Prognostic index for clinical Stage I cutaneous malignant melanoma.

abstract：:Homozygous deletion of the methylthioadenosine phosphorylase (MTAP) gene is a frequent event in a wide variety of human cancers and is a possible molecular target for therapy. One potential therapeutic strategy to target MTAP-deleted tumors involves combining toxic purine analogues such as 6'-thioguanine (6TG) or 2'-f...

journal_title：Cancer research

authors： Tang B,Lee HO,An SS,Cai KQ,Kruger WD

更新日期：2018-08-01 00:00:00

abstract：:Similarly to p53, p73alpha and p73beta induce growth arrest and/or apoptosis in response to DNA damage or when exogenously expressed. However, how they trigger apoptosis remains unresolved. After stable transduction of either p73alpha or p73beta, a greater apoptotic response was observed for p73beta in both primary an...

journal_title：Cancer research

authors： Gonzalez S,Perez-Perez MM,Hernando E,Serrano M,Cordon-Cardo C

更新日期：2005-03-15 00:00:00

abstract：:Exposures to carcinogens present in the diet, in cigarette smoke, or in the environment have been associated with increased risk of bladder and colorectal cancer. The aromatic amines and their metabolites, a class of carcinogen implicated in these exposures, can be N- or O-acetylated by the NAT1 and NAT2 enzymes. Acet...

journal_title：Cancer research

authors： Bell DA,Badawi AF,Lang NP,Ilett KF,Kadlubar FF,Hirvonen A

更新日期：1995-11-15 00:00:00

abstract：:Cervical cancer develops from precancerous high-grade cervical intraepithelial neoplasia (CIN) harboring a transforming infection with high-risk human papillomavirus, which is characterized by p16(INK4a) overexpression. Once such a lesion has developed, progression toward an invasive squamous cell carcinoma (SCC) may ...

journal_title：Cancer research

authors： Wilting SM,Steenbergen RD,Tijssen M,van Wieringen WN,Helmerhorst TJ,van Kemenade FJ,Bleeker MC,van de Wiel MA,Carvalho B,Meijer GA,Ylstra B,Meijer CJ,Snijders PJ

更新日期：2009-01-15 00:00:00

abstract：:Eighteen-day-old fetal urogenital sinus mesenchyme (UGM), 0-day-old neonatal seminal vesicle mesenchyme (SVM), 0-day-old neonatal bulbourethral gland mesenchyme (BUG-M), and 3-day-old neonatal urinary bladder mesenchyme (BLM) were isolated from rats and combined in vitro with 0.5-mm cubes of the R3327 androgen-depende...

journal_title：Cancer research

authors： Hayashi N,Cunha GR,Wong YC

更新日期：1990-08-01 00:00:00

abstract：:Germ-line p53 mutations have been identified in most families with Li-Fraumeni syndrome (LFS). For germ-line p53 mutation carriers, there is considerable variability with respect to age of cancer onset and tumor type, suggesting that additional genetic effects influence the clinical severity and tumor spectrum. To ide...

journal_title：Cancer research

authors： Wu CC,Shete S,Amos CI,Strong LC

更新日期：2006-08-15 00:00:00

abstract：:We have developed a model system for assessing the demethylating potential of external agents. Disruption in the DNA methylation pattern was evaluated at the translational level of the Escherichia coli beta-galactosidase coding gene (lacZ). We have constructed a clonal cell line (A4/4 cells) derived from the adenoviru...

journal_title：Cancer research

authors： Biard DS,Maratrat M,Thybaud V,Melcion C,Sarasin A

更新日期：1992-10-01 00:00:00

abstract：:Between June 1977 and December 1979, 72 evaluable patients with childhood non-T-cell acute lymphoblastic leukemia were induced into complete remission using vincristine, prednisone, and doxorubicin. All received asparaginase consolidation and central nervous system prophylaxis with cranial irradiation and intrathecal ...

journal_title：Cancer research

authors： Sallan SE,Hitchcock-Bryan S,Gelber R,Cassady JR,Frei E 3rd,Nathan DG

更新日期：1983-11-01 00:00:00

abstract：:Cancer metastasis is a leading cause of cancer morbidity and mortality. More needs to be learned about mechanisms that control this process. In particular, the role of chemokine receptors in metastasis remains controversial. Here, using a highly metastatic breast cancer (4T1) model, we show that lung metastasis is a f...

journal_title：Cancer research

authors： Olkhanud PB,Baatar D,Bodogai M,Hakim F,Gress R,Anderson RL,Deng J,Xu M,Briest S,Biragyn A

更新日期：2009-07-15 00:00:00

abstract：:We recently reported trophic response of transplantable mouse colon cancer cells (MC-26) to pentagastrin, in vivo, and demonstrated gastrin receptors on MC-26 cells, in vitro. In the present study, growth of MC-26 cells in mice, in response to pentagastrin, was studied in relation to binding kinetics and capacity of g...

