Establishment and molecular characterization of a novel leukemic cell line with Philadelphia chromosome expressing p230 BCR/ABL fusion protein.

abstract：:PE-35 mouse monoclonal antibody (MoAb) (IgG1) detecting an epithelial antigen with a molecular weight of 35,000 was characterized serologically. Immunoperoxidase staining and double immunoenzymatic staining showed that PE-35 antigen is predominantly on nonlymphoid cells in the medulla of thymus. By immunoelectron micr...

journal_title：Cancer research

authors： Takahashi T,Ueda R,Nishida K,Namikawa R,Fukami H,Matsuyama M,Masaoka A,Imaizumi M,Takahashi T

更新日期：1988-04-01 00:00:00

abstract：:In L1210 cells in culture, 3-deazaguanine (DG), a relatively new purine analog, was found to inhibit DNA and protein synthesis but not total RNA synthesis. The effect of the drug on protein synthesis was therefore further examined. Polyadenylic acid-containing RNA synthesis was not decreased by DG treatment, suggestin...

journal_title：Cancer research

authors： Rivest RS,Irwin D,Mandel HG

更新日期：1982-10-01 00:00:00

abstract：:L-Histidinol, an analogue of the amino acid L-histidine, has been reported to be able to increase the specificity of 5-fluorouracil (FUra), through both protection of normal tissues at risk and potentiation of leukemic cell killing. It is postulated that this occurs through prevention of the entry of normal cells into...

journal_title：Cancer research

authors： Edelstein MB,Heilbrun LK

更新日期：1988-03-15 00:00:00

abstract：:Helicobacter pylori-induced gastritis is the strongest singular risk factor for gastric adenocarcinoma. Matrix metalloproteinase-7 (MMP-7) is a proteolytic enzyme that can modify the intestinal microbial replicative niche as well as affect tumorigenesis, and H. pylori stimulates expression of MMP-7 in gastric epitheli...

journal_title：Cancer research

authors： Ogden SR,Noto JM,Allen SS,Patel DA,Romero-Gallo J,Washington MK,Fingleton B,Israel DA,Lewis ND,Wilson KT,Chaturvedi R,Zhao Z,Shyr Y,Peek RM Jr

更新日期：2010-01-01 00:00:00

abstract：:We reported previously that 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3], a hormonally active form of vitamin D3, markedly enhanced methylcholanthrene-induced transformation of BALB 3T3 A31-1-1 cells. When the cells were treated with methylcholanthrene (1 microgram/ml) for 72 h and then with 1 alpha,25(OH)2D3 (5...

journal_title：Cancer research

authors： Sasaki K,Chida K,Hashiba H,Kamata N,Abe E,Suda T,Kuroki T

更新日期：1986-02-01 00:00:00

abstract：:Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL, and Mcl-1) is commonly associated with tumor maintenance, progression, and chemoresistance. We previously reported the discovery of ABT-737, a potent, small-molecule Bcl-2 family protein inhibitor. A major limitation of ABT-737 is that it is not or...

journal_title：Cancer research

authors： Tse C,Shoemaker AR,Adickes J,Anderson MG,Chen J,Jin S,Johnson EF,Marsh KC,Mitten MJ,Nimmer P,Roberts L,Tahir SK,Xiao Y,Yang X,Zhang H,Fesik S,Rosenberg SH,Elmore SW

更新日期：2008-05-01 00:00:00

abstract：:In the present study, we examined the role of prolactin and glucocorticoids in regulating bcl-x transcription in mammary epithelial cells. We report that dexamethasone, but not prolactin, induced native bcl-x gene expression in a dose-dependent manner in HC11 cells and enhanced serum-starved HC11 cell survival. This e...

journal_title：Cancer research

authors： Schorr K,Furth PA

更新日期：2000-11-01 00:00:00

abstract：:A rat lung cell population had been treated with benzo(a)pyrene, and a set of different epithelial cell lines was derived from it. These cell lines carried either a wild-type or mutant p53 gene and represented grading states of neoplastic development. We demonstrate here that the cells lacking both wild-type p53 allel...

journal_title：Cancer research

authors： Biard DS,Martin M,Rhun YL,Duthu A,Lefaix JL,May E,May P

更新日期：1994-07-01 00:00:00

abstract：:Migration from the primary tumor is a crucial step in the metastatic cascade. Cells with various degrees of adhesion and motility migrate and are launched into the bloodstream as single circulating tumor cells (CTC) or multicellular CTC clusters. The frequency and size distributions of these clusters have been recentl...

journal_title：Cancer research

authors： Bocci F,Kumar Jolly M,Onuchic JN

更新日期：2019-11-01 00:00:00

abstract：:We previously reported that MX2, a new morpholino anthracycline, showed marked effects on pleiotropic drug-resistant sublines of murine P388 leukemia in vivo as well as in vitro. In this study we examine the in vitro cytotoxicity against pleiotropic drug-resistant sublines of human tumor cell lines. MX2 was effective ...

