Modulation by retinoic acid (RA) of squamous cell differentiation, cellular RA-binding proteins, and nuclear RA receptors in human head and neck squamous cell carcinoma cell lines.

abstract：:The frequency of H-ras, K-ras, and N-ras mutations and the presence of high-risk human papillomavirus (HPV 16, 18, and 33) DNA were studied in 75 paraffin-embedded specimens obtained from 68 Japanese patients with a variety of prostate carcinomas by using polymerase chain reaction and DNA hybridization with sequence-s...

journal_title：Cancer research

authors： Anwar K,Nakakuki K,Shiraishi T,Naiki H,Yatani R,Inuzuka M

更新日期：1992-11-01 00:00:00

abstract：:The human nm23 gene, a candidate metastatic suppressor gene, consists of two genes, nm23-H1 and nm23-H2. The potential mutation in the nm23-H1 gene was examined in colorectal cancer using a reverse transcription polymerase chain reaction amplification followed by DNA sequencing analysis. Genomic alterations in the nm2...

journal_title：Cancer research

authors： Wang L,Patel U,Ghosh L,Chen HC,Banerjee S

更新日期：1993-02-15 00:00:00

abstract：:Spy1A is a unique cell cycle activator known to mediate cell cycle progression and override the DNA damage response. This study focused on determining the role of this protein on postnatal mammary gland morphogenesis and neoplasia. Herein, we show that Spy1A levels are tightly regulated during mammary gland developmen...

journal_title：Cancer research

authors： Golipour A,Myers D,Seagroves T,Murphy D,Evan GI,Donoghue DJ,Moorehead RA,Porter LA

更新日期：2008-05-15 00:00:00

abstract：:Reactive oxygen species play a critical role in the onset of apoptosis induced by various extracellular stimuli, including ionizing radiation. Therefore active regulation of reactive oxygen species-metabolizing enzymes may be one response to an apoptotic stimulus. In this regard, HP100 cells, H(2)O(2)-resistant varian...

journal_title：Cancer research

authors： Nenoi M,Ichimura S,Mita K,Yukawa O,Cartwright IL

更新日期：2001-08-01 00:00:00

abstract：:Angiogenesis is essential for tumor growth and metastasis. It is regulated by numerous angiogenic factors, one of the most important being vascular endothelial growth factor (VEGF). Recently VEGF-B and VEGF-C, two new VEGF family members, have been identified that bind to the tyrosine kinase receptors flt-1 (VEGFR1), ...

journal_title：Cancer research

authors： Gunningham SP,Currie MJ,Han C,Turner K,Scott PA,Robinson BA,Harris AL,Fox SB

更新日期：2001-04-01 00:00:00

abstract：:Accurate diagnosis of primitive childhood sarcomas continues to be a formidable problem because these malignancies generally demonstrate very little morphological evidence of their tissue of origin. One of these tumor classes, the Ewing's sarcoma family of peripheral primitive neuroectodermal tumors (pPNETs), are thou...

journal_title：Cancer research

authors： Sorensen PH,Shimada H,Liu XF,Lim JF,Thomas G,Triche TJ

更新日期：1995-03-15 00:00:00

abstract：:Retinoids that regulate cell growth, differentiation, and apoptosis have shown promising results in preclinical studies and in a few clinical trials of cancer chemoprevention and therapy. However, the clinical use of retinoids is limited by resistance of certain malignant cells to their antitumor effects and by side e...

journal_title：Cancer research

authors： Chun KH,Benbrook DM,Berlin KD,Hong WK,Lotan R

更新日期：2003-07-01 00:00:00

abstract：:Mutagenesis of protooncogenes has been postulated to contribute to the initiation and progression of human cancer. Activating mutations in the H-ras gene are predominantly single-base substitutions and are most frequently identified at codons 12, 13, and 61. We have analyzed the effects of DNA sequence context at spec...

journal_title：Cancer research

authors： Hoffmann JS,Fry M,Ji J,Williams KJ,Loeb LA

更新日期：1993-06-15 00:00:00

abstract：:Treatment of mice and rats with the adrenal steroid, dehydroepiandrosterone (DHEA), protects against spontaneous and chemically induced tumors. The mechanism of the chemopreventive action of DHEA, however, remains uncertain. DHEA has been reported to inhibit cholesterol biosynthesis. Mevalonic acid constitutes the bas...

journal_title：Cancer research

authors： Schulz S,Nyce JW

更新日期：1991-12-15 00:00:00

abstract：:Proteasomal degradation of p53 by human papilloma virus (HPV) E6 oncoprotein plays a pivotal role in the survival of cervical carcinoma cells. Abrogation of HPV-E6-dependent p53 destruction can therefore be a good strategy to combat cervical carcinomas. Here, we show that a small-molecule reactivation of p53 and induc...

