Dose response of hepatocyte replication in rats following continuous exposure to diethylnitrosamine.

abstract：:Identification and reversal of treatment resistance mechanisms of clinically refractory tumor cells is critical for successful cancer therapy. Here we show that ATP-binding cassette member B5 (ABCB5) identifies therapy-refractory tumor cells in colorectal cancer patients following fluorouracil (5-FU)-based chemoradiat...

journal_title：Cancer research

authors： Wilson BJ,Schatton T,Zhan Q,Gasser M,Ma J,Saab KR,Schanche R,Waaga-Gasser AM,Gold JS,Huang Q,Murphy GF,Frank MH,Frank NY

更新日期：2011-08-01 00:00:00

abstract：:Triple-negative breast cancers (TNBC), which include the basal-like and claudin-low disease subtypes, are aggressive malignancies for which effective therapeutic targets are lacking. NF-κB activation has an established role in breast malignancy, and it is higher in TNBC than other breast cancer subtypes. On this basis...

journal_title：Cancer research

authors： Ito-Kureha T,Koshikawa N,Yamamoto M,Semba K,Yamaguchi N,Yamamoto T,Seiki M,Inoue J

更新日期：2015-01-01 00:00:00

abstract：:Aromatase is a key enzyme in intratumoral estrogen production required for the production of estrogens through the conversion of serum androgens in postmenopausal breast cancer patients. There have been, however, controversies regarding the intratumoral localization of aromatase in human breast carcinoma tissues. Ther...

journal_title：Cancer research

authors： Miki Y,Suzuki T,Tazawa C,Yamaguchi Y,Kitada K,Honma S,Moriya T,Hirakawa H,Evans DB,Hayashi S,Ohuchi N,Sasano H

更新日期：2007-04-15 00:00:00

abstract：:Between June 1977 and December 1979, 72 evaluable patients with childhood non-T-cell acute lymphoblastic leukemia were induced into complete remission using vincristine, prednisone, and doxorubicin. All received asparaginase consolidation and central nervous system prophylaxis with cranial irradiation and intrathecal ...

journal_title：Cancer research

authors： Sallan SE,Hitchcock-Bryan S,Gelber R,Cassady JR,Frei E 3rd,Nathan DG

更新日期：1983-11-01 00:00:00

abstract：:Pancreatic neuroendocrine tumors (PanNET) were classified into grades (G) 1 to 3 by the World Health Organization in 2017, but the precise mechanisms of PanNET initiation and progression have remained unclear. In this study, we used a genetically engineered mouse model to investigate the mechanisms of PanNET formation...

journal_title：Cancer research

authors： Yamauchi Y,Kodama Y,Shiokawa M,Kakiuchi N,Marui S,Kuwada T,Sogabe Y,Tomono T,Mima A,Morita T,Matsumori T,Ueda T,Tsuda M,Nishikawa Y,Kuriyama K,Sakuma Y,Ota Y,Maruno T,Uza N,Masuda A,Tatsuoka H,Yabe D,Minamiguc

更新日期：2020-09-01 00:00:00

abstract：:Mice were treated with several different potentially carcinogenic components of tobacco smoke. The chemicals used were: 4-aminobiphenyl and aniline-HCl, which are found in high concentrations in sidestream tobacco smoke; hydrazine sulfate, which is found in high concentrations in mainstream tobacco smoke; and 2-methyl...

journal_title：Cancer research

authors： Sonnenfeld G,Hudgens RW

更新日期：1983-10-01 00:00:00

abstract：:The occurrence of spontaneous skin papillomas in Japanese newts (Cynops pyrrhogaster) from Niigata prefecture in Northern Japan was monitored over four seasons covering a period of 2 years. Of 13,613 newts, 249 were found to possess papillomas. The percentage of newts with papillomas was highest in autumn, ranging fro...