journal_title：Cancer research

authors： Watanabe M,Komeshima N,Naito M,Isoe T,Otake N,Tsuruo T

更新日期：1991-01-01 00:00:00

abstract：:Low income, poor diet, obesity, and a lack of exercise are interrelated lifestyle factors that can profoundly alter our biologic make up to increase cancer risk, growth, and development. We recently reported a potential mechanistic link between carbohydrate-derived metabolites and cancer, which may provide a biologic ...

journal_title：Cancer research

authors： Turner DP

更新日期：2015-05-15 00:00:00

abstract：:Animal models, particularly mouse models, play a central role in the study of the etiology, prevention, and treatment of human prostate cancer. While tissue culture models are extremely useful in understanding the biology of prostate cancer, they cannot recapitulate the complex cellular interactions within the tumor m...

journal_title：Cancer research

authors： Ittmann M,Huang J,Radaelli E,Martin P,Signoretti S,Sullivan R,Simons BW,Ward JM,Robinson BD,Chu GC,Loda M,Thomas G,Borowsky A,Cardiff RD

更新日期：2013-05-01 00:00:00

abstract：:Natural killer (NK) cells are cytotoxic lymphocytes involved in innate immunity. NK-92, a human NK cell line, may be targeted to tumor-associated antigens in solid malignancies where it exhibits antitumor efficacy, but its clinical utility for treating brain tumors is limited by an inability to cross the blood-brain b...

journal_title：Cancer research

authors： Alkins R,Burgess A,Ganguly M,Francia G,Kerbel R,Wels WS,Hynynen K

更新日期：2013-03-15 00:00:00

abstract：:Treatment of human HL-60 or KG1A leukemia cells with the topoisomerase II inhibitor etoposide resulted in extensive DNA degradation. When DNA integrity was analyzed by agarose gel electrophoresis, a nucleosomal ladder became evident 1.5-2 h after addition of etoposide to cells, increased in intensity over 6 h, and per...

journal_title：Cancer research

authors： Kaufmann SH

更新日期：1989-11-01 00:00:00

abstract：:The concentration of potassium (K+) and sodium (Na+) was measured in breast cyst fluid (BCF) from 611 cysts greater than 3 ml aspirated in 520 women with gross cystic disease of the breast. These women were enrolled, from 1983 on, in a cohort study aimed at assessing the relationship between cyst type, as defined by t...

journal_title：Cancer research

authors： Naldoni C,Costantini M,Dogliotti L,Bruzzi P,Bucchi L,Buzzi G,Torta M,Angeli A

更新日期：1992-04-01 00:00:00

abstract：:The correlation between the clinical outcome in patients with esophageal squamous cell carcinoma and coamplification of the proto-oncogenes int-2 and hst-1, which are partially homologous to angiogenesis-inducing fibroblast growth factor, was analyzed retrospectively. Coamplification of these genes was examined by slo...

journal_title：Cancer research

authors： Kitagawa Y,Ueda M,Ando N,Shinozawa Y,Shimizu N,Abe O

更新日期：1991-03-01 00:00:00

abstract：:The specific activity of cyclic adenosine 3':5'-monophosphate phosphodiesterase was measured in lymphocytes isolated from the blood of normal subjects, from patients with chronic lymphocytic leukemia, and from tonsil tissue. The mean specific activity of cyclic adenosine 3':5'-monophosphate phosphodiesterase in the ly...

journal_title：Cancer research

authors： Scher NS,Quagliata F,Malathi VG,Faig D,Melton RA,Silber R

更新日期：1976-11-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a highly aggressive, heterogeneous disease with poor prognosis and no effective targeted therapies. EGFR is highly expressed in basal-like TNBC and is considered as a potential therapeutic target. However, EGFR targeting exerts only marginal clinical benefits, possibly due to ac...

journal_title：Cancer research

authors： Verma N,Müller AK,Kothari C,Panayotopoulou E,Kedan A,Selitrennik M,Mills GB,Nguyen LK,Shin S,Karn T,Holtrich U,Lev S

更新日期：2017-01-01 00:00:00

abstract：:Recent evidence from our laboratory and from others suggested that pretreatment with alpha-difluoromethylornithine (DFMO) sensitizes some human and rodent tumor cell lines to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Many human tumor cells are resistant to chloroethylnitrosourea-induced DNA interstrand cross-linkin...

journal_title：Cancer research

authors： Seidenfeld J,Barnes D,Block AL,Erickson LC

更新日期：1987-09-01 00:00:00

abstract：:Ligand-induced activation of peroxisome proliferator-activated receptor gamma (PPARgamma) inhibits proliferation in cancer cells in vitro and in vivo; however, the downstream targets remain undefined. We report the identification of a peroxisome proliferator response element in the promoter region of the Na(+)/H(+) tr...

journal_title：Cancer research

authors： Kumar AP,Quake AL,Chang MK,Zhou T,Lim KS,Singh R,Hewitt RE,Salto-Tellez M,Pervaiz S,Clément MV

更新日期：2009-11-15 00:00:00

abstract：:It has previously been shown that 6-nitrochrysene can be activated to electrophilic species capable of reacting with DNA through metabolic pathways that form N-hydroxy-6-aminochrysene or trans-1,2-dihydroxy-1,2-dihydro-6-aminochrysene as critical intermediates. Since the lung is a known target tissue for the carcinoge...

