Abstract：
:L-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-beta]thiazole hydrochloride (LMS), when used in concert with 1,3-bis(2-chloroethyl)-1-nitrosourea, resulted in a significantly higher percentage of long-term leukemic-free survivors. The additive effect provided by LMS treatment was evident during the immunosuppressed period induced by 1,3-bis(2-chloroethyl)-1-nitrosourea treatment and when tumor load was minimal. Treatment with LMS alone did not appear to possess any significant antitumor effect. The beneficial effect of LMS treatment may be attributable to the immunostimulatory activity reported for this drug. LMS appears to possess characteristics that make it an excellent candidate for use as an immunostimulant in cancer combined modality treatment.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Chirigos MA,Fuhrman F,Pryor Jsubject
Has Abstractpub_date
1975-04-01 00:00:00pages
927-31issue
4eissn
0008-5472issn
1538-7445journal_volume
35pub_type
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