journal_title：Cancer research

authors： Asashima M,Komazaki S,Satou C,Oinuma T

更新日期：1982-09-01 00:00:00

abstract：:Interactions between connective tissue substrates and proteinases localized to the surface of cancer cells are implicated in cancer invasion. In this report we have compared the enrichment of collagen and gelatin degrading activities and cysteine proteinase(s) in well-characterized (enzyme markers and electron microsc...

journal_title：Cancer research

authors： Zucker S,Wieman JM,Lysik RM,Wilkie D,Ramamurthy NS,Golub LM,Lane B

更新日期：1987-03-15 00:00:00

abstract：:An experimental system designed for tracing the estradiol kinetics in target cells by specific antibodies has been applied to human breast cancer. Several major defects of the estradiol receptor mechanism have been demonstrated. The detected changes (lack of cytoplasmic receptors, impaired nuclear transfer of estradio...

journal_title：Cancer research

authors： Nenci I

更新日期：1978-11-01 00:00:00

abstract：:Detailed ultrastructure of a new type of retrovirus (Sm-MTV) released by cultured cells (Sm-MT) of a spontaneous mammary tumor from a house musk shrew Suncus murinus, Insectivora, is described. The virus particles were revealed as three forms: intracellular; budding; and extracellular. The intracellular type A particl...

journal_title：Cancer research

authors： Yamashiro JM,Tsutsui Y,Nagayoshi S,Saga S,Takahashi M,Aoyama A,Hayakawa S,Yokoi T,Oda S,Yokoyama A

更新日期：1986-06-01 00:00:00

abstract：:Gene-targeting studies have shown that Delta-like 4 (Dll4) is required for normal embryonic vascular remodeling, but the mechanisms underlying Dll4 regulatory functions are not well defined. We generated primary human umbilical vascular endothelial cells that express Dll4 protein to study Dll4 function and previously ...

journal_title：Cancer research

authors： Williams CK,Segarra M,Sierra Mde L,Sainson RC,Tosato G,Harris AL

更新日期：2008-03-15 00:00:00

abstract：:Spontaneous tumorigenesis was evaluated in male p53-knockout (p53-/-) mice treated with dehydroepiandrosterone (DHEA), quercetin, d-limonene, or all-trans retinoic acid to determine whether tumor development in these mice can be modulated by cancer-chemopreventive agents. DHEA-treated mice experienced a delay in tumor...

journal_title：Cancer research

authors： Hursting SD,Perkins SN,Haines DC,Ward JM,Phang JM

更新日期：1995-09-15 00:00:00

abstract：:The frequency of H-ras, K-ras, and N-ras mutations and the presence of high-risk human papillomavirus (HPV 16, 18, and 33) DNA were studied in 75 paraffin-embedded specimens obtained from 68 Japanese patients with a variety of prostate carcinomas by using polymerase chain reaction and DNA hybridization with sequence-s...

journal_title：Cancer research

authors： Anwar K,Nakakuki K,Shiraishi T,Naiki H,Yatani R,Inuzuka M

更新日期：1992-11-01 00:00:00

abstract：:Despite the impressive results obtained in animal models, the clinical use of tumor necrosis factor-alpha (TNF) as an anticancer drug is limited by severe toxicity. We have shown previously that targeted delivery of TNF to aminopeptidase N (CD13), a marker of angiogenic vessels, improved the therapeutic index of this ...

journal_title：Cancer research

authors： Curnis F,Gasparri A,Sacchi A,Longhi R,Corti A

更新日期：2004-01-15 00:00:00

abstract：:The sonic hedgehog (SHH) receptor Patched 1 (Ptch1) is critical for embryonic development, and its loss is linked to tumorigenesis. Germ line inactivation of one copy of Ptch1 predisposes to basal cell carcinoma and medulloblastoma in mouse and man. In many cases, medulloblastoma arising from perturbations of Ptch1 fu...