journal_title：Cancer research

authors： Delclos KB,el-Bayoumy K,Casciano DA,Walker RP,Kadlubar FF,Hecht SS,Shivapurkar N,Mandal S,Stoner GD

更新日期：1989-06-01 00:00:00

abstract：:Micropthalmia transcription factor (Mitf) is involved in melanocyte development and differentiation. The current study was undertaken to determine whether there is a relationship between Mitf expression and survival in patients with intermediate-thickness (1.0-4.0 mm) melanoma. Original paraffin blocks or slides of th...

journal_title：Cancer research

authors： Salti GI,Manougian T,Farolan M,Shilkaitis A,Majumdar D,Das Gupta TK

更新日期：2000-09-15 00:00:00

abstract：:8-Chloroadenosine 3',5'-monophosphate has been reported to inhibit growth of various mammalian cell lines at micromolar concentrations. We have used Chinese hamster ovary cell lines with mutated cyclic AMP-dependent protein kinase or altered cyclic nucleotide metabolism to show that a metabolite, 8-chloroadenosine, is...

journal_title：Cancer research

authors： Van Lookeren Campagne MM,Villalba Díaz F,Jastorff B,Kessin RH

更新日期：1991-03-15 00:00:00

abstract：:The effects of transforming growth factor-beta (TGF beta) on a human colon carcinoma cell line (MOSER) were investigated. TGF beta, at low concentrations (between 0.1 and 1.0 ng/ml), inhibited the proliferation of MOSER cells both in monolayer culture and soft agarose, in a dose-dependent manner. MOSER cells adapted t...

journal_title：Cancer research

authors： Hoosein NM,Brattain DE,McKnight MK,Levine AE,Brattain MG

更新日期：1987-06-01 00:00:00

abstract：:Immunophotodiagnosis uses a fluorescence-labeled monoclonal antibody (MAb) that recognizes a tumor-associated antigen to image the fluorescence emitted from the fluorophore-bound MAb that has localized in the tissue. It may be used to diagnose malignant or precancerous lesions, to delineate the margins for tumor resec...

journal_title：Cancer research

authors： Soukos NS,Hamblin MR,Keel S,Fabian RL,Deutsch TF,Hasan T

更新日期：2001-06-01 00:00:00

abstract：:Four hundred and forty-seven human tumor specimens were accessioned and processed for clonogenic assay, yielding 374 specimens, representing 23 different histiotypes, adequate for culture. Different levels of viable cell inoculum density produced contrasting effects between 255 solid tumors as compared to 72 malignant...

journal_title：Cancer research

authors： Page RH,Tilchen EJ,Davis HL

更新日期：1988-07-15 00:00:00

abstract：:The ShcA adaptor protein transduces oncogenic signals downstream of receptor tyrosine kinases. We show here that breast tumors engage the ShcA pathway to increase their metabolism. ShcA signaling enhanced glucose catabolism through glycolysis and oxidative phosphorylation, rendering breast cancer cells critically depe...

journal_title：Cancer research

authors： Im YK,Najyb O,Gravel SP,McGuirk S,Ahn R,Avizonis DZ,Chénard V,Sabourin V,Hudson J,Pawson T,Topisirovic I,Pollak M,St-Pierre J,Ursini-Siegel J

更新日期：2018-09-01 00:00:00

abstract：:Mean plasma hypoxanthine (Hyp) concentrations determined by high-pressure liquid chromatography were 0.56 microM (range, 0.2 to 1.9 microM) in 16 normal subjects, 0.68 microM (range, 0.1 to 1.1 microM) in 10 untreated acute leukemic subjects, and 0.89 microM (range, 0.3 to 2.6 microM) in 14 solid tumor patients. Despi...

journal_title：Cancer research

authors： Wung WE,Howell SB

更新日期：1984-07-01 00:00:00

abstract：:By using the newly developed adhesive tumor cell culture system, we analyzed the chromosomal constitutions of primary lung tumor and nonmalignant normal lung tissue from 10 previously untreated patients with non-small cell lung cancer. Chromosomal analyses were successfully carried out in banded chromosome preparation...

journal_title：Cancer research

authors： Lee JS,Pathak S,Hopwood V,Tomasovic B,Mullins TD,Baker FL,Spitzer G,Neidhart JA

更新日期：1987-12-01 00:00:00

abstract：:15-Lipoxygenase (15-LOX)-2 is expressed in benign prostate secretory cells and benign prostate produces 15S-hydroxyeicosatetraenoic acid (15S-HETE) from exogenous arachidonic acid (AA). In contrast, 15S-LOX-2 and 15S-HETE formation are reduced in prostate carcinoma (Pca). The mechanisms whereby reduced 15-LOX-2 may co...

journal_title：Cancer research

authors： Shappell SB,Gupta RA,Manning S,Whitehead R,Boeglin WE,Schneider C,Case T,Price J,Jack GS,Wheeler TM,Matusik RJ,Brash AR,Dubois RN

更新日期：2001-01-15 00:00:00