journal_title：Cancer research

authors： Singh P,Walker JP,Townsend CM Jr,Thompson JC

更新日期：1986-04-01 00:00:00

abstract：:The signaling pathways that mediate the development of pancreatic ductal adenocarcinoma (PDAC) downstream of mutant Kras remain incompletely understood. Here, we focus on ribosomal protein S6 (rpS6), an mTOR effector not implicated previously in cancer. Phosphorylation of rpS6 was increased in pancreatic acinar cells ...

journal_title：Cancer research

authors： Khalaileh A,Dreazen A,Khatib A,Apel R,Swisa A,Kidess-Bassir N,Maitra A,Meyuhas O,Dor Y,Zamir G

更新日期：2013-03-15 00:00:00

abstract：:Isoprenoid inhibitors are being evaluated as agents for the treatment of cancer. Their antitumor activity is attributed to inhibition of post-translational modification of Ras, which is crucial for its translocation and attachment to the plasma membrane, and ultimate involvement in signal transduction. However, whethe...

journal_title：Cancer research

authors： Efuet ET,Keyomarsi K

更新日期：2006-01-15 00:00:00

abstract：:Growing epidemiologic evidence supports chronic inflammation as a mechanism of ovarian carcinogenesis. An association between a circulating marker of inflammation, C-reactive protein (CRP), and ovarian cancer risk has been consistently observed, yet, potential heterogeneity of this association by tumor and patient cha...

journal_title：Cancer research

authors： Peres LC,Mallen AR,Townsend MK,Poole EM,Trabert B,Allen NE,Arslan AA,Dossus L,Fortner RT,Gram IT,Hartge P,Idahl A,Kaaks R,Kvaskoff M,Magliocco AM,Merritt MA,Quirós JR,Tjonneland A,Trichopoulou A,Tumino R,van Gils

更新日期：2019-10-15 00:00:00

abstract：:The p27 tumor suppressor negatively regulates G1 cell cycle progression. However, human malignancies rarely select for deletion/inactivation of p27, a hallmark of tumor suppressor genes. Instead, p27 is degraded or relocalized to the cytoplasm in aggressive malignancies, supporting the notion that p27 sequestration fr...

journal_title：Cancer research

authors： Denicourt C,Saenz CC,Datnow B,Cui XS,Dowdy SF

更新日期：2007-10-01 00:00:00

abstract：:The protein tyrosine phosphatase gamma (PTP gamma) gene has recently been suggested as a candidate tumor suppressor gene involved in the oncogenesis of human lung and renal cancers, although no direct evidence for PTP gamma mutations has been demonstrated thus far. We explored the status of PTP gamma in 31 human lung ...

journal_title：Cancer research

authors： Tsukamoto T,Takahashi T,Ueda R,Hibi K,Saito H,Takahashi T

更新日期：1992-06-15 00:00:00

abstract：:The inhibition of dihydrofolate reductase from L1210 leukemia cells as well as the inhibition of intact L1210 cells, both sensitive and resistant, to methotrexate by over 100, 4,6-diamino-2,2-dihydro-2,2-dimethyl-1-(X-phenyl)-s-triazines was studied. Quantitative structure-activity relationships were derived for the t...

journal_title：Cancer research

authors： Selassie CD,Strong CD,Hansch C,Delcamp TJ,Freisheim JH,Khwaja TA

更新日期：1986-02-01 00:00:00

abstract：:High levels of anti-phosphatidylinositol (PtdIns) autoantibodies (autoAb) have been previously described in sera of cancer patients and in plasma of dimethylbenzanthracene-treated female Sprague-Dawley rats. The presence of anti-PtdIns autoAb was tested in a model of highly malignant sarcomas induced by a single dose ...

journal_title：Cancer research

authors： Faiderbe S,Chagnaud JL,Geffard M

更新日期：1992-05-15 00:00:00

abstract：:Immune effector cells integrate signals that define the nature and magnitude of the subsequent response. Experimental measures for immune cell-mediated lysis of tumors or virally infected targets rely on average responses of permeability or apoptotic changes within a population of targets. Here, we examined individual...

journal_title：Cancer research

authors： Buchser WJ,Laskow TC,Pavlik PJ,Lin HM,Lotze MT

更新日期：2012-06-15 00:00:00

abstract：:Induction of an apoptotic cell death was studied in a mouse T-cell hybridoma. Apoptosis was induced in these cells following exposure to dexamethasone, X-radiation, 43 degrees C heat shock, A254 light, and hydrogen peroxide. In 5-Gy-exposed cells, a radiation-induced G2 phase cell cycle progression block was maximum b...

journal_title：Cancer research

authors： Warters RL

更新日期：1992-02-15 00:00:00

abstract：:Tumor-associated macrophages (TAM) are a major inflammatory infiltrate in tumors and a major component of the protumor function of inflammation. TAM in established tumors generally have an M2 phenotype with defective production of interleukin-12 (IL-12) and high IL-10. Here, we report that defective responsiveness of ...

