DNA fingerprinting of 7,12-dimethylbenz[a]anthracene-induced and spontaneous CD-1 mouse liver tumors.

abstract：:We describe two flow cytometric assays performed on populations of cells which have been stained with various fluorescent tracer molecules by the scrape-loading technique. One assay uses a simple one-color analysis on a flow cytometer by quantitating the fluorescence intensity of scrape-loaded lucifer yellow CH (LY) i...

journal_title：Cancer research

authors： Kavanagh TJ,Martin GM,el-Fouly MH,Trosko JE,Chang CC,Rabinovitch PS

更新日期：1987-11-15 00:00:00

abstract：:Herpesvirus saimiri (HVS) was propagated in vero cells for 3 passages at 39 degrees and cloned 3 times at 34 degrees. This virus was inoculated into cotton-topped marmoset and squirrel monkeys; all inoculated monkeys became infected as HVS was reisolated after their circulating lymphocytes were cultured with vero cell...

journal_title：Cancer research

authors： Falk L,Wright J,Deinhardt F,Wolfe L,Schaffer P,Benyesh-Melnick M

更新日期：1976-02-01 00:00:00

abstract：:Smoking prevention will decrease lung cancer incidence in time. However, early detection would improve lung cancer prognosis in subjects at risk provided that specific markers could be identified. We previously reported that retinoic acid receptor (RAR) and retinoid X receptor (RXR) expression was altered in lung tumo...

journal_title：Cancer research

authors： Martinet N,Alla F,Farré G,Labib T,Drouot H,Vidili R,Picard E,Gaube MP,Le Faou D,Siat J,Borelly J,Vermylen P,Bazarbachi T,Vignaud JM,Martinet Y

更新日期：2000-06-01 00:00:00

abstract：:The human papillomavirus type 16 (HPV-16), the type most often associated with cervical cancer, immortalizes primary keratinocytes and inhibits serum/calcium-stimulated differentiation in culture. In this study, we have used a model of keratinocyte immortalization based upon HPV-16 to analyze perturbation of function ...

journal_title：Cancer research

authors： Wilding J,Vousden KH,Soutter WP,McCrea PD,Del Buono R,Pignatelli M

更新日期：1996-11-15 00:00:00

abstract：:Tumor graft models (also known as patient-derived xenografts or PDX) are based on the transfer of primary tumors directly from the patient into an immunodeficient mouse. Because PDX mice are derived from human tumors, they offer a tool for developing anticancer therapies and personalized medicine for patients with can...

journal_title：Cancer research

authors： Siolas D,Hannon GJ

更新日期：2013-09-01 00:00:00

abstract：:The current study is a continuation of our previous work showing that bone marrow activated in interleukin 2 has antitumor and antiviral activity in vitro. The antitumor efficacy of IL-2-activated bone marrow cells in vivo was assessed here. Our results indicated that bone marrow cells activated in IL-2 for 3 days (AB...

journal_title：Cancer research

authors： Agah R,Malloy B,Kerner M,Girgis E,Bean P,Twomey P,Mazumder A

更新日期：1989-11-01 00:00:00

abstract：:Human breast cancers are known to preferentially metastasize to skeletal sites, however, the mechanisms that mediate the skeletal preference (orthotropism) of specific types of cancers remains poorly understood. There is a significant clinical correlation between the expression of bone sialoprotein (BSP) and skeletal ...

journal_title：Cancer research

authors： Barnes GL,Javed A,Waller SM,Kamal MH,Hebert KE,Hassan MQ,Bellahcene A,Van Wijnen AJ,Young MF,Lian JB,Stein GS,Gerstenfeld LC

更新日期：2003-05-15 00:00:00

abstract：:A common single nucleotide polymorphism (SNP), rs6983267, at 8q24.21 has recently been shown to associate with colorectal cancer (CRC). Three independent SNP association studies showed that rs6983267 contributes to CRC with odds ratios (OR) of 1.17 to 1.22. Here, we genotyped a population-based series of 1,042 patient...

