Cellular pharmacology of MX2, a new morpholino anthracycline, in human pleiotropic drug-resistant cells.

abstract：:This report describes an early and direct action of oncogenic agents and its apparent consequences. Chemical carcinogen has been found to interact principally with a specific polypeptide in livers of normal rats. Short-term ingestion of carcinogen causes marked reductions in the concentrations of both the carcinogen:p...

journal_title：Cancer research

authors： Blackburn GR,Andrews JP,Rao KV,Sorof S

更新日期：1980-12-01 00:00:00

abstract：:cis- and trans-diamminedichloroplatinum(II) (PDD) produced a DNA cross-linking effect in mouse leukemia L1210 cells, which was demonstrable after subtoxic treatments with the DNA alkaline elution technique. Cross-linking effects developed following treatments with concentrations as low as 1 micron for cis-PDD and 5 mi...

journal_title：Cancer research

authors： Zwelling LA,Kohn KW,Ross WE,Ewig RA,Anderson T

更新日期：1978-06-01 00:00:00

abstract：:LMO2 is a transcription regulator involved in human T-cell leukemia, including some occurring in X-SCID gene therapy trials, and in B-cell lymphomas and prostate cancer. LMO2 functions in transcription complexes via protein-protein interactions involving two LIM domains and causes a preleukemic T-cell development bloc...

journal_title：Cancer research

authors： Appert A,Nam CH,Lobato N,Priego E,Miguel RN,Blundell T,Drynan L,Sewell H,Tanaka T,Rabbitts T

更新日期：2009-06-01 00:00:00

abstract：:The effects of sodium butyrate, dimethyl sulfoxide (DMSO), and retinoic acid on the growth, morphology, carcinoembryonic antigen content, cell surface membrane-associated enzyme activities, and glycoprotein profiles of a human rectal adenocarcinoma cell line (HRT-18) in culture were compared. All three agents reversib...

journal_title：Cancer research

authors： Tsao D,Morita A,Bella A Jr,Luu P,Kim YS

更新日期：1982-03-01 00:00:00

abstract：:Elevated expression of Bmi-1 is associated with many cancers, including breast cancer. Here, we examined the oncogenic potential of Bmi-1 in MCF10A cells, a spontaneously immortalized, nontransformed strain of human mammary epithelial cells (HMEC). Bmi-1 overexpression alone in MCF10A cells did not result in oncogenic...

journal_title：Cancer research

authors： Datta S,Hoenerhoff MJ,Bommi P,Sainger R,Guo WJ,Dimri M,Band H,Band V,Green JE,Dimri GP

更新日期：2007-11-01 00:00:00

abstract：:The ubiquitin proteasome system is responsible for the proteolysis of important cell cycle and apoptosis-regulatory proteins. In this paper we report that the dipeptidyl proteasome inhibitor, phthalimide-(CH2)8CH-(cyclopentyl) CO-Arg(NO2)-Leu-H (CEP1612), induces apoptosis and inhibits tumor growth of the human lung c...

journal_title：Cancer research

authors： Sun J,Nam S,Lee CS,Li B,Coppola D,Hamilton AD,Dou QP,Sebti SM

更新日期：2001-02-15 00:00:00

abstract：:Neoplasms in fish normally show poor abilities for metastasis, and there are no reports on intestinal cancer with metastasis to other organs. In aquaculture production, carnivorous salmonids in Northern Europe receive commercial feeds with plant ingredients. Such contents have been shown to cause chronic intestinal in...

journal_title：Cancer research

authors： Dale OB,Tørud B,Kvellestad A,Koppang HS,Koppang EO

更新日期：2009-05-15 00:00:00

abstract：:We studied the conditions required for eradication by immunization of occult lymph node metastases which remained after surgical removal of an intradermally transplanted cavian hepatoma. Guinea pigs that received no postsurgical treatment all died with progressively growing lymph node metastases. The growth of these m...

journal_title：Cancer research

authors： Ashley MP,Zbar B,Hunter JT,Rapp HJ,Sugimoto T

更新日期：1980-11-01 00:00:00

abstract：:Although African-American (AA) patients with prostate cancer tend to develop greater therapeutic resistance and faster prostate cancer recurrence compared with Caucasian-American (CA) men, the molecular mechanisms of this racial prostate cancer disparity remain undefined. In this study, we provide the first comprehens...

journal_title：Cancer research

authors： Kumar R,Bhat TA,Walsh EM,Chaudhary AK,O'Malley J,Rhim JS,Wang J,Morrison CD,Attwood K,Bshara W,Mohler JL,Yadav N,Chandra D

更新日期：2019-04-01 00:00:00

abstract：:The pharmacological properties of garlic and its derivatives are long known, and their underling mechanisms are being extensively investigated. In this study we have addressed the effects of diallyl disulfide (DADS), an oil-soluble garlic molecule, on cell growth of neuroblastoma cell SH-SY5Y, focusing on the redox ev...

