Advanced glycation end-products: a biological consequence of lifestyle contributing to cancer disparity.

abstract：:In continuation of earlier studies on murine neoplastic liver lesions, we characterized by histochemical methods the phenotype of hepatocellular adenomas and carcinomas induced by single injections of diethylnitrosamine (1.25, 2.5, or 5.0 micrograms/g of body weight) in 15-day-old C57BL/6 x male C3H F1 mice. The hepat...

journal_title：Cancer research

authors： Hacker HJ,Mtiro H,Bannasch P,Vesselinovitch SD

更新日期：1991-04-01 00:00:00

abstract：:Microbial carboxyl and catechol siderophores have been shown to have natural iron-chelating abilities, suggesting that hyaluronic acid (HA) and the catechol compound, gallic acid (GA), may have iron-coordinating activities. Here, a photoresponsive self-gelling hydrogel that was both injectable and could be applied to ...

journal_title：Cancer research

authors： Ko S,Park JY,Oh YK

更新日期：2019-12-15 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) expand in tumor-bearing hosts and play a central role in cancer immune evasion by inhibiting adaptive and innate immunity. They therefore represent a major obstacle for successful cancer immunotherapy. Different strategies have thus been explored to deplete and/or inactivate MDS...

journal_title：Cancer research

authors： Alizadeh D,Trad M,Hanke NT,Larmonier CB,Janikashvili N,Bonnotte B,Katsanis E,Larmonier N

更新日期：2014-01-01 00:00:00

abstract：:Phospholipase D (PLD) has emerged as a critical regulator of cell proliferation and survival signaling. We show for the first time that elevated expression of PLD isozymes attenuates expression of the tumor suppressors early growth response-1 (Egr-1) and the phosphatase and tensin homologue deleted on chromosome 10 (P...

journal_title：Cancer research

authors： Kim J,Lee YH,Kwon TK,Chang JS,Chung KC,Min DS

更新日期：2006-01-15 00:00:00

abstract：:Systemic delivery of anticancer agents is accompanied by many unwanted side effects that can be mitigated by encapsulation of antineoplastic agents. However, encapsulation necessitates a technique for controlled delivery to the cancerous tissue. We have developed a novel drug delivery system that releases drug from st...

journal_title：Cancer research

authors： Nelson JL,Roeder BL,Carmen JC,Roloff F,Pitt WG

更新日期：2002-12-15 00:00:00

abstract：:The genetic status of cyclin genes was examined in a panel of 47 colorectal carcinoma cell lines. Cyclin D2 was found to be amplified in one tumor and cyclin E in another. In each of the two cases, the amplified cyclin gene was overexpressed at the protein or mRNA level. Cyclin D1, previously shown to be amplified in ...

journal_title：Cancer research

authors： Leach FS,Elledge SJ,Sherr CJ,Willson JK,Markowitz S,Kinzler KW,Vogelstein B

更新日期：1993-05-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) commonly develops resistance to chemotherapy, yet markers predictive of chemoresistance in this disease are lacking. Here, we define WNT10B-dependent biomarkers for β-CATENIN/HMGA2/EZH2 signaling predictive of reduced relapse-free survival. Concordant expression of HMGA2 and EZH2 p...

journal_title：Cancer research

authors： El Ayachi I,Fatima I,Wend P,Alva-Ornelas JA,Runke S,Kuenzinger WL,Silva J,Silva W,Gray JK,Lehr S,Barch HC,Krutilina RI,White AC,Cardiff R,Yee LD,Yang L,O'Regan RM,Lowry WE,Seagroves TN,Seewaldt V,Krum SA,Miranda

更新日期：2019-03-01 00:00:00

abstract：:After many years of productive study on the signaling networks, posttranslational regulatory control of effector molecules remains an intensely investigated and continuously evolving field of research to connect signaling with phenotypic changes. In recent years, there have been intriguing results on the interaction o...

journal_title：Cancer research

authors： Kumar R,Hung MC

更新日期：2005-04-01 00:00:00

abstract：:The structural features of the free prostate-specific antigen (F-PSA) present in human blood have not been clarified up to now, and it is, therefore, not known why F-PSA is not complexed by the protease inhibitors that are present in human blood in large amounts. This lack of information is mainly attributable to the ...

journal_title：Cancer research

authors： Peter J,Unverzagt C,Krogh TN,Vorm O,Hoesel W

更新日期：2001-02-01 00:00:00

abstract：:The metabolic changes in rat hepatoma cell line, AH70 cells, after coculturing with Kupffer cells were visualized using a silicon-intensified target camera and subsequent processing with a computer-assisted digital imaging processor. In cocultured tumor cells, nonactivated Kupffer cells reduced mitochondrial energizat...

journal_title：Cancer research

authors： Kurose I,Miura S,Fukumura D,Yonei Y,Saito H,Tada S,Suematsu M,Tsuchiya M