journal_title：Cancer research

authors： Tuupanen S,Niittymäki I,Nousiainen K,Vanharanta S,Mecklin JP,Nuorva K,Järvinen H,Hautaniemi S,Karhu A,Aaltonen LA

更新日期：2008-01-01 00:00:00

abstract：:Cancer-secreted, extracellular vesicle (EV)-encapsulated miRNAs enable cancer cells to communicate with each other and with noncancerous cells in tumor pathogenesis and response to therapies. Here, we show that treatment with a sublethal dose of chemotherapeutic agents induces breast cancer cells to secrete EV with th...

journal_title：Cancer research

authors： Shen M,Dong C,Ruan X,Yan W,Cao M,Pizzo D,Wu X,Yang L,Liu L,Ren X,Wang SE

更新日期：2019-07-15 00:00:00

abstract：:Loss of serine or threonine phosphorylation sites from exon 3 of beta-catenin has been identified in approximately half of colorectal tumors which lack adenomatous polyposis coli (APC) mutations, but the overall contribution of beta-catenin mutations to sporadic colorectal tumorigenesis is unclear. We therefore used P...

journal_title：Cancer research

authors： Samowitz WS,Powers MD,Spirio LN,Nollet F,van Roy F,Slattery ML

更新日期：1999-04-01 00:00:00

abstract：:Annexin II mRNA coding for a calcium binding protein was found to be absent in prostate cancer by subtractive hybridization and Northern analysis. In contrast to high expression in normal and benign hyperplastic glandular and basal epithelium, Annexin II heavy (p36) and light (p11) chains in 31/31 prostate cancer spec...

journal_title：Cancer research

authors： Chetcuti A,Margan SH,Russell P,Mann S,Millar DS,Clark SJ,Rogers J,Handelsman DJ,Dong Q

更新日期：2001-09-01 00:00:00

abstract：:In order to elucidate the response of mitochondria to the increase in cellular energy demand after hepatectomy, we have examined the effects of partial hepatectomy and hepatic artery ligation on the energy-transducing system of rat liver mitochondria. Specific content of DNA in the mitochondria increased on the first ...

journal_title：Cancer research

authors： Nagino M,Tanaka M,Nishikimi M,Nimura Y,Kubota H,Kanai M,Kato T,Ozawa T

更新日期：1989-09-01 00:00:00

abstract：:Radioimmunoassay has been used to measure acetylated and deacetylated deoxyguanosine C-8 DNA adducts of 2-acetylaminofluorene in liver and kidney DNA of male Wistar-Furth rats fed a dietary regimen of 0.02 or 0.04% 2-acetylaminofluorene. When adduct formation was monitored during continuous feeding up to 60 days, subs...

journal_title：Cancer research

authors： Poirier MC,True B,Laishes BA

更新日期：1982-04-01 00:00:00

abstract：:While the therapeutic activity of the deoxycytidine analogue decitabine is thought to reflect its ability to reactivate methylation-silenced genes, this agent is also known to trigger p53-dependent DNA damage responses. Here, we report that p53-inducible ribonucleotide reductase (p53R2/RRM2B) is a robust transcription...

journal_title：Cancer research

authors： Link PA,Baer MR,James SR,Jones DA,Karpf AR

更新日期：2008-11-15 00:00:00

abstract：:Two murine monoclonal antibodies, 2H6G5 (IgM) and 4A9E10 (IgG3), were obtained by using either cultured human hepatocellular carcinoma cells (PLC/PRF/5) or the acidic glycolipid mixture prepared from the same cells as immunogens. The antigen in PLC/PRF/5 cell membranes recognized by both antibodies was identified as a...

