Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2-down-regulated lung cancer.

abstract：:Growth factors play an important role in regulating neural stem cell proliferation and differentiation. This study shows that platelet-derived growth factor (PDGF) induces a partial differentiation of neural stem/progenitor cells (NSPCs) in the absence of other mitogens in vitro. NSPCs thus acquire an immature morphol...

journal_title：Cancer research

authors： Erlandsson A,Brännvall K,Gustafsdottir S,Westermark B,Forsberg-Nilsson K

更新日期：2006-08-15 00:00:00

abstract：:An animal model to investigate the invasive and metastatic properties of human bladder transitional cell carcinoma (HTCC) was established. Two long-term HTCC cell lines (RT4 and EJ) and one HTCC cell line derived in our laboratory (LD-71) were tumorigenic when injected s.c. into nude mice but had little potential to i...

journal_title：Cancer research

authors： Ahlering TE,Dubeau L,Jones PA

更新日期：1987-12-15 00:00:00

abstract：:Immunostimulatory CpG oligodeoxynucleotides (ODNs) can enhance the therapeutic effect of monoclonal antibodies (mAbs) by enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Distinct classes of CpG ODNs have been found recently to stimulate different effector cell populations. We used murine cancer models t...

journal_title：Cancer research

authors： van Ojik HH,Bevaart L,Dahle CE,Bakker A,Jansen MJ,van Vugt MJ,van de Winkel JG,Weiner GJ

更新日期：2003-09-01 00:00:00

abstract：:The hyperthermic sensitivity of cultured human glioblastoma cells was determined in 1 degree increments from 42 through 46 degrees over the pH range of 6.1 to 7.4. These cells were 5 to 10 times less heat sensitive than were Chinese hamster ovary cells and are among the most resistant cells examined in cell culture. A...

journal_title：Cancer research

authors： Gerweck LE,Richards B

更新日期：1981-03-01 00:00:00

abstract：:SMYD3 methyltransferase is nearly undetectable in normal human tissues but highly expressed in several cancers, including breast cancer, although its contributions to pathogenesis in this setting are unclear. Here we report that histone H2A.Z.1 is a substrate of SMYD3 that supports malignancy. SMYD3-mediated dimethyla...

journal_title：Cancer research

authors： Tsai CH,Chen YJ,Yu CJ,Tzeng SR,Wu IC,Kuo WH,Lin MC,Chan NL,Wu KJ,Teng SC

更新日期：2016-10-15 00:00:00

abstract：:Angiogenesis is essential for the growth of solid tumors. We have observed previously that the vascular endothelial cells of astrocytic brain tumors express human telomerase reverse transcriptase (hTERT) mRNA, suggesting a role for telomerase in the angiogenesis of these neoplasms. Here, we used an in vitro model to d...

journal_title：Cancer research

authors： Falchetti ML,Pierconti F,Casalbore P,Maggiano N,Levi A,Larocca LM,Pallini R

更新日期：2003-07-01 00:00:00

abstract：:Regulation of tyrosine aminotransferase gene expression was studied in an adult rat hepatocyte line (RALA255-10G) which is temperature sensitive for the maintenance of the differentiated liver phenotype. Glucocorticoid hormones such as cortisol were necessary for expression of the aminotransferase gene. In the absence...

journal_title：Cancer research

authors： Chou JY,Yeoh GC

更新日期：1987-10-15 00:00:00

abstract：:Advances in cancer research and personalized medicine will require significant new bridging infrastructures, including more robust biorepositories that link human tissue to clinical phenotypes and outcomes. In order to meet that challenge, four cancer centers formed the Text Information Extraction System (TIES) Cancer...

journal_title：Cancer research

authors： Jacobson RS,Becich MJ,Bollag RJ,Chavan G,Corrigan J,Dhir R,Feldman MD,Gaudioso C,Legowski E,Maihle NJ,Mitchell K,Murphy M,Sakthivel M,Tseytlin E,Weaver J