journal_title：Cancer research

authors： Filomeni G,Aquilano K,Rotilio G,Ciriolo MR

更新日期：2003-09-15 00:00:00

abstract：:Continued monitoring of a family for new malignant tumors has revealed diverse immunological and neoplastic disorders during a 15-year period. In 1966, the proband developed lymphoma. In 1975, his antibody titers to Epstein-Barr virus (EBV) became elevated, and again, he developed a malignant lymphoma. He also had bor...

journal_title：Cancer research

authors： Purtilo DT,Liao SA,Sakamoto K,Snyder LM,DeFlorio D Jr,Bhawan J,Paquin L,Yang JP,Hutt-Fletcher LM,Muralidharan K,Raffa P,Saemundsen AK,Klein G

更新日期：1981-11-01 00:00:00

abstract：:Verapamil has been shown to enhance immunotoxin activity but only at concentrations that are too high for in vivo use. Therefore, four structural analogues of verapamil (D792, D595, D528, and Sz45) were evaluated for their ability to enhance the in vitro activity of immunotoxins made with either ricin A chain or Pseud...

journal_title：Cancer research

authors： Pirker R,FitzGerald DJ,Raschack M,Frank Z,Willingham MC,Pastan I

更新日期：1989-09-01 00:00:00

abstract：:: Cancer cells in quiescence (G0 phase) are resistant to death, and re-entry of quiescent cancer cells into the cell-cycle plays an important role in cancer recurrence. Here we show that two p53-responsive miRNAs utilize distinct but complementary mechanisms to promote cancer cell quiescence by facilitating stabilizat...

journal_title：Cancer research

authors： La T,Liu GZ,Farrelly M,Cole N,Feng YC,Zhang YY,Sherwin SK,Yari H,Tabatabaee H,Yan XG,Guo ST,Liu T,Thorne RF,Jin L,Zhang XD

更新日期：2018-12-01 00:00:00

abstract：:N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide (NFTA) metabolism was examined in vitro using microsomes prepared from rat liver and renal cortex and from rabbit liver and renal cortex and outer and inner medulla. NFTA nitroreduction was observed with each tissue. Three mol of NADPH were used per mol of NFTA reduced. Sub...

journal_title：Cancer research

authors： Mattammal MB,Zenser TV,Palmier MO,Davis BB

更新日期：1985-01-01 00:00:00

abstract：:PRL-3, an oncogenic dual-specificity phosphatase, is overexpressed in 50% of acute myelogenous leukemia (AML) and associated with poor survival. We found that stable expression of PRL-3 confers cytokine independence and growth advantage of AML cells. However, how PRL-3 mediates these functions in AML is not known. To ...

journal_title：Cancer research

authors： Chong PS,Zhou J,Cheong LL,Liu SC,Qian J,Guo T,Sze SK,Zeng Q,Chng WJ

更新日期：2014-06-01 00:00:00

abstract：:In a study of human breast carcinomas in short-term organ culture, in which plasminogen activator modulation by estrogen was used as a test of estrogen sensitivity (R. Mira-y-Lopez and L. Ossowski, Cancer Res., 47: 3558-3564, 1987), we found that the number of estrogen and progesterone receptor-positive cancers showin...

journal_title：Cancer research

authors： Mira-y-Lopez R,Ossowski L

更新日期：1990-01-01 00:00:00

abstract：:The inactivation of p53 functions enhances the efficiency and decreases the latency of producing induced pluripotent stem cells (iPSC) in culture. The formation of iPSCs in culture starts with a rapid set of cell divisions followed by an epigenetic reprogramming of the DNA and chromatin. The mechanisms by which the p5...

journal_title：Cancer research

authors： Yi L,Lu C,Hu W,Sun Y,Levine AJ

更新日期：2012-11-01 00:00:00

abstract：:Chinese hamster V-79 cells were treated with high cytotoxic or low noncytotoxic concentrations of the highly carcinogenic and mutagenic (-)-(1R,2S,3S,4R)-3,4-dihydroxy-1, 2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene [(-)-B[c]PhDE; fjord-region diol epoxide] or its biologically less active (+)-(1S,2R,3R,4S) enantiome...

journal_title：Cancer research

authors： Wei SJ,Chang RL,Cui XX,Merkler KA,Wong CQ,Yagi H,Jerina DM,Conney AH

更新日期：1996-08-15 00:00:00

abstract：:Metastatic prostate cancer continues to pose a difficult therapeutic challenge. Prostate cancer progression is associated with aberrant O-glycosylation of cancer cell surface receptors, but the functional impact of such events is uncertain. Here we report spontaneous metastasis of human prostate cancer xenografts that...

journal_title：Cancer research

authors： Tsai CH,Tzeng SF,Chao TK,Tsai CY,Yang YC,Lee MT,Hwang JJ,Chou YC,Tsai MH,Cha TL,Hsiao PW

更新日期：2016-10-01 00:00:00

abstract：:Emerging technologies allow broad profiling of the cancer genome for differential DNA methylation relative to benign cells. Herein, bisulfite-modified DNA from lymph nodes with either reactive hyperplasia or follicular lymphoma (FL) were analyzed using a commercial C/UpG genotyping assay. Two hundred fifty-nine differ...

