Abstract：
:We analyzed the epidermal growth factor receptor gene using a complementary DNA probe of the epidermal growth factor receptor gene in 21 uncultured primary breast carcinomas and found that the gene was amplified in three of these tumors. We further demonstrated by immunohistochemistry using a monoclonal antibody to the epidermal growth factor receptor that the receptor protein product of this gene was overexpressed and displayed elevated kinase activity. Our data indicate that one of the molecular mechanisms for overexpression of epidermal growth factor receptor in human breast cancer is epidermal growth factor receptor gene amplification without rearrangement in a subset of tumors.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Ro J,North SM,Gallick GE,Hortobagyi GN,Gutterman JU,Blick Msubject
Has Abstractpub_date
1988-01-01 00:00:00pages
161-4issue
1eissn
0008-5472issn
1538-7445journal_volume
48pub_type
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