journal_title：Cancer research

authors： Saccani A,Schioppa T,Porta C,Biswas SK,Nebuloni M,Vago L,Bottazzi B,Colombo MP,Mantovani A,Sica A

更新日期：2006-12-01 00:00:00

abstract：:Cancer is a complex disorder extremely dependent on its microenvironment and highly regulated by multiple intracellular and extracellular stimuli. Studies show that reactive oxygen and nitrogen species (RONS) play key roles in cancer initiation and progression. Accumulation of RONS caused by imbalance between RONS gen...

journal_title：Cancer research

authors： Moldogazieva NT,Lutsenko SV,Terentiev AA

更新日期：2018-11-01 00:00:00

abstract：:Cell-cycle inhibition has yet to offer a generally effective approach to cancer treatment, but a full evaluation of different combinations of cell-cycle inhibitors has not been evaluated. Cyclin A2, a core component of the cell cycle, is often aberrantly expressed in cancer where it may impact cell proliferation. In t...

journal_title：Cancer research

authors： Gopinathan L,Tan SL,Padmakumar VC,Coppola V,Tessarollo L,Kaldis P

更新日期：2014-07-15 00:00:00

abstract：:The N-myc gene is transiently expressed during normal embryonic development and abnormally expressed in several tumors of neuroendocrine origin. Little is known of the function of the N-myc gene product in either normal or neoplastic tissue. We utilized synthetic antisense oligodeoxynucleotides to specifically inhibit...

journal_title：Cancer research

authors： Rosolen A,Whitesell L,Ikegaki N,Kennett RH,Neckers LM

更新日期：1990-10-01 00:00:00

abstract：:Previous studies have identified RRR-alpha-tocopheryl succinate (vitamin E succinate, VES) as a potential chemotherapeutic agent. VES induces human breast cancer cells to undergo apoptosis in a concentration- and time-dependent manner by restoring transforming growth factor beta (TGF-beta) and Fas (CD95) apoptotic sig...

journal_title：Cancer research

authors： Yu W,Sanders BG,Kline K

更新日期：2003-05-15 00:00:00

abstract：:The effect of different preparative procedures for electron microscopy on the size and shape of murine oncornaviruses has been studied. With conventional negative staining procedures using neutral sodium phosphotungstate, both murine mammary tumor virus and murine leukemia virus appeared in head-and-tail forms, with a...

journal_title：Cancer research

authors： Sarkar NH,Manthey WJ,Sheffield JB

更新日期：1975-03-01 00:00:00

abstract：:Multidrug-resistant cells are thought to maintain low intracellular cytotoxic drug concentration though the active efflux of drugs across the cell membrane. It is presently believed that P-glycoprotein mediates this energy-dependent drug efflux by interacting directly with various lipophilic compounds. In this report,...

journal_title：Cancer research

authors： Zordan-Nudo T,Ling V,Liu Z,Georges E

更新日期：1993-12-15 00:00:00

abstract：:Stromal-epithelial interactions and the bioactive molecules produced by these interactions maintain tissue homeostasis and influence carcinogenesis. Bioactive prostaglandins produced by prostaglandin synthases and secreted by the prostate into seminal plasma are thought to support reproduction, but their endogenous ef...

journal_title：Cancer research

authors： Kim J,Yang P,Suraokar M,Sabichi AL,Llansa ND,Mendoza G,Subbarayan V,Logothetis CJ,Newman RA,Lippman SM,Menter DG

更新日期：2005-07-15 00:00:00

abstract：:The s.c. administration of gamma-L-glutaminyl-4-hydroxybenzene (GHB) to neonatal black mice produced a prompt, generalized, and selective swelling and lysis of the melanocytes of the hair follicles. The findings indicate that this cytotoxic effect was dependent upon the intracellular activation of GHB by tyrosinase. S...

journal_title：Cancer research

authors： Burger PC,Kemper LA,Vogel FS

更新日期：1979-05-01 00:00:00

abstract：:N-2-(Diethylaminoethyl)-9-hydroxyellipticinium chloride (DHE) is a structural analogue of ellipticine that is currently a leading compound for clinical trials. We have investigated the mechanism of DNA damage by this compound in murine L1210 leukemia cells using the method of alkaline elution. Although DHE was about 1...

journal_title：Cancer research

authors： Djuric Z,Everett CK,Valeriote FA

更新日期：1992-03-15 00:00:00

abstract：:This is the first report on estrogen-dependent growth of human-derived colon carcinoma cells. Under selected conditions, growth of subconfluent Caco-2 cells is triggered by estradiol. Cell growth is estradiol concentration dependent, with maximal effect occurring at about 0.4 nM. Growth is prevented by two different a...

journal_title：Cancer research

authors： Di Domenico M,Castoria G,Bilancio A,Migliaccio A,Auricchio F

更新日期：1996-10-01 00:00:00