journal_title：Cancer research

authors： Killian JK,Bilke S,Davis S,Walker RL,Killian MS,Jaeger EB,Chen Y,Hipp J,Pittaluga S,Raffeld M,Cornelison R,Smith WI Jr,Bibikova M,Fan JB,Emmert-Buck MR,Jaffe ES,Meltzer PS

更新日期：2009-02-01 00:00:00

abstract：:Murine sarcoma virus (Moloney strain) (MSV-M)-induced tumors are unusual in that they regularly appear less than 2 weeks after virus inoculation, progress for 1 to 2 weeks, and are rejected by normal adult BALB/c mice. Rejectio leaves the animals immune to tumor induction. In the present study, presensitization of nor...

journal_title：Cancer research

authors： Wood GW

更新日期：1976-12-01 00:00:00

abstract：:A transplanted rat lymphosarcoma (SGT-4), induced by Gross virus and inoculated s.c. into the foot of a normal syngeneic rat, initially grew but ultimately regressed. The tumor cells metastasized to the regional popliteal, lumbar, and inguinal lymph nodes and formed massive metastatic foci there. These lymph node meta...

journal_title：Cancer research

authors： Kodama T,Gotohda E,Takeichi N,Kuzumaki N,Kobayashi H

更新日期：1975-07-01 00:00:00

abstract：:Clinical response of liver metastases treated by high-dose intraarterial chemotherapy (HDIAC) delivered via the hepatic artery was predicted by a modification of the human tumor colony-forming assay (HTCFA) originally described by Hamburger and Salmon [Science (Wash. DC), 197:461-463, 1977. In a first set of experimen...

journal_title：Cancer research

authors： Link KH,Aigner KR,Kuehn W,Schwemmle K,Kern DH

更新日期：1986-09-01 00:00:00

abstract：:Angiogenesis is one of the crucial events for cancer development and growth. Two members of the vascular endothelial growth factor (VEGF) family, VEGF-A and placental growth factor (PlGF), which are able to heterodimerize if coexpressed in the same cell, are both required for pathologic angiogenesis. We have generated...

journal_title：Cancer research

authors： Tarallo V,Vesci L,Capasso O,Esposito MT,Riccioni T,Pastore L,Orlandi A,Pisano C,De Falco S

更新日期：2010-03-01 00:00:00

abstract：:In order to determine the potential role of sex steroid and 1,25-dihydroxyvitamin D3 in the spreading of colorectal cancer, previously hypothesized from epidemiological and experimental data, specific androgen (AR, n = 94), estrogen (ER, n = 60), progesterone (PGR, n = 50), and 1,25-dihydroxyvitamin D3 receptors (VDR,...

journal_title：Cancer research

authors： Meggouh F,Lointier P,Saez S

更新日期：1991-02-15 00:00:00

abstract：:Heat stress may enhance the effect of apoptosis-inducing agents in resistant tumor cells. One such agent is the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which has attracted intense interest for its ability to induce apoptosis in tumors without affecting nonmalignant cells. We therefore tested w...

journal_title：Cancer research

authors： Pespeni MH,Hodnett M,Abayasiriwardana KS,Roux J,Howard M,Broaddus VC,Pittet JF

更新日期：2007-03-15 00:00:00

abstract：:Telomerase activity (TA) is detected in most human cancers but, with few exceptions, not in normal somatic cells. Little is known about TA in soft tissue tumors. We have examined a series of benign and malignant soft tissue tumors for TA using the telomerase repeat amplification protocol assay. Analysis of the express...

journal_title：Cancer research

authors： Yan P,Coindre JM,Benhattar J,Bosman FT,Guillou L

更新日期：1999-07-01 00:00:00

abstract：:Although significant advances in radiotherapy have increased its effectiveness in many cancer settings, general strategies to widen the therapeutic window between normal tissue toxicity and malignant tumor destruction would still offer great value. CD47 blockade has been found to confer radioprotection to normal tissu...

journal_title：Cancer research

authors： Soto-Pantoja DR,Terabe M,Ghosh A,Ridnour LA,DeGraff WG,Wink DA,Berzofsky JA,Roberts DD

更新日期：2014-12-01 00:00:00

abstract：:The fate of circulating tumor cells is an important determinant of their ability to form distant metastasis. Here, we demonstrate the use of in vivo flow cytometry as a powerful new method for detecting quantitatively circulating cancer cells. We specifically examine the circulation kinetics of two prostate cancer cel...

journal_title：Cancer research

authors： Georgakoudi I,Solban N,Novak J,Rice WL,Wei X,Hasan T,Lin CP

更新日期：2004-08-01 00:00:00

abstract：:Polyglutamyl derivatives of methotrexate (MTX) and 10-deazaaminopterin (10-DAM) containing a total of one through six glutamate residues (Glu residues) were tested as inhibitors of dihydrofolate reductase (DHFR) derived from sheep, chicken, and beef liver. The ability of dihydropteroylpentaglutamate to antagonize the ...

journal_title：Cancer research

authors： Kumar P,Kisliuk RL,Gaumont Y,Nair MG,Baugh CM,Kaufman BT

更新日期：1986-10-01 00:00:00