journal_title：Cancer research

authors： Zhao CY,Szekely L,Bao W,Selivanova G

更新日期：2010-04-15 00:00:00

abstract：:The Notch signaling pathway is required in both nonneoplastic neural stem cells and embryonal brain tumors, such as medulloblastoma, which are derived from such cells. We investigated the effects of Notch pathway inhibition on medulloblastoma growth using pharmacologic inhibitors of gamma-secretase. Notch blockade sup...

journal_title：Cancer research

authors： Fan X,Matsui W,Khaki L,Stearns D,Chun J,Li YM,Eberhart CG

更新日期：2006-08-01 00:00:00

abstract：:Primary cell cultures derived from human skin epithelium metabolized benzo(a)pyrene to three classes of compounds: phenols, quinones, and dihydrodiols. The relative proportions of metabolites varied according to the skin donor but differed from the pattern of metabolites in rat liver microsome preparations. While appr...

journal_title：Cancer research

authors： Fox CH,Selkirk JK,Price FM,Croy RG,Sanford KK,Cottler-Fox M

更新日期：1975-12-01 00:00:00

abstract：:A deletion in an Alu repetitive sequence in the fifth intron of the c-sis gene of meningioma patients was previously described (M. Smidt et al., J. Clin. Invest., 86:1151-1157, 1990). The authors analyzed the structure of this intron in DNA from peripheral blood leukocytes and tumor samples of 86 patients with sporadi...

journal_title：Cancer research

authors： Smidt M,Dumanski JP,Collins VP,Ratner L

更新日期：1991-08-15 00:00:00

abstract：:Plasmin is shown to play a crucial role in many pathophysiologic processes primarily through its ability to degrade extracellular matrix (ECM) and/or mobilizing growth factors that are sequestered in the ECM. Cysteine-rich 61 (CCN1) is a matricellular protein of which expression is up-regulated in cancer and various v...

journal_title：Cancer research

authors： Pendurthi UR,Tran TT,Post M,Rao LV

更新日期：2005-11-01 00:00:00

abstract：:The peptide N-formyl-Met-Leu-Phe stimulates chemotaxis and metastasis in rat Walker carcinosarcoma cells by a receptor-mediated pathway. Since oxygen radical generation follows chemotactic stimulation in leukocytes, we looked for similar responses in the Walker tumor. Upon incubation with 10(-6) M N-formyl-Met-Leu-Phe...

journal_title：Cancer research

authors： Leroyer V,Werner L,Shaughnessy S,Goddard GJ,Orr FW

更新日期：1987-09-15 00:00:00

abstract：:In contrast to methotrexate (MTX) and aminopterin (AMT), the 8-deaza analogues of these antifolates are not substrates for rabbit liver aldehyde oxidase. Since they are not converted to 7-hydroxy derivatives, they have been investigated with regard to their cytotoxicity for CCRF-CEM cells, transport into these cells, ...

journal_title：Cancer research

authors： Kuehl M,Brixner DI,Broom AD,Avery TL,Blakley RL

更新日期：1988-03-15 00:00:00

abstract：:In this report, we describe methods used to analyze the protein composition of sectioned frozen prostatic tissues by two-dimensional gel electrophoresis. Our results show a high degree of homology in two-dimensional electrophoretograms of proteins extracted from frozen sections of malignant prostate glands. Such homol...

journal_title：Cancer research

authors： Guevara J Jr,Herbert BH,Raymond AK,Batsakis JG

更新日期：1986-07-01 00:00:00

abstract：:Resistance of human renal cell carcinoma (RCC) and melanoma to the apoptosis-inducing effects of IFNs was postulated to result from epigenetic silencing of genes by DNA methylation, a common feature of human cancers. To reverse silencing, 5-AZA-deoxycytidine (5-AZA-dC) or selective depletion of DNA methyltransferase 1...

journal_title：Cancer research

authors： Reu FJ,Leaman DW,Maitra RR,Bae SI,Cherkassky L,Fox MW,Rempinski DR,Beaulieu N,MacLeod AR,Borden EC

更新日期：2006-03-01 00:00:00

abstract：:Mutated ras genes are powerful transforming agents in vitro and are found in a wide variety of human tumors in vivo. We characterized the histopathology and p21 protein expression associated with tumorigenesis in line 69 transgenic mice carrying an activated, human c-Ha-ras gene on the Y-chromosome (A. C. Andres, C. A...

journal_title：Cancer research

authors： Nielsen LL,Discafani CM,Gurnani M,Tyler RD

更新日期：1991-07-15 00:00:00

abstract：:beta-Catenin is an ubiquitously expressed cytoplasmic protein that has a crucial role in both cadherin-mediated cell-cell adhesion and as a downstream signaling molecule in the wingless/Wnt pathway. Activating mutations in exon 3 of the beta-catenin gene, at the phosphorylation sites for ubiquitination and degradation...