更新日期：2015-12-15 00:00:00

abstract：:This is the first report on estrogen-dependent growth of human-derived colon carcinoma cells. Under selected conditions, growth of subconfluent Caco-2 cells is triggered by estradiol. Cell growth is estradiol concentration dependent, with maximal effect occurring at about 0.4 nM. Growth is prevented by two different a...

journal_title：Cancer research

authors： Di Domenico M,Castoria G,Bilancio A,Migliaccio A,Auricchio F

更新日期：1996-10-01 00:00:00

abstract：:We have shown previously that IgM from Ehrlich tumor (ET)-immunized mice, recognizing ET cell surface carbohydrates, protects control mice to a subsequent tumor challenge. The factors involved in such IgM-mediated protection were unknown, since it was independent of complement activation. Here, we have extended these ...

journal_title：Cancer research

authors： Gil J,Alvarez R,Viñuela JE,Ruiz de Morales JG,Bustos A,De la Concha EG,Subiza JL

更新日期：1990-11-15 00:00:00

abstract：:The possible mutagenic potential of exposure to 1.5 GHz electromagnetic near field (EMF) was investigated using brain tissues of Big Blue mice (BBM). Male BBM were locally exposed to EMF in the head region at 2.0, 0.67, and 0 W/kg specific absorption rate for 90 min/day, 5 days/week, for 4 weeks. No gliosis or degener...

journal_title：Cancer research

authors： Takahashi S,Inaguma S,Cho YM,Imaida K,Wang J,Fujiwara O,Shirai T

更新日期：2002-04-01 00:00:00

abstract：:We measured the tissue concentration of human urokinase receptor (uPAR) in 22 breast carcinomas and 9 benign breast lesions using in vitro quantitative autoradiography. Tissue sections were incubated with increasing concentrations of 125I-pro-urokinase in the presence or absence of unlabeled competitor. Breast carcino...

journal_title：Cancer research

authors： Del Vecchio S,Stoppelli MP,Carriero MV,Fonti R,Massa O,Li PY,Botti G,Cerra M,D'Aiuto G,Esposito G

更新日期：1993-07-01 00:00:00

abstract：:IL6-PE40 and IL6-PE664Glu are chimeric molecules composed of interleukin 6 (IL6) fused to a truncated form (PE40) or a full-length mutated form (PE664Glu) of Pseudomonas exotoxin. Both forms of IL6-Pseudomonas exotoxin are cytotoxic to IL6 receptor-bearing tumor cell types in culture. In this report, we show that both...

journal_title：Cancer research

authors： Siegall CB,Kreitman RJ,FitzGerald DJ,Pastan I

更新日期：1991-06-01 00:00:00

abstract：:Mortality or incidence rates of ten major neoplasms in migrants from several countries, their respective countries of origin, their American-born offspring, and United States whites were compared. Rates in succeeding generations of Americans increased most rapidly for colon cancer and most slowly for breast cancer, wi...

journal_title：Cancer research

authors： Thomas DB,Karagas MR

更新日期：1987-11-01 00:00:00

abstract：:Although altered expression of platelet-derived growth factor (PDGF)-A is a hallmark of many cancers, the importance of pro-PDGF-A conversion to PDGF-A in tumorigenesis and the cognate protease(s) is unknown. Pro-PDGF-A processing occurs at pairs of basic residues, likely involving the proprotein convertases (PCs). In...

journal_title：Cancer research

authors： Siegfried G,Khatib AM,Benjannet S,Chrétien M,Seidah NG

更新日期：2003-04-01 00:00:00

abstract：:A patient with refractory acute myeloid leukemia was treated with tiazofurin, an agent that causes inhibition of tumor cell proliferation by depressing GTP concentrations in the malignant cells. The initial dose of 1100 mg/m2 was ineffective clinically and biochemically. Dose escalations to 1650, 2200, and finally 330...