更新日期：1993-06-01 00:00:00

abstract：:Cachexia is a life-threatening wasting syndrome lacking effective treatment, which arises in many cancer patients. Although ostensibly induced by multiple tumor-produced cytokines (tumorkines), their functional contribution to initiation and progression of this syndrome has proven difficult to determine. In this study...

journal_title：Cancer research

authors： Chen JL,Walton KL,Qian H,Colgan TD,Hagg A,Watt MJ,Harrison CA,Gregorevic P

更新日期：2016-09-15 00:00:00

abstract：:Reduced oxygenation, or hypoxia, inhibits differentiation and facilitates stem cell maintenance. Hypoxia commonly occurs in solid tumors and promotes malignant progression. Hypoxic tumors are aggressive and exhibit stem cell-like characteristics. It remains unclear, however, whether and how hypoxia regulates cancer ce...

journal_title：Cancer research

authors： Kim Y,Lin Q,Zelterman D,Yun Z

更新日期：2009-12-15 00:00:00

abstract：:Published studies of the cancer experiences of children vaccinated with Bacillus Calmette-Guérin in antituberculosis programs were reviewed and the strengths and weaknesses of each evaluated. There is little evidence that vaccination outside of the neonatal period is effective. If there is an effect of neonatal vaccin...

journal_title：Cancer research

authors： Hoover RN

更新日期：1976-02-01 00:00:00

abstract：:Sputum samples obtained during the screening phase of a chemoprevention trial in heavy smokers were evaluated independently by trained cytotechnologists and classified for degree of cellular atypia according to the method of Saccommano et al. (G. Saccommano et al., Cancer (Phila.), 33: 256-270, 1974). The level of agr...

journal_title：Cancer research

authors： Browman GP,Arnold A,Levine MN,D'Souza T,Turner-Smith LM,Cayco R,Johnstone B,Birse R

更新日期：1990-02-15 00:00:00

abstract：:Hexosaminidase activity in prostatic tissue has been compared in 15 patients with benign prostatic hyperplasia and 15 patients with prostatic carcinoma. The ratio of enzymatic activity for the two substrates tested (p-nitrophenyl-2-acetamido-2-deoxy-beta-D-glucopyranoside and p-nitrophenyl-2-acetamido-2-deoxy-beta-D-g...

journal_title：Cancer research

authors： Whitehurst GB,Mashburn JP,Pretlow TG 2nd,Bradley EL Jr,Boohaker EA

更新日期：1982-10-01 00:00:00

abstract：:Mithramycin (MIT) and tolfenamic acid (TA) inhibit the activity of the transcription factor Sp1. In the present study, we investigated whether pancreatic cancer treatment with a combination of these compounds has a synergistic effect on Sp1 activity, tumor growth, and their underlying response mechanisms. Treatment of...

journal_title：Cancer research

authors： Jia Z,Gao Y,Wang L,Li Q,Zhang J,Le X,Wei D,Yao JC,Chang DZ,Huang S,Xie K

更新日期：2010-02-01 00:00:00

abstract：:DNA index and S-phase fraction of 490 primary breast carcinomas were measured by flow cytometry, using paraffin-embedded tissue as a starting point. All patients had involvement of axillary lymph nodes and all were randomized onto one of the Ludwig Breast Cancer Trials I-IV between July 1978 and August 1981. The prese...

journal_title：Cancer research

authors： Hedley DW,Rugg CA,Gelber RD

更新日期：1987-09-01 00:00:00

abstract：:Biomarkers for early detection of epithelial ovarian cancer (EOC) are urgently needed. Patients can generate antibodies to tumor-associated antigens (TAAs). We tested multiplex detection of antibodies to candidate ovarian TAAs and statistical modeling for discrimination of sera of EOC patients and controls. Binding of...

journal_title：Cancer research

authors： Erkanli A,Taylor DD,Dean D,Eksir F,Egger D,Geyer J,Nelson BH,Stone B,Fritsche HA,Roden RB

更新日期：2006-02-01 00:00:00

abstract：:Elastin-like polypeptides (ELPs) composed of a VPGXG repeat undergo a reversible phase transition in aqueous solution. They are hydrophilic and soluble in aqueous solution below their transition temperature (T(t)), but they become hydrophobic and aggregate when the temperature is raised above their T(t). In this study...

journal_title：Cancer research

authors： Raucher D,Chilkoti A

更新日期：2001-10-01 00:00:00

abstract：:Rat R2k rhabdomyosarcoma cells were transfected with the human H-ras oncogene, which resulted in increased resistance to cell kill in vitro by a single dose of 137Cs gamma-rays. A subline carrying one oncogene showed an increase in the quasi-threshold dose (Dq) from 0.88 to 1.48 Gy. Another subline containing six onco...