journal_title：Cancer research

authors： Hiraiwa N,Iida N,Ishizuka I,Itai S,Shigeta K,Kannagi R,Fukuda Y,Imura H

更新日期：1988-12-01 00:00:00

abstract：:The pattern of proliferation of epithelial cells in esophageal epithelium was studied by means of [3H]deoxythymidine labeling of esophageal epithelium in subjects from Huixian, Henan Province, China, a high-risk geographical region for esophageal cancer. Comparisons were made among patterns of cell proliferation obser...

journal_title：Cancer research

authors： Wang LD,Lipkin M,Qui SL,Yang GR,Yang CS,Newmark HL

更新日期：1990-05-01 00:00:00

abstract：:From February 7-11, 2011, the multidisciplinary Lorentz Workshop Circulating Tumor Cell (CTC) Isolation and Diagnostics: Toward Routine Clinical Use was held in Leiden (The Netherlands) to discuss progress and define challenges and potential solutions for development of clinically useful circulating tumor cell (CTC) d...

journal_title：Cancer research

authors： van de Stolpe A,Pantel K,Sleijfer S,Terstappen LW,den Toonder JM

更新日期：2011-09-15 00:00:00

abstract：:3,3',5-Triiodo-L-thyronine (200 microgram/100 g) is shown to be a potent liver parenchymal cell mitogen in the rat, and thyroidectomy is seen to severely inhibit hepatocyte proliferation in regenerating rat liver. Taken together, these observations point to a crucial role for the iodothyronine in liver cell hyperplasi...

journal_title：Cancer research

authors： Short J,Klein K,Kibert L,Ove P

更新日期：1980-07-01 00:00:00

abstract：:Phosphoglucose isomerase/autocrine motility factor (PGI/AMF) is a housekeeping gene product/cytokine that catalyzes a step in glycolysis and gluconeogenesis, and acts as a multifunctional cytokine associated with aggressive tumors. PGI/AMF has been correlated significantly with breast cancer progression and poor progn...

journal_title：Cancer research

authors： Funasaka T,Hogan V,Raz A

更新日期：2009-07-01 00:00:00

abstract：:Thirteen patients with metastatic breast carcinoma were given injections of 50-1593 micrograms of 131I-monoclonal antibody (MAb) B6.2 immunoglobulin G and F(ab')2 for pharmacokinetic evaluation and radioimmunoimaging. Blood clearance of the 131I-MAb-B6.2 was biphasic. The mean half-times (t 1/2 alpha, t 1/2 beta) for ...

journal_title：Cancer research

authors： Hayes DF,Zalutsky MR,Kaplan W,Noska M,Thor A,Colcher D,Kufe DW

更新日期：1986-06-01 00:00:00

abstract：:The influences of pure human pluripotent colony-stimulating factor, highly purified pluripoietin alpha, pure recombinant human tumor necrosis factor alpha, pure recombinant human gamma-interferon, and natural prostaglandin E1 (PGE1) were evaluated on colony formation of multipotential and erythroid progenitor cells in...

journal_title：Cancer research

authors： Lu L,Welte K,Gabrilove JL,Hangoc G,Bruno E,Hoffman R,Broxmeyer HE

更新日期：1986-09-01 00:00:00

abstract：:The in vivo efficacy of the antitumor, immunosuppressive antibiotic mycophenolic acid is known to be limited by its rapid conversion to the biologically inactive 7-0-glucuronide, catalyzed by UDP-glucuronosyl transferase activity, which is widely distributed among normal tissues, including intestinal epithelium. We ha...

journal_title：Cancer research

authors： Franklin TJ,Jacobs V,Jones G,Plé P,Bruneau P

更新日期：1996-03-01 00:00:00

abstract：:Hedgehog (Hh) and transforming growth factor-beta (TGF-beta) family members are involved in numerous overlapping processes during embryonic development, hair cycle, and cancer. Herein, we show that TGF-beta induces the expression of the Hh signaling molecules Gli1 and Gli2 in various human cell types, including normal...

journal_title：Cancer research

authors： Dennler S,André J,Alexaki I,Li A,Magnaldo T,ten Dijke P,Wang XJ,Verrecchia F,Mauviel A

