Abstract：
:Spy1A is a unique cell cycle activator known to mediate cell cycle progression and override the DNA damage response. This study focused on determining the role of this protein on postnatal mammary gland morphogenesis and neoplasia. Herein, we show that Spy1A levels are tightly regulated during mammary gland development and that ectopic expression stimulates precocious development and results in disrupted morphology of the gland. This follows the same trend as the oncogene c-Myc, and we show that Spy1A expression is regulated downstream of c-Myc signaling. Importantly, we show that overexpression of Spy1A accelerates tumorigenesis in vivo. Collectively, this work is the first report that the Spy1/RINGO family of proteins may play an essential role in regulating both normal and abnormal growth processes in the breast.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Golipour A,Myers D,Seagroves T,Murphy D,Evan GI,Donoghue DJ,Moorehead RA,Porter LAdoi
10.1158/0008-5472.CAN-07-6453subject
Has Abstractpub_date
2008-05-15 00:00:00pages
3591-600issue
10eissn
0008-5472issn
1538-7445pii
68/10/3591journal_volume
68pub_type
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