journal_title：Cancer research

authors： Rashid A,Gao YT,Bhakta S,Shen MC,Wang BS,Deng J,Fraumeni JF Jr,Hsing AW

更新日期：2001-04-15 00:00:00

abstract：:Mean plasma hypoxanthine (Hyp) concentrations determined by high-pressure liquid chromatography were 0.56 microM (range, 0.2 to 1.9 microM) in 16 normal subjects, 0.68 microM (range, 0.1 to 1.1 microM) in 10 untreated acute leukemic subjects, and 0.89 microM (range, 0.3 to 2.6 microM) in 14 solid tumor patients. Despi...

journal_title：Cancer research

authors： Wung WE,Howell SB

更新日期：1984-07-01 00:00:00

abstract：:Patients with human papillomavirus (HPV+)-associated head and neck cancer (HNC) show significantly improved survival outcome compared with those with HPV-negative (HPV-) tumors. Published data examining this difference offers conflicting results to date. We systematically investigated the radiation sensitivity of all ...

journal_title：Cancer research

authors： Kimple RJ,Smith MA,Blitzer GC,Torres AD,Martin JA,Yang RZ,Peet CR,Lorenz LD,Nickel KP,Klingelhutz AJ,Lambert PF,Harari PM

更新日期：2013-08-01 00:00:00

abstract：:The initiation-promotion model for the production of skin tumors in mice has proven useful for studying the influence of nutritional variations on stages in neoplasia. Specifically, restriction in caloric intake or fat level in the diet as well as a supplemental retinoid protect against tumor promotion. In contrast, t...

journal_title：Cancer research

authors： Boutwell RK

更新日期：1983-05-01 00:00:00

abstract：:Female Sprague-Dawley rats were treated at 53 days of age with a single intubation of 7,12-dimethylbenzanthracene (DMBA). Three days after carcinogen treatment, the animals were treated with retinyl acetate (RA) (at 3 dietary levels), hormone inhibition (HI) [tamoxifen (1-rho-beta-dimethylaminoethoxyphenyl-trans-1,2-d...

journal_title：Cancer research

authors： Welsch CW,DeHoog JV

更新日期：1983-02-01 00:00:00

abstract：:The effects of streptozotocin (SZ) and N-nitrosobis(2-oxopropyl)amine (BOP), separately or in combination, on the pancreas, common duct, and gallbladder, all target tissues of BOP, were studied in Syrian golden hamsters. Groups of hamsters were treated with either a single dose (20 mg/kg body weight) of BOP (BOP group...

journal_title：Cancer research

authors： Pour PM,Kazakoff K,Carlson K

更新日期：1990-03-01 00:00:00

abstract：:Cellular interaction with the extracellular milieu plays a significant role in normal biological and pathologic processes. Excessive degradation of basement membrane matrix by proteolytic enzymes is a hallmark of tumor invasion and metastasis, and aspartyl proteinase cathepsin D is implicated as a major contributor to...

journal_title：Cancer research

authors： Khalkhali-Ellis Z,Hendrix MJ

更新日期：2007-04-15 00:00:00

abstract：:Metabolic reprogramming of cancer cells and the tumor microenvironment are emerging as key factors governing tumor growth, metastasis, and response to therapies including immune checkpoint inhibitors. It has been recognized that rapidly proliferating cancer cells, tumor-infiltrating lymphocytes, and vascular endotheli...

journal_title：Cancer research

authors： Ngwa VM,Edwards DN,Philip M,Chen J

更新日期：2019-08-15 00:00:00

abstract：:The cell line AR230 was established from the peripheral blood mononuclear cells of a patient with chronic myeloid leukemia and t(9;22) translocation bearing a variant type of BCR/ABL rearrangement. AR230 expresses a BCR/ABL fusion protein with a molecular mass of 230 kilodaltons (kDa) due to the insertion of 180 amino...

journal_title：Cancer research

authors： Wada H,Mizutani S,Nishimura J,Usuki Y,Kohsaki M,Komai M,Kaneko H,Sakamoto S,Delia D,Kanamaru A

更新日期：1995-07-15 00:00:00

abstract：:To define transcriptional dependencies of triple-negative breast cancer (TNBC), we identified transcription factors highly and specifically expressed in primary TNBCs and tested their requirement for cell growth in a panel of breast cancer cell lines. We found that EN1 (engrailed 1) is overexpressed in TNBCs and its d...

journal_title：Cancer research

authors： Peluffo G,Subedee A,Harper NW,Kingston N,Jovanović B,Flores F,Stevens LE,Beca F,Trinh A,Chilamakuri CSR,Papachristou EK,Murphy K,Su Y,Marusyk A,D'Santos CS,Rueda OM,Beck AH,Caldas C,Carroll JS,Polyak K

更新日期：2019-08-15 00:00:00

abstract：:Eighty-five antibodies recognizing breast cancer-selective antigens were conjugated to ricin toxin A-chain using a disulfide linkage. The cytotoxicities of the resulting immunotoxins were determined on breast cancer cells and normal human fibroblasts. Twenty-four antibodies formed immunotoxins that were toxic to at le...

journal_title：Cancer research

authors： Bjorn MJ,Ring D,Frankel A

更新日期：1985-03-01 00:00:00