journal_title：Cancer research

authors： Hermens AF,Bentvelzen PA

更新日期：1992-06-01 00:00:00

abstract：:The sodium iodide symporter (NIS) is a classical iodide pump typically localized within the cell plasma membrane in thyroid cells, where NIS expression is believed to ensure success of mainstay radioiodide therapy in thyroid cancers. Although radioiodide uptake is generally reduced in thyroid cancer tissue, intracellu...

journal_title：Cancer research

authors： Feng F,Yehia L,Ni Y,Chang YS,Jhiang SM,Eng C

更新日期：2018-11-01 00:00:00

abstract：:Forestomach papillomas and skin papillomas were induced very efficiently by a single dose administration of the chemical carcinogen methylnitrosourea (MNU) in transgenic mice (rasH2 line) carrying human hybrid c-Ha-ras genes, which encode the prototype p21 gene product. The incidence of forestomach papillomas was dose...

journal_title：Cancer research

authors： Ando K,Saitoh A,Hino O,Takahashi R,Kimura M,Katsuki M

更新日期：1992-02-15 00:00:00

abstract：:Exposure of tumor cells to cytotoxic agents simultaneously activates a variety of intracellular signaling pathways. Some of these pathways involve enzymes from the protein kinase C (PKC) family of serine/threonine kinases. This family includes isoenzymes that negatively influence cell death, whereas other demonstrate ...

journal_title：Cancer research

authors： Filomenko R,Poirson-Bichat F,Billerey C,Belon JP,Garrido C,Solary E,Bettaieb A

更新日期：2002-03-15 00:00:00

abstract：:Two human B-cell lines carrying a 14;18 chromosome translocation [t(14;18)(q32;q21)], designated FL-218 and FL-318, were established from effusion cells of two Japanese patients manifesting the transformed histology of follicular lymphoma. The FL-218 and FL-318 cell lines were composed of cells in the hyperdiploid ran...

journal_title：Cancer research

authors： Amakawa R,Fukuhara S,Ohno H,Tanabe S,Horii M,Matsuyama F,Kato I,Kakita T,Nagauchi O

更新日期：1990-04-15 00:00:00

abstract：:The retinoblastoma (Rb)-E2F transcriptional regulatory pathway plays a major role in cell-cycle regulation, but its role in invasion and metastasis is less well understood. We find that many genes involved in the invasion of cancer cells, such as matrix metalloproteinases (MMP), have potential E2F-binding sites in the...

journal_title：Cancer research

authors： Johnson JL,Pillai S,Pernazza D,Sebti SM,Lawrence NJ,Chellappan SP

更新日期：2012-01-15 00:00:00

abstract：:Energy restriction (ER) inhibits mammary carcinogenesis and results in a marked reduction in tumor size, effects likely to be explained by ER-mediated induction of apoptosis. The goal of this study was to investigate the molecular mechanism(s) accounting for apoptosis induction. To do this, chemically induced mammary ...

journal_title：Cancer research

authors： Thompson HJ,Zhu Z,Jiang W

更新日期：2004-02-15 00:00:00

abstract：:We identified DD3(PCA3) as one of the most prostate cancer-specific genes at present (M. J. Bussemakers et al. Cancer Res., 59: 5975-5979, 1999). Consequently, DD3(PCA3) is an interesting candidate for use as a diagnostic and/or prognostic marker. In this study we developed a method for the accurate quantification of ...

journal_title：Cancer research

authors： de Kok JB,Verhaegh GW,Roelofs RW,Hessels D,Kiemeney LA,Aalders TW,Swinkels DW,Schalken JA

更新日期：2002-05-01 00:00:00

abstract：:To analyze the humoral immune response to melanoma, human-mouse hybridomas were generated by the fusions of regional lymph node lymphocytes of patients with the mouse myeloma cell line M5. Six stable hybridomas were cloned from six separate lymphocyte parents obtained from three patients. Ascites were obtained from nu...

journal_title：Cancer research

authors： Kan-Mitchell J,Imam A,Kempf RA,Taylor CR,Mitchell MS

更新日期：1986-05-01 00:00:00

abstract：:In a recent study, we showed that the plant alkaloid camptothecin (CPT) and its derivatives 9-nitro-CPT (9NC) and 9-amino-CPT (9AC) inhibit growth of both human melanocytes (MEL cells) and their malignant counterparts, malignant melanoma (BRO) cells in vitro. This growth inhibition was accompanied by an increase in th...

journal_title：Cancer research

authors： Pantazis P,Early JA,Mendoza JT,DeJesus AR,Giovanella BC

更新日期：1994-02-01 00:00:00

abstract：:Emerging evidence indicates the presence of tumor-initiating cells (TIC) or cancer stem cells in osteosarcoma. However, no study has shown specific markers to identify osteosarcoma TICs with in vivo tumor formation ability. Additionally, there has been a lack of investigations gauging the contribution of osteosarcoma ...

journal_title：Cancer research

authors： Adhikari AS,Agarwal N,Wood BM,Porretta C,Ruiz B,Pochampally RR,Iwakuma T

更新日期：2010-06-01 00:00:00