journal_title：Cancer research

authors： Tricot GJ,Jayaram HN,Nichols CR,Pennington K,Lapis E,Weber G,Hoffman R

更新日期：1987-09-15 00:00:00

abstract：:We analyzed the epidermal growth factor receptor gene using a complementary DNA probe of the epidermal growth factor receptor gene in 21 uncultured primary breast carcinomas and found that the gene was amplified in three of these tumors. We further demonstrated by immunohistochemistry using a monoclonal antibody to th...

journal_title：Cancer research

authors： Ro J,North SM,Gallick GE,Hortobagyi GN,Gutterman JU,Blick M

更新日期：1988-01-01 00:00:00

abstract：:NGR-TNF is a derivative of TNF-α that targets tumor blood vessels and enhances penetration of chemotherapeutic drugs. Because of this property, NGR-TNF is being tested in combination with chemotherapy in various phase II and III clinical trials. Here we report that chromogranin A (CgA), a protein present in variable a...

journal_title：Cancer research

authors： Dondossola E,Gasparri AM,Colombo B,Sacchi A,Curnis F,Corti A

更新日期：2011-09-01 00:00:00

abstract：:Although in vivo targeting of tumors using fluorescently labeled probes has greatly gained in importance over the last few years, most of the clinically applied reagents lack tumor cell specificity. Our novel tumor cell-penetrating peptide-based probe (TPP) recognizes an epitope of Hsp70 that is exclusively present on...

journal_title：Cancer research

authors： Stangl S,Varga J,Freysoldt B,Trajkovic-Arsic M,Siveke JT,Greten FR,Ntziachristos V,Multhoff G

更新日期：2014-12-01 00:00:00

abstract：:FOXP3 is inactivated in breast cancer cells by a number of mechanisms, including somatic mutations, deletion, and epigenetic silencing. Because the mutation and deletion are usually heterozygous in the cancer samples, it is of interest to determine whether the gene can be induced for the purpose of cancer therapy. Her...

journal_title：Cancer research

authors： Liu Y,Wang Y,Li W,Zheng P,Liu Y

更新日期：2009-07-15 00:00:00

abstract：:Despite their extensive clinical and pathologic heterogeneity, all malignant germ cell tumors (GCT) are thought to originate from primordial germ cells. However, no common biological abnormalities have been identified to date. We profiled 615 microRNAs (miRNA) in pediatric malignant GCTs, controls, and GCT cell lines ...

journal_title：Cancer research

authors： Palmer RD,Murray MJ,Saini HK,van Dongen S,Abreu-Goodger C,Muralidhar B,Pett MR,Thornton CM,Nicholson JC,Enright AJ,Coleman N,Children's Cancer and Leukaemia Group.

更新日期：2010-04-01 00:00:00

abstract：:Recently, we have shown that prostate epithelium-specific deficiency for p53 and Rb tumor suppressors leads to metastatic cancer, exhibiting features of both luminal and neuroendocrine differentiation. Using stage-by-stage evaluation of carcinogenesis in this model, we report that all malignant neoplasms arise from th...

journal_title：Cancer research

authors： Zhou Z,Flesken-Nikitin A,Nikitin AY

更新日期：2007-06-15 00:00:00

abstract：:The laminin alpha5 chain is a component of laminin-10 (alpha5beta1gamma1) and -11 (alpha5beta2gamma1). In this study, we have screened 113 overlapping synthetic peptides from the laminin alpha5 globular domain (G-domain) for cell attachment activity with B16-F10 cells using peptide-coated dishes. Eleven attachment-act...

journal_title：Cancer research

authors： Hibino S,Shibuya M,Engbring JA,Mochizuki M,Nomizu M,Kleinman HK

更新日期：2004-07-15 00:00:00

abstract：:Smoking prevention will decrease lung cancer incidence in time. However, early detection would improve lung cancer prognosis in subjects at risk provided that specific markers could be identified. We previously reported that retinoic acid receptor (RAR) and retinoid X receptor (RXR) expression was altered in lung tumo...

