Abstract：
:Antibodies to formalin-fixed, syngeneic melanoma cells were prepared in mice, purified by immunoaffinity chromatography, and tested for binding activity to viable melanoma cells. The radiolabeled antibodies detected congruent to 9 X 10(6) melanoma antigenic sites/cell. The calculated average association constant (Ka) for the antibody population was 7 to 10 X 10(7) M-1. The antibody was shown to block the binding of melanocyte-stimulating hormone in competitive cell surface binding studies. Results are discussed conceptually in terms of the potentially important role that the humoral immune response may play in the phenomenon of tumor progression.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Winkelhake JL,Elcombe BM,Hodach Asubject
Has Abstractpub_date
1979-08-01 00:00:00pages
3058-64issue
8eissn
0008-5472issn
1538-7445journal_volume
39pub_type
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