journal_title：Cancer research

authors： Lee Y,Miller HL,Russell HR,Boyd K,Curran T,McKinnon PJ

更新日期：2006-07-15 00:00:00

abstract：:We measured the tissue concentration of human urokinase receptor (uPAR) in 22 breast carcinomas and 9 benign breast lesions using in vitro quantitative autoradiography. Tissue sections were incubated with increasing concentrations of 125I-pro-urokinase in the presence or absence of unlabeled competitor. Breast carcino...

journal_title：Cancer research

authors： Del Vecchio S,Stoppelli MP,Carriero MV,Fonti R,Massa O,Li PY,Botti G,Cerra M,D'Aiuto G,Esposito G

更新日期：1993-07-01 00:00:00

abstract：:Cellular pools of free arachidonic acid are tightly controlled through enzymatic release of the fatty acid and subsequent utilization by downstream enzymes including the cyclooxygenases. Arachidonic acid cleavage from membrane phospholipids is accomplished by the actions of phospholipase A(2) (PLA(2)). Upon release, f...

journal_title：Cancer research

authors： Ilsley JN,Nakanishi M,Flynn C,Belinsky GS,De Guise S,Adib JN,Dobrowsky RT,Bonventre JV,Rosenberg DW

更新日期：2005-04-01 00:00:00

abstract：:The linear chromosomes of vertebrates terminate in telomeres that consist of a tandemly repeated hexameric sequence, 5'TTAGGG3'. Telomeres form a protective loop structure (t-loop), which is thought to prevent them from being recognized as a double-strand break. Approximately 10% of human tumors prevent shortening of ...

journal_title：Cancer research

authors： Fasching CL,Neumann AA,Muntoni A,Yeager TR,Reddel RR

更新日期：2007-08-01 00:00:00

abstract：:Epidermal growth factor receptor vIII (EGFRvIII) is a tumor-specific, ligand-independent, constitutively active variant of the EGFR. Its expression has been detected in gliomas and various other human malignancies. To more fully characterize the function and potential biological role of EGFRvIII in regulating cell pro...

journal_title：Cancer research

authors： Tang CK,Gong XQ,Moscatello DK,Wong AJ,Lippman ME

更新日期：2000-06-01 00:00:00

abstract：:Bortezomib is a proteasome inhibitor with proven efficacy in multiple myeloma and non-Hodgkin's lymphoma. This study reports the effects of bortezomib in B-cell lymphoma cell lines with differing sensitivity to bortezomib to investigate factors that influence sensitivity. Bortezomib induced a time- and concentration-d...

journal_title：Cancer research

authors： Strauss SJ,Higginbottom K,Jüliger S,Maharaj L,Allen P,Schenkein D,Lister TA,Joel SP

更新日期：2007-03-15 00:00:00

abstract：:Risk assessment of dioxins is currently based on induction of liver tumors in rats. The toxicity of dioxins is characterized by large sensitivity differences among animal species and even strains of the same species, which complicates the risk assessment. The significance of these differences in dioxin-induced carcino...

journal_title：Cancer research

authors： Viluksela M,Bager Y,Tuomisto JT,Scheu G,Unkila M,Pohjanvirta R,Flodström S,Kosma VM,Mäki-Paakkanen J,Vartiainen T,Klimm C,Schramm KW,Wärngård L,Tuomisto J

更新日期：2000-12-15 00:00:00

abstract：:Linomide is a p.o. active antiangiogenic agent that has been demonstrated to be effective in suppressing the in vivo growth of rat and human prostatic cancer xenografts. The present studies were conducted to determine whether the angiogenic molecules, vascular endothelial growth factor/vascular permeability factor (VE...

journal_title：Cancer research

authors： Joseph IB,Isaacs JT

更新日期：1997-03-15 00:00:00

abstract：:The degree of heterogeneity among cancer stem cells (CSC) remains ill-defined and may hinder effective anti-CSC therapy. Evaluation of oral cancers for such heterogeneity identified two compartments within the CSC pool. One compartment was detected using a reporter for expression of the H3K4me3 demethylase JARID1B to ...