journal_title：Cancer research

authors： Martinet N,Alla F,Farré G,Labib T,Drouot H,Vidili R,Picard E,Gaube MP,Le Faou D,Siat J,Borelly J,Vermylen P,Bazarbachi T,Vignaud JM,Martinet Y

更新日期：2000-06-01 00:00:00

abstract：:The formation of 7-(2-hydroxyethyl)guanine (7-HEG) in DNA of target and nontarget tissues was investigated in male B6C3F1 mice (20/group) and F344 rats (10/group) exposed to 0, 3, 10, 33, 100, or 300 (rats only) ppm ethylene oxide (ETO) by inhalation for 6 h/day for 4 weeks (5 days/week) and mice exposed to 100 ppm ET...

journal_title：Cancer research

authors： Walker VE,Fennell TR,Upton PB,Skopek TR,Prevost V,Shuker DE,Swenberg JA

更新日期：1992-08-15 00:00:00

abstract：:Salvage of preformed nucleosides requires transport across the plasma membrane by sodium-dependent (concentrative) and sodium-independent (equilibrative) mechanisms. These transport systems are also the route of cellular uptake for nucleoside analogues, including gemcitabine (2',2'-difluorodeoxycytidine), a deoxycytid...

journal_title：Cancer research

authors： Rauchwerger DR,Firby PS,Hedley DW,Moore MJ

更新日期：2000-11-01 00:00:00

abstract：:Prognostic tests for patients with early-stage lung cancer may provide needed guidance on postoperative surveillance and therapeutic decisions. We used a novel strategy to develop and validate a prognostic classifier for early-stage lung cancer. Specifically, we focused on 42 genes with roles in lung cancer or cancer ...

journal_title：Cancer research

authors： Akagi I,Okayama H,Schetter AJ,Robles AI,Kohno T,Bowman ED,Kazandjian D,Welsh JA,Oue N,Saito M,Miyashita M,Uchida E,Takizawa T,Takenoshita S,Skaug V,Mollerup S,Haugen A,Yokota J,Harris CC

更新日期：2013-07-01 00:00:00

abstract：:Identification of factors that mediate visceral and bone metastatic spread and subsequent bone remodeling events is highly relevant to successful therapeutic intervention in advanced human prostate cancer. TBX2, a T-box family transcription factor that negatively regulates cell-cycle inhibitor p21, plays critical role...

journal_title：Cancer research

authors： Nandana S,Tripathi M,Duan P,Chu CY,Mishra R,Liu C,Jin R,Yamashita H,Zayzafoon M,Bhowmick NA,Zhau HE,Matusik RJ,Chung LW

更新日期：2017-03-15 00:00:00

abstract：:Human enhancer of filamentation 1 (HEF1; also known as NEDD9 or Cas-L) is a scaffolding protein that is implicated in regulating diverse cellular processes, such as cellular attachment, motility, cell cycle progression, apoptosis, and inflammation. Here, we identify HEF1 as a novel hypoxia-inducible factor-1alpha (HIF...

journal_title：Cancer research

authors： Kim SH,Xia D,Kim SW,Holla V,Menter DG,Dubois RN

更新日期：2010-05-15 00:00:00

abstract：:Successful chemotherapy accounts for both tumor-related factors and host immune response. Compelling evidence suggests that some chemotherapeutic agents can induce an immunogenic type of cell death stimulating tumor-specific immunity. Here, we show that cyclophosphamide (CTX) exerts two types of actions relevant for t...

journal_title：Cancer research

authors： Schiavoni G,Sistigu A,Valentini M,Mattei F,Sestili P,Spadaro F,Sanchez M,Lorenzi S,D'Urso MT,Belardelli F,Gabriele L,Proietti E,Bracci L

更新日期：2011-02-01 00:00:00