Abstract：
:In the present study, we examined the role of prolactin and glucocorticoids in regulating bcl-x transcription in mammary epithelial cells. We report that dexamethasone, but not prolactin, induced native bcl-x gene expression in a dose-dependent manner in HC11 cells and enhanced serum-starved HC11 cell survival. This effect was mediated through the glucocorticoid receptor and independent of STAT-5 activity. We propose that the mechanism through which glucocorticoids enhance mammary epithelial cell survival is by increasing steady-state levels of bcl-xL, RNA.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Schorr K,Furth PAsubject
Has Abstractpub_date
2000-11-01 00:00:00pages
5950-3issue
21eissn
0008-5472issn
1538-7445journal_volume
60pub_type
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