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Association of DNA methylation of phosphoserine aminotransferase with response to endocrine therapy in patients with recurrent breast cancer.

Abstract：

:To understand the biological basis of resistance to endocrine therapy is of utmost importance in patients with steroid hormone receptor-positive breast cancer. Not only will this allow us prediction of therapy success, it may also lead to novel therapies for patients resistant to current endocrine therapy. DNA methylation in the promoter regions of genes is a prominent epigenetic gene silencing mechanism that contributes to breast cancer biology. In the current study, we investigated whether promoter DNA methylation could be associated with resistance to endocrine therapy in patients with recurrent breast cancer. Using a microarray-based technology, the promoter DNA methylation status of 117 candidate genes was studied in a cohort of 200 steroid hormone receptor-positive tumors of patients who received the antiestrogen tamoxifen as first-line treatment for recurrent breast cancer. Of the genes analyzed, the promoter DNA methylation status of 10 genes was significantly associated with clinical outcome of tamoxifen therapy. The association of the promoter hypermethylation of the strongest marker, phosphoserine aminotransferase (PSAT1) with favorable clinical outcome was confirmed by an independent quantitative DNA methylation detection method. Furthermore, the extent of DNA methylation of PSAT1 was inversely associated with its expression at the mRNA level. Finally, also at the mRNA level, PSAT1 was a predictor of tamoxifen therapy response. Concluding, our work indicates that promoter hypermethylation and mRNA expression of PSAT1 are indicators of response to tamoxifen-based endocrine therapy in steroid hormone receptor-positive patients with recurrent breast cancer.

journal_name

Cancer Res

journal_title

Cancer research

authors

Martens JW,Nimmrich I,Koenig T,Look MP,Harbeck N,Model F,Kluth A,Bolt-de Vries J,Sieuwerts AM,Portengen H,Meijer-Van Gelder ME,Piepenbrock C,Olek A,Höfler H,Kiechle M,Klijn JG,Schmitt M,Maier S,Foekens JA

doi

10.1158/0008-5472.CAN-05-0064

subject

Has Abstract

pub_date

2005-05-15 00:00:00

pages

4101-17

issue

10

eissn

0008-5472

issn

1538-7445

pii

65/10/4101

journal_volume

65

pub_type

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