I,Kayano H,Taniwaki M,Matsuda A,Bessho M

更新日期：2001-12-01 00:00:00

abstract：:Radiation leukemia virus-induced leukemia of a male C57BL/6 mouse, B6RV2, is immunogenic to female BALB/c X C57BL/6 F1 mice. In these mice, B6RV2 tumors regressed after initial growth, and after tumor regression the mice were resistant to repeated inocula of up to 10(8) B6RV2 cells. Serum from these mice reacted with ...

journal_title：Cancer research

authors： Nakayama E,Uenaka A,Stockert E,Obata Y

更新日期：1984-11-01 00:00:00

abstract：:Most squamous cell carcinomas of the head and neck (HNSCC) overexpress ERBB1/EGFR, but EGF receptor (EGFR)-targeted therapies have yielded disappointing clinical results in treatment of this cancer. Here, we describe a novel interaction between EGFR and the ligand EphrinB1 (EFNB1), and we show that EFNB1 phosphorylati...

journal_title：Cancer research

authors： Vermeer PD,Colbert PL,Wieking BG,Vermeer DW,Lee JH

更新日期：2013-09-15 00:00:00

abstract：:Loss of imprinting (LOI) of the insulin-like growth factor II (IGFII) gene is a frequent phenomenon in colorectal tumor tissues. Previous reports indicated that subjects with colorectal neoplasias show LOI of IGFII in circulating lymphocytes. Furthermore, LOI of IGFII is strongly related to the methylation of a differ...

journal_title：Cancer research

authors： Kaaks R,Stattin P,Villar S,Poetsch AR,Dossus L,Nieters A,Riboli E,Palmqvist R,Hallmans G,Plass C,Friesen MD

更新日期：2009-07-01 00:00:00

abstract：:Lipoblastomas are pediatric neoplasms resulting from transformation of adipocytes. These benign tumors are typically composed of adipose cells in different stages of maturation within a variably myxoid matrix, and they contain clonal rearrangements of chromosome band 8q12. Because lipoblastomas resemble embryonic adip...

journal_title：Cancer research

authors： Hibbard MK,Kozakewich HP,Dal Cin P,Sciot R,Tan X,Xiao S,Fletcher JA

更新日期：2000-09-01 00:00:00

abstract：:Tumor infiltrating lymphocytes (TIL) were isolated from 22 tumors obtained from 15 patients with metastatic melanoma. In 18 of the 22 tumors, a substantial number of lymphocytes was isolated with an average lymphoid cell:tumor cell ratio of 1.26. The TIL were predominantly cytotoxic/suppressor T-lymphocytes with an av...

journal_title：Cancer research

authors： Itoh K,Tilden AB,Balch CM

更新日期：1986-06-01 00:00:00

abstract：:To elucidate the role of the recently identified FHIT gene, located at 3p14.2 in human brain tumor carcinogenesis, a total of 259 tumors were analyzed for loss of heterozygosity (LOH) at microsatellite loci D3S1313, D3S1234, D3S1300, and D3S1481. In primary brain tumors, LOH was detected at a frequency of 8.4% (n = 21...

journal_title：Cancer research

authors： Frank S,Müller J,Plaschke J,Hahn M,Hampl J,Hampl M,Pistorius S,Schackert G,Schackert HK

更新日期：1997-07-01 00:00:00

abstract：:The zinc finger gene MZF-1 is preferentially expressed in primitive hematopoietic cells and plays an important role in regulating myelopoiesis. Regulators of development are potential targets for neoplastic transformation. This study investigated whether unregulated expression of MZF-1 could function as an oncogene. R...

journal_title：Cancer research

authors： Hromas R,Morris J,Cornetta K,Berebitsky D,Davidson A,Sha M,Sledge G,Rauscher F 3rd

更新日期：1995-08-15 00:00:00

abstract：:Melanoma-derived lipoprotein lipase inhibitor (MLPLI) is a factor purified from the conditioned medium of a human melanoma cell line, SEKI, which induced severe cachexia in tumor-bearing nude mice. Amino acid sequencing revealed that the amino-terminal portion was identical to that of leukemia-inhibitory factor (LIF)....

journal_title：Cancer research

authors： Mori M,Yamaguchi K,Honda S,Nagasaki K,Ueda M,Abe O,Abe K

更新日期：1991-12-15 00:00:00

abstract：:Non-small cell lung cancer (N-SCLC) is generally unresponsive to chemotherapy even without previous drug treatment, as opposed to small cell lung cancer (SCLC), which is initially responsive to chemotherapy. The mechanisms of this intrinsic resistance are unknown. This study was designed to investigate the role of DNA...

journal_title：Cancer research

authors： Zeng-Rong N,Paterson J,Alpert L,Tsao MS,Viallet J,Alaoui-Jamali MA

更新日期：1995-11-01 00:00:00

abstract：:In 2002, the National Cancer Institute created the Initiative for Chemical Genetics (ICG), to enable public research using small molecules to accelerate the discovery of cancer-relevant small-molecule probes. The ICG is a public-access research facility consisting of a tightly integrated team of synthetic and analytic...

journal_title：Cancer research

authors： Tolliday N,Clemons PA,Ferraiolo P,Koehler AN,Lewis TA,Li X,Schreiber SL,Gerhard DS,Eliasof S

