Abstract：
:Annexin II mRNA coding for a calcium binding protein was found to be absent in prostate cancer by subtractive hybridization and Northern analysis. In contrast to high expression in normal and benign hyperplastic glandular and basal epithelium, Annexin II heavy (p36) and light (p11) chains in 31/31 prostate cancer specimens were lost immunohistochemically. In glands involved by prostate intraepithelial neoplasia, 65% lost both chains in glandular epithelial cells, whereas basal cells were all positively stained. Southern analysis of cancer DNA showed no noticeable deletion in p36 gene. LNCaP cells treated with 5-azacytidine re-expressed p36, suggesting methylation could be responsible for the silencing.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Chetcuti A,Margan SH,Russell P,Mann S,Millar DS,Clark SJ,Rogers J,Handelsman DJ,Dong Qsubject
Has Abstractpub_date
2001-09-01 00:00:00pages
6331-4issue
17eissn
0008-5472issn
1538-7445journal_volume
61pub_type
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