journal_title：Cancer research

authors： Facompre ND,Harmeyer KM,Sole X,Kabraji S,Belden Z,Sahu V,Whelan K,Tanaka K,Weinstein GS,Montone KT,Roesch A,Gimotty PA,Herlyn M,Rustgi AK,Nakagawa H,Ramaswamy S,Basu D

更新日期：2016-09-15 00:00:00

abstract：:Oncogenic BRAF alleles are both necessary and sufficient for cellular transformation, suggesting that chemical inhibition of the activated mutant protein kinase may reverse the tumor phenotype. Here, we report the characterization of SB-590885, a novel triarylimidazole that selectively inhibits Raf kinases with more p...

journal_title：Cancer research

authors： King AJ,Patrick DR,Batorsky RS,Ho ML,Do HT,Zhang SY,Kumar R,Rusnak DW,Takle AK,Wilson DM,Hugger E,Wang L,Karreth F,Lougheed JC,Lee J,Chau D,Stout TJ,May EW,Rominger CM,Schaber MD,Luo L,Lakdawala AS,Adams JL,

更新日期：2006-12-01 00:00:00

abstract：:FoxP3 is a member of the forkhead family of transcription factors critically involved in the development and function of CD25(+) regulatory T cells (Treg). Until recently, FoxP3 expression was thought to be restricted to the T-cell lineage. However, using immunohistochemistry and flow cytometric analysis of human mela...

journal_title：Cancer research

authors： Ebert LM,Tan BS,Browning J,Svobodova S,Russell SE,Kirkpatrick N,Gedye C,Moss D,Ng SP,MacGregor D,Davis ID,Cebon J,Chen W

更新日期：2008-04-15 00:00:00

abstract：:Thirteen variables were evaluated for their significance in predicting the survival of 148 patients in a retrospective study with clinical Stage I cutaneous malignant melanoma. The variables studied were histological type, tumor thickness, level of invasion, mitotic activity, pigmentation type, existence of ulceration...

journal_title：Cancer research

authors： Hacene K,Le Doussal V,Brunet M,Lemoine F,Guerin P,Hebert H

更新日期：1983-06-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) has been shown to link growth factor signaling and posttranscriptional control of translation of proteins that are frequently involved in cell cycle progression. However, the role of this pathway in cell survival has not been demonstrated. Here, we report that rapamycin, a spec...

journal_title：Cancer research

authors： Hosoi H,Dilling MB,Shikata T,Liu LN,Shu L,Ashmun RA,Germain GS,Abraham RT,Houghton PJ

更新日期：1999-02-15 00:00:00

abstract：:The ability of all-trans-retinoic acid (RA) to modulate the growth and squamous differentiation of four head and neck squamous cell carcinoma cell lines (183, 886, 1483, and SqCC/Y1) was examined, and the relationship of their state of squamous differentiation and RA responsiveness to the expression of cytosolic RA-bi...

journal_title：Cancer research

authors： Zou CP,Clifford JL,Xu XC,Sacks PG,Chambon P,Hong WK,Lotan R

更新日期：1994-10-15 00:00:00

abstract：:It has been postulated that the expression of the ribonucleoprotein telomerase is necessary to overcome cellular senescence and that malignant tumors must express telomerase to maintain their immortality. In most human adult tissues, telomerase activity is not detected. In contrast, several murine tissues express vari...

journal_title：Cancer research

authors： Bednarek A,Budunova I,Slaga TJ,Aldaz CM

更新日期：1995-10-15 00:00:00

abstract：:Estrogen receptor α (ERα) is a key regulator of breast growth and breast cancer development. Here, we report how ERα impacts these processes by reprogramming metabolism in malignant breast cells. We employed an integrated approach, combining genome-wide mapping of chromatin-bound ERα with estrogen-induced transcript a...

journal_title：Cancer research

authors： Jia M,Andreassen T,Jensen L,Bathen TF,Sinha I,Gao H,Zhao C,Haldosen LA,Cao Y,Girnita L,Moestue SA,Dahlman-Wright K

更新日期：2016-10-01 00:00:00