更新日期：2006-09-15 00:00:00

abstract：:We have evaluated 4 radioiodinated mouse monoclonal anticarcinoembryonic antigen antibodies (MAbs) by using the GW-39 human colorectal tumor xenograft transplanted i.m. in immunocompetent hamsters to determine whether there were any differences in their tumor localization properties. Additional comparisons were made t...

journal_title：Cancer research

authors： Sharkey RM,Primus FJ,Shochat D,Goldenberg DM

更新日期：1988-04-01 00:00:00

abstract：:Two human pancreatic cell lines, MIA PaCa 2 and Capan 2, were treated by photodynamic therapy in vitro with Photophrin (0.01-25 micrograms/ml; 24 h) and then light (1-50 J/cm2; lambda = 630 nm). The following model was fit to 6 datasets with weighted nonlinear regression: [sequence: see text] The symbols are: E, cell ...

journal_title：Cancer research

authors： Moesta KT,Greco WR,Nurse-Finlay SO,Parsons JC,Mang TS

更新日期：1995-07-15 00:00:00

abstract：:We previously found that a Salmonella typhimurium vector engineered to secrete soluble tumor antigen induces CD4(+) T cells resistant to CD4(+)CD25(+) regulatory T cells (Treg) and that glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR) signal is involved in the development of this resist...

journal_title：Cancer research

authors： Nishikawa H,Kato T,Hirayama M,Orito Y,Sato E,Harada N,Gnjatic S,Old LJ,Shiku H

更新日期：2008-07-15 00:00:00

abstract：:Prostate-specific membrane antigen (PSMA), initially defined by monoclonal antibody (mAb) 7E11, is a now well-characterized type 2 integral membrane glycoprotein expressed in a highly restricted manner by prostate epithelial cells. 7E11 has been shown to bind an intracellular epitope of PSMA that, in viable cells, is ...

journal_title：Cancer research

authors： Liu H,Moy P,Kim S,Xia Y,Rajasekaran A,Navarro V,Knudsen B,Bander NH

更新日期：1997-09-01 00:00:00

abstract：:DNA methylation aberrations have been implicated in acquired resistance to platinum drugs in ovarian cancer. In this study, we elucidated an epigenetic signature associated with platinum drug resensitization that may offer utility in predicting the outcomes of patients who are coadministered a DNA methyltransferase in...

journal_title：Cancer research

authors： Fang F,Cardenas H,Huang H,Jiang G,Perkins SM,Zhang C,Keer HN,Liu Y,Nephew KP,Matei D

更新日期：2018-02-01 00:00:00

abstract：:The eukaryotic translation initiation factor 4E (eIF4E) is frequently overexpressed in human cancers in relation to disease progression and drives cellular transformation, tumorigenesis, and metastatic progression in experimental models. Enhanced eIF4E function results from eIF4E overexpression and/or activation of th...

journal_title：Cancer research

authors： Graff JR,Konicek BW,Carter JH,Marcusson EG

更新日期：2008-02-01 00:00:00

abstract：:The expression of cytochrome P450 genes directly within target cells is an important determinant of human susceptibility to cancers, birth defects, and other chemically initiated diseases. One pivotal gene, CYP1A1, codes for an inducible cytochrome P450 isozyme (P450IA1) responsible for the bioactivation of numerous c...

journal_title：Cancer research

authors： Omiecinski CJ,Redlich CA,Costa P

更新日期：1990-07-15 00:00:00

abstract：:Inactivation of p53 signaling by mutation of p53 itself or abrogation of its normal function by other transfactors, such as MDM2, is a key event in the development of most human cancers. To identify novel regulators of p53, we have used a phenotype-based selection in which a total cDNA library in a retroviral vector h...

journal_title：Cancer research

authors： Agarwal MK,Ruhul Amin AR,Agarwal ML

更新日期：2007-01-01 00:00:00

abstract：:Matrix metalloproteinase-2 (MMP-2) expression is often up-regulated in advanced cancers and known to play an important role in tumor angiogenesis. We previously showed that adenoviral-mediated delivery of siRNA for MMP-2 (Ad-MMP-2-Si) inhibited lung cancer growth, angiogenesis, and metastasis. In this study, we invest...

journal_title：Cancer research

authors： Chetty C,Lakka SS,Bhoopathi P,Kunigal S,Geiss R,Rao JS

更新日期：2008-06-15 00:00:00

abstract：:Glycine N-methyltransferase (GNMT) affects genetic stability by (a) regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine and (b) binding to folate. Based on the identification of GNMT as a 4 S polyaromatic hydrocarbon-binding protein, we used liver cancer cell lines that expressed GNMT either transien...

journal_title：Cancer research

authors： Chen SY,Lin JR,Darbha R,Lin P,Liu TY,Chen YM

更新日期：2004-05-15 00:00:00

abstract：:The polyglutamylation of aminopterin and methotrexate (N10-methylaminopterin) was compared in the Ehrlich ascites tumor in vitro. Three poly-gamma-glutamyl conjugates of methotrexate and aminopterin were detected, although at an equal (1 microM) extracellular drug concentration, the net accumulation of aminopterin pol...

journal_title：Cancer research

authors： Matherly LH,Voss MK,Anderson LA,Fry DW,Goldman ID

更新日期：1985-03-01 00:00:00