更新日期：2007-07-15 00:00:00

abstract：:Applications of mathematical modeling can improve outcome predictions of cancer therapy. Here we present a kinetic model incorporating effects of radiosensitivity, tumor repopulation, and dead-cell resolving on the analysis of tumor volume regression data of 80 cervical cancer patients (stages 1B2-IVA) who underwent r...

journal_title：Cancer research

authors： Huang Z,Mayr NA,Yuh WT,Lo SS,Montebello JF,Grecula JC,Lu L,Li K,Zhang H,Gupta N,Wang JZ

更新日期：2010-01-15 00:00:00

abstract：:Cytidine dialdehyde inhibited the growth of leukemia L1210 cells in culture at a 50% inhibitory concentration of 3.5 X 10(-5) M and, when administered i.p. at 200 mg/kg daily for 5 days, increased the mean survival of L1210 tumor-bearing mice by up to 171%. Given by the s.c. or i.v. routes, the compound was ineffectiv...

journal_title：Cancer research

authors： Kinahan JJ,Pavelic ZP,Leonard RJ,Bloch A,Grindey GB

更新日期：1980-03-01 00:00:00

abstract：:Microsatellite instability (MSI) is a hallmark of mismatch repair (MMR) deficiency. High levels of MSI at mononucleotide and dinucleotide repeats in colorectal cancer (CRC) are attributed to inactivation of the MMR genes, hMLH1 and hMSH2. CRC with low levels of MSI (MSI-L) exists; however, its molecular basis is uncle...

journal_title：Cancer research

authors： Haugen AC,Goel A,Yamada K,Marra G,Nguyen TP,Nagasaka T,Kanazawa S,Koike J,Kikuchi Y,Zhong X,Arita M,Shibuya K,Oshimura M,Hemmi H,Boland CR,Koi M

更新日期：2008-10-15 00:00:00

abstract：:Proteolysis-inducing factor (PIF) is a sulfated glycoprotein produced by cachexia-inducing tumors, which induces atrophy of skeletal muscle. PIF has been shown to bind specifically with high affinity (K(d), in nanomolar) to sarcolemma membranes from skeletal muscle of both the mouse and the pig, as well as murine myob...

journal_title：Cancer research

authors： Todorov PT,Wyke SM,Tisdale MJ

更新日期：2007-12-01 00:00:00

abstract：:One set of genes sufficient for transformation of primary human cells uses the combination of Ha-Ras-V12, the telomerase catalytic subunit hTERT, SV40 large tumor antigen (LT), and SV40 small tumor antigen (ST). Whereas SV40 LT inactivates the retinoblastoma protein and p53, the contribution of ST is poorly understood...

journal_title：Cancer research

authors： Moreno CS,Ramachandran S,Ashby DG,Laycock N,Plattner CA,Chen W,Hahn WC,Pallas DC

更新日期：2004-10-01 00:00:00

abstract：:Recent reports have variously described expression of Fas ligand (FasL) or its absence in human tumors. The importance of the Fas-FasL mechanism for the immune evasion by tumors provided a strong rationale for the examination of FasL expression and function in squamous cell carcinoma of the head and neck (SCCHN), whic...

journal_title：Cancer research

authors： Gastman BR,Atarshi Y,Reichert TE,Saito T,Balkir L,Rabinowich H,Whiteside TL

更新日期：1999-10-15 00:00:00

abstract：:Renal cell carcinoma is characterized by an accumulation of complex chromosomal alterations during tumor progression. Chromosome 3p deletions are known to occur early in the carcinogenesis, but the nature of subsequent events, their interrelationships, and their sequence is poorly understood, as one usually only obtai...

journal_title：Cancer research

authors： Jiang F,Desper R,Papadimitriou CH,Schäffer AA,Kallioniemi OP,Richter J,Schraml P,Sauter G,Mihatsch MJ,Moch H

更新日期：